#345: The IMMUNITY Gamechanger | Thymosin alpha-1 Peptide (Cancer, Aging & Autoimmune) with Nat Niddam

In this episode, I sit down with Dr. Ian White—one of the most exciting researchers in regenerative medicine today. If you’re even a little bit curious about how to hack aging or have heard the buzz about things like plasma exchanges, exosomes, or why on earth lobsters never seem to grow old, you’re in for a treat.   What we discuss: Expanding autologous hematopoietic stem cells and FDA challenges ... 00:08:28 Heterochronic parabiosis, plasma exchange, and aging signals ... 00:17:35 Nature’s clues: Lobsters, jellyfish, and biological age reset ... 00:24:02 Entropy, epigenetics, and limiting factors in aging ... 00:27:56 Vision: Youthful healthspan, not just longer lifespan ... 00:32:43 Amniotic fluid as a source of rejuvenation ... 00:36:01 Therapeutic results: burns, ulcers, and immune modulation ... 01:03:18 Exosomes vs. stem cells: Definitions and market problems ... 01:02:31 How exosomes function and the importance of source ... 00:51:23 Ensuring safe and effective regenerative therapies ... 01:00:10 Guidance for patients interested in exosome therapy ... 01:09:42 Dr. White’s research legacy and goals ... 01:14:04   Our Amazing Sponsors: Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at  troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there. NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It’s about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you’d get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase.  Berberine Breakthrough - Take 15 min. before a meal and your body will push carbs and glucose into your muscles to be used as fuel instead of turning them into fat. Enjoy more stable energy without the post-meal crash. Visit bioptimizers.com/bionat and enter the code BIONAT to get 10% off your order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Today, I've got something special for you: a solo episode where I look back at the past six months and handpick the five episodes and ideas that truly changed the game for me—and, based on your feedback, for many of you too.   Episodes from this podcast: #300: Breast Cancer Overdiagnosis, Mammogram Myths, The REAL Risks For Women And Bold NEW Alternatives With Dr. Jenn Simmons #302: If You Have Creeky or Painful Joints and BIG Dreams of Staying Active, These Nonsurgical Solutions Are The NEW Way Forward - With Dr. Jeff Gross #309: Cordycepin and Methylene Blue: Two Game-Changers For Better Energy, Focus, Sleep, and So Much More With Dr. Scott Sherr #312: Age-Defying Bone Health: Preventing Osteoporosis with Science-Backed Interventions and Reversal Techniques You Can Try TODAY With Doug Lucas #318: Lies He Taught In Medical School: The METABOLIC Secret To Reversing Chronic Disease with Dr. Robert Lufkin   What I discuss: Exosomes for regeneration: cartilage, bone, and joint repair ... 00:02:19 Exosomes vs. PRP and stem cells—key differences ... 00:05:20 Managing inflammation before regenerative treatments ... 00:06:09 Exosomes in neurology & anti-aging ... 00:07:01 Regulation, safety, and advances in exosome therapy ... 00:08:33 Mammogram controversy: risks, overdiagnosis, and dense breasts ... 00:10:00 Alternatives: QT scan benefits and radiation-free screening ... 00:15:21 Optimizing mitochondrial health—importance & methylene blue ... 00:18:28 Widespread mitochondrial dysfunction & modern disruptors ... 00:21:03 How methylene blue supports energy & cautions ... 00:23:17 Bone health: density vs. quality, collagen, and vibration plates ... 00:31:17 Mechanical input & gaps in traditional osteoporosis care ... 00:34:22 Lifestyle reversal of chronic disease ... 00:37:15 Medical system limitations & patient health agency ... 00:39:25 Fasting and metabolic health—power & nuance ... 00:48:06   Our Amazing Sponsors: Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

I’m your host, Nathalie Niddam, and today I’m thrilled to bring you a truly fascinating conversation with Dr. Stephanie Canestraro—a chiropractor, functional medicine practitioner, and someone with an incredible personal story about overcoming chronic illness. Dr. Canestraro works with elite athletes, including NHL players, but her expertise comes from her own journey through mysterious health challenges that eventually led her to discover the vital role of the lymphatic system.   What we discuss: Dr. Canestraro’s personal health journey and lymphatic issues ... 00:07:58 Explanation of the lymphatic system ... 00:10:33 Superficial vs. deep lymphatics and fascia’s role ... 