This EndoLife podcast

Could MCAS/Mast Cells Be Contributing to Your Endo Belly and IBS Symptoms?

12/07/2026
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A couple of months back I did an episode on mast cells, MCAS and endometriosis - so, if you haven’t listened to that episode, it’s a short one, and I would listen to it to get you up to speed on what mast cells are and their function, what MCAS is and what the connection is to endo.

Today, we are talking about how MCAS, or even just mast cells, could be contributing to your endo belly, IBS and/or SIBO.

If you want to learn more about the root causes of endo belly and IBS in the endo demographic, and you’re keen to understand the SIBO, MCAS, POTS and hEDS connection too, I am running a free workshop on Thursday July 23rd, 6pm British Summer time, live on Zoom. If you can’t attend it live, you’ll be able to watch the replay. You’ll learn what the emerging evidence is showing us about endometriosis and the gut microbiome, some of the key root causes behind endo belly, co-conditions to look out for, and what kind of treatments you might need to consider. 

To sign up, go to: https://www.theendobellycoach.com/free-endo-belly-workshop and I’ve put the link in my show notes.


References

1) https://pubmed.ncbi.nlm.nih.gov/24286351/

2) https://www.sciencedirect.com/science/article/pii/S2666379124005275, https://pmc.ncbi.nlm.nih.gov/articles/PMC4819856/, https://jgld.ro/jgld/index.php/jgld/article/view/229, https://onlinelibrary.wiley.com/doi/10.1111/nmo.14339

3) https://sa1s3.patientpop.com/assets/docs/295890.pdf

4) https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2036.2011.04684.x

5) https://pubmed.ncbi.nlm.nih.gov/9287964/

6) https://pubmed.ncbi.nlm.nih.gov/19596012/

7) https://pubmed.ncbi.nlm.nih.gov/14988823/

8) Evidence for mast cell activation in patients with therapy-resistant irritable bowel syndrome - PubMed

9) Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life - PubMed

10) https://www.scivisionpub.com/pdfs/small-intestinal-bacterial-overgrowth-is-common-in-mast-cell-activation-syndrome-1371.pdf, https://sa1s3.patientpop.com/assets/docs/295890.pdf

11) https://sa1s3.patientpop.com/assets/docs/295890.pdf

12) https://www.scivisionpub.com/pdfs/small-intestinal-bacterial-overgrowth-is-common-in-mast-cell-activation-syndrome-1371.pdf, https://sa1s3.patientpop.com/assets/docs/295890.pdf, The Suggested Relationships Between Common GI Symptoms and Joint Hypermobility, POTS, and MCAS - PMC

13) https://pmc.ncbi.nlm.nih.gov/articles/PMC9102523/


Podcast links

https://www.theendobellycoach.com/podcast/what-does-mcas-have-to-do-with-endo

https://www.theendobellycoach.com/podcast/lipopolysaccharides-endo-pain-growth


Need more help or want to learn how to work with me?

Ways to work with me:

⁠One to one coaching info and application⁠‍ ‍- £500 off this July.

Endo Sessions: Single and mini-package one to one endo coaching

SIBO Sessions: Single and mini-package one to one SIBO coaching

Live and Thrive with Endo 2.0 DIY online course

⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠

⁠This EndoLife, It Starts with Breakfast digital cookbook⁠


Affiliate Partnerships

mBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.

Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.

Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFE


Free resources:

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