Nerves, Skin, and Immunity: Understanding Keloids through the Lens of the Immune System - GSS 3.0 (1/5) - Takunda Ngwenya

Hosted by ⁠⁠⁠⁠⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. --Thumbi Ndung’u is a faculty member at the Africa Health Research Institute (AHRI) in Durban, South Africa; Professor and Victor Daitz Chair in HIV/TB Research at the HIV Pathogenesis Programme, University of KwaZulu-Natal; Programme Director for the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE); Professor of Infectious Diseases at University College London, UK; Associate Member of the Ragon Institute; Adjunct Professor of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health; and Provost's Visiting Professor of HIV Virology and Immunology at Imperial College London, UK. He is the recipient of several awards for scientific excellence and leadership contributions, including the South African Medical Research Council Gold Scientific Achievement Award, the Leadership Award in Public Health Practice from the Harvard T. H. Chan School of Public Health, and the KT Jeang Retrovirology Prize in recognition of outstanding work on HIV. He has also received grant funding from the Bill and Melinda Gates Foundation, the Wellcome Trust, the Science for Africa Foundation, the Howard Hughes Medical Institute, the South African National Research Foundation, the National Institutes of Health, and others. His research focuses on understanding interactions between HIV and the immune system and how these may be harnessed and translated for HIV prevention or cure. --In this episode, he talks about his journey with HIV and immunology that has spanned at least three decades and birthed several groundbreaking contributions, the most recent being Africa’s first HIV cure trial for women living with the virus.

ImmunoAfrica's Graduate Student Series offers emerging and aspiring immunologists the opportunity to connect with, learn from, and be inspired by some of the most talented immunology graduate students from Africa.For its third edition, this year, we feature 5 PhD students representing 5 African countries, namely Zimbabwe, South Africa, Benin, Cameroon, and Ethiopia. Our guests share their unique stories, perspectives, and contributions to the field of immunology, particularly within the African context.--Hosted by ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. --Takunda Lameck Ngwenya is a PhD researcher in Neuroscience and Immunology at King’s College London, United Kingdom, where he explores how the immune system and nervous system interact in chronic skin conditions like keloid scars. Originally from Zimbabwe, Takunda holds a distinction-graded MSc in Medicine (Chemical Biology) from the University of Cape Town, South Africa, where he worked on a project that aimed to develop novel recombinant immunodiagnostic & -therapeutics for Triple Negative Breast Cancer. He has a multidisciplinary background spanning immunology, molecular biology, and translational medicine. Takunda is also an advocate for research that addresses underrepresented health issues in global communities.Timestamps: 00:00 - intro, about guest01:27 - career background, early journey into immunology06:08 - navigating the steep learning-growth curve09:42 - findings from master's research project on cancer immunotherapy17:23 - updates on PhD research (pain, itch, and immune responses in keloids)23:28 - are there models or cell lines for studying keloids?28:15 - potential future applications/implications of findings29:36 - can keloids be cured solely via surgical resection?31:15 - keloids vs cancers32:12 - strengthening immunological research and development in Africa (funding, collaboration, opportunities, and the role of AI)45:08 - fun tasks (2 truths and 1 lie; a difficult term in the field)49:56 - outro

Hosted by ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. --Annie Elong is a Research Instructor in the Center for Vaccine Innovation at the La Jolla Institute for Immunology. Elong received her Ph.D. in Immunology investigating the role of autoreactive T and B cells in patients with Multiple Sclerosis (MS), an autoimmune disease affecting the Central Nervous System (CNS). Her research focus has since broadened, to human infectious diseases and mouse models in the group of Dr. Sujan Shresta at La Jolla. She has led key projects aimed at understanding the adaptive immune response to infection with flaviviruses, particularly dengue and Zika, contributing towards the development of efficient vaccines. During the pandemic, Elong investigated the role of pre-existing immunity to human common cold coronaviruses and the interplay between antibody and T cell responses in shaping the outcome of SARS-CoV-2 infection. In this episode, Elong talks about her journey through and contributions to the field, which has crisscrossed T cells, antibodies, autoimmunity and vaccines. In addition, she discusses the critical roles pan vaccines could play in the fight against viral diseases and shares part of her ongoing plans to elucidate how T cells mediate neuropathologies associated with viral infections.--To participate in our Quizzes, visit our social media platforms via the links below.- ImmunoAfrica: ⁠⁠linktr.ee/immuno.africa⁠⁠- Immunopaedia: ⁠⁠immunopaedia.org.za⁠⁠-- Timestamps:00:00 – podcast intro00:47 – guest intro01:50 – overview of career journey, getting into immunology and infectious diseases research04:32 – PhD research (T cells and multiple sclerosis): findings, implications11:00 – navigating the switch from autoimmunity to viral immunology and vaccines13:27 – ImmunoAfrica x Immunopaedia quiz interlude14:16 – navigating switches: why every scientist has the recipe for surviving career/research switches18:30 – postdoctoral research (Dengue and Zika viruses: T cells, antibodies, and pan-vaccines): findings, implications30:26 – more on pan-vaccines; immunology x global health crosstalk45:10 – what's next?47:51 – closing remarks: why you need a mentor52:20 – outro

