Ep. 372 Metabolism Repair for Women: Strategies and Insights with Dr. Lara Briden

I am delighted to have Shawn Wells, affectionately known as the Ingredientologist, joining me again today. Shawn is a leading nutritional biochemist and health optimization expert. He is also a biohacker and the formulator of over 500 supplements, foods, beverages, and cosmeceuticals.  In our conversation today, we cover how to evaluate the quality of supplements, explain what proprietary blends represent, and explore several exciting new supplements like Peptide 185, Paraxanthine, and various nootropic agents. Shawn shares his optimal supplement stacks for sleep, metabolism, gut health, and regulating blood sugar, diving into the impact of delivery systems, including transdermal approaches and IV therapies. He also offers guidance on setting intentions and affirmations around supplement consumption.  I trust that you will find this conversation with Shawn Wells as enjoyable and informative as I did while recording it. IN THIS EPISODE YOU WILL LEARN: Shawn shares his concerns about quality control in supplement manufacturing. Why it is essential to buy supplements only from trusted brands when ordering from big retailers Shawn discusses the potential benefits of the new supplement, Peptide 185, for muscle protein synthesis. The potential leucine holds for age-related muscle loss and sports nutrition.  Shawn dives into the physical effects of the caffeine metabolite paraxanthine. BDNF-boosting ingredients for neuroplasticity and brain protection How adaptogenic herbs can increase resilience and improve sleep quality, energy, and focus Shawn highlights the importance of physical movement and proper posture for maintaining physical health. How a leaky gut can lead to immunological problems and cognitive impairment Shawn explores the effectiveness of supplementation versus methods like high-intensity interval training for boosting NAD levels. Shawn explains how to use intention and affirmations to maximize the absorption of supplements. Bio: Shawn Wells: Shawn Wells MPH, LDN, RD, CISSN, FISSN is the world’s leading nutritional biochemist and expert on health optimization. Meet the Ingredientologist, a visionary scientist behind over 1000 groundbreaking formulations, including 25 patented ingredients like Paraxanthine, Teacrine, Dynamine, and Dihydroberberine. Once a Chief Clinical Dietitian, he has empowered thousands with innovative health solutions like keto, paleo, fasting, and supplements, overcoming his own battles with Epstein-Barr Virus, Chronic Fatigue Syndrome, and more. As a world-renowned thought leader on mitochondrial health, he has spoken on five continents and featured in acclaimed documentaries and podcasts. Discover his practical, research-backed solutions in "The ENERGY Formula," hailed by USA Today, Forbes, and an Amazon best-seller. Experience greater resilience and boundless energy under his expert guidance. Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Shawn Wells On his website  Shawn’s biohacking book, The Energy Formula On Instagram, YouTube, Facebook, LinkedIn, Twitter, Pinterest, and TikTok  Previous Episode Mentioned Ep. 126 – Plant Medicine: Bio-Hacking Your Way to Optimum Health featuring Shawn Wells

I am thrilled to have Gary Taubes back on the show today. (He was with me before on episode 137. Gary is an investigative science and health journalist whose work has been pivotal in catalyzing the low-carb keto movement. He has written many books, including his most recent, Rethinking Diabetes, and his articles are in many of the best anthologies. He has also received many science awards. Today's discussion is particularly significant, given the recent report from the American Diabetes Association revealing that the annual cost of diabetes in the United States reached a staggering $412.9 billion in 2022, with individuals diagnosed with diabetes now representing one in every four dollars spent on healthcare.  In our discussion today, we dive into the history of diabetes, pertinent statistics, the prevailing standard of care, and the transformative influence of insulin on diabetes management and reactive hypoglycemia. Gary provides insights into his reactions to GLP ones, the integration of medical and nutrition science into the medical field, and the influence of organizations such as the American Diabetes Association, AHA, USDA, and NIH. Our discussion also extends to the effects of pharmaceuticals, the shortcomings in our approach to diabetes management and existing models, and the challenge the low-carb community faces. Stay tuned for today's eye-opening conversation, where we shed light on the complexities surrounding diabetes care, explaining how simple lifestyle changes can tremendously improve quality of life. IN THIS EPISODE YOU WILL LEARN: Rethinking Diabetes is a groundbreaking exploration of diabetes diagnosis, management, and treatment Gary discusses the evolution of evidence-based medicine Why the traditional medical approach to treating diabetes is inadequate How the guidelines of the American Diabetes Association were based on outdated assumptions  How medical treatments compare with lifestyle changes for managing diabetes Controversies surrounding how the pharmaceutical industry has influenced the way medical associations have shaped their diabetes management policies How medical guidelines and dietary advice have evolved What constitutes a healthy diet? How patients often have trouble following diet recommendations, despite their best intentions Is obesity a hormonal disorder or caused by overeating?   Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Gary Taubes On his website Twitter Facebook Previous Episode Mentioned: Ep. 137 – High Blood Sugar Levels And Its Long-Term Damage with Gary Taubes Book Mentioned: Rethinking Diabetes What Science Reveals About Diet, Insulin, and Successful Treatments is available from most bookstores or on Amazon.

