How SIBO and IBS Could Be the Root Cause of Your Interstitial Cystitis

Today I want to talk about Ehlers-Danlos syndrome and the hypermobility spectrum disorders, and how they may be contributing to your endo belly, IBS and/or SIBOReferences1) https://www.ehlers-danlos.com/what-is-eds/2) https://www.ehlers-danlos.com/what-is-hsd/3) https://pubmed.ncbi.nlm.nih.gov/28145606/4) https://pubmed.ncbi.nlm.nih.gov/39990556/ 5) https://jchr.org/index.php/JCHR/article/view/53636) https://sibosos.com/joint-hypermobility-syndromes-an-important-underlying-cause-of-recurrent-sibo-with-dr-alena-guggenheim/ 7) Higher prevalence of joint hypermobility in constipation predominant irritable bowel syndrome - PubMed8) S0476 High Prevalence of Methane Predominant Small Bowel Bacterial Overgrowth and Constipation in Patients With Hypermobile Ehlers-Danlos Syndrome9) Severe Gastrointestinal Dysmotility in Patients With Ehlers-Danlos Syndrome: Case Series - 1 Center Experience10) S3153 Hypermobile Ehlers-Danlos Syndrome and Visceroptosis, Visceroptosis and the Ehlers-Danlos Syndrome - PMC11) ​​https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.64182, https://www.dovepress.com/the-investigation-and-management-of-the-abdominopelvic-vascular-compre-peer-reviewed-fulltext-article-VHRM12) Pelvic Congestion Syndrome: The Gynecological Perspective - PMC, https://pubmed.ncbi.nlm.nih.gov/27177709/13) https://pmc.ncbi.nlm.nih.gov/articles/PMC9810002/ 14)https://www.theendobellycoach.com/podcast/delayed-gastric-emptying-endo-sibo-gastroparesis, https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/full#ref30Podcast episodeshttps://www.theendobellycoach.com/podcast/endometriosis-and-ehlers-danlos-syndromehttps://www.theendobellycoach.com/podcast/delayed-gastric-emptying-endo-sibo-gastroparesishttps://www.theendobellycoach.com/podcast/endo-eds-adhdhttps://www.theendobellycoach.com/podcast/low-fodmap-diet-endometriosis-pots-edshttps://www.theendobellycoach.com/podcast/sibo-relapse-endometriosishttps://www.theendobellycoach.com/podcast/endo-adhd-linkhttps://www.theendobellycoach.com/podcast/pelvic-congestion-syndrome-endometriosis-dr-alexis-cutchinsClinicsThe London Hypermobility Unit (UK)Dr Ahmed (UK)Dr Alexis Cutchins(USA)ChroniusCare (USA)The EDS Clinic (USA)Compression SyndromesInterview with Dr Alexis CutchinsSMA syndromeMALSMay-Thurner syndromeNutcracker syndromeNeed more help or want to learn how to work with me?Ways to work with me:⁠One toone coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Please note - due to graphs and example images, this podcast might be best consumed as the original video here: https://youtu.be/z04DCzoSgxYThis week on the podcast I am interview Rose Mackenzie, Clinical Manager behind Mira, the hormone monitor that I use with clients, to discuss tracking and understanding your hormonal patterns.I use Mira with my clients to:Identify what their hormones are up to when their endo symptoms are at their worst.Identify whether my clients are in perimenopause or menopause and what stage.Track and manage PMOS.Help clients with their fertility journey.And even identify if hormone fluctuations make their co-conditions (like MCAS and POTS) worse.In this episode, Rose and I will be covering:What is the Mira, how does it work, what is the validity of the testing and how does it compare to the hormone tests we can get at the doctor's surgery? How can we use it?How might the Mira be helpful for tracking endo symptoms and what might be influencing them?How can we use Mira to monitor perimenopause and/or menopause? What patterns are we looking for?How can we use Mira for monitoring PMOS (a co-condition of endo)?How can we use Mira for fertility?Are there any co-conditions of endo that we could monitor with Mira?You don’t have to have a Mira or want to buy one to benefit from this conversation. We’re going to be talking about hormones in endo, peri, PMOS and more, and discussing what patterns, signs and symptoms to look for when identifying hormone issues.However, if you do want to purchase one after listing to this episode, use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