Hosted by ⁠⁠⁠⁠⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. --Dr. Lorraine Pfavayi is a Postdoctoral Research Associate at the University of Edinburgh and a TIBA Postdoctoral Fellow. She holds a DPhil in Clinical Medicine from the University of Oxford, where she investigated fungal allergic diseases in regions co-endemic with parasitic infections. Her current research focuses on developing point-of-care diagnostic tools for schistosomiasis, a neglected tropical disease commonly linked with fresh water snails. She is also involved in the Affected Voices programme, which promotes the inclusion of people with lived experience of neglected tropical diseases (NTDs) in health policy and service delivery. Her work is driven by a commitment to integrating basic science with global health policy to deliver equitable, context-relevant solutions for vulnerable communities.In this episode, Pfavayi discusses the need for context-relevant approaches to addressing the burden of neglected tropical diseases (NTDs) in Africa and highlights how her ongoing work centers local contexts, community persepctives, and African-led approaches in the development of solutions for NTDs.--To participate in our Quizzes, visit our social media platforms via the links below.- ImmunoAfrica: ⁠linktr.ee/immuno.africa⁠- Immunopaedia: ⁠immunopaedia.org.za⁠-- Timestamps:00:00 – podcast intro01:05 – guest intro01:50 – overview of career journey, getting into NTDs research03:40 – what are NTDs? why NTDs?06:52 – key contributions towards NTDs research; factoring in under-5 for schistosomiasis management14:16 – ImmunoAfrica x Immunopaedia quiz interlude15:07 – involving local communities in the entire project pipeline of research studies16:17 – PhD research: fungal allergies in NTDs-endemic communities26:21 – post-doctoral research project: towards tailoring NTDs innovations and interventions for infants and young children; local communities36:30 – highlights of findings43:40 – the role of mentors in her career development 44:45 – final remarks: dealing with imposter syndrome46:32 – outro

Hosted by ⁠⁠⁠⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠⁠⁠⁠. --Thumbi Ndung’u is a faculty member at the Africa Health Research Institute (AHRI) in Durban, South Africa; Professor and Victor Daitz Chair in HIV/TB Research at the HIV Pathogenesis Programme, University of KwaZulu-Natal; Programme Director for the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE); Professor of Infectious Diseases at University College London, UK; Associate Member of the Ragon Institute; Adjunct Professor of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health; and Provost's Visiting Professor of HIV Virology and Immunology at Imperial College London, UK. He is the recipient of several awards for scientific excellence and leadership contributions, including the South African Medical Research Council Gold Scientific Achievement Award, the Leadership Award in Public Health Practice from the Harvard T. H. Chan School of Public Health, and the KT Jeang Retrovirology Prize in recognition of outstanding work on HIV. He has also received grant funding from the Bill and Melinda Gates Foundation, the Wellcome Trust, the Science for Africa Foundation, the Howard Hughes Medical Institute, the South African National Research Foundation, the National Institutes of Health, and others. His research focuses on understanding interactions between HIV and the immune system and how these may be harnessed and translated for HIV prevention or cure. --In this episode, he talks about his journey with HIV and immunology that has spanned at least three decades and birthed several groundbreaking contributions, the most recent being Africa’s first HIV cure trial for women living with the virus.--To participate in our Trivia questions, visit our social media platforms via the links below.- ImmunoAfrica: linktr.ee/immuno.africa- Immunopaedia: immunopaedia.org.za-- Timestamps:00:00 – podcast intro01:05 – guest intro02:00 – starting out, maximising opportunities: from a coffee farm to veterinary school05:19 – getting into immunology research07:16 – ImmunoAfrica x Immunopaedia quiz interlude I            08:40 – making a mark in immunology, from Nairobi to Harvard | isolating subtype C strain of HIV12:15 – misconceptions and big questions in HIV research17:30 – research and contributions leading up to the HIV Cure Project21:04 – convincing people living with HIV to stay off medications (antiretroviral therapy, ART) for trial23:51 – integrating socioeconomic empowerment into biomedical research | The FRESH project25:45 – designing, conducting the HIV Cure trial | more on The FRESH project31:50 – major findings from, next steps for the HIV Cure trial39:40 – why only women were recruited for the cure trial41:33 – adverse outcomes in participants43:40 – ImmunoAfrica x Immunopaedia quiz interlude II45:00 – coming up with new ideas46:52 – visibility for scientists and its role in strengthening local R&D53:32 – experience with mentorship: paying it forward 56:55 – final remarks 57:42 - outro 

