495: Are You At Risk for Dementia? The Most Overlooked Cholesterol Marker You Need to Know with Dr. Thomas Dayspring

Today, I am thrilled to reconnect with Dr. Kelly Caspersen, a urologist who empowers women to live their best love lives. She is a two-time author, with her latest being The Menopause Moment. In our conversation, we cover a wide range of topics, from navigating UTI purgatory and understanding the vaginal microbiome to how vaginal estrogen can dramatically reduce the risk of sepsis and death in the ICU. We unpack the evolving language of hormones- specifically progesterone, estrogen, and testosterone and we examine censorship and bias on social media, and the differences between prescribers and non-prescribers. We explore the effects of SSRIs on bone and brain health, changes in self-perception in middle age, and the effects of the baby boomer generation and the Women’s Health Initiative, exposing the medical gaslighting behind the use it or lose it narrative. We also offer practical options for women who cannot take hormones, and Dr. Kelly shares her go-to supplements and those she avoids. This conversation is one of my recent favorites. Dr. Kelly’s enthusiasm is contagious, and her straightforward approach makes complex topics clear, practical, and unforgettable. IN THIS EPISODE, YOU WILL LEARN: Why recurrent UTIs can feel like UTI purgatory How hormone terminology is evolving, and what that means for women in midlife The value of vaginal estrogen, and the potential it holds for saving women’s lives How the approaches of prescribers and non-prescribers differ How SSRIs can raise the risk of bone fractures  The brain health and self-perception shifts that often occur in midlife  Why the use it or lose it belief is misleading, and how it veers into medical gaslighting How the baby boomer generation and the Women’s Health Initiative still influence women’s healthcare today Some alternative options for women who cannot take hormones Dr. Kelly shares her preferred supplements and those she avoids Bio:  Dr. Kelly Casperson, MD Urologist • Author • Podcaster • Women's Health Thought Leader Dr. Kelly Casperson is a board-certified urologist, best-selling author, and top-ranked international podcaster empowering women to take control of their health, hormones, and sexuality. Known for blending science with storytelling, she transforms complex medical topics into relatable and actionable insights that help women live fully and fearlessly—especially in midlife. With her signature candor and evidence-based clarity, Dr. Casperson dismantles long-held myths around sex, menopause, and desire. Her acclaimed podcast, You Are Not Broken, has become a go-to resource for hundreds of thousands of women seeking real answers about their bodies and brains. Her groundbreaking work integrates urology, neuroscience, and mindset coaching to drive lasting change in intimacy, confidence, and overall well-being. As a keynote speaker and educator, Dr. Casperson challenges outdated norms in medicine while offering bold, science-backed solutions. She’s on a mission to build a world where women are educated, empowered, and no longer afraid of their own bodies. Whether she’s on stage, in a clinic, or behind the mic, Dr. Casperson is leading a health revolution—one smart, honest conversation at a time. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Kelly Casperson On her website On Instagram You Are Not Broken (Podcast) The Menopause Moment is available on Amazon and Barnes and Noble.

I am delighted to connect with Shanna Pearson today. She is the Founder and President of Expert ADHD Coaching, which is the most extensive ADHD coaching program of its kind in the world, providing one-on-one, action-based coaching for adults who are easily distracted and seeking personal, professional, and financial success. Shanna is also the author of Invisible ADHD.  In our discussion, we take a clear and practical look at what ADHD really is. We unpack the chemical changes that occur in the brain, highlighting the gender differences, and exploring why women have become the lost generation and why so many people get misdiagnosed. We also discuss common conditions that often accompany ADHD, the challenges of social conditioning, and share practical tools for addressing ADHD. Whether you have ADHD or you struggle with overwhelm, this discussion offers helpful insights and strategies that are sure to make a real difference. IN THIS EPISODE, YOU WILL LEARN: What ADHD truly is The brain biochemistry of those with ADHD How ADHD differs in men and women Why Shanna refers to women whose ADHD is undiagnosed until perimenopause or menopause as a lost generation    How ADHD in women often gets misdiagnosed How hormonal changes during perimenopause and menopause impact ADHD symptoms How societal expectations tend to exacerbate ADHD symptoms in women Strategies for managing ADHD Lifestyle factors that are essential for managing ADHD symptoms How her book, Invisible ADHD, can help anyone struggling with ADHD or overwhelm Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Shanna Pearson Expert ADHD Coaching   Purchase your copy of Invisible ADHD here, or on Amazon