Today, I am thrilled to reconnect with one of my favorite physicians, Dr. Lara Briden, a naturopathic doctor specializing in women's health.  Dr. Briden is on a mission to help women achieve natural menstrual cycles without relying on hormonal birth control. She has authored several books, including her latest, Metabolism Repair for Women. In our conversation today, we dive into why we cannot consciously control energy balance, the impact of ultra-processed foods, epigenetic factors in obesity, the significance of satiety hormones, the role of muscle, and the effects of visceral fat versus subcutaneous fat. We also discuss ways to assess metabolic health and explore various treatments.  This insightful discussion with Dr. Lara Briden is bound to captivate and inform all our listeners. Stay tuned for more. IN THIS EPISODE YOU WILL LEARN: Why energy balance is not under our conscious control How the regulatory mechanism in the body naturally reduces hunger and burns energy How ultra-processed foods were created to be addictive and lead to overeating How the adiponectin hormone impacts insulin sensitivity and satiety The importance of maintaining muscle mass and avoiding sarcopenia, particularly during menopause The difference between subcutaneous and visceral fat Measuring and managing visceral fat How High triglycerides often indicate insulin resistance The limitations of the fasting insulin test Using the entrainment of circadian rhythm to improve metabolic health The benefits of addressing gut problems for improving metabolic health Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Lara Briden On her website On social media: @Lara Briden  Dr. Briden’s latest book is titled The Metabolism Reset in Australia and New Zealand. Everywhere else, it is titled Metabolism Repair for Women Other Books by Dr. Briden Period Repair Manual Hormone Repair Manual Previous Episode Mentioned Ep. 220: A Detailed Guide to Healthy Hormones with Dr. Lara Briden

I am sincerely honored to connect with Walter Green today.  Walter served as the Board Chairman and CEO of Harrison Conference Services for 25 years and played a significant role in the Young Presidents Organisation. Since selling his company, he has dedicated himself to supporting various nonprofits, focusing on education and health for the underserved.  Walter’s work is powerfully inspiring. I initially heard him on one of Peter Attia’s podcasts, which moved me so profoundly that I shared it with anyone willing to listen. In our conversation today, Walter shares his background and we discuss how I took purposeful action after hearing him talk on the podcast. We dive into gender socialization and emotional expression, the value of authenticity and integrity, the concept of saying it now, and the importance of intentionality and boundaries. We also discuss crucial elements of making meaningful connections, cultivating deep, authentic friendships, and transforming our lives to become agents of change.  Having this conversation with Walter was invaluable for me, and I have no doubt you will also love it. IN THIS EPISODE YOU WILL LEARN: Reflecting on his 60 years of marriage, Walter highlights the importance of deep passion and respect in enduring relationships. Walter offers his perspective on authenticity and openness in relationships, emphasizing the importance of being true to yourself. How Walter values authenticity in his relationships and finds it hard to be open and vulnerable with those who are not candid and authentic   How Walter’s career in finance influenced his relationships Walter talks about gratitude and shares how at the age of 71, he shared stories with people he loved on Zoom, inspiring the Say It Now movement. Walter shares his journey of intentional living, explaining the importance of thinking backward and aligning your actions with your ideal outcomes. Why it is essential to consider the context of every decision you make in all aspects of life The importance of finding your purpose and living in the present   The benefits of developing deep and long-lasting relationships How to identify those who have made a difference in your life Walter discusses love languages, sharing the importance of understanding how others prefer to receive love and affection. Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Walter Green On Just Say It Now website On This Is the Moment website (For Walter’s book) Walter’s Ted Talk: Why We Should Eulogize the Living Peter Attia’s Podcast: The impact of gratitude, serving others, embracing mortality, and living intentionally with Walter Green

