This EndoLife podcast

Gut Motility and Enteric Nervous System Dysfunction in Endo

27/09/2026
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This week we’re travelling again, heading over to the Isle of Wight, and we have a lot of packing to do, so this week is a real bite sized episode, but an important one.

You may remember me talking about a study showing 80% of participants with endometriosis also had SIBO. But what many people don’t know, and what I think doesn’t get enough focus, is that this study also found 100% of participants had a dysfunction of their small intestine motility.


References

1) https://pubmed.ncbi.nlm.nih.gov/9660426/

2)  https://www.sciencedirect.com/topics/medicine-and-dentistry/migrating-motor-complex

3) Diagnosis and management of small intestinal bacterial overgrowth - PubMed, Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth - PubMed, The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine - PubMed, The migrating motor complex: control mechanisms and its role in health and disease - PubMed,Gastrointestinal motility disorders and bacterial overgrowth - PubMed, Modern concepts of small intestinal bacterial overgrowth - PMC

4) Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth - PubMed, Development and Validation of a Biomarker for Diarrhea-Predominant Irritable Bowel Syndrome in Human Subjects | PLOS One, Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model - PubMed

5)  https://pubmed.ncbi.nlm.nih.gov/39990556/

6) https://www.sciencedirect.com/science/article/pii/S001502829800096X#BIB27, Role of Insulin Signaling in Prostaglandins SynthesisUniversity of Toledohttps://openjournals.utoledo.edu › download


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