A while back I did an episode on Postural Orthostatic Tachycardia Syndrome and Dysautonomia and its connection to endometriosis.If you haven’t listened to that episode, I’ve linked it in the show notes.Today I want to do a short episode on how POTS may be connected to your endo belly and IBS symptoms.References1) Gastrointestinal (GI) Disease Burden in Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Abnormalities Found on High-Resolution Motility Testing: 566, Managing gastrointestinal manifestations in patients with PoTS: a UK DGH experience - The British Journal of Cardiology, Gastrointestinal Symptoms in Postural Tachycardia Syndrome: a Systematic Review - PMC2) https://pmc.ncbi.nlm.nih.gov/articles/PMC7282488/3) Severe Gastrointestinal Dysmotility in Patients With Ehlers-Danlos Syndrome: Case Series - 1 Center Experience, Prevalence and Predictors of Gastrointestinal Dysmotility in Patients with Hypermobile Ehlers-Danlos Syndrome: A Tertiary Care Center Experience - PMC, Gastrointestinal problems in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders, An overview of Ehlers Danlos syndrome and the link between postural orthostatic tachycardia syndrome and gastrointestinal symptoms with a focus on gastroparesis4) https://pmc.ncbi.nlm.nih.gov/articles/PMC7255528/ , https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/, https://pubmed.ncbi.nlm.nih.gov/26376608/, https://assets.cureus.com/uploads/original_article/pdf/30528/1612430138-1612430130-20210204-18203-dyitxb.pdf5) https://www.ncbi.nlm.nih.gov/books/NBK470542/ , https://www.mayoclinic.org/diseases-conditions/dumping-syndrome/symptoms-causes/syc-20371915 , https://gutscharity.org.uk/advice-and-information/conditions/dumping-syndrome/6) https://journals.lww.com/ajg/fulltext/2016/10001/gastrointestinal__gi__disease_burden_in_patients.566.aspx7) https://www.autonomicneuroscience.com/article/S1566-0702(18)30015-8/fulltextPodcasts Delayed gastric emptyingLow FODMAP diet and endometriosisLow FODMAP diet and POTSPOTS 101ClinicsDr Gall(UK)Dr Alexis Cutchins(USA)ChroniusCare (USA)The EDS Clinic (USA)Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

So today marks the 400th This EndoLife episode! But it occurred to me that my first full episode on SIBO was episode 90! So for some of you, you may wonder why it’s such a big deal in my mind for people with endo. So I wanted to share some of the ways that SIBO can affect our endo symptoms, outside of the usual endo belly issues. References(1) https://pubmed.ncbi.nlm.nih.gov/39959963/2) Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights - PubMed3) https://pmc.ncbi.nlm.nih.gov/articles/PMC5056566/4) https://pubmed.ncbi.nlm.nih.gov/21868492/,https://www.sciencedirect.com/science/article/abs/pii/S03012115140029915) https://www.theendobellycoach.com/podcast/how-the-brain-increases-endo-pain-and-how-pelvic-pain-becomes-chronic-with-christie-uipi-of-curable?rq=christie6) https://www.theendobellycoach.com/podcast/lipopolysaccharides-endo-pain-growth7) https://pubmed.ncbi.nlm.nih.gov/20087090/, https://pmc.ncbi.nlm.nih.gov/articles/PMC6326213/, https://pubmed.ncbi.nlm.nih.gov/33973308/8) https://www.sciencedirect.com/science/article/pii/S0031938421000391, https://pubmed.ncbi.nlm.nih.gov/18422970/, https://journals.lww.com/ajg/fulltext/2020/02000/acg_clinical_guideline__small_intestinal_bacterial.9.aspx, https://pmc.ncbi.nlm.nih.gov/articles/PMC3607857/, https://journals.lww.com/ctg/fulltext/2018/06000/Brain_fogginess,_gas_and_bloating__a_link_between.6.aspx?ref=podcastdisclosed.com9)https://youtu.be/daNnGb-dnmM?si=S0ofly2WWYjSZZm010) https://pubmed.ncbi.nlm.nih.gov/39990556/11)https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(25)00111-6/abstract, https://pmc.ncbi.nlm.nih.gov/articles/PMC7203274/, https://pmc.ncbi.nlm.nih.gov/articles/PMC5440042/12) https://journals.lww.com/ajg/fulltext/2020/02000/acg_clinical_guideline__small_intestinal_bacterial.9.aspxNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today I want to talk briefly about the possible connection between endo, SIBO, IBS and UTIs. Now this could be a deep dive episode but I am giving you some of the top lines and the most recent research, and I’ve put a few links to more detailed episodes in the show