I’m honored to reconnect with Dr. Felice Gersh today! She is a multi-award-winning physician with dual board certification in OB-GYN and Integrative Medicine. We connected once before in Episode 221, where we spoke about PCOS and metabolic health. Today, Dr. Gersh joins me to dive into perimenopause and menopause. We discuss various issues surrounding the Women’s Health Initiative, and talk about estrogen as a family of hormones, estrogen-mimicking chemicals, synthetic hormones, and oral contraceptives. We get into the importance of thyroid function, the pro-inflammatory state of a loss of estrogen in perimenopause and menopause, and the importance of nutrition and exercise for the metabolism. We also speak about the lesser-known changes that occur in menopause, including changes in body odor, constipation, sarcopenia, osteoporosis, and vocal changes.  I intend to invite Dr. Gersh back to discuss women and mitochondrial health and to talk about her latest book, Menopause: The Fifty Things You Need to Know.  Stay tuned to find out what menopause really is and what it does to a woman’s metabolic system. IN THIS EPISODE YOU WILL LEARN: Dr. Gersh discusses the Women’s Health Initiative study and its devastating effects. The difference between synthetic and bioidentical hormones. How chronic diseases of aging can be delayed when hormones are incorporated along with other lifestyle refinements. What do hormones do? Why every immune cell in the body has receptors for vital hormones. Why menopause cannot be defined by a specific moment in time. Changes that occur physiologically during the perimenopause years. How hormones can change the perimenopause paradigm entirely. Why perimenopause translates into many sleep issues. Why phytoestrogens are nature’s gift to women. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website  Connect with Dr. Felice Gersh On her website: Integrative Medical Group of Irvine On Instagram All of Dr. Gersh’s books are available on Amazon Episode 221 on PCOS with Dr. Felice Gersh Resource Mentioned Go to www.toxicology.gov to see all the ingredients in birth control pills listed as endocrine disruptors.

Today, I am delighted to connect with my dear friend, Dr. Mariza Snyder. Dr. Snyder is a best-selling author, dedicated wife, and wellness advocate passionately committed to empowering women through lifestyle changes, whole food nutrition, essential oils, and other health practices.  In our discussion today, we dive into the perimenopausal journey, looking at the warning signs and ways to rediscover ourselves. We explore the impact of lifestyle choices and the importance of understanding cravings in middle age, offering practical strategies for navigating perimenopause and menopause. We get into the benefits of continuous glucose monitors and glucometers, the critical role of fiber and fermented foods, and the supplements Dr. Snyder recommends for optimal brain health. We also address gut health and the misconception that constipation is normal.  I am confident you will find my conversation with Dr. Snyder as enlightening and enjoyable as I did. IN THIS EPISODE YOU WILL LEARN: Why women need to educate themselves about perimenopause and its symptoms Common early signs of perimenopause How lifestyle choices significantly impact the severity of perimenopause symptoms Why women must eat enough protein Importance of maintaining stable blood sugar levels Benefits of using continuous glucose monitors How strength training helps women maintain muscle mass and functional strength The benefits of fermented foods for supporting the gut microbiome Why managing stress and getting enough sleep are essential Brain-boosting supplements Dr. Snyder recommends How to avoid constipation  Bio: Dr. Mariza Snyder Dr. Mariza Snyder is a functional practitioner, women’s hormone expert, and the author of eight books: The newest book, The Essential Oils Menopause Solution, focuses on solutions for women in perimenopause and menopause and the #1 National Bestselling book, The Essential Oils Hormone Solution, focuses on balancing women’s hormones naturally. For the past fifteen years, she has lectured at wellness centers, conferences, and corporations on hormone health, metabolic health, nutrition, and detoxification. She has been featured on Dr. Oz, Oprah Magazine, Fox News Health, MindBodyGreen, and in many publications. Dr. Mariza is also the host of the top-rated Energized Podcast, (with over 11 million downloads) designed to empower women to become the CEO of their health. Check out her website, drmariza.com, for women's hormone tips, including recipes and supplementation.  Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Mariza Snyder On Instagram Energized with Dr. Mariza (Podcast) Dr. Snyder’s books are available on Amazon

