Stem cell niches, why do we need them to work?

Trigger Warning! This episode discusses topics centring around weight and weight loss, and diet culture. If you feel these topics may be triggering for you, feel free to switch to another of our episodes instead. In this episode, we delve into the world of diabetes treatment, exploring the benefits and side effects of Ozempic, a popular drug used to treat type 2 diabetes. We also discuss the recent shortages of Ozempic and the impact it has had on patients. We also take a closer look at alternative treatments for diabetes, specifically stem cell therapies for type 1 diabetes. We discuss the potential benefits of this cutting-edge treatment and the progress made in this field. Join us as we explore the exciting advancements in diabetes treatment and the various options available for patients.

In this episode, we discussed artificial intelligence's role in stem cell therapies by diving into the work of Cellino, a start-up biotech led by Nabiha Saklayen (co-founder) and Marina Madrid (co-founder) and Matthias Wagner. Their patented technology could hold some of the answers to how AI can help automate the stem cell manufacturing process making future treatments more affordable, scalable and standardised.Also, stick around to the end; you might even get a cheeky book recommendation.You can find the video we were talking about on Youtube: https://www.youtube.com/watch?v=CmnCHDoyfX

In this episode of Seriously Stem Cells, we sit down with, Thea Collier-Lawlor,  a master's student from the Stem Cells & Regenerative Therapies: From Bench to Market program at King's College London. Our guest shares her passion for stem cells and discusses the importance of studying this innovative field. She also sheds light on the benefits of stem cell research and provides insights into her personal experience as a stem cell researcher. Join us as we dive deep into the world of stem cells and explore the exciting opportunities this field has to offer.

In today's episode. Pim will be sharing her understanding of stem cell therapies which are used in the field of sports medicine. She will dive deep into the type of injuries you can find in various sports and the benefits of stem cells used on specific sports injuries. The episode will be answering the following questions surrounding this topic: What is stem cell therapy? What types of stem cell therapies can be used for which sports injuries? What are the advantages and disadvantages of stem cell therapies in sports medicine?

Today we are back with our first guest episode with KCL's top Professor in Stem Cells, Dr Dusko Illic, who happens to be my professor from Stem Cells & Regenerative Therapies: From Bench to Market masters program. In the episode, we will debunk some stem cells myths and dive deep into what you need to know about stem cells in our 'Stem Cells in Context' segment: Is genetic modification in embryos ethical or not? How important is regulation for the genetic modification future? What is the importance of companies on accountability for misleading the predicted success of their stem cell-based products? What are the challenges and the future of sustainability in the life sciences (including stem cells) industry? Having a leg in the commercial sector, our professor's advice on investment in the stem cell industry is something you cannot miss. He specifically highlights what makes me most excited by the stem cell industry. In his words, "It will be as exciting as the discovery of antibiotics". We also value the man behind the science with a series of 'Getting to know you' questions in the new segment.

In this episode, Ayo and I are back and we are discussing the topic of growing the brain outside a body is a reality worth exploring. We dive into the beneficial uses of brain growth outside the body and the challenges that come with it. We close the episode with the ethics surrounding this topic. Give us a listen and let us know what you think! Follow us on Instagram under 'seriouslystemcells' or our website seriouslystemcells.wordpress.com/

In this episode, we're giving audiences an update on the latest news of stem cell technologies. The episode highlights the collaboration between a clinical-stage biotech company, Arcellx, and a biopharmaceutical giant, Kite, a Gilead company, on the CART therapy candidate targeting BCMA antigen on multiple myeloma (MM) known as CART-ddBCMA. The candidate is based on a proprietary platform technology D-Domain of Arcellx that aims to improve the efficiency and effective of CART target recognition. Here is more about the candidate in the episode based on the press conference news of Kite and Arcellx.

In today's episode, I will be discussing the relevance of Neural Stem Cells or NSCs in the treatment of neurological disease, with a focus on multiple sclerosis. Ayo and I have decided to split the episode into two parts, this is part I so there is more coming!  These are the subtopics that will be mentioned in the episode: Neural Stem Cells brief background Current neurological disorders treatment What is Multiple Sclerosis (MS) How do NSCs play a role in MS treatments? Challenges and future directions of NSC transplantation  For a more detailed explanation of NSC and MS, visit our website seriouslystemcells.wordpress.com/

In this week's episode, Ayo and I discuss the topic of haematopoietic stem cells or HSCs. We continue our exploration into the world of stem cells. The episode starts off with a recap of the previous episode and an introduction to the HSCs world.  The episode introduces HSCs system or haematopoiesis and its importance to the transplantation of HSCs. The factors, both extrinsic and intrinsic, which affect the storage and regulation of HSC are also discussed. Ayo dives deep into the diseases affected by an abnormality or lack of HSC. We finish off the episode with therapeutic treatments by HSCs, including HSC transplantation and gene therapy is discussed at length.  We encourage our listeners to write and comment on the work we do. Please visit us on https://seriouslystemcells.wordpress.com

In this episode, we briefly introduce stem cells and their niches. Our discussion  focuses on the following topics: Stem cells as a good field of study The applications of stem cells Mechanical & Biochemical signalling pathways associated with stem cell niches Age-related stem cell niches How modulating stem cell niches can be important in therapy These are the articles mentioned in this episode: 'No place like home: anatomy and function of the stem cell niche’  (Jones & Wagers, 2008) 'Blood-borne revitalization of the aged brain' (Castellano, Kirby, Wyss-Coray, 2015) 'Therapeutic targeting of a stem cell niche'  (Adams et al,  2007)