What Does the Latest Research Tell Us About Endo Belly and the Microbiome of People With Endo?

Today’s episode is a brief introduction to the mystery of the endo belly in the luteal phase, and some pointers to get you started. References1) https://www.mdpi.com/2077-0383/12/22/7176#B44-jcm-12-071762) https://pmc.ncbi.nlm.nih.gov/articles/PMC9150547/3) Irritable Bowel Syndrome and the Menstrual Cycle - PubMed, Change in bowel habits during menstruation: are IBD patients different? - PubMed4) https://www.ahajournals.org/doi/10.1161/hypertensionaha.107.107136, https://pmc.ncbi.nlm.nih.gov/articles/PMC3154522/, https://pmc.ncbi.nlm.nih.gov/articles/PMC3984489/5) https://pmc.ncbi.nlm.nih.gov/articles/PMC4527267/, https://pmc.ncbi.nlm.nih.gov/articles/PMC7883586/, https://pmc.ncbi.nlm.nih.gov/articles/PMC3901893/PodcastsFlax oestrogen metabolismFlax constipationImproving progesteroneKiwis for constipationMagnesium citrateGingerPeppermintNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

If you want to learn more about the root causes of endo belly and IBS in the endo demographic, and you’re keen to understand the SIBO, MCAS, POTS and hEDS connection too, I am running a free workshop on Thursday July 23rd, 6pm British Summer time, live on Zoom. If you can’t attend it live, you’ll be able to watch the replay. You’ll learn what the emerging evidence is showing us about endometriosis and the gut microbiome, some of the key root causes behind endo belly, co-conditions to look out for, and what kind of treatments you might need to consider.  To sign up, go to: https://www.theendobellycoach.com/free-endo-belly-workshop and I’ve put the link in my show notes.References1) https://journals.lww.com/co-gastroenterology/fulltext/2025/11000/modern_concepts_of_small_intestinal_bacterial.5.aspx2) https://www.gastrojournal.org/article/S0016-5085(19)38954-1/pdf, https://pmc.ncbi.nlm.nih.gov/articles/PMC3607857/, https://pubmed.ncbi.nlm.nih.gov/29915215/3) Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights - PubMed4) https://pubmed.ncbi.nlm.nih.gov/39959963/5) Endometriosis and irritable bowel syndrome: A systematic review and meta-analyses - PMC, https://pubmed.ncbi.nlm.nih.gov/32949284/, https://pubmed.ncbi.nlm.nih.gov/32004880/, https://pmc.ncbi.nlm.nih.gov/articles/PMC10316551/, https://pubmed.ncbi.nlm.nih.gov/18715239/6) The relationship between small intestinal bacterial overgrowth and irritable bowel syndrome - PubMed, Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study - PubMed, The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: relationship with irritable bowel syndrome - PubMed, Irritable bowel syndrome and small intestinal bacterial overgrowth: meaningful association or unnecessary hype - PubMed7) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://www.mdpi.com/2076-2607/11/8/20898) https://pubmed.ncbi.nlm.nih.gov/39990556/9) https://pmc.ncbi.nlm.nih.gov/articles/PMC3413773/10) https://pubmed.ncbi.nlm.nih.gov/21840904/, https://pubmed.ncbi.nlm.nih.gov/40262193/11) https://pubmed.ncbi.nlm.nih.gov/39990556/12) https://www.theendobellycoach.com/podcast/mcas-and-endo-belly, https://www.theendobellycoach.com/podcast/what-does-mcas-have-to-do-with-endo?rq=MCAS13) https://journals.lww.com/ajg/fulltext/2016/10001/gastrointestinal__gi__disease_burden_in_patients.566.aspx‍ ‍Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

A couple of months back I did an episode on mast cells, MCAS and endometriosis - so, if you haven’t listened to that episode, it’s a short one, and I would listen to it to get you up to speed on what mast cells are and their function, what MCAS is and what the connection is to endo.Today, we are talking about how MCAS, or even just mast cells, could be contributing to your endo belly, IBS and/or SIBO.If you want to learn more about the root causes of endo belly and IBS in the endo demographic, and you’re keen to understand the SIBO, MCAS, POTS and hEDS connection too, I am running a free workshop on Thursday July 23rd, 6pm British Summer time, live on Zoom. If you can’t attend it live, you’ll be able to watch the replay. You’ll learn what the emerging evidence is showing us about endometriosis and the gut microbiome, some of the key root causes behind endo belly, co-conditions to look out for, and what kind of treatments you might need to consider.  