Hosted by ⁠⁠⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠⁠⁠. --Launching in April 2025, our special TB Immunology series and first-ever disease-focused series dives deep into the science, challenges, and success stories behind the fight to end tuberculosis.We’re joined by leading scientists whose work in TB prevention, diagnosis, treatment, and vaccine development is shaping the current landscape of the disease in Africa and globally.Whether you're actively involved in TB research or simply curious about the field, this experience promises to be both eye-opening and engaging.The seventh and final episode in the series features Professor Mohlopheni Jackson Marakalala who is currently the Director of the South African Medical Research Council (SAMRC) Centre for Tuberculosis Research at Stellenbosch University (SU), South Africa.Marakalala completed his PhD in Chemical Pathology at the University of Cape Town (2008), receiving the Bronte Stewart Research Prize for the most meritorious PhD thesis. He then completed a total of 8 year postdoctoral training; 4 years in the Institute of Infectious Disease and Molecular Medicine (IDM) at UCT and 4 years in Immunology and Infectious Diseases at Harvard TH Chan School of Public Health. Between 2016 and 2019, he was a Senior Lecturer at UCT and a Visiting Scientist at Harvard. From 2019 until his recent appointment as the Unit Director of the SAMRC Centre for TB Research, he has been a Wellcome Trust International Fellow and Faculty member at Africa Health Research Institute (AHRI) and an Associate Professor at University College London (UCL). His laboratory’s primary interest is on infectious diseases, particularly immunopathogenesis of Tuberculosis, with an aim of developing host-directed therapies targeting mediators of lung damage. His other interests are in understanding strategies utilized by mycobacteria to survive various arms of the immune system. Work in his lab has been funded by grants from SA Medical Research Council, Wellcome Trust and Bill and Melinda Gates Foundation. Personal achievements include recognition as a ‘Rising Star’ at the 2019 Grand Challenges meeting, NRF Emerging Researcher Excellence Award (2018), SA Medical Research Council Scientific Merit award (Silver medal) (2016); UCT 2016 College of Fellows Young Researcher Award; and the Next Einstein Forum (2016) Fellowship. In this episode, he talks about how we may rethink funding for TB research in light of recent cuts which have dealt the field a heavy blow. In addition, he shares some of the plans and perspectives he brings to his recent role as Director of the SAMRC Centre for Tuberculosis Research.Timestamps:00:00 - intro01:35 - journey to current role and work in TB03:42 - qualities and factors that have shaped his career06:21 - contributions to TB research; training younger scientists12:14 - funding cuts and impact on his ongoing work15:29 - does external funding limit what aspects of TB research can be studied in Africa?20:49 - what alternative funding models do we start exploring to support local TB research?26:32 - the role of scientists and scientific councils29:40 - will Africa have the market to foster bio-entrepreneurship?33:44 - plans and perspectives for current role - Director of the SAMRC-SU Centre for Tuberculosis Research40:05 - closing remarks; future of TB in Africa42:40 - Outro