Today, I am thrilled to connect with Farmer Lee Jones, who oversees The Chef's Garden, a family-owned regenerative farm dedicated to cultivating the most flavorful and nutrient-rich vegetables, herbs, and microgreens.  With a legacy of over three decades, The Chef's Garden has been the go-to supplier for some of the finest chefs and restaurants worldwide.  Join us as we dive deep into the differences between regenerative agriculture and traditional industrial farming, looking at the importance of flavor-focused cultivation, the limitations of USDA guidelines in determining mineral efficacy, how the pandemic affected the operations of the Chef's Garden, the rising trends of seasonal eating in the vegetable industry, and the differences between hybrid and GMO products.  Get ready for an enlightening conversation with Farmer Lee Jones, whose infectious enthusiasm for sustainable farming practices is bound to leave you inspired. IN THIS EPISODE YOU WILL LEARN: The differences between regenerative agriculture and traditional industrial farming Why traditional industrial farming is unsustainable, and how it negatively impacts soil and human health The benefits of regenerative agriculture Why Farmer Lee grows for flavor, not just for nutritional levels The importance of maintaining healthy soil  How Farmer Lee managed to keep his team together and maintain his farming operations during the pandemic Why it is essential to pay attention to the packaging and labeling when purchasing produce The nutritional benefits of microgreens Farmer Lee explains the difference between GMO and hybrid vegetables Why we need to tune into our bodies and understand what they need instead of relying on artificially available produce throughout the year Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Farmer Lee Jones On Instagram    The Chef’s Garden on Instagram (For vegetable box subscriptions) The Culinary Vegetable Institute on Instagram

I am delighted to have Jessie Inchauspe, the Glucose Goddess, joining me on the podcast today! Metabolic health is my passion! It is a huge area of focus in my work, and Jessie is truly a gift in the space! She is a rising star author and biochemist with a clear and accessible way of explaining the science behind glucose metabolism.  Jessie joins me today to discuss the impact of glucose metabolism and spikes. We dive into her background and how an accident created her pain-to-purpose story. We discuss the role of continuous glucose monitors and how glucose spikes impact our mitochondria, inflammation, and oxidative stress. We get into glycation and aging, how weight gain is a protective aspect of glucose spikes- or hyperglycemia, and the role of vinegar, movement, and fiber. We also talk about Jessie’s new book, her opinions on fasting, and so much more.  I loved interviewing Jessie! Her enthusiasm is contagious, and it is easy to understand why she is such a beloved author in the health and wellness space! IN THIS EPISODE YOU WILL LEARN: Jessie shares how an accident led her to where she is today. How a continuous glucose monitor changed everything for Jessie. How Jessie came up with her simple principles to steady glucose levels. What is the purpose of glucose in the body? How do glucose spikes impact our mitochondria? Jessie shares a fascinating vinegar hack for reducing side effects and symptoms of glucose spikes. How being metabolically unhealthy impacts the aging process. The benefits of having savory breakfasts and eating vegetables first with every meal. Jessie talks about her new book, The Glucose Goddess Method. How gaining weight protects our bodies from the impact of glucose spikes. How walking or moving after meals balances blood sugar levels. Why is blood sugar so important? Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Connect with Jessie Inchauspe On her website   On Instagram Jessie’s books The Glucose Goddess Method Glucose Revolution