To sign up, go to: https://www.theendobellycoach.com/free-endo-belly-workshop and I’ve put the link in my show notes.References1) https://pubmed.ncbi.nlm.nih.gov/24286351/2) https://www.sciencedirect.com/science/article/pii/S2666379124005275, https://pmc.ncbi.nlm.nih.gov/articles/PMC4819856/, https://jgld.ro/jgld/index.php/jgld/article/view/229, https://onlinelibrary.wiley.com/doi/10.1111/nmo.143393) https://sa1s3.patientpop.com/assets/docs/295890.pdf4) https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2036.2011.04684.x5) https://pubmed.ncbi.nlm.nih.gov/9287964/6) https://pubmed.ncbi.nlm.nih.gov/19596012/7) https://pubmed.ncbi.nlm.nih.gov/14988823/8) Evidence for mast cell activation in patients with therapy-resistant irritable bowel syndrome - PubMed9) Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life - PubMed10) https://www.scivisionpub.com/pdfs/small-intestinal-bacterial-overgrowth-is-common-in-mast-cell-activation-syndrome-1371.pdf, https://sa1s3.patientpop.com/assets/docs/295890.pdf11) https://sa1s3.patientpop.com/assets/docs/295890.pdf12) https://www.scivisionpub.com/pdfs/small-intestinal-bacterial-overgrowth-is-common-in-mast-cell-activation-syndrome-1371.pdf, https://sa1s3.patientpop.com/assets/docs/295890.pdf, The Suggested Relationships Between Common GI Symptoms and Joint Hypermobility, POTS, and MCAS - PMC13) https://pmc.ncbi.nlm.nih.gov/articles/PMC9102523/Podcast linkshttps://www.theendobellycoach.com/podcast/what-does-mcas-have-to-do-with-endohttps://www.theendobellycoach.com/podcast/lipopolysaccharides-endo-pain-growthNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

As I am still recovering from covid, today’s episode is a short bite sized episode looking at what the recent research is telling us about the endo belly and the gut microbiome of people with endo. References1) https://pmc.ncbi.nlm.nih.gov/articles/PMC10316551/2) https://pubmed.ncbi.nlm.nih.gov/28303579/3) Endometriosis and irritable bowel syndrome: A systematic review and meta-analyses - PMC4) https://pubmed.ncbi.nlm.nih.gov/32949284/, https://pubmed.ncbi.nlm.nih.gov/32004880/, https://pmc.ncbi.nlm.nih.gov/articles/PMC10316551/5) https://pubmed.ncbi.nlm.nih.gov/18715239/6) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/7) https://www.mdpi.com/2076-2607/11/8/20898) https://www.mdpi.com/2077-0383/12/22/7176#B44-jcm-12-07176Podcast linksBeta-glucuronidase:https://www.theendobellycoach.com/podcast/sibo-gut-dysbiosis-elevated-oestrogenShort chain fatty acids:https://www.theendobellycoach.com/podcast/endometriosis-short-chain-fatty-acidshttps://www.theendobellycoach.com/podcast/endometriosis-propionate-acetatehttps://www.theendobellycoach.com/podcast/endometriosis-butyrateTools and treatments:https://www.theendobellycoach.com/podcast/phgg-endo-belly-sibo-ibshttps://www.theendobellycoach.com/podcast/endometriosis-ibs-psyllium-huskhttps://www.theendobellycoach.com/podcast/kiwis-for-constipationhttps://www.theendobellycoach.com/podcast/flax-chia-constipationNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Antibiotics, understandably, have a bad reputation because of how much they’ve been overused in the past few decades, and the impact that has had on our gut microbiomes and overall health, not to mention, resistance development.So, when it comes to antibiotics for SIBO, most of my clients are initially hesitant to consider them, and will typically opt for antimicrobial herbs instead.However, there are some potential benefits of antibiotics for endometriosis, so I thought it was worth sharing these with you, so that if you find yourself having to treat SIBO, you can make an informed decision about which path you’d like to take.References1) Dr Siebecker estimates, in course: