Overcoming EGFR-TKI resistance: Emerging therapies and biomarker strategies in NSCLC

touchCLINICAL PERSPECTIVES for touchONCOLOGY and touchRESPIRATORY Module 1: Beyond EGFR: Addressing actionable drug resistance mechanisms In this module, Professors Jänne and Girard explore the challenges of resistance to EGFR-targeted therapies in non-small cell lung cancer. They discuss how mechanisms such as MET and HER2 amplification drive resistance to first-line osimertinib, review emerging targeted strategies to overcome these barriers, and highlight the importance of biomarker testing and managing treatment side effects when shaping second-line options for patients. Course director Prof. Pasi Jänne, Dana-Farber Cancer Institute, Boston, MA, USA The clinical expert Prof. Nicholas Girard, Institut Curie, Paris, France Module 2: Bridging resistance gaps post–EGFR-TKI: Expanding NSCLC treatment beyond actionable targets In this module, Professor Pasi Jänne and Dr. Helena Yu discuss the evolving management of EGFR-mutant NSCLC after EGFR-TKI progression. They address challenges of unexplained resistance, review combination and ADC treatment approaches, and highlight key factors such as patient selection, safety and emerging biomarkers Course director Prof. Pasi Jänne, Dana-Farber Cancer Institute, Boston, MA, USA The clinical expert Dr Helena Yu, Memorial Sloan Kettering Cancer Center, New York, NY, USA This touchPODCAST is for HCPs only. This activity is funded by an educational grant from AstraZeneca Ltd.  This medical education is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website:   add url

touchEXPERT FOCUS for touchOPHTHALMOLOGY Listen to a series of interviews with two medical retina specialists and a biomarker expert who will provide their insights into the pathophysiology of diabetic macular oedema (DMO), including the inflammatory mechanisms of disease and how they may impact treatment. The faculty will also consider the clinical utility of optical coherence tomography (OCT) imaging biomarkers and emerging evidence on the evolving role of corticosteroids in the management of DMO. The experts: Prof. Stela Vujosevic, Medical Retina Unit, IRCCS MultiMedica and University of Milan, Milan, Italy Prof. Francesco Bandello, University Vita-Salute, San Raffaele Scientific Institute, Milan, Italy Prof. Laurent Kodjikian, University of Lyon and Croix-Rousse University Hospital, Lyon, France This touchPODCAST is for HCPs outside of the UK and USA. This activity is funded by an independent medical education grant from Alimera Sciences Europe Ltd. The activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website: www.touchOPHTHALMOLOGY.com

touchPANEL DISCUSSION for touchNEUROLOGY Listen to a panel of experts in epilepsy as they discuss how to promptly and accurately diagnose and manage Lennox–Gastaut syndrome (LGS). Moderated by a leading European expert, this episode brings together faculty from the Gulf region and Japan, as they explore diagnostic approaches in their regions, before sharing their unique regional perspectives and real-world experience in caring for patients with LGS.   The experts Prof. Nicola Specchio: Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy Dr Raidah Al-Baradie: King Fahad Specialist Hospital, Dammam, Saudi Arabia Dr Taoufik Alsaadi: American Center for Neurology, Abu Dhabi, Dubai, UAE Prof. Eiji Nakagawa: National Center of Neurology and Psychiatry, Tokyo, Japan Prof. Hideo Yamanouchi: Saitama Medical University, Saitama, Japan Chapters The disease state of LGS (00:00–18:47) Managing patients with LGS in the Gulf (18:48–37:00) Managing patients with LGS in Japan (37:01–56:25) This touchPODCAST is for HCPs outside of the UK only.  This activity is supported by an independent medical educational grant from Jazz Pharmaceuticals.  Jointly provided by Partners for Advancing Clinical Education and touchIME. touchIME is an EBAC® accredited provider. For further information visit: touchneurologyime.org/diagnosis-treatment-lennox-gastaut-syndrome/

touchEXPERT FOCUS for touchCARDIO Listen to short interviews with two expert cardiologists discussing the role of current and emerging therapeutic classes that aim to address the unmet needs of patients with hypertrophic cardiomyopathy. The faculty will review current therapeutic approaches for managing obstructive versus nonobstructive hypertrophic cardiomyopathy to highlight existing gaps in patient care. They will then discuss the latest data for emerging therapeutic classes and consider how they may address patients’ unmet needs in the future.    The experts Dr Martin Maron, Lahey Hospital & Medical Center, Burlington, MA, USA Dr Michelle Michels, Erasmus MC, Rotterdam, The Netherlands This touchPODCAST is for healthcare professionals outside of the UK. This activity is supported by an independent medical educational grant from Cytokinetics, Inc. Jointly provided by Partners for Advancing Clinical Education and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website:  https://touchcardio.com/

