#233 The Science of Hunger: GLP-1, Appetite Control & Natural Weight Management With Sarah Kennedy

Why does hunger feel so loud — and why does willpower so often fail?In this illuminating episode, Sarah Kennedy, founder and CEO of Calocurb, unpacks the biology of hunger, the gut-brain axis, and the powerful role of GLP-1 in appetite regulation. Drawing on over 15 years and $30 million of New Zealand government-backed science, Sarah explains why hunger is driven by our most primitive brain systems — and how understanding this biology can finally bring peace with food.We explore how bitter taste receptors in the gut stimulate appetite-suppressing hormones, why dieting can actually increase hunger over time, and how natural GLP-1 activation differs fundamentally from pharmaceutical injections like Ozempic.We explore:The evolutionary biology of hunger and food noiseHow GLP-1, CCK and PYY regulate appetiteWhy calorie restriction backfires long-termNatural vs synthetic GLP-1 pathwaysHow appetite regulation supports metabolic health, insulin sensitivity & longevityThis is a science-grounded, compassionate conversation that reframes hunger — not as a personal failure, but as biology you can finally work with.This episode was brought to you by:CalocurbSupport this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

What happens when life gives you a second chance?In this powerful episode, world-record mountaineer, author, and resilience expert Jenn Drummond shares how surviving a near-fatal car crash became the defining line between the life she was living — and the life she chose to claim.From promising she’d “do something significant” if she lived, to summiting Everest and completing the second-highest peaks on every continent, Jenn reveals why courage isn’t something you’re born with — it’s something you build, one brave step at a time.We explore:How trauma can become a catalyst for purposeWhy courage is trained, not innateThe mindset that turns fear into forward motionWhat it means to shift from success to significanceHow to model resilience for your children — and yourselfThis is a deeply human conversation about choosing life, rewriting identity, and climbing the inner mountains that matter most.This episode was brought to you by:CarolbikeKineonCalocurbSupport this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

What if your cravings, emotional eating, and daily food choices weren’t driven by lack of willpower — but by biology, psychology, and an environment designed to hijack your instincts?In this eye-opening episode, visionary entrepreneur and creator of WildFit, Eric Edmeades, breaks down the evolutionary roots of hunger, the truth about sugar and stress, and why most modern diets fail. Eric reveals how our ancient programming collides with today’s food landscape — and how to reclaim our natural vitality by understanding what the body is truly asking for.With warmth, clarity, and powerful storytelling, Eric guides us through the deeper emotional patterns behind eating, the role of seasonal nutrition, and how to finally achieve food freedom without discipline, restriction, or shame.We explore:The evolutionary roots of hunger, cravings & emotional eatingWhy diets fail — and how to reset your body’s real nutritional needsThe WildFit method for sustainable health & metabolic healingSugar, stress & the biology of modern overeatingHow to eat in alignment with your natural rhythms and instinctsThis conversation will transform the way you think about food — and the way you nourish your life. Tune in and learn how to return to your most vibrant, instinctive, healthy self.Support this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

What if health optimization wasn’t just for the elite — but something every teacher, firefighter, and family could access?In this inspiring episode, Jim Donnelly, founder and CEO of Humanaut Health (and former founder of Restore Hyper Wellness), shares how he’s building the most comprehensive, prevention-driven longevity model to date. From advanced diagnostics and regenerative medicine to behavior change and coaching, Jim reveals what it truly takes to add 10–20 healthy, vibrant years to life.He opens up about the loss of his father, surviving a near-fatal car accident, and how stem cell therapy transformed his recovery — all of which shaped his mission to scale health optimization with integrity, accessibility, and world-class medical excellence.We explore:Why foundational habits (sleep, movement, nutrition, stress) drive 90% of resultsHow Humanaut uses 150+ diagnostics to find root causesWhy regenerative medicine works best on a healthy foundationHow to democratize longevity without sacrificing qualityWhat it takes to reverse metabolic dysfunction — 86% success in under 6 monthsThis conversation is a powerful reminder that the future of medicine is preventive, personalized, and incredibly hopeful.Tune in and discover what’s possible when we invest in health — not after we’re sick, but while we’re thriving.Support this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