00:15:20 Personal stories of lymphatic stagnation and deep lymph solutions ... 00:17:03 Why movement isn’t always enough for lymph flow ... 00:2447 Modern challenges: EMFs, toxins, fascia, and liver ... 00:25:00 Lymph, anxiety, and the vagus nerve ... 00:35:40 Tools and approaches for lymph support ... 00:39:22 Body-wide impact of fascia ... 00:43:47 Frequency medicine and resilience strategies ... 00:51:16   Our Amazing Sponsors: Bio-Shield by Young Goose - It’s a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer.  Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at  troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there.  OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

In this episode, I’m thrilled to sit down with Dr. Robert Melillo, a clinical neuroscientist with nearly 40 years of experience decoding the mysteries of the brain and how our modern lifestyle—and especially technology—are changing it. If you’ve ever worried about what all that screen time means for your kids’ developing brains (or your own), this conversation is going to give you a whole new perspective.   What we discuss: Left/right brain imbalance and modern tech’s impact ... 00:12:31 Gut health, peptides, and foundational health tips ... 00:05:37 Dr. Melillo’s journey, research, and clinical experience ... 00:08:04 Technology’s rapid evolution vs. brain adaptation ... 00:12:31 Making brain health more accessible ... 00:15:39 Biohacking brain interventions: risks and basics ... 00:17:34 ADHD, OCD, and the connectivity problem ... 00:20:14 How brain imbalances manifest and can be changed ... 00:23:45 Root causes: movement, milestones, and environment ... 00:39:09 Functional treatment: targeted, practical steps ... 00:47:25 Technology, lifestyle, and the left-brain epidemic ... 00:55:50 Correcting imbalances at any age ... 01:06:02 Dr. Melillo’s resources and how to learn more ... 01:14:38   Our Amazing Sponsors: CAROL Bike: With its cutting-edge, science-backed method, CAROL Bike can boost your VO2max by 12% in just 8 weeks—essentially rewinding your fitness clock by a decade. The folks at CAROL Bike are offering a 100-day FREE trial! Visit http://carolbike.pxf.io/Nat or use code NAT100 for a free 100-day trial. Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off. Berkeley Life: Nitric oxide is key for blood flow, energy, brain clarity, and even healthy blood pressure. When you subscribe at BerkeleyLife.com/NAT, you’ll get a free tube of 50 nitric oxide test strips with your first delivery, so you can track how your body responds. Visit BerkeleyLife.com/NAT and click “Subscribe” to get started.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Today I’m joined by my friend and fellow biohacker, Dave Korsunsky, founder of Heads Up Health. In this episode, we take you on a journey through the evolution of biohacking—from the early days when continuous glucose monitors were a novelty and cryotherapy sounded like science fiction, all the way to the sophisticated, data-driven tools we have at our fingertips today.   What we discuss:  Dave’s journey: Heads Up Health and the rise of health data ... 00:08:18 Making sense of health metrics: Knowing if protocols work ... 00:10:06 GLP-1s: muscle loss risks, proper technique, and hydration ... 00:16:18 Clinical stories: HRV, autoimmune disease, and diabetes management ... 00:25:57 The foundational power of sleep, hydration, and micro-experiments ... 00:34:14 Core metrics: HRV, blood sugar, sleep, and their significance ... 00:40:46 The promise and impact of new longevity diagnostics ... 00:50:42 No-equipment longevity tests: grip, hang, balance, sit-to-stand ... 01:00:31 Aggregate your data and run micro-experiments ... 01:05:25   Our Amazing Sponsors: Bio-Shield by Young Goose - It’s a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer.  Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at  troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there.  OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Welcome back to the Longevity Podcast! I’m your host, Nathalie Niddam—a nutritionist, human potential and epigenetic coach, and devoted biohacker. Today, I’m tackling one of your most-requested topics: Thymosin Alpha 1, a peptide that keeps lighting up conversations in my communities.   Resources from the episode:  Thymosin alpha 1: A comprehensive review of the literature   What we discuss: Overview of Thymosin alpha-1 ... 00:02:16 Medical uses, orphan drug status, and immune effects ... 00:03:53 Contraindications and vaccine adjuvant potential ... 00:05:01 Benefits in sepsis, infections, and elderly ... 