I am thrilled to connect with my friend and colleague, Dr. Anthony Youn, today.  Dr. Youn is a nationally recognized board-certified plastic surgeon and the author of many best-selling books. He has a massive social media presence and hosts the widely acclaimed podcast The Holistic Plastic Surgery Show. In our conversation today, we dive into Dr. Youn’s new book, Younger for Life, and he offers valuable insights on skin health and overall well-being. We explore the aging process and address oxidative-free radical damage, chronic inflammation, autophagy, and the impact of processed foods. We also explore helpful supplements for skin support, examine the concept of greenwashing, and discuss sunscreen, exfoliation, in-office treatments, breast implant illness, and the impact of lifestyle choices. Stay tuned for more! IN THIS EPISODE YOU WILL LEARN: How to avoid aging too quickly through nutrition and lifestyle changes How sugar and seed oils impact skin aging The benefits of collagen supplements for healthier skin  Hormonal changes that affect the metabolism and skin health after menopause The importance of screening the ingredients in skincare products How chemical sunscreens differ from physical sunblocks Using Retinol for anti-aging and skin health Non-invasive fat reduction treatments and their potential risks Dr. Youn discusses breast implant illness What you need to look out for when using Botox Connect with Cynthia Thurlow Follow on X ⁠Instagram⁠ ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠[email protected]⁠ Connect with Dr. Anthony Youn On his ⁠website⁠ ⁠Youn Beauty⁠   ⁠Instagram⁠ ⁠YouTube

Today, I am delighted to connect with Dr. Heather Quaile. She is a double board-certified women's health nurse practitioner and advanced forensic nurse with specialty training in female sexual medicine. Her training focused on integrative gynecology. Today, we dive into trauma-informed care, defining big and little T trauma, examining how adverse childhood events impact gynecologic care, and clarifying how chronic stress and trauma affect ovarian aging. We discuss the role of recalibration of the nervous and autonomic nervous systems during perimenopause and menopause, and explore the importance of estrogen in supporting serotonin, dopamine, and adrenal health in middle age. We cover GLP-1s, reframing packaging around vaginal estrogen, FDA approval for testosterone, the new terminology of PET, and holistic management of low libido, and we also tackle the genitourinary syndrome of menopause, new terminology, barriers, self-advocacy, and the significance of pelvic floor Health.  This conversation with Dr. Quaile is truly invaluable. She is a most helpful resource on everything related to integrative gynecology, sexual medicine, and self-advocacy. IN THIS EPISODE, YOU WILL LEARN: How big and little T trauma differ What trauma-informed care is, and why it is particularly relevant for women in perimenopause and menopause Symptoms and behaviors that indicate trauma in women How the interrelationship between estradiol and serotonin affects our worldview, self-perception, sleep, and relationships  The benefits of addressing any hormonal imbalances before using GLP-1s for weight loss The pros and cons of gaining FDA approval for testosterone and commercializing it   Factors that could cause decreased libido in middle-aged women The genitourinary changes that occur in different life phases of women, or with cancer, or when going through gender reassignment How PET (progesterone, estrogen, and testosterone) terminology is evolving to include women outside of perimenopause and menopause  The five questions Dr. Quaile has in her DSDS (decreased sexual desire screener) for clinicians, to get to the root cause of hypoactive sexual desire disorder in patients The importance of women being comfortable about advocating for themselves Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Heather Quaile On her website  Instagram

We have the next episode in our series of thyroid-focused podcasts today. In this episode, Dr. Shawn Tassone, Dr. Alan Christianson, and Dr. Amie Hornaman join me to dive into medications, treatment options, personal preferences, and the fear that often drives medical decision-making. We discuss the current prevalence of thyroid-related conditions and why iodine remains a controversial topic in thyroid physiology. We also cover the role of micronutrients and the impact and symptoms of hypothyroidism, clarifying the concept of thyroid pause, and the specific lab tests required for evaluation, in addition to sharing some practical strategies.  Dr. Shawn Tassone advocates for a personalized approach to thyroid treatment, often preferring desiccated or compounded medications over standard synthetics, depending on patient response, insurance coverage, and symptom relief. He also addresses the ongoing resistance within conventional endocrinology to T3-based therapies, despite clear clinical improvements in patients using them. Dr. Alan Christianson explains that the dramatic rise in thyroid disorders over recent decades is due to increased iodine exposure, particularly from processed foods, dairy, supplements, and cosmetics. While iodine is essential for thyroid function, even small excesses can overwhelm the system, triggering autoimmune responses. However, reducing iodine intake can significantly improve or even reverse thyroid dysfunction in many people. Dr. Amie Hornaman explains that optimal thyroid function is essential for overall health, and the active thyroid hormone, T3, is needed by every cell in the body. She highlights the importance of comprehensive thyroid testing to detect dysfunction often missed by standard TSH tests, particularly in women over 40 or those experiencing symptoms linked to perimenopause, menopause, or Hashimoto’s. This enlightening conversation, with three leading thyroid authorities, is packed with valuable insights, so you should revisit it more than once. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Shawn Tassone On his website Instagram (Appointments: drshawntassone) Call Dr. Tassone’s office: 512 956029 Facebook Connect with Dr. Alan Christianson On his website Facebook, Instagram, Pinterest, and YouTube Connect with Dr. Amie Hornaman On her website Facebook and Instagram YouTube The Thyroid Fixer Podcast Ep 243 Balancing your hormones and thyroid health with Dr. Shawn Tassone Ep. 154 Thyroid & Intermittent Fasting Reset: How to Normalize Your Thyroid Function with Dr. Alan Christianson Ep. 426 Thyroid Health Masterclass: Labs, Diets & Autoimmune Insights with Dr. Amie Hornaman (DCN)

