291 | Venki Ramakrishnan on the Biology of Death and Aging

Emergence is a centrally important concept in science and philosophy. Indeed, the existence of higher-level emergent properties helps render the world intelligible to us -- we can sensibly understand the macroscopic world around us without a complete microscopic picture. But there are various different ways in which emergence might happen, and a tendency for definitions of emergence to rely on vague or subjective criteria. Recently Achyuth Parola and I wrote a paper trying to clear up some of these issues: What Emergence Can Possibly Mean. In this solo podcast I discuss the way we suggest to think about emergence, with examples from physics and elsewhere.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/11/11/295-solo-emergence-and-layers-of-reality/Support Mindscape on Patreon.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to the November 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!Support Mindscape on Patreon.Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2024/11/04/ama-november-2024/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Erwin Schrödinger said that the important characteristic of life is that it "goes on doing something... for a much longer period than we would expect an inanimate piece of matter to keep going under similar circumstances." Living organisms are in constant motion inside; so where does this stability and persistence come from? Addy Pross points to a novel kind of chemical phenomenon -- "dynamic kinetic stability" (DKS), a feature that enables a chemical "fountain" to persist in the presence of an energy source. This suggests an interesting perspective on the question of life's origin, and perhaps on the origin of consciousness.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/10/28/294-addy-pross-on-dynamics-stability-and-life/Addy Pross received his Ph.D. in chemistry from the University of Sydney. He is currently Professor Emeritus of Chemistry at Ben-Gurion University. He has held visiting positions in the University of Lund, Stanford University, Rutgers University, University of California at Irvine, University of Padova, the Australian National University Canberra, and the University of Sydney. He is the author of What Is Life? How Chemistry Becomes Biology.Web pageAmazon author pageGoogle Scholar publicationsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A large economy is one of the best examples we have of complex dynamics. There are multiple components arranged in complicated overlapping hierarchies, out-of-equilibrium dynamics, nonlinear coupling and feedback between different levels, and ubiquitous unpredictable and chaotic behavior. Nevertheless, many economic models are based on relatively simple equilibrium principles. Doyne Farmer is among a group who think that economists need to start taking the tools of complexity theory seriously, as he argues in his recent book Making Sense of Chaos: A Better Economics for a Better World.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/10/21/293-doyne-farmer-on-chaos-crashes-and-economic-complexity/J. Doyne Farmer received his Ph.D. in physics from the University of California, Santa Cruz. He is currently Director of the Complexity Economics program and Baillie Gifford Professor of Complex Systems Science at the University of Oxford, External Professor at the Santa Fe Institute, and Chief Scientist at Macrocosm. He was the founder of the Complex Systems Group in the Theoretical Division at Los Alamos National Laboratory, and co-founder of The Prediction Company.Web siteOxford web pageGoogle Scholar publicationsAmazon author pageWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

It's not immoral to kick a rock; it is immoral to kick a baby. At what point do we start saying that it is wrong to cause pain to something? This question has less to do with "consciousness" and more to do with "sentience" -- the ability to perceive feelings and sensations. Philosopher Jonathan Birch has embarked on a careful study of the meaning of sentience and how it can be identified in different kinds of organisms, as he discusses in his new open-access book The Edge of Sentience. This is an example of a question at the boundary of philosophy and biology with potentially important implications for real-world policies.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/10/14/292-jonathan-birch-on-animal-sentience/Jonathan Birch received his Ph.D. in the philosophy of science from the University of Cambridge. He is currently a Professor in the Department of Philosophy Logic and Scientific Method at the London School of Economics and Political Science (LSE). He is one of the authors of the New York Declaration on Animal Consciousness, and has advised the British government on matters of animal cruelty and sentience.Web siteLSE web pageGoogle scholar publicationsPhilPeople profileWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to the October 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!Support Mindscape on Patreon.Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2024/10/07/ama-october-2024/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Aging and death happen to the best of us, but there are increasing efforts to do something about it. That effort requires that we have some reasonable understanding of why aging happens, and what processes are involved. You will be unsurprised to learn that it's complicated. Venki Ramakrishnan, who won the Nobel Prize for his work on the ribosome, investigates what we know about aging in his book Why We Die: The New Science of Aging and the Quest for Immortality. We talk about aging and death, and manage to get some thoughts in about ribosomes. Venki and many other great communicators will be speaking at New Scientist Live, which takes place at ExCeL London between 12 - 14 October 2024, and is also streamed live as well as on-demand.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/30/291-venki-ramakrishnan-on-the-biology-of-death-and-aging/Venkatraman (Venki) Ramakrishnan received his Ph.D. in physics from Ohio University. He is currently Group Leader at the MRC Laboratory of Molecular Biology, Cambridge, England, and is a Fellow of Trinity College. He previously served as President of the Royal Society of London. He shared the Nobel Prize in Chemistry for his work uncovering the structure of the ribosome.Lab web pageNobel citationGoogle scholar publicationsWikipediaAmazon author pageSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

