
AI has existed for decades, but modern deep learning is finally delivering precision decisions in clinic. Dr. Spratt details how ArteraAI’s predictive biomarker—validated on long-term randomized data—can spare roughly two-thirds of eligible men from ADT without compromising outcomes. We unpack ADT’s quality-of-life trade-offs, practical training and nutrition strategies to preserve muscle, and where AI is headed next (post-surgery models, higher-risk disease). You’ll also hear a clear framework for shared decision-making so men are treated as people, not just numbers.
Key Points
✅ AI meets prostate cancer. ArteraAI, developed by Dr. Daniel Spratt’s team, is now part of the NCCN guidelines—helping doctors know which patients truly benefit from hormone therapy.
✅ Two-thirds can skip ADT. Long-term data from the RTOG 9408 trial show most men can avoid the side effects of hormone therapy without affecting outcomes.
✅ Quality of life first. Treatments should improve survival or well-being—if they don’t, they shouldn’t be used.
✅ Lifestyle still matters. Exercise, protein, and resistance training help men on ADT preserve muscle and energy.
✅ The future is personalized. New AI models will soon guide therapy for higher-risk patients and integrate full-body health data for truly tailored care.
⏱️ Time-Stamped Highlights
- 00:00 – Why AI in prostate cancer now? From buzzword to bedside with ArteraAI.
- 01:30 – Deep learning vs. “human-defined” inputs; beyond Gleason to hundreds of slide features.
- 03:10 – Landmark validation: RTOG 9408 and how the model predicts who benefits from ADT.
- 05:00 – ADT trade-offs: longevity vs. libido, energy, bone/muscle; treat only if it improves life or survival.
- 07:15 – “Exercise is medicine”: the 10-minute rule, protein targets, and resistance training on ADT.
- 09:00 – Current indication: primarily intermediate-risk (Gleason 7) men receiving radiation.
- 10:45 – What’s next: models for higher-risk and post-prostatectomy patients; shorter-course ADT questions.
- 13:00 – “Black box” & explainability: why robust external validation matters for trust.
- 15:10 – Access & coverage: ordering via online portal; CMS coverage; what patients can ask their doctors.
- 17:20 – Shared decision-making: reduce PSA anxiety; treat the person, not the number.
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