Stargardt disease and the role of vitamin A: Disease pathogenesis and the promise of oral therapies

touchIN CONVERSATION for touchNEUROLOGY and touchONCOLOGY Management of neurofibromatosis type 1 (NF1)–associated plexiform neurofibromas in adults requires individualized decisions that account for symptoms, function, resectability and patient goals. Listen to NF1 experts Prof. Allan Belzberg, a neurosurgeon, and Dr. Angela Hirbe, an oncologist, as they discuss targeted therapy, adverse-effect monitoring and management, and multidisciplinary approaches to assessing pain, function and quality of life to inform care decisions. The experts Dr. Angela Hirbe, Washington University, St Louis, MO, USA Prof. Allan Belzberg, Johns Hopkins Medicine, Baltimore, MD, USA This touchPODCAST is for HCPs globally, excluding the UK. This activity is funded by an independent medical education grant from Alexion and SpringWorks Therapeutics, Inc.  This activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our websites: www.touchNEUROLOGY.com or www.touchONCOLOGY.com

touchPANEL DISCUSSION for touchNEUROLOGY Hear from three experts as they share practical insights into recognizing and diagnosing Lennox–Gastaut syndrome across the lifespan, navigating the complexities of polytherapy, and addressing the cognitive, behavioral, functional, and quality of life challenges that extend beyond seizure control. The experts: Dr. Elaine Wirrell —Mayo Clinic, Rochester, MN, USA Prof. Lieven Lagae—University Hospitals of Leuven, Belgium Prof. Antonio Gil-Nagel—Ruber Internacional Hospital, Madrid, Spain This activity is supported by an independent medical education grant from Jazz pharmaceuticals. Jointly provided by Partners for Advancing Clinical Education and touchIME. touchIME is an EBAC® accredited provider. This activity is for HCPs outside of the UK, with a focus on Japan and the Gulf. It is designed for neurologists, pediatric neurologists, epilepsy specialists, neurology nurses, and pediatricians.   For further information, please visit our website: www.touchNEUROLOGY.com

touchEXPERT FOCUS for touchOPHTHALMOLOGY Listen to an interview with Dr. Christine Kay on the role of vitamin A in the retina, how vitamin A processing is disrupted in Stargardt disease, and the mechanism of action, emerging clinical evidence, and key safety considerations for emerging oral therapies. The expert: Dr. Christine Kay, Vitreoretinal Associates, Gainesville, FL, USA This activity is funded by an independent medical education grant from Alkeus Pharmaceuticals, Inc. This activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. This touchPODCAST is for HCPs outside of the UK.   For further information visit our website: www.touchOPHTHALMOLOGY.com

Dr. Melinda Gooderham, Prof. Dr. Falk Bechara, and Dr. Daniel Stein discuss how evolving therapies are reshaping HS management and multidisciplinary care, with patient perspectives highlighting the impact of coordinated care and effective disease control. The multidisciplinary team Dr. Melinda Gooderham - SKiN Centre for Dermatology, Peterborough, Ontario, Canada Prof. Dr. Falk Bechara - Ruhr University Bochum, Germany Dr. Daniel Stein - George Washington University, Washington, DC, USA This touchPODCAST is for HCPs only. This activity is supported by an independent medical education grant from UCB. Jointly provided by Partners for Advancing Clinical Education and touchIME. touchIME is an EBAC® accredited provider.  For further information visit our website:  touchDERMATOLOGY.com and touchIMMUNOLOGY.com

Dr. Melinda Gooderham, Prof. Dr. Falk Bechara, and Dr. Daniel Stein discuss the medical and surgical decision-making challenges in perineal and genital HS, including common diagnostic pitfalls, how to integrate medical and surgical treatment, and the unique role of urology in managing complex disease.  The multidisciplinary team Dr. Melinda Gooderham - SKiN Centre for Dermatology, Peterborough, Ontario, Canada Prof. Dr. Falk Bechara - Ruhr University Bochum, Germany Dr. Daniel Stein - George Washington University, Washington, DC, USA This touchPODCAST is for HCPs only. This activity is supported by an independent medical education grant from UCB. Jointly provided by Partners for Advancing Clinical Education and touchIME. touchIME is an EBAC® accredited provider.  For further information visit our website:  touchDERMATOLOGY.com and touchIMMUNOLOGY.COM