Hosted by ⁠⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠⁠. --Launching in April 2025, our special TB Immunology series and first-ever disease-focused series dives deep into the science, challenges, and success stories behind the fight to end tuberculosis.We’re joined by leading scientists whose work in TB prevention, diagnosis, treatment, and vaccine development is shaping the current landscape of the disease in Africa and globally.Whether you're actively involved in TB research or simply curious about the field, this experience promises to be both eye-opening and engaging.The sixth and penultimate episode in the series features Fatoumatta Darboe. Originally from The Gambia, Fatoumatta currently works as an Assistant Professional Researcher at the University of California, San Francisco in the United States. Darboe ventured into TB research during her master's programme at the Medical Research Council Unit The Gambia (MRCG) at London School of Hygiene and Tropical Medicine (LSHTM), where she also completed a postdoctoral training.For her PhD at the South African Tuberculosis Vaccine Initiative (SATVI), she sought to define TB correlates of disease risk in several South African cohorts of individuals co-infected with Mycobacterium tuberculosis (Mtb) and Human Immunodeficiency Virus (HIV). This work resulted in the validation and publication of an 11-gene biomarker (Darboe11), which predicted and diagnosed TB disease, and predicted treatment responses in several TB/HIV co-infected cohorts. In this episode, she takes us on her long-standing relationship with TB, including how her interest in TB-HIV coinfection developed. She shares updates on ongoing projects exploring a fascinating pathway implicated in TB and HIV and immunogenic antibodies for TB.Additionally, she talks about what fuels her advocacy for female education and representation in leadership, and why it's important to audit one's "circle" according to their goals.Timestamps:00:00 - intro01:17 - early journey, getting into TB research06:46 - navigating growth with minimal supervision10:20 - journey to SATVI; PhD research highlights14:07 - current projects14:48 - TB-HIV co-infection; TB risk in PLWH 17:45 - understanding the kynurenine-tryptophan (KT) pathway in HIV/TB19:00 - is the KT pathway relevant in TB aside from HIV?21:13 - potential application of findings23:40 - using bacteriophage to unravel TB antibody responses28:33 - which TB strains are targeted in antibody response study?29:56 - challenges, barriers, and sacrifices38:00 - closing remarks38:58 - Outro

Hosted by ⁠⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠⁠. --Launching in April 2025, our special TB Immunology series and first-ever disease-focused series dives deep into the science, challenges, and success stories behind the fight to end tuberculosis.We’re joined by leading scientists whose work in TB prevention, diagnosis, treatment, and vaccine development is shaping the current landscape of the disease in Africa and globally.Whether you're actively involved in TB research or simply curious about the field, this experience promises to be both eye-opening and engaging.The fifth episode in the series features Anele Gela, a Research Officer at the South African Tuberculosis Vaccine Initiative, University of Cape Town, where he studies host determinants of protective immunity against Mycobacterium tuberculosis (Mtb). Anele first ventured into TB research during his postdoctoral fellowship at SATVI. He completed his PhD degree in Lund University, Sweden, studying asthma, and previously worked with coronaviruses. During his post-doctoral training, he was actively involved in several projects aimed at addressing the role of donor-unrestricted T (DURT) cells in TB immunity and vaccination. In his current role as a research officer, he provides scientific and operational oversight of immunological and laboratory aspects of TB vaccine projects. One such project is the H56:IC31 TB vaccine trial, which was conducted at multiple sites in South Africa and Tanzania.  In this episode, we talk about his journey into studying vaccine immune responses for TB, why vaccines matter, and the need for stronger public engagement in the field.  Timestamps:00:00 - intro01:40 - why vaccines are important; different vaccine types 06:11 - career journey; from coronaviruses to TB 12:20 - PhD research and key findings14:15 - key TB-related projects19:40 - how clinical trials run; projects and findings25:33 - more findings, lessons from trials28:09 - on TB revaccination and BCG effectiveness31:33 - challenges with getting a TB vaccine 36:44 - public engagement in TB vaccine clinical trials38:26 - engaging with public and private agencies to attract investment in biomedical research and development42:15 - Outro