I am thrilled to present the last class of our Lipid Masterclass series today with the esteemed Dr. Thomas Dayspring. Dr. Dayspring is board-certified in internal medicine and clinical lipidology and is a fellow of the American College of Physicians and the National Lipid Association.  Today, we round things out by diving into medications for lipid abnormalities and discussing lipid physiology, with Dr. Dayspring shedding light on insulin resistance and statins and cautioning against statin use for those predisposed to diabetes or insulin resistance. He also explains why LDL particle size is not worth testing and discusses ways to identify specific laboratory abnormalities.  Be sure to stay tuned for the AMA session to follow, where Dr. Dayspring will answer listeners’ questions.  It has been a privilege engaging with Dr. Dayspring throughout this masterclass series. I know you will have learned a lot from it! IN THIS EPISODE YOU WILL LEARN: · The lack of research and consistency in addressing the needs of women in various stages of life · Dr. Dayspring discusses the use of bile acid sequestrants for lowering LDL cholesterol · Dr. Dayspring discusses the history of bile acid sequestrant use, explaining why their use is limited · How bempedoic acid and statins lower LDL cholesterol · Potential contraindications for bempedoic acid · The benefits and risks of using fibrates to reduce heart attacks · Dr. Dayspring explains why fibrates work best for genetic hypertriglyceridemia · Why reducing ApoB is essential for atherosclerosis patients, especially for high-risk patients · Dr. Dayspring explains why small LDL particles are dangerous · The ideal ApoB level for those who have no heart disease and are not diabetic  Bio: Thomas Dayspring MD is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. After practicing in New Jersey for 37 years, in 2012, he moved to Virginia to serve as an educational director for a nonprofit cardiovascular foundation until mid-2019 as a Chief Academic Advisor for two major CV laboratories. Since then, he has served as a virtual cardiovascular/lipidology educator. Career-wise, he has given over 4000 domestic (in all 50 states) and several international lectures, including over 600 CME programs on atherothrombosis, lipids/lipoproteins (and their treatment), vascular biology, biomarker testing, and women’s cardiovascular issues. He has authored several manuscripts and lipid textbook chapters and performed several podcasts. For several years, he was an Associate Editor of the Journal of Clinical Lipidology. He received the 2011 National Lipid Association’s Presidents Award for services to clinical lipidology and the 2023 Foundation of NLA Clinician/Educator Award. He has over 34K followers on his educational Twitter (X) feed (@Drlipid). He has Gold Heart Member status as a professional member of the American Heart Association, and he serves as a Social Media Ambassador for the European Atherosclerosis Society and the National Lipid Association. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Thomas Dayspring On Twitter (@DrLipid) On LinkedIn

I am delighted to reconnect with Dr. Anurag Singh today, the Chief Medical Officer at Timeline Nutrition. He joined me once before on Episode 268.  I invited Dr. Singh back to discuss the latest research on GLP-1 agonists like Wegovy, Semaglutide, and Ozempic, which are gaining significant traction with projected sales exceeding $100 billion by 2030, potentially affecting 9% of the US population. In our conversation, we explore the contributors to our metabolic health crisis by looking at the research surrounding GLP-1 agonists, the physiology of GLP-1 peptides, and the influencing elements Dr. Singh refers to as the trifecta. We dive into the loss of muscle mass and strength, sarcopenia, and frailty associated with these drugs, and Dr. Singh shares his concerns about their impact on bone health, the gut microbiome, and their use in younger patients. We also get into lifestyle measures, mitochondrial health, hallmarks of aging, Akkermansia, and the importance of advocacy and patient empowerment.  Today’s compelling and invaluable discussion with Dr. Anurag Singh highlights crucial insights into GLP-1 agonists and their broader health implications. I know it will provide significant value for our listeners. IN THIS EPISODE YOU WILL LEARN: Dr. Singh breaks down what GLP-1 agonist drugs are and how they work. How our modern-day lifestyles contribute to poor metabolic health The benefits and side-effects of using GLP-1 agonist treatments for improving metabolic health Why strength training is essential for preventing muscle loss and frailty in middle-aged women What are the potential long-term effects of SARMs on muscle mass and health? Why dietary counseling is essential for those taking GLP-1 agonist drugs The benefits of supplements for boosting mitochondrial health  Dr. Singh discusses a research study on combining lithium with GLP-1 agonists to improve the muscle quality of those with muscle-wasting conditions. Why akkermansia is essential for GLP production   Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website  Submit your questions to [email protected] Connect with Dr. Anurag Singh Timeline Mitopure Email Dr. Singh: [email protected]  Previous Episode Mentioned Ep. 268: Understanding the Biology of Aging with Evolved Supplementation and Nutrition, featuring Dr. Anurag Singh