https://siboprocourse.siboinfo.com/?ref=15748-Allison-Siebecker2) https://www.siboinfo.com/antibiotics.html3)  https://pmc.ncbi.nlm.nih.gov/articles/PMC5299503/, https://www.cghjournal.org/article/S1542-3565(09)01331-7/fulltext4) https://pmc.ncbi.nlm.nih.gov/articles/PMC5299503/, https://www.cghjournal.org/article/S1542-3565(09)01331-7/fulltext, https://www.siboinfo.com/antibiotics.html5) https://pubmed.ncbi.nlm.nih.gov/24788320/, https://pubmed.ncbi.nlm.nih.gov/19996983/, https://www.siboinfo.com/antibiotics.html6) https://pubmed.ncbi.nlm.nih.gov/29574688/, https://www.siboinfo.com/antibiotics.html7) https://pubmed.ncbi.nlm.nih.gov/28078798/ , https://pubmed.ncbi.nlm.nih.gov/26780631/,  https://www.siboinfo.com/sibo-antibiotics.html, https://pubmed.ncbi.nlm.nih.gov/19243285/8) https://pubmed.ncbi.nlm.nih.gov/24788320/, https://pubmed.ncbi.nlm.nih.gov/19996983/, https://www.siboinfo.com/antibiotics.html, https://pubmed.ncbi.nlm.nih.gov/29574688/, https://www.siboinfo.com/antibiotics.html9) https://www.triosmartbreath.com/intestinal-sulfide-overproduction, https://pubmed.ncbi.nlm.nih.gov/9558280/10) https://www.sciencedirect.com/org/science/article/pii/S263383862400004611) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://www.mdpi.com/2076-2607/11/8/208912) https://pmc.ncbi.nlm.nih.gov/articles/PMC6554192/13) https://www.sciencedirect.com/science/article/pii/S0002937824007506#bib2614) https://academic.oup.com/humrep/article/39/Supplement_1/deae108.658/770380215) https://pubmed.ncbi.nlm.nih.gov/21806984/, https://pubmed.ncbi.nlm.nih.gov/20816942/, https://pmc.ncbi.nlm.nih.gov/articles/PMC2957776/, 16) https://pmc.ncbi.nlm.nih.gov/articles/PMC10855755/17)  https://pmc.ncbi.nlm.nih.gov/articles/PMC5543406/18) https://www.theendobellycoach.com/podcast/lipopolysaccharides-endo-pain-growth19) https://pubmed.ncbi.nlm.nih.gov/21806984/, https://pmc.ncbi.nlm.nih.gov/articles/PMC11617758/, https://pmc.ncbi.nlm.nih.gov/articles/PMC5543406/20) https://pubmed.ncbi.nlm.nih.gov/20852272/, https://pubmed.ncbi.nlm.nih.gov/12120885/, https://pubmed.ncbi.nlm.nih.gov/25244596/, https://pubmed.ncbi.nlm.nih.gov/30555323/, 21) https://pmc.ncbi.nlm.nih.gov/articles/PMC10458414/, https://www.sciencedirect.com/org/science/article/pii/S2633838624000046Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet. Get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today I want to talk about lipopolysaccharides and their role in endo growth and pain.References1) https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1363455/full2) Bacterial contamination hypothesis: a new concept in endometriosis - PMC, Evaluation of microecological therapy in endometriosis through modulation of the gut microbiota | European Journal of Medical Research3) Bacterial contamination hypothesis: a new concept in endometriosis - PMC, Significant increased isolation of Escherichia coli in Iranian women with endometriosis: a case control – study - PMC, The bidirectional relationship between endometriosis and microbiome - PMC4) Bacterial contamination hypothesis: a new concept in endometriosis - PMC, The process of microbial translocation - PubMed5) https://pmc.ncbi.nlm.nih.gov/articles/PMC7033038/6) https://link.springer.com/article/10.1007/s10620-005-2574-07) https://pubmed.ncbi.nlm.nih.gov/21070397/, https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1505834/full, https://pmc.ncbi.nlm.nih.gov/articles/PMC9101724/8) https://pubmed.ncbi.nlm.nih.gov/19148789/9) https://pmc.ncbi.nlm.nih.gov/articles/PMC10954893/, https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1380713/full10) https://celiac.org/2024/04/25/new-research-shows-higher-risk-of-reproductive-disorders-for-women-with-celiac-disease/, https://pmc.ncbi.nlm.nih.gov/articles/PMC3988867/, https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/283195311) https://pmc.ncbi.nlm.nih.gov/articles/PMC12030604/12) Modern concepts of small intestinal bacterial