notes.References1) https://pubmed.ncbi.nlm.nih.gov/39990556/2) Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights - PubMed, https://pubmed.ncbi.nlm.nih.gov/39959963/3) https://pubmed.ncbi.nlm.nih.gov/17932763/4) https://pubmed.ncbi.nlm.nih.gov/33620539/5) The relationship between small intestinal bacterial overgrowth and irritable bowel syndrome - PubMed6) Urinary Tract Infections Caused by Klebsiella pneumoniae and Prolonged Treatment with Trimethoprim/Sulfamethoxazole - PMC7) https://journals.lww.com/co-gastroenterology/fulltext/2025/11000/modern_concepts_of_small_intestinal_bacterial.5.aspx8) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://pmc.ncbi.nlm.nih.gov/articles/PMC8688745/9) https://uqora.com/blogs/urinary-tract-infections/biofilms-recurrent-utis10) https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.711746/full, https://www.sciencedirect.com/science/article/pii/S2405456925000082#b003011) https://www.nhs.uk/conditions/urinary-tract-infections-utis/12) https://pubmed.ncbi.nlm.nih.gov/17932763/13) https://www.theendobellycoach.com/podcast/lipopolysaccharides-endo-pain-growth14) https://pmc.ncbi.nlm.nih.gov/articles/PMC12030604/15)  https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1363455/full, Bacterial contamination hypothesis: a new concept in endometriosis - PMC, Evaluation of microecological therapy in endometriosis through modulation of the gut microbiota | European Journal of Medical Research16) https://pubmed.ncbi.nlm.nih.gov/8284844/, https://link.springer.com/article/10.1007/s00192-025-06213-yPodcastshttps://www.theendobellycoach.com/podcast/utis-endohttps://www.theendobellycoach.com/podcast/root-causes-of-bladder-pain-with-endometriosishttps://www.theendobellycoach.com/podcast/how-your-nervous-system-affects-interstitial-cystitis-and-endo-painhttps://www.theendobellycoach.com/podcast/new-ic-subtypeshttps://www.theendobellycoach.com/podcast/nutrition-bladder-pain-brianne-thorntonhttps://www.theendobellycoach.com/podcast/ic-sibo-endo-connectionhttps://www.theendobellycoach.com/podcast/diet-and-natural-treatment-options-for-interstitial-cystitis-and-bladder-painNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today’s episode is a brief introduction to the mystery of the endo belly in the luteal phase, and some pointers to get you started. References1) https://www.mdpi.com/2077-0383/12/22/7176#B44-jcm-12-071762) https://pmc.ncbi.nlm.nih.gov/articles/PMC9150547/3) Irritable Bowel Syndrome and the Menstrual Cycle - PubMed, Change in bowel habits during menstruation: are IBD patients different? - PubMed4) https://www.ahajournals.org/doi/10.1161/hypertensionaha.107.107136, https://pmc.ncbi.nlm.nih.gov/articles/PMC3154522/, https://pmc.ncbi.nlm.nih.gov/articles/PMC3984489/5) https://pmc.ncbi.nlm.nih.gov/articles/PMC4527267/, https://pmc.ncbi.nlm.nih.gov/articles/PMC7883586/, https://pmc.ncbi.nlm.nih.gov/articles/PMC3901893/PodcastsFlax oestrogen metabolismFlax constipationImproving progesteroneKiwis for constipationMagnesium citrateGingerPeppermintNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

If you want to learn more about the root causes of endo belly and IBS in the endo demographic, and you’re keen to understand the SIBO, MCAS, POTS and hEDS connection too, I am running a free workshop on Thursday July 23rd, 6pm British Summer time, live on Zoom. If you can’t attend it live, you’ll be able to watch the replay. You’ll learn what the emerging evidence is showing us about endometriosis and the gut microbiome, some of the key root causes behind endo belly, co-conditions to look out for, and what kind of treatments you might need to consider.  