Pain might feel like an inevitable part of aging — but what if it’s actually fixable?In this episode, Forrest Smith, CEO and co-founder of Kineon, unpacks the cutting-edge science behind red light and laser therapy, why inflammation is the real driver of pain and accelerated aging, and how daily, targeted phototherapy can transform mobility, energy, and long-term health.We explore the link between inflammation and chronic disease, the surprising gut–brain–thyroid connection, and why repairing internal tissue with the right light wavelengths can dramatically shift your health trajectory.We cover:The four pillars of red light therapy at the cellular levelWhy treating inflammation is key to longevity and mobilityHow gut health, thyroid function & brain health connect through lightRed light protocols for pain relief, energy, mood & recoveryHow Kineon’s Move+ Pro is disrupting traditional pain managementIf you want to stay active, mobile, and pain-free for life, this conversation is a must-listen.Tune in and learn how to use light to heal your body from the inside out.Support this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

When it comes to longevity, your gut might hold the master key. In this fascinating episode, Colleen Cutcliffe, PhD, CEO and co-founder of Pendulum Therapeutics, reveals how a single gut bacterium—Akkermansia muciniphila—is transforming the future of metabolic and hormonal health.From her daughter’s early health challenges to pioneering live Akkermansia in supplement form, Colleen shares her journey from biotech to natural therapeutics. Discover how the microbiome impacts metabolism, energy, brain function, menopause, and even GLP-1 hormone production—the same pathway drugs like Ozempic mimic.We explore:Why 88% of Americans are metabolically unhealthyThe gut’s role as the root system of longevityHow Akkermansia acts as “the glue” for gut lining integrityThe connection between gut bacteria and women’s hormonesBreakthroughs in microbiome-based therapies and “bugs as drugs”Whether you’re curious about reversing metabolic dysfunction or optimizing your healthspan naturally, this episode is your deep dive into the science and soul of gut health.Sponsors: Carol Bike: Get $300 off from Oct 17 – Dec 26, 2025, with code CLAUDIA, and enjoy an ongoing $100 off afterward. Visit carolbike.com/claudia and use code CLAUDIA at checkout.Pendulum: Get 20% off your first membership order at pendulumlife.com/CLAUDIA20, your discount applies automatically.Juvent: Get $300 off the Juvent Micro-Impact Platform at juvent.com/CLAUDIA and check out with code CLAUDIA.Kineon: Get 10% off your MOVE+ Pro at kineon.io/claudiaCalocurb: Get 10% off at calocurb.com/longevityandlifestyle with code CLAUDIA10 at checkout.Support this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

When it comes to longevity, your gut might hold the master key. In this fascinating episode, Colleen Cutcliffe, PhD, CEO and co-founder of Pendulum Therapeutics, reveals how a single gut bacteriu, Akkermansia muciniphila - is transforming the future of metabolic and hormonal health.From her daughter’s early health challenges to pioneering live Akkermansia in supplement form, Colleen shares her journey from biotech to natural therapeutics. Discover how the microbiome impacts metabolism, energy, brain function, menopause, and even GLP-1 hormone production—the same pathway drugs like Ozempic mimic.We explore:Why 88% of Americans are metabolically unhealthyThe gut’s role as the root system of longevityHow Akkermansia acts as “the glue” for gut lining integrityThe connection between gut bacteria and women’s hormonesBreakthroughs in microbiome-based therapies and “bugs as drugs”Whether you’re curious about reversing metabolic dysfunction or optimizing your healthspan naturally, this episode is your deep dive into the science and soul of gut health.This episode is brought to you by Pendulum - get 20% off your first membership order at pendulumlife.com/CLAUDIA20, your discount applies automatically.Support this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