Module 1: Beyond EGFR: Addressing actionable drug resistance mechanisms touchCLINICAL PERSPECTIVES for touchONCOLOGY and touchRESPIRATORY In this module, Professors Jänne and Girard explore the challenges of resistance to EGFR-targeted therapies in non-small cell lung cancer. They discuss how mechanisms such as MET and HER2 amplification drive resistance to first-line osimertinib, review emerging targeted strategies to overcome these barriers, and highlight the importance of biomarker testing and managing treatment side effects when shaping second-line options for patients. Course director Prof. Pasi Jänne, Dana-Farber Cancer Institute, Boston, MA, USA The clinical expert Prof. Nicholas Girard, Institut Curie, Paris, France This touchPODCAST is for HCPs only. This activity is funded by an educational grant from AstraZeneca Ltd.  This medical education is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website:   touchONCOLOGY: https://touchoncologyime.org/egfr-tki-resistance-strategies-nsclc/ touchRESPIRATORY: https://touchrespiratoryime.org/egfr-tki-resistance-strategies-nsclc/  

touchEXPERT FOCUS for touchONCOLOGY Listen to insights from Prof. Jean-Pascal Machiels on optimizing the use of immunotherapy in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) and the potential future role of immunotherapy in resectable locally advanced HNSCC. The expert: Prof. Jean-Pascal Machiels, Cliniques universitaires Saint-Luc, Brussels, Belgium This touchPODCAST is for HCPs outside of the UK. This activity is funded by an independent medical education grant from Merck Sharp & Dohme LLC. The activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website: www.touchONCOLOGY.com

touchIN CONVERSATION for touchCARDIOLOGY and touchENDOCRINOLOGY Listen to two experts as they discuss the diagnosis, treatment and how to support patients with FCS. They cover how to recognize key clinical signs and symptoms, strategies to help manage symptoms, reduce triglyceride levels and prevent complications. They  also share key insights from their experience with novel targeted therapies for FCS. The expert(s) Professor Antonio Gallo, Sorbonne University Hospital Pitié-Salpêtrière, Paris, France Dr Vikesh Singh, Johns Hopkins University School of Medicine, Baltimore, MD, USA This touchPODCAST is for HCPs in the USA and Europe only. This activity is funded by an independent medical education grant from Arrowhead Pharmaceuticals, Inc. This activity is jointly provided by USF Health and touchIME.  touchIME is an EBAC® accredited provider. For further information visit our websites: https://touchcardioime.org/fcs-unmasked/ and https://touchendocrinologyime.org/fcs-unmasked/

touchEXPERT FOCUS for touchHAEMATOLOGY Prof. Lucia de Franceschi, a leading expert in sickle cell disease, examines the clinical manifestations and burden of the condition, reviews current and emerging treatments and offers guidance on comprehensive lifespan care that addresses complications, quality of life, and disparities, while highlighting the essential role of multidisciplinary support. The experts Prof. Lucia de Franceschi, University of Verona, Italy This touchPODCAST is for HCPs outside of the UK. This activity is funded by an independent medical education grant from Agios Pharmaceuticals, Inc. The activity is jointly provided by USF Health and touchIME. touchIME is an EBAC® accredited provider. For further information visit our website: www.touchHAEMATOLOGY.com

touchEXPERT FOCUS for touchENDOCRINOLOGY, touchCARDIO and touchNEUROLOGY Listen to a series of short expert interviews on timely diagnosis and individualized care for Fabry disease, using genetic and clinical insights. Our faculty discuss strategies to reduce diagnostic delays, identify clinically relevant genetic variants and tailor treatment based on each patient's genotype–phenotype correlations. The experts Dr Raphael Schiffmann, Texas Christian University, Fort Worth, TX, USA Ms Dawn Laney, Emory Genetic Clinical Trials Center, Atlanta, GA, USA Dr Ozlem Goker-Alpan, Lysosomal Disorders Research and Treatment Center (LDRTC), Fairfax, VA, USA This touchPODCAST is for HCPs outside of the UK. This activity is funded by an independent medical education grant from Amicus Therapeutics Inc. This activity is jointly provided by USF Health and touchIME. For further information visit our websites:  www.touchENDOCRINOLOGY.com www.touchCARDIO.com and www.touchNEUROLOGY.com

touchCASES for touchONCOLOGY Listen to three experts as they discuss how patient and disease characteristics may inform treatment selection in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC). They will discuss the cases of three patients which will cover first-line and second-line treatments as well as key considerations for their treatment plans in their patients' cases. The experts: Dr Nabil Saba, Winship Cancer Institute, Emory University, Atlanta, GA, USA Dr Victoria Villaflor, Chao Family Comprehensive Cancer Center, UCI Health, Orange, CA, USA This activity is for HCPs in the USA only This activity is funded by an independent medical education grant from Coherus Biosciences. This activity is jointly provided by USF Health and touchIME. For further information visit our website: https://touchoncologyime.org/treatment-selection-in-r-m-npc/