To sign up, go to: https://www.theendobellycoach.com/free-endo-belly-workshop and I’ve put the link in my show notes.References1) https://journals.lww.com/co-gastroenterology/fulltext/2025/11000/modern_concepts_of_small_intestinal_bacterial.5.aspx2) https://www.gastrojournal.org/article/S0016-5085(19)38954-1/pdf, https://pmc.ncbi.nlm.nih.gov/articles/PMC3607857/, https://pubmed.ncbi.nlm.nih.gov/29915215/3) Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights - PubMed4) https://pubmed.ncbi.nlm.nih.gov/39959963/5) Endometriosis and irritable bowel syndrome: A systematic review and meta-analyses - PMC, https://pubmed.ncbi.nlm.nih.gov/32949284/, https://pubmed.ncbi.nlm.nih.gov/32004880/, https://pmc.ncbi.nlm.nih.gov/articles/PMC10316551/, https://pubmed.ncbi.nlm.nih.gov/18715239/6) The relationship between small intestinal bacterial overgrowth and irritable bowel syndrome - PubMed, Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study - PubMed, The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: relationship with irritable bowel syndrome - PubMed, Irritable bowel syndrome and small intestinal bacterial overgrowth: meaningful association or unnecessary hype - PubMed7) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://www.mdpi.com/2076-2607/11/8/20898) https://pubmed.ncbi.nlm.nih.gov/39990556/9) https://pmc.ncbi.nlm.nih.gov/articles/PMC3413773/10) https://pubmed.ncbi.nlm.nih.gov/21840904/, https://pubmed.ncbi.nlm.nih.gov/40262193/11) https://pubmed.ncbi.nlm.nih.gov/39990556/12) https://www.theendobellycoach.com/podcast/mcas-and-endo-belly, https://www.theendobellycoach.com/podcast/what-does-mcas-have-to-do-with-endo?rq=MCAS13) https://journals.lww.com/ajg/fulltext/2016/10001/gastrointestinal__gi__disease_burden_in_patients.566.aspx‍ ‍Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

A couple of months back I did an episode on mast cells, MCAS and endometriosis - so, if you haven’t listened to that episode, it’s a short one, and I would listen to it to get you up to speed on what mast cells are and their function, what MCAS is and what the connection is to endo.Today, we are talking about how MCAS, or even just mast cells, could be contributing to your endo belly, IBS and/or SIBO.If you want to learn more about the root causes of endo belly and IBS in the endo demographic, and you’re keen to understand the SIBO, MCAS, POTS and hEDS connection too, I am running a free workshop on Thursday July 23rd, 6pm British Summer time, live on Zoom. If you can’t attend it live, you’ll be able to watch the replay. You’ll learn what the emerging evidence is showing us about endometriosis and the gut microbiome, some of the key root causes behind endo belly, co-conditions to look out for, and what kind of treatments you might need to consider.  To sign up, go to: https://www.theendobellycoach.com/free-endo-belly-workshop and I’ve put the link in my show notes.References1) https://pubmed.ncbi.nlm.nih.gov/24286351/2) https://www.sciencedirect.com/science/article/pii/S2666379124005275, https://pmc.ncbi.nlm.nih.gov/articles/PMC4819856/, https://jgld.ro/jgld/index.php/jgld/article/view/229, https://onlinelibrary.wiley.com/doi/10.1111/nmo.143393) https://sa1s3.patientpop.com/assets/docs/295890.pdf4) https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2036.2011.04684.x5) https://pubmed.ncbi.nlm.nih.gov/9287964/6) https://pubmed.ncbi.nlm.nih.gov/19596012/7) https://pubmed.ncbi.nlm.nih.gov/14988823/8) Evidence for mast cell activation in patients with therapy-resistant irritable bowel syndrome - PubMed9) Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life - PubMed10) https://www.scivisionpub.com/pdfs/small-intestinal-bacterial-overgrowth-is-common-in-mast-cell-activation-syndrome-1371.pdf, https://sa1s3.patientpop.com/assets/docs/295890.pdf11) https://sa1s3.patientpop.com/assets/docs/295890.pdf12) https://www.scivisionpub.com/pdfs/small-intestinal-bacterial-overgrowth-is-common-in-mast-cell-activation-syndrome-1371.pdf, https://sa1s3.patientpop.com/assets/docs/295890.pdf, The Suggested Relationships Between Common GI Symptoms and Joint Hypermobility, POTS, and MCAS - PMC13) https://pmc.ncbi.nlm.nih.gov/articles/PMC9102523/Podcast linkshttps://www.theendobellycoach.com/podcast/what-does-mcas-have-to-do-with-endohttps://www.theendobellycoach.com/podcast/lipopolysaccharides-endo-pain-growthNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍- £500 off this July.Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