00:07:40 Mechanisms of action and immune modulation ... 00:08:31 Antimicrobial properties and hospital study highlights ... 00:09:13 Support in aging, cancer, chemo, and mold toxicity ... 00:09:53 Cautions for autoimmune and sensitive individuals ... 00:13:04 Potential cancer therapy support and anti-inflammatory effects ... 00:14:48 Wound healing, safety, and administration ... 00:20:23 Risks, final cautions, and practitioner advice ... 00:23:15 App resource, newsletter, and wrap-up ... 00:25:24   Our Amazing Sponsors: Masszymes by BiOptimizers - is the most complete, most potent digestive enzyme with over 102% MORE PROTEASE than the nearest competitor. That’s crucial, because protein is the most complex macronutrient to break down. Try MassZymes at bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Welcome back to the Longevity Podcast! In this episode, I have the pleasure of sitting down with James Strole, a beacon in the radical longevity space and the visionary founder behind People Unlimited and RAADfest. James shares the personal journey that led him into the world of life extension—shaped by a spiritually open-minded mother, a pivotal loss, and a lifelong desire to challenge the idea that aging is inevitable. Get 10% off your tickets to RAADfest using code: "niddam"   What we discuss: James Strole’s personal journey to radical longevity ... 00:04:00 Spiritual roots and early inspiration ... 00:10:00 Transition from spiritual to scientific approaches ... 00:13:00 Launching RAADfest and the shift toward hard science ... 00:16:00 Evolution of the longevity movement over the decade ... 00:21:00 Access to longevity innovations and RAAD Clinics ... 00:22:00 Most exciting developments: gene therapy and age reversal ... 00:24:00 Daily longevity pillars: diet, movement, mindset ... 00:26:00 Mindset and embracing the possibility of immortality ... 00:35:00 Overcoming skepticism and “against nature” arguments ... 00:41:00 Societal implications of extreme longevity ... 00:44:00 Are we at the tipping point? The “era of immortality” ... 00:47:00 Advice for newcomers: join the conversation and community ... 00:50:00   Our Amazing Sponsors: NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It’s about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you’d get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Mitoblue by Wizard Sciences - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase. Mimio: A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you’re eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Welcome back to the Longevity Podcast! I’m so excited to share today’s episode with you, because it’s one that’s deeply personal and truly inspiring. I had the pleasure of sitting down with Dr. Tudor Marinescu, a remarkable physician I met during one of the Sedona retreats I co-host. Although he began his career as a trauma and orthopedic surgeon in Germany, Dr. Tudor’s path soon led him far beyond traditional medicine. Now, he’s known for his transformative work in osteopathy, neural therapy, and the exploration of how trauma—both physical and emotional—can shape our health and longevity.   Find an amazing practitioner like Dr. Tudor near you:  https://klinghardtinstitute.com/art-practitioners/ for A.R.T https://cranialacademy.org/find-a-physician/ for Osteopathy  https://naant.org/by-any-word/ for Neural therapy https://www.doctortudor.com/   What we discuss: Dr. Tudor’s pivotal moments and holistic shift ... 00:08:23 Osteopathy principles and the body as a memory bank ... 00:14:30 How emotions, trauma, and fascia affect healing ... 00:18:58 History of mind-body separation in medicine ... 00:21:38 Integration of spiritual, emotional, and physical healing ... 00:26:11 Understanding fascia: structure, hydration, and movement ... 00:38:00 Neural therapy and procaine’s role in trauma release ... 00:54:08 Breaking trauma cycles: autonomic nervous system reset ... 00:59:54 Linking physical symptoms to emotional and spiritual health ... 01:09:38 Blending allopathic with holistic and ancestral medicine ... 01:20:46 How to find qualified holistic practitioners ... 01:26:39 Dr. Tudor’s contact info and Sedona retreat details ... 01:31:07 Final thoughts and disclaimer ... 01:33:53   Our Amazing Sponsors: Peptide Pro App: can help manage every part of your peptide protocol. From smart scheduling to real-time dose checklists, note taking, and easy calculations. Listeners receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today. BEAM Minerals - are one of the most overlooked contributors to a healthy gut. They help feed and support your microbiome. Research shows that good gut bacteria rely on essential minerals like calcium, magnesium, zinc, iron, and phosphorus to thrive.. Head over to www.beamminerals.com and use code NAT20 for 20% off your first order and give your gut the simple support it deserves! Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. Filled with key peptides for healing! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Welcome back to the Longevity Podcast! I’m so excited for today’s episode, where I sit down with Chris Rhodes—nutritional biochemist, fasting researcher, and CEO of Mimio Health—to dive deep into one of the most fascinating emerging topics in longevity science: fasting mimetics. If you’ve ever wanted to get the regenerative, anti-inflammatory, and health-boosting effects of fasting, but struggled to actually fast for 36 hours or more (trust me, I get it!), this conversation is for you. Listeners of this podcast can visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.   What we discuss: Meet Chris Rhodes and his biomimetic research journey ... 00:05:18 Unlocking fasting benefits without prolonged fasting ... 00:09:10 Supplements vs. pharmaceuticals for longevity ... 00:10:53 Fasting protocols, timing, and metabolic switching ... 00:15:23 Risks of fasting, evolutionary adaptation, and muscle/bone loss ... 00:18:34 Ketones, brain energy, and cognitive adaptation ... 00:22:48 How fasting activates longevity and repair pathways ... 00:26:23 Key cellular pathways: AMPK, mTOR, NAD, sirtuins ... 00:28:04 Mimio research: discovering and testing fasting metabolites ... 00:33:35 The four main fasting mimetic molecules explained ... 00:42:04 Practical benefits: who should use fasting mimetics & safety ... 00:59:00 Mimio in use: hunger control, GLP-1 support, and older adults ... 01:03:37   Our Amazing Sponsors: Qualia NAD+ - This vital molecule powers cellular energy, supports DNA health, aids detox, and helps keep your body remain youthful. Visit qualialife.com/nathalie to try Qualia NAD+, backed by a 100-day money-back guarantee, and use promo code NATHALIE for 15% off! OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. Check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. Bio-Shield by Young Goose - A broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you’re an existing customer.     More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Welcome back to the Longevity Podcast! I’m your host, Nathalie Niddam—nutritionist, human potential and epigenetic coach, and I’m excited to share another solo episode with you. Today, I’m diving into a topic that really resonated with my community on Instagram: five essential habits I wish everyone in their 40s (and honestly, any age!) knew to set themselves up for better health and longevity—without spending a dime.   Resources from the episode: • Grounding – The universal anti-inflammatory remedy • Associations between bedtime eating or drinking, sleep duration and wake after sleep onset: findings from the American time use survey • Meal Timing and Anthropometric and Metabolic Outcomes • Meal Timing, Aging, and Metabolic Health • Obstructive sleep apnea and neurodegenerative diseases: A bidirectional relation • Investigation on the Effect of Oral Breathing on Cognitive Activity Using Functional Brain Imaging   What we discuss: Digestive bitters before meals: benefits and how to use ... 00:02:10 Digestive bitters: impact on digestion, absorption, and immune system ... 00:04:01 Digestive bitters: sources, supplements, and usage tips ... 00:08:17 Training your glymphatic system for brain health ... 00:09:12 Tips to support glymphatic drainage: sleep, exercise, hydration, nutrition, sleep position ... 00:10:19 Grounding: definition, science, and health impact ... 00:13:39 How to ground in urban environments; grounding sheets and tools ... 00:17:08 Eating dinner three hours before bed: why and how ... 00:19:02 Early dinner vs. skipping breakfast for metabolic health ... 00:21:36 Circadian rhythm alignment tips and jet lag hacks ... 00:24:05 Nasal breathing vs. mouth breathing: importance and intro to solutions ... 00:24:36 Mouth breathing risks, sleep apnea, and cognitive implications ... 00:26:52 Practical tools and professionals for correcting mouth breathing ... 00:29:12 Summary of the five key longevity tips ... 00:31:59   Our Amazing Sponsors: MitoBlue by Wizard Sciences - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically—Methylene Blue, NMN, PQQ, Apigenin and Ginseng. Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group