David Sacks, Anthropic, & the White House, Regeneron’s Deafness Cure 4/24/26

The FDA has approved Regeneron’s gene therapy for a rare form of inherited deafness, and it’s free for Americans. Regeneron CEO Leonard Schleifer discusses the breakthrough treatment, drug pricing, AI’s role in medical innovation, and what breakthroughs might come next. Co-chair of the President’s Council of Advisors on Science and Technology David Sacks was one of the original executives at PayPal, alongside Elon Musk and Peter Thiel. As an AI and crypto advisor to President Trump, the All In Podcast co-host is helping shape AI regulation and policy in the United States. He comments on the government’s complicated relationship with Anthropic and the ongoing feud between Elon Musk and Sam Altman. Plus, a U.S. soldier was arrested for his winning Polymarket bet on the capture of Venezuelan leader Nicolás Maduro, and Intel reported a blowout quarter.   David Sacks - 17:43 Leonard Schleifer - 29:21   In this episode: Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Nasdaq CEO Adena Friedman discusses the exchange’s latest financial results, the IPO pipeline–including SpaceX’s potential listing–and the 23 hours a day, 5 days a week U.S. equity trading coming in December.CNBC’s Steve Liesman shares the results of the latest CNBC All-America Economic Survey: 40% of people nationwide approve of the President’s overall job performance. Amid surging fuel prices and the Iran war, President Trump’s net approval rating fell 10 points to -18, the lowest ever measured for his two terms.  Plus, Arkansas Governor Sarah Huckabee Sanders discusses the President’s approval ratings and his handling of the war in Iran.   Steve Liesman - 2:44 Adena Friedman - 12:57 Gov. Sarah Huckabee Sanders - 30:41   In this episode: Sarah Huckabee Sanders, @SarahHuckabee Steve Liesman, @steveliesman Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

United Airlines CEO Scott Kirby discusses his company’s latest financial report and responds to President Trump’s comments on a potential United-American merger. Plus, an executive order on medical treatments for serious mental health issues bumped psychedelics stocks higher. Psychedelics investor and founder Christian Angermayer explains the industry’s opportunity for mental health–and for investors.  Dan Murphy Scott Kirby & Phil LeBeau - 15:13 Christian Angermayer - 30:21   In this episode: Christian Angermayer, @C_Angermayer Dan Murphy, @dan_murphy Phil LeBeau, @Lebeaucarnews Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In an extended interview, President Donald Trump discusses negotiations with Iran, the U.S. alliance with Israel, and the future of America’s presence in the region. The President also weighs in on inflation, the White House’s relationship with Anthropic, and the possibility of consolidation in the airline industry. Plus, Steve Liesman reports on Kevin Warsh’s Fed chair confirmation hearing, and both President Trump and Warren Buffett address the biggest corporate headline of the day: Apple CEO Tim Cook, handing over the reins to John Ternus in September.    President Trump - 17:45   In this episode: President Donald Trump, @realDonaldTrump MacKenzie Sigalos, @KenzieSigalos Steve Liesman, @steveliesman Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

As concerns mount regarding the health of the private credit ecosystem, Oaktree Capital Management co-chairman Howard Marks offers perspective–and some investing advice–when it comes to private lending. Former FDA Commissioner Dr. Scott Gottlieb discusses Eli Lilly’s deal to expand its cancer treatment pipeline as well as President Trump’s executive order on therapeutic psychedelics. Plus, Kevin Warsh’s Fed Chair nomination hearing is this week, and Anthropic’s Mythos is at work within the NSA, despite being blacklisted by the US government.    Steve Liesman          14:36 Howard Marks             23:54 Dr. Scott Gottlieb          41:27   In this episode: Steve Liesman, @steveliesman Andrew Ross Sorkin, @andrewrsorkin Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Katie Kramer,  @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In the Middle East, Israel and Lebanon have agreed to a 10-day ceasefire, and Iran declared the Strait of Hormuz open to shipping. Meanwhile, President Trump reassures Americans that the war in Iran is going “swimmingly.” Former Assistant Secretary of State Mark Kimmitt discusses the negotiations in the region and the leverage of each stakeholder. In business, Anthropic may be bringing its Mythos LLM to some government agencies, and Netflix’s CEO Reed Hastings is stepping down. Plus, obesity expert Dr. Angela Fitch addresses the link between GLP-1s and mental health.    Mark Kimmitt - 14:04 Dr. Angela Fitch - 24:32   In this episode: Kelly Evans, @KellyCNBC Joe Kernen, @JoeSquawk Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