Dr. Melinda Gooderham and Dr. Jillian Kerry discuss the unique challenges of hidradenitis suppurativa in women, including vulvar disease, hormonal influences, pregnancy, and the importance of collaboration between dermatology and obstetrics and gynecology. The multidisciplinary team Dr. Melinda Gooderham - SKiN Centre for Dermatology, Peterborough, Ontario, Canada Dr. Jillian Kerry - University of Saskatchewan, Saskatoon, Canada This touchPODCAST is for HCPs only. This activity is supported by an independent medical education grant from UCB. Jointly provided by Partners for Advancing Clinical Education and touchIME. touchIME is an EBAC® accredited provider.  For further information visit our website:  touchDERMATOLOGY.com and touchIMMUNOLOGY.COM

Dr. Melinda Gooderham and Prof. Dr. Falk Bechara discuss opportunities for earlier recognition and referral of hidradenitis suppurativa, including key clinical clues, referral pathways, and the impact of diagnostic delay. A patient perspective highlights the importance of timely diagnosis and coordinated care. The multidisciplinary team Dr. Melinda Gooderham - SKiN Centre for Dermatology, Peterborough, Ontario, Canada Prof. Dr. Falk Bechara - Ruhr University Bochum, Germany This touchPODCAST is for HCPs only. This activity is supported by an independent medical education grant from UCB. Jointly provided by Partners for Advancing Clinical Education and touchIME. touchIME is an EBAC® accredited provider.  For further information visit our website:  touchDERMATOLOGY.com and touchIMMUNOLOGY.COM

touchEXPERT FOCUS for touchINFECTIOUS DISEASES Listen to a series of short interviews with three leading experts discussing preference-sensitive care for people living with HIV. Faculty consider the evolving landscape of simplified ART options, including long-acting injectable regimens, and provide practical strategies to align treatment choices with individual goals and preferences. They also discuss the value and feasibility of integrating patient-reported outcome assessments into routine care for people living with HIV. The experts: Prof. Chloe Orkin – Barts Health NHS Trust and Queen Mary University of London, UK Dr. Brenda Crabtree-Ramirez – Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico Prof. Jürgen Rockstroh – HIV Outpatient Clinic, University of Bonn, Bonn, Germany This touchPODCAST is for healthcare professionals outside of the UK. This activity is funded by an independent medical education grant from ViiV Healthcare. This activity is provided by touchIME. For further information visit our website: https://touchinfectiousdiseasesime.org/empowering-choice-in-hiv/  

touchEXPERT FOCUS for touchNEUROLOGY, touchIMMUNOLOGY, touchOPHTHALMOLOGY    Dr. Eoin Flanagan shares his expert insights on myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and how to distinguish it from other demyelinating diseases like multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-positive NMOSD). As part of the interview, Dr. Flanagan describes MOGAD’s pathogenesis and explains how to achieve an early accurate diagnosis using the latest diagnostic frameworks.   The expert Dr. Eoin Flanagan, Mayo Clinic, Rochester, MN, USA   This activity is funded by an independent medical education grant from UCB. It is jointly provided by USF Health and touchIME.   This touchPODCAST is for healthcare professionals in the USA only.   For further information, please visit our websites: www.touchNEUROLOGY.com, www.touchIMMUNOLOGY.com, www.touchOPHTHALMOLOGY.com

touchMDT for touchIMMUNOLOGY, touchHEMATOLOGY, touchDERMATOLOGY, and touchONCOLOGY Listen to key experts from a multidisciplinary team discuss the diagnosis, classification, and management of patients with systemic mastocytosis. They provide their key insights on effectively recognizing systemic mastocytosis, integrating key classification criteria from the ICC and WHO, and how multidisciplinary care is needed to effectively manage patients with systemic mastocytosis.   The multidisciplinary team Allergist/Immunologist: Dr. Cem Akin, University of Michigan Health, Ann Arbor, MI, USA Allergist/Immunologist: Dr. Theo Gülen, Karolinska University Hospital, Stockholm, Sweden Hematologist: Dr. Tsewang Tashi, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT, USA This touchPODCAST is for HCPs outside of the UK. This activity is funded by an unrestricted independent medical education grant from BluePrint Medicines Corporation.  This activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website: www.touchHEMATOLOGY.com, www.touchIMMUNOLOGY.com, www.touchDERMA.com, or www.touchONCOLOGY.com