Key Takeaways from ACC.25 Major Trials and Presentations

In this week’s View, Dr. Eagle examines weight management in pregnancy related to cardiovascular disease (CVD) risk. He then considers how the addition of early ezetimibe to statin could reduce CVD after myocardial infarction (MI). Finally, Dr. Eagle explores the PARTNER-3 study results which compare transcatheter aortic valve replacement (TAVR) to surgical aortic valve replacement (SAVR) and the echocardiographic outcomes at five years.  Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle examines the effects on patients who have undergone pre-ablation transesophageal echocardiogram (TEE) versus those who have not. He then discusses a recent paper investigating the superiority of transcatheter aortic valve implantation (TAVI) to surgical aortic valve replacement (SAVR) at one year in women with severe aortic stenosis (AS). Finally, Dr. Eagle explores OCEANIC-AF, a study that analyzes the differences in outcomes in patients with and without prior use of oral anti-coagulants (OACs).   Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at the major trials and presentations from the recently concluded ACC.25 in Chicago. This episode includes coverage of practice-changing and practice-validating trials including:   Evolut Low Risk: Transcatheter aortic valve replacement (TAVR) noninferior to surgical aortic valve replacement (SAVR) at 5-Year Follow-Up   SMART-CHOICE 3: Clopidogrel shows benefit over aspirin monotherapy following percutaneous coronary intervention (PCI)  DAPA-TAVI: Dapagliflozin safe and effective in older adults with heart failure (HF) undergoing transcatheter aortic valve implantation (TAVI)  STRIDE: Semaglutide improves peripheral artery disease (PAD) outcomes  RIVAWAR: Rivaroxaban as effective as warfarin for post-myocardial infarction (MI) left ventricle (LV) thrombus   API-CAT: Extended anticoagulant therapy with reduced-dose apixaban noninferior to full-dose in patients with active cancer and venous thromboembolism (VTE)    Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at the latest clinical guidance on the management of cardiogenic shock. He then discusses trends in mortality after mitral repair and TAVR. Finally, Dr. Eagle offers a brief exploration into how direct-to-physician industry marketing affects rates of guideline-directed medical therapy (GDMT) surrounding heart failure patients.    Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle examines the dose-response relationship between smoking and subclinical cardiovascular disease markers. He then discusses how the effect of poor sleep increases diabetes risk in women who have had gestational diabetes. Finally, Dr. Eagle offers a look into imaging post-transcatheter aortic valve replacement (TAVR) in patients who may have valve failure.    Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at a sex-based analysis of short-term dual antiplatelet therapy (DAPT) in patients receiving percutaneous coronary intervention (PCI) who are deemed at high-risk for bleeding. He then discusses the potential value of dapagliflozin in patients with severe heart failure (HF). Finally, Dr. Eagle explores non-pharmacologic therapies to reduce morbidity and improve function in HF patients.   Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at the optimal threshold for identifying a myocardial infarction (MI) after PCI. He then discusses myocardial fibrosis and its prognostic features in patients undergoing treatment for severe aortic valve stenosis. Finally, Dr. Eagle explores the relationship between bleeding after initiation of anticoagulation and cancer diagnoses.   Subscribe to Eagle’s Eye View    

In this week’s View, Dr. Eagle looks at the potential exposure-dependent protective effect of SGLT2 inhibitors on aortic valve stenosis progression. He then discusses the potential value of earlier ablation for atrial fibrillation versus later ablation. Finally, Dr. Eagle explores new guidance for sports participation by athletes with cardiac abnormalities.  Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at arrhythmia recurrence and rhythm control after catheter ablation for atrial fibrillation. He then discusses long-term outcomes in transthyretin amyloid cardiomyopathy in patients treated with tafamidis. Finally, Dr. Eagle explores a population study on the effect of sodium restriction in food and its potential effects on blood pressure.   Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at tighter blood pressure control in patients who are postpartum. He then discusses beta blocker therapy in patients with Takotsubo syndrome. Finally, Dr. Eagle explores secondary prevention and medications around the world.  Subscribe to Eagle’s Eye View