overgrowth13) https://link.springer.com/article/10.1186/s40001-025-03334-4, https://pmc.ncbi.nlm.nih.gov/articles/PMC11370979/, https://pmc.ncbi.nlm.nih.gov/articles/PMC5902457/, https://link.springer.com/article/10.1186/s40001-025-03334-414) https://pubmed.ncbi.nlm.nih.gov/20511671/15) https://academic.oup.com/humrep/article-abstract/27/12/3417/65278216) https://link.springer.com/article/10.1186/s40001-025-03334-417) https://www.theendobellycoach.com/podcast/phgg-endo-belly-sibo-ibs18) https://pmc.ncbi.nlm.nih.gov/articles/PMC5740511/, https://pmc.ncbi.nlm.nih.gov/articles/PMC9645259/, https://www.mdpi.com/1422-0067/26/24/12021, https://www.imrpress.com/journal/FBL/31/1/10.31083/FBL4552419) https://www.theendobellycoach.com/podcast/probiotics-for-sibo-treatment, https://www.theendobellycoach.com/podcast/sibo-endometriosis-and-interstitial-cystitis-connection-wth-dr-allison-siebecker, https://www.theendobellycoach.com/podcast/endo-belly-endometriosis-how-to-treat-sibo-ibs-allison-siebecker Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today I want to talk very briefly on endo belly and IBS symptoms, and the three SIBO type gases and the specific symptoms they can cause, so that you can look for clues as to whether SIBO is behind your gut issues.References:https://pubmed.ncbi.nlm.nih.gov/29228433/, https://pubmed.ncbi.nlm.nih.gov/12591062/, https://pubmed.ncbi.nlm.nih.gov/22262197/, https://pubmed.ncbi.nlm.nih.gov/24627585/(https://www.youtube.com/watch?v=daNnGb-dnmM , https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234906, https://pubmed.ncbi.nlm.nih.gov/21286935/, https://eposters.ddw.org/ddw/2022/ddw-2022/354401/maria.jesus.villanueva-millan.comprehensive.characterization.of.the.html)https://pubmed.ncbi.nlm.nih.gov/21286935/https://www.siboinfo.com/what-is-sibo.htmlhttps://pubmed.ncbi.nlm.nih.gov/39959963/Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

LDN stands for low dose naltrexone. It is an immune modulating drug that also regulates the body’s pain relief system.It is non-addictive and safe, but it can come with side effects, so we’ll get to that - as thankfully, they can be reduced or eradicated entirely.Low-dose naltrexone works in two ways: it blocks opioid receptors which forces the body to increase its levels of other natural pain relieving chemicals, like endorphins.  But it also calms down immune cells in the brain called microglia. When these cells are overactive, they release inflammatory chemicals like cytokines that can drive symptoms like pain, fatigue, poor sleep, and brain fog, but are also heavily involved in endometriosis, so by dampening this response, LDN may help reduce inflammation-related symptoms in chronic inflammatory pain conditions.References:https://pmc.ncbi.nlm.nih.gov/articles/PMC3962576/https://www.gidoctor.net/wp-content/uploads/2024/11/1291965.pdf, https://pubmed.ncbi.nlm.nih.gov/17539894/, https://www.siboinfo.com/sibo-prevention.htmlhttps://www.gidoctor.net/wp-content/uploads/2024/11/1291965.pdfhttps://ldnresearchtrust.org/can-ldn-help-mast-cell-activation-syndrome-mcas, Does Low Dose Naltrexone help with Mast Cell Activation or Allergic or Histamine Reactions? | LDN Research Trust, Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment | BMJ Case ReportsComorbidity analysis and clustering of endometriosis patients using electronic health records - PubMedhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10039621/https://pubmed.ncbi.nlm.nih.gov/33228882/https://ldnresearchtrust.org/conditions, https://ldnresearchtrust.org/hashimoto-thyroiditis-and-low-dose-naltrexone-ldn-paula-johnsonhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7528597/https://www.siboinfo.com/what-causes-sibo.html, Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth - PubMed, Development and Validation of a Biomarker for Diarrhea-Predominant Irritable Bowel Syndrome in Human Subjects | PLOS One, Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model - PubMedNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