Hosted by ⁠⁠⁠⁠Wealth Okete⁠⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠⁠. --Launching in April 2025, our special TB Immunology series and first-ever disease-focused series dives deep into the science, challenges, and success stories behind the fight to end tuberculosis.We’re joined by leading scientists whose work in TB prevention, diagnosis, treatment, and vaccine development is shaping the current landscape of the disease in Africa and globally.Whether you're actively involved in TB research or simply curious about the field, this experience promises to be both eye-opening and engaging.The fourth episode in the series features Solomon Jauro, a veterinarian and postdoctoral researcher at the University of Pittsburgh, where he studies tuberculosis in non-human primates (macaque models). Solomon trained as a veterinarian and obtained his master's degree at the University of Maiduguri, Nigeria, before proceeding to the University of Pretoria, South Africa, for his PhD.Unlike previous guests, Solomon's work on TB only took off during his postdoctoral fellowship, as his earlier work had focused on antimicrobial resistance and anthrax vaccine immune responses. In this episode, he talks about how his research on macaques co-infected with TB and simian immunodeficiency virus, SIV (a HIV-like virus) could shape current understanding of human TB-HIV coinfection, in the context BCG vaccine-induced immune responses.In addition to sharing what it'd take for his findings to be translated into humans, he also reflected on why African institutions should create structures that foster collaboration, particularly among young scientists.Timestamps:00:00 - Intro01:13 - MSc/PhD project; getting into TB02:03 - More on PhD project: anthrax vaccines05:25 - Macaques as 'ideal' models for understanding human TB08:51 - TB-SIV co-infection in macaques10:32 - Evaluating TB/HIV immune responses from intravenous vs intradermal BCG administration I16:33 - BCG'osis in humans18:09 - Evaluating TB/HIV immune responses from intravenous vs intradermal BCG administration II21:48 - SIV viral load and BCG-induced TB protection29:24 - Attenuated BCG for juvenile macaques32:08 - Translating findings from macaque models to human patients32:56 - Does BCG'osis associate with vaccination routes?36:00 - If not TB, then what?38:00 - Closing remarks: how African institutions can foster collaboration among scientists41:20 - Outro

Hosted by ⁠⁠⁠Wealth Okete⁠⁠⁠, The Immunology in Africa Podcast explores narratives at the nexus of immunology & Africa. We ask professors, postdocs, PhD students, and everyone in between to tell us about their journey into immunology, the questions driving their current work, and the impact they hope to make on the continent.To support our efforts towards amplifying African stories of immunology, you can ⁠⁠⁠⁠buy us coffee⁠⁠⁠⁠ or ⁠⁠⁠⁠nominate a guest⁠⁠⁠⁠. --Launching in April 2025, our special TB Immunology series and first-ever disease-focused series dives deep into the science, challenges, and success stories behind the fight to end tuberculosis.We’re joined by leading scientists whose work in TB prevention, diagnosis, treatment, and vaccine development is shaping the current landscape of the disease in Africa and globally.Whether you're actively involved in TB research or simply curious about the field, this experience promises to be both eye-opening and engaging.The third episode in the series features Paul Ogongo, an assistant professional researcher and former postdoctoral fellow at the University of California, San Francisco. Originally from Kenya, Paul trained in his home country and South Africa before moving to UCSF for a postdoctoral position. His work has mostly explored T cell responses to TB, highlighting the roles of an important immune cell regulator, IL-17, in the control or progression of the disease. At UCSF, Paul's investigation of T cell-associated immune responses to TB seeks to unravel distinct antigens that could improve future vaccine design against TB. Till date, BCG remains the only approved vaccine against TB; although several other potential candidates are in clinical trials.In this episode, Paul shares key highlights from his work on TB antigens and the promise they hold for design of vaccines that could prevent TB disease progression. He also reflects on some of his experiences with failure and the key advances he anticipates in TB immunology over the next decade. Timestamps:00:00 - Intro01:39 - Unravelling the TB spectrum (active TB vs. subclinical TB; TB exposure vs. TB control)08:02 - On why 'latent TB' isn't truly 'latent'09:15 - Investigating active TB (PhD research project and findings)16:09 - Studying TB at the lungs vs in blood20:09 - Evaluating T cell responses to rare variable antigens (findings and implications)32:04 - TB in diabetic individuals36:22 - Dealing with failure 41:49 - Closing remarks: TB immunology over the coming decade46:43 - Outro