As the DHS shutdown has crossed 60 days, pressure is on House Republicans to end the standoff. DHS Secretary Markwayne Mullin discusses the latest in the funding battle, Democratic demands for ICE reforms, policy changes at the department, and the real-world impact of the prolonged shutdown. As Anthropic’s “Mythos” model grows more advanced, concerns about AI risk are also accelerating. Stuart Russell, UC Berkeley professor and president of the International Association for Safe and Ethical AI, explains the potential harms of increasingly powerful systems, the push for safer development, and the case for regulation. Plus, the Trump administration taps automakers to boost weapons production, and LIV Golf faces a potential shutdown as Saudi backers weigh pulling funding.   Dan Murphy - 08:11 Sec. Markwayne Mullin - 19:07 Stuart Russell - 29:49   In this episode: Sec. Markwayne Mullin, @SenMullin Kelly Evans, @KellyCNBC Michael Santoli, @michaelsantoli Joe Kernen, @JoeSquawk Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

House Minority Leader Hakeem Jeffries (D-NY) offers his party’s perspective on the Iran War, the President’s delivery on the economy, and America’s affordability crisis. This week, the market digested multiple economic data sets. On Tuesday, the producer price index, a gauge of pipeline costs for final demand goods and services, made the biggest 12-month gain since February 2023. Today, the Bureau of Labor Statistics showed that U.S. import prices rose less than expected in March, and petroleum import prices increased 9.4% as the war in Iran drove energy prices higher. CNBC’s Steve Liesman and Rick Santelli break down the data and the market’s expectations for that data, and Cleveland Fed President Beth Hammack explains what the numbers could mean for the Fed’s next interest rate decision. Plus, CNBC’s Phil LeBeau discusses the potential for airline mergers in the current administration, Anthropic is reportedly turning down VC money, and Kevin Warsh’s Fed nomination hearing has been scheduled after a delay.    Phil LeBeau - 11:13 House Minority Leader Hakeem Jeffries - 19:33 Steve Liesman & Rick Santelli - 36:48 Beth Hammack - 42:47   In this episode: Hakeem Jeffries, @RepJeffries Phil LeBeau, @Lebeaucarnews Steve Liesman, @steveliesman Rick Santelli, @RickSantelli Kelly Evans, @KellyCNBC Michael Santoli, @michaelsantoli Joe Kernen, @JoeSquawk Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Lowe’s is launching annual subscription service HomeCare+ to deepen the company’s relationship with customers. CEO Marvin Ellison discusses the initiative, the investment he’s making in trade skill training, the future of the labor market, and the ideal housing environment for his bottom line. Then, Robert Frank reports on the Iran War’s impact on luxury shoppers in the Middle East and, by extension, on luxury conglomerate LVMH. Plus, United Airlines CEO Scott Kirby reportedly pitched a merger with American, and CNBC’s Steve Liesman reports that the NFIB small business optimism index for March of 2026 fell to its lowest level since the Liberation Day tariffs in April of 2025.    Steve Liesman - 6:46 Marvin Ellison - 16:24 Robert Frank - 33:19   In this episode: Steve Liesman, @steveliesman Robert Frank, @robtfrank Kelly Evans, @KellyCNBC Joe Kernen, @JoeSquawk Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

President Trump has announced a blockade of the Strait of Hormuz after peace talks between the U.S. and Iran failed over the weekend. Founder and senior chairman of Evercore Roger Altman discusses the business community’s response to the conflict, CNBC’s Dan Murphy reports from the UAE, and former NATO Secretary General Jens Stoltenberg discusses the perspective of U.S. allies around the world as the Iran War continues. Plus, McDonald’s is exploring an expansion to its beverage menu, and Rory McIlroy won the Masters for the second year in a row.    Dan Murphy - 08:27 Roger Altman - 21:37 Jens Stoltenberg - 34:16   In this episode:  Dan Murphy, @dan_murphy Kelly Evans, @KellyCNBC Joe Kernen, @JoeSquawk Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.