What’s the true return on investment when it comes to your health? In this special episode, Claudia joins Liz Bradford on the Health ROI Show to share how she reversed her biological age by 17 years, all while running multiple businesses and raising a family. Together, they unpack the data-driven strategies that deliver the biggest health ROI: from optimizing sleep and managing stress to rebalancing hormones and designing sustainable daily systems that work for high performers.You’ll learn:Why your “why” is the foundation of lasting transformationThe non-negotiables that drive real energy and focusHow to use data to personalize your health optimizationSimple, high-impact longevity habits anyone can start todayIf you’ve ever felt too busy to prioritize your health, this episode will shift your mindset — and your biology. Tune in to discover how to maximize your energy, longevity, and vitality, one smart investment at a time.Sponsors: Carol Bike: Get $300 off from Oct 17 – Dec 26, 2025, with code CLAUDIA, and enjoy an ongoing $100 off afterward. Visit carolbike.com/claudia and use code CLAUDIA at checkout.Pendulum: Get 20% off your first membership order at pendulumlife.com/CLAUDIA20, your discount applies automatically.Juvent: Get $300 off the Juvent Micro-Impact Platform at juvent.com/CLAUDIA and check out with code CLAUDIA.Kineon: Get 10% off your MOVE+ Pro at kineon.io/claudiaCalocurb: Get 10% off at calocurb.com/longevityandlifestyle with code CLAUDIA10 at checkout.Support this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

What if the secret to longevity wasn’t more movement but the right kind of movement?In this episode, Peter Simonson, President, Co-Founder, and Board Member of Juvent, reveals how NASA-backed micro-impact technology is transforming bone density, balance, and vitality from the ground up.We unpack the science of mechanotherapy, how gentle vibrations can stimulate bones and circulation, and why this “passive exercise” could be a game-changer for aging well — especially for those recovering from injury or struggling with mobility.We explore:The link between bone health and longevityHow NASA research inspired Juvent’s micro-impact platformThe surprising benefits for balance, circulation, and energyWhy strong bones equal longer, healthier livesSponsors: This episode is brought to you by Juvent, creators of the Micro-Impact Platform. A breakthrough technology that helps improve circulation, bone health, and reduce pain naturally. Just stand on it for 20 minutes a day and let gentle micro-impacts work at the cellular level to support healing and mobility. Get $300 off the Juvent Micro-Impact Platform at juvent.com/CLAUDIA with code CLAUDIASupport this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations

Are Hidden Toxins Silently Aging You From the Inside Out?Brain fog. Fatigue. Anxiety. Hormonal chaos.For millions, these symptoms aren’t just “stress” — they’re signs of toxic overload.In this episode, Dr. Chris Shade, founder of Quicksilver Scientific and one of the world’s leading experts on mercury and detoxification, reveals how environmental toxins, heavy metals, and everyday exposures are quietly disrupting your mitochondria, hormones, and brain — and what you can do to reverse it.This isn’t another “detox fad.” It’s cutting-edge biochemistry meets practical longevity science — from the man who helped Tony Robbins recover from severe mercury toxicity.Dr. Shade shares how to safely clear toxins, repair your mitochondria, and reignite your body’s natural longevity systems — without wrecking your energy in the process.Together, we explore:◼️ The truth about mercury, heavy metals & how they destroy energy and focus◼️ The link between toxins, inflammation, and accelerated aging◼️ Glutathione: the “master antioxidant” and anti-aging molecule explained◼️ How stress blocks detox pathways and why calm equals longevity◼️ The 3-step detox process: Drain, Move, Bind — and how to do it safely◼️ Practical daily habits to support liver, bile, and mitochondrial health◼️ The role of peptides, saunas, and bitters in next-generation detox protocolsThis Episode was brought to you by:Juvent: Get $300 off the Juvent Micro-Impact Platform at juvent.com/CLAUDIA with code CLAUDIA.Pendulum: Get 20% off your first membership order with Pendulum at pendulumlife.com/CLAUDIA20Carol Bike: Get $300 off from CarokBike, from Oct 17 – Dec 26, 2025, with code CLAUDIA, and enjoy an ongoing $100 off afterward. Visit carolbike.com and use code CLAUDIA at checkout.Support this podcast at — https://redcircle.com/the-longevity-and-lifestyle-podcast/donations