As I am still recovering from covid, today’s episode is a short bite sized episode looking at what the recent research is telling us about the endo belly and the gut microbiome of people with endo. References1) https://pmc.ncbi.nlm.nih.gov/articles/PMC10316551/2) https://pubmed.ncbi.nlm.nih.gov/28303579/3) Endometriosis and irritable bowel syndrome: A systematic review and meta-analyses - PMC4) https://pubmed.ncbi.nlm.nih.gov/32949284/, https://pubmed.ncbi.nlm.nih.gov/32004880/, https://pmc.ncbi.nlm.nih.gov/articles/PMC10316551/5) https://pubmed.ncbi.nlm.nih.gov/18715239/6) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/7) https://www.mdpi.com/2076-2607/11/8/20898) https://www.mdpi.com/2077-0383/12/22/7176#B44-jcm-12-07176Podcast linksBeta-glucuronidase:https://www.theendobellycoach.com/podcast/sibo-gut-dysbiosis-elevated-oestrogenShort chain fatty acids:https://www.theendobellycoach.com/podcast/endometriosis-short-chain-fatty-acidshttps://www.theendobellycoach.com/podcast/endometriosis-propionate-acetatehttps://www.theendobellycoach.com/podcast/endometriosis-butyrateTools and treatments:https://www.theendobellycoach.com/podcast/phgg-endo-belly-sibo-ibshttps://www.theendobellycoach.com/podcast/endometriosis-ibs-psyllium-huskhttps://www.theendobellycoach.com/podcast/kiwis-for-constipationhttps://www.theendobellycoach.com/podcast/flax-chia-constipationNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Antibiotics, understandably, have a bad reputation because of how much they’ve been overused in the past few decades, and the impact that has had on our gut microbiomes and overall health, not to mention, resistance development.So, when it comes to antibiotics for SIBO, most of my clients are initially hesitant to consider them, and will typically opt for antimicrobial herbs instead.However, there are some potential benefits of antibiotics for endometriosis, so I thought it was worth sharing these with you, so that if you find yourself having to treat SIBO, you can make an informed decision about which path you’d like to take.References1) Dr Siebecker estimates, in course: https://siboprocourse.siboinfo.com/?ref=15748-Allison-Siebecker2) https://www.siboinfo.com/antibiotics.html3)  https://pmc.ncbi.nlm.nih.gov/articles/PMC5299503/, https://www.cghjournal.org/article/S1542-3565(09)01331-7/fulltext4) https://pmc.ncbi.nlm.nih.gov/articles/PMC5299503/, https://www.cghjournal.org/article/S1542-3565(09)01331-7/fulltext, https://www.siboinfo.com/antibiotics.html5) https://pubmed.ncbi.nlm.nih.gov/24788320/, https://pubmed.ncbi.nlm.nih.gov/19996983/, https://www.siboinfo.com/antibiotics.html6) https://pubmed.ncbi.nlm.nih.gov/29574688/, https://www.siboinfo.com/antibiotics.html7) https://pubmed.ncbi.nlm.nih.gov/28078798/ , https://pubmed.ncbi.nlm.nih.gov/26780631/,  https://www.siboinfo.com/sibo-antibiotics.html, https://pubmed.ncbi.nlm.nih.gov/19243285/8) https://pubmed.ncbi.nlm.nih.gov/24788320/, https://pubmed.ncbi.nlm.nih.gov/19996983/, https://www.siboinfo.com/antibiotics.html, https://pubmed.ncbi.nlm.nih.gov/29574688/, https://www.siboinfo.com/antibiotics.html9) https://www.triosmartbreath.com/intestinal-sulfide-overproduction, https://pubmed.ncbi.nlm.nih.gov/9558280/10) https://www.sciencedirect.com/org/science/article/pii/S263383862400004611) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://www.mdpi.com/2076-2607/11/8/208912) https://pmc.ncbi.nlm.nih.gov/articles/PMC6554192/13) https://www.sciencedirect.com/science/article/pii/S0002937824007506#bib2614) https://academic.oup.com/humrep/article/39/Supplement_1/deae108.658/770380215) https://pubmed.ncbi.nlm.nih.gov/21806984/, https://pubmed.ncbi.nlm.nih.gov/20816942/, https://pmc.ncbi.nlm.nih.gov/articles/PMC2957776/, 16) https://pmc.ncbi.nlm.nih.gov/articles/PMC10855755/17)  https://pmc.ncbi.nlm.nih.gov/articles/PMC5543406/18) https://www.theendobellycoach.com/podcast/lipopolysaccharides-endo-pain-growth19) https://pubmed.ncbi.nlm.nih.gov/21806984/, https://pmc.ncbi.nlm.nih.gov/articles/PMC11617758/, https://pmc.ncbi.nlm.nih.gov/articles/PMC5543406/20) https://pubmed.ncbi.nlm.nih.gov/20852272/, https://pubmed.ncbi.nlm.nih.gov/12120885/, https://pubmed.ncbi.nlm.nih.gov/25244596/, https://pubmed.ncbi.nlm.nih.gov/30555323/, 21) https://pmc.ncbi.nlm.nih.gov/articles/PMC10458414/, https://www.sciencedirect.com/org/science/article/pii/S2633838624000046Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet. Get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