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A physical therapist reviews the medical chart of a patient who has been taking prednisone daily for 20 months to manage an autoimmune condition. The patient presents with central adiposity, hypertension, proximal muscle weakness, and purple abdominal striae. Which of the following BEST describes the physiologic mechanism responsible for this clinical presentation?
Option 1- Excess aldosterone secretion
Option 2- Excess growth hormone secretion
Option 3- Chronic insulin resistance
Option 4- Sustained cortisol elevation
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