It's a wonder democracy works at all -- a collection of people with potentially different interests have to agree to abide by majority vote even when it goes against their desires. But as we know, it doesn't always work, and racial and ethnic tensions are one of its biggest challenges. Hahrie Han studies the ground-up workings of democracy, how people can come together to successfully enact change. In her new book Undivided: The Quest for Racial Solidarity in an American Church, she investigates an example where democracy apparently has worked remarkably well, and asks what lessons we can draw from it.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/23/290-hahrie-han-on-making-multicultural-democracy-work/Hahrie Han recieved her Ph.D. in political science from Stanford University. She is currently the Director of the SNF Agora Institute, the Stavros Niarchos Foundation Professor of Political Science, and Faculty Director of the P3 Research Lab at Johns Hopkins University. She was named the Social Innovation Thought Leader of the Year by the World Economic Forum, is a Fellow of the American Academy of Arts and Sciences, and gave the 2024 Tanner Lectures on Human Values at Harvard University, among other awards.Web siteJohns Hopkins web pageGoogle Scholar publicationsAmazon author pageSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

As an experimental facility, the Large Hadron Collider at CERN in Geneva has been extraordinarily successful, discovering the Higgs boson and measuring multiple features of particle-physics interactions at unprecedented energies. But to theorists, the results have been somewhat frustrating, as we were hoping to find brand-new phenomena beyond the Standard Model. There is nothing to do but to keep looking, recognizing that we have to choose our methods judiciously. I talk with theoretical physicist Cari Cesarotti about what experimental results the modern particle physicist most looks forward to, and how we might eventually get there, especially through the prospect of a muon collider.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/16/289-cari-cesarotti-on-the-next-generation-of-particle-experiments/Cari Cesarotti received her Ph.D. in physics from Harvard University. She is currently a postdoctoral fellow at MIT. Her research is on particle phenomenology theory, with an eye toward experimental searches. Among her awards are the Sakurai Dissertation Award in Theoretical Physics from the American Physical Society and the Young Scientist Award at the 14th International Conference on the Identification of Dark Matter.Web siteMIT web pagePublications at inSpireSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

It wasn't that long ago, historically speaking, that you might put on your tuxedo or floor-length evening gown to go out and hear a live opera or symphony. But today's world is faster, more technologically connected, and casual. Is there still a place for classical music in the contemporary environment? Max Richter, whose new album In a Landscape releases soon, proves that there is. We talk about what goes into making modern classical music, how musical styles evolve, and why every note should count.Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/09/09/288-max-richter-on-the-meaning-of-classical-music-today/Max Richter trained in composition and piano at Edinburgh University, at the Royal Academy of Music, and with Luciano Berio in Florence. He was a co-founder of the ensemble Piano Circus. His first solo album, "Memoryhouse," was released in 2002. He has since released numerous solo albums, as well as extensive work on soundtracks for film and television, ballet, opera, and collaborations with visual artists.Web siteYouTubeSpotifyWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.