There are several reasons why SIBO and gut dysbiosis can influence endo growth, but today, I want to talk about just one of them, and that’s β-glucuronidase. References:1) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/2)  https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/3) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1402-6431, https://pmc.ncbi.nlm.nih.gov/articles/PMC3768652/4) https://pubmed.ncbi.nlm.nih.gov/33839907/5) https://academic.oup.com/humupd/article/28/1/92/6412766, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261362, https://www.mdpi.com/1422-0067/24/22/16301, https://www.mdpi.com/1467-3045/47/7/502, https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1363455/full, https://www.mdpi.com/2077-0383/12/22/71766) https://www.fertstert.org/article/S0015-0282(23)00241-8/fulltext7) https://www.mdpi.com/2077-0383/12/22/7176, https://academic.oup.com/humupd/article/28/1/92/6412766, https://www.maturitas.org/article/S0378-5122(17)30650-3/fulltext, https://e-jmm.org/pdf/10.6118/jmm.240248) https://www.researchgate.net/publication/222032497_Dietary_fiber_and_activity_of_intestinal_tissue_ss-glucuronidase_in_rats, https://www.clinicalnutritionopenscience.com/article/S2667-2685(25)00039-7/pdf, https://pmc.ncbi.nlm.nih.gov/articles/PMC2858007/9) https://pmc.ncbi.nlm.nih.gov/articles/PMC6474371/,  https://pubmed.ncbi.nlm.nih.gov/17474873/, https://www.clinicalnutritionopenscience.com/article/S2667-2685(25)00039-7/pdf, https://www.sciencedirect.com/science/article/abs/pii/S027153171500315210) https://www.sciencedirect.com/science/article/pii/S0022316622105158, https://www.cancernetwork.com/view/high-fat-diet-not-associated-increased-estrogen-postmenopausal-women11) https://www.clinicalnutritionopenscience.com/article/S2667-2685(25)00039-7/pdf12) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/, https://pubmed.ncbi.nlm.nih.gov/32249416/13) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/14) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/15) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/, https://pubmed.ncbi.nlm.nih.gov/33733438/, https://www.sciencedirect.com/science/article/pii/S014181301939277316) https://pubmed.ncbi.nlm.nih.gov/12197785/, https://pubmed.ncbi.nlm.nih.gov/2346674/17) https://pubmed.ncbi.nlm.nih.gov/33733438/18) https://www.sciencedirect.com/science/article/abs/pii/S0308814623016242, https://www.theendobellycoach.com/podcast/phgg-endo-belly-sibo-ibs19) https://www.tandfonline.com/doi/pdf/10.1271/bbb.58.136420) https://journals.lww.com/co-gastroenterology/fulltext/2025/11000/modern_concepts_of_small_intestinal_bacterial.5.aspx21) https://www.monashfodmap.com/blog/getting-enough-fibre/23) https://www.theendobellycoach.com/podcast/low-fodmap-diet-endometriosis, https://www.theendobellycoach.com/podcast/low-fodmap-diet-endometriosis-siboNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA - You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

This week on the podcast I want to do a mini episode on improving your progesterone to oestrogen ratio in the luteal phase. And the reason being is that I track a lot of my client’s hormones with Mira, which is an at home hormone tracker, and I frequently see higher oestrogen levels and lower progesterone levels in the luteal phase.References:1) https://academic.oup.com/jcem/article-abstract/77/5/1215/26499612) https://pmc.ncbi.nlm.nih.gov/articles/PMC4700980/3) https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-e/4) https://www.fertstert.org/article/s0015-0282(0300657-5/5) https://rbej.biomedcentral.com/articles/10.1186/s12958-023-01126-1, https://www.mdpi.com/2072-6643/15/12/2773, https://onlinelibrary.wiley.com/doi/full/10.1155/2021/5529741, https://pmc.ncbi.nlm.nih.gov/articles/PMC3484190/Oxidative stress episodes:https://www.theendobellycoach.com/podcast/what-is-oxidative-stress?https://www.theendobellycoach.com/podcast/endo-early-perimenopause-menopause?https://www.theendobellycoach.com/podcast/lower-oxidative-stress-strategiesAffiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFENeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coaching⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