I am happy to connect with Coach Bronson Dant today. He has spent over a decade guiding and training people in health and fitness. He discovered the benefits of a whole-food, animal-based ketogenic diet for optimizing metabolic health and performance, and wrote The Ultimate Ketogenic Fitness Book. In our discussion today, we dive into the powerful story of Coach Bronson’s pain-to-purpose journey. We explore the value of mindset and examine how age-related changes impact muscle, inflammation, and metabolic flexibility. He shares his three pillars of muscle health related to nutrient density, bioavailability, and satiety, and we examine the importance of sleep, the impact of extremes in exercise, and the value of stress management. We also unravel the complexities of weight loss resistance, and Coach Bronson discusses his research from the Journal of Nutrition Metabolism and Health Science, sharing his perspective on macros and functional movement in menopausal women. IN THIS EPISODE YOU WILL LEARN: Coach Bronson shares his three pillars for nutrition The limitations of basing nutrition on calories alone How the hormone piece impacts effective weight management How to avoid physical deterioration through fitness and nutrition Why Coach Bronson advocates for living life to the fullest and dying quickly How does muscle mass impact metabolic health? The importance of taking a balanced approach to weight loss How sleep aids muscle recovery and growth  Stress management, nutrition, and fitness for overall well-being How alcohol affects our health and fitness The benefits of combining functional movement training and proper nutrition for older adults  Connect with Cynthia Thurlow Follow on X, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to [email protected] Connect with Bronson Dant On his ⁠website⁠  ⁠YouTube⁠ and ⁠Instagram⁠ ⁠The Ultimate Ketogenic Fitness Bundle⁠

Today, I am thrilled to connect with Dr. Austin Perlmutter, a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, podcaster, and entrepreneur. He is on a mission to help people get their brains unstuck for better mental and cognitive health.  In our conversation today, we explore brain inflammation and its connection to longevity, the differences between acute and chronic inflammation, the influence of environmental factors, and how exposure to negative news and biases can elevate stress and affect our brain health. We examine how consumer culture promotes stress and disconnection, and we unpack the immune-metabolic effects of estrogen and its impact on neuroplasticity and our ability to learn. We also focus on the role of nutrition and nutraceuticals, and we discuss the relationship between the brain, gut, and the vagus nerve. This discussion with Dr. Austin Perlmutter is rich and insightful, and I look forward to welcoming him back for further exploration into the science and research. IN THIS EPISODE, YOU WILL LEARN: Why brain inflammation becomes an issue for many women as they navigate middle age and beyond How inflammation leads to constant changes in our cognitive and mental state Various environmental factors and other inputs that could influence brain inflammation Some easy ways to positively impact your brain health and cognition How chronic stress affects the brain How the gut microbiome and the gut immune system influence cognitive and mental health The long-term health benefits of avoiding processed foods and following a Mediterranean diet  The importance of being conscientious and purposeful about the quality of the foods you eat Dr. Perlmutter shares easy and cost-effective ways to improve your cognitive, mental, and overall health Bio: Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, published researcher, and a leading expert on how lifestyle and environmental factors impact mental health. His mission is to help people reclaim their mental and physical health by addressing the biological basis of “stuckness” that disrupts brain function and emotional balance. He is a co-producer of the Alzheimer’s: The Science of Prevention series and the host of the Better Brain Blueprint series, where he provides actionable strategies to support brain resilience. Dr. Perlmutter currently serves as the Managing Director at Big Bold Health, a food-as-medicine company focused on helping people rejuvenate health through better immune function, where he has published a pioneering study exploring the effects of plant nutrients on human aging through epigenetics. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Austin Perlmutter On his website On social media: @draustinperlmutter Find out more about the research on immuno-metabolism pathways  Big Bold Health on social media: @bigboldhealth

We have the second episode in a series of conversations with Dr. Thomas Dayspring today.  The esteemed Dr. Dayspring is an expert on internal medicine and clinical lipidology. In this episode, we continue with our last conversation, diving into Lp(a) and the influences of gender, race, and menopause. We explain how estrogen is a PCSK9 inhibitor and explore the significance of brain health and risks for dementia. We tackle cholesterol synthesis and discuss the side effects of statins, clarifying who is most susceptible to their impact on the brain. We also examine the significance of the desmosterol biomarker, highlighting the level to aim for, especially when making decisions regarding cholesterol medications, and we answer one question from a listener.  You may want to listen to this insightful conversation with the renowned Dr. Dayspring more than once. He has graciously agreed to return and film additional episodes, where we will dive into more questions from listeners.  IN THIS EPISODE, YOU WILL LEARN: Why Lp(a) is like a wolf in sheep's clothing for many individuals How Lp(a) levels are higher in African Americans and women, especially after menopause  Dr. Dayspring highlights that Lp(a) particles are even more pro-inflammatory than LDL particles How PCSK9 inhibitors are the only drugs that significantly reduce Lp(a) Why do women have a higher risk of dementia than men? Dr. Dayspring explains ApoE as the key lipoprotein for brain cholesterol transport. How statins cross the blood-brain barrier to lower brain cholesterol Why desmosterol levels matter New therapies that can lower ApoB and Lp(a) Why imaging is essential for menopausal women with elevated ApoB and Lp(a) Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Thomas Dayspring On X (@Drlipid) On LinkedIn Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations  Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?

We have another episode in our series of sponsored podcasts today, with brands I like, know, and trust. I am delighted to reconnect with Angelo Keely, the founder and CEO of Kion, a supplement company that focuses on helping people look good, feel young, and be strong. In our discussion today, Angelo explains essential aminos, highlighting their importance and clarifying how to differentiate between various protein powders and other forms of protein. We explore the significance of bioavailability, anabolic resistance, and changes in body composition, discussing how protein needs increase with age and how dieting and caloric restriction can augment our protein requirements. We also cover the results of intermittent fasting, examining how sleep, stress, and lifestyle requirements can change with menopause. I regularly take Kion essential amino acids. They have generously offered a discount for our community. Use the link in the show notes to get 20% off your next Kion purchase. IN THIS EPISODE, YOU WILL LEARN: The importance of eating sufficient protein as you age How various protein sources, such as animal protein, plant protein, whey protein, and essential amino acids, differ Strategies to buffer your protein intake and support your body as you navigate middle age and beyond Why Leucine is vital for muscle protein synthesis Why you should only source your amino acid supplements from trusted brands that follow the science How much protein do you need to maintain your body composition as you age? Why sleep is crucial for muscle protein synthesis How supplementing with essential amino acids helps you maintain your muscle mass throughout your life   The benefits of body scans for a better understanding of your body composition Connect with Cynthia Thurlow   Follow on X Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Angelo Keely Get a 20% discount on Kion products

I am deeply honored to reconnect with Dr. Thomas Dayspring, who joined me in 2024 for an immensely popular five-part series. Dr. Dayspring is certified in internal medicine and clinical lipidology. He is a distinguished fellow of both the American College of Physicians and the National Lipid Association.  Today, we have the first episode in a new series of conversations with Dr. Dayspring, in which he will share more of his perspective and answer more questions from listeners. In our discussion, we review the basics about cholesterol, triglycerides, and lipoproteins, exploring the factors that contribute to the development of cardiovascular disease, the significance of ApoB and Lp(a), and the risk factors for younger women. We also dive into the limitations of traditional allopathic medicines, and Dr. Dayspring shares his views on lipids, lipid changes in menopause, specific ways to address ApoB, some of the challenges associated with statin therapy, and more.  Dr. Dayspring brings a wealth of experience and expertise to this discussion, and you are sure to find this series as invaluable as the last. IN THIS EPISODE, YOU WILL LEARN: Dr. Dayspring revisits the differences between cholesterol, triglycerides, and lipoproteins What atherosclerosis is, and why it is concerning Dr. Dayspring explains the structure and function of lipoproteins The role of ApoB in lipoprotein particles and its significance in atherosclerosis Some of the risk factors for lipid abnormalities in younger women Lipid changes that occur as women transition from perimenopause to menopause  Dr. Dayspring shares his take on statin therapy Ways to address high ApoB Dr. Dayspring’s suggested goals for ApoB therapy Connect with Cynthia Thurlow   Follow on ⁠X⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠ Check out Cynthia’s ⁠website⁠ Submit your questions to ⁠[email protected]⁠ Connect with Dr. Thomas Dayspring On⁠ X⁠ (@Drlipid) On⁠ LinkedIn⁠ ⁠Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations⁠  ⁠Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?⁠