Everyone Is Talking About Lp(a): What It Means for Your Heart and What to Do If Yours Is High with Dr. Michael Twyman

This episode is brought to you by BUBS Naturals, Momentous, and Cozy Earth.  Today on The Dhru Purohit Show, I sit down with my personal cardiologist, Dr. Michael Twyman, to discuss lipoprotein(a)—why it’s making headlines, what an early press release from a recent drug trial revealed, and the important questions that still remain. Dr. Twyman also explains why testing your Lp(a) levels can help you better understand your risk and how this marker fits into the bigger picture of your overall heart health. Dr. Michael Twyman founded Apollo Cardiology in St. Louis, Missouri. He combines conventional cardiology with functional medicine, mitochondrial optimization, and cutting-edge biohacking to help patients understand and reduce their cardiovascular risk. With an integrative approach that goes far beyond standard care, Dr. Twyman has helped hundreds of patients take control of their heart health. In this episode, Dhru and Dr. Twyman dive into: (00:00) Why Lp(a) Could Be a Hidden Heart-Risk Factor (1:42) Why It's Making Headlines (3:28) The Debate: Lowering Cholesterol vs. Addressing Other Risks (9:16) The New Trials That Shocked Cardiologists (16:31) Optimal Levels and How Do You Test It (20:27) What a Cleerly Scan Can Reveal About Your Heart (23:27) Dhru Breaks Down His Own Test Results (29:18) How Concerned Should You Be About Lp(a) (32:04) How to Lower Inflammation and Protect Your Heart (36:32) Beware of Misleading Claims About Lowering Lp(a) (44:45) A Comprehensive Approach to Heart Health (47:43) How to Work With Dr. Twyman Also mentioned in this episode: Dr. Eric Topol Substack on Atherosclerosis  "This Causes Heart Attacks!" - Diet & Lifestyle Habits To Clean Out Your Arteries For Longevity The WARNING SIGNS Of Heart Disease & How To Help PREVENT IT | Dr. Michael Twyman Cleerly Test  Large Cohort Study Reveals Vanishingly Small Rates of Lipoprotein(a) Testing For more on Dr. Twyman, follow him on Facebook, Instagram, X/Twitter, LinkedIn, YouTube, or visit his Websites: Dr. Twyman and Apollo Cardiology. This episode is brought to you by BUBS Naturals, Momentous, and Cozy Earth. Support your skin and your health with BUBS Naturals Collagen Peptides. Head to BUBSNaturals.com and use code DHRU for 20% off your order. Right now, Momentous is offering our listeners up to 35% off their first order with promo code DHRU. Head to livemomentous.com and use code DHRU for 35% off your first subscription. Right now, get 20% off your Cozy Earth sheets and sleepwear. Just head over to cozyearth.com/dhru and use the code DHRUP. Sign up for Dhru’s Try This Newsletter *Nothing discussed in this podcast should be construed as medical advice; always consult a qualified healthcare professional regarding your individual health needs. Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by LMNT, Puori, and Birch Living. Today on The Dhru Purohit Show, I sit down with Dr. Leedia Riman to explore why many women begin snoring after pregnancy or during hormonal transitions and how it can affect their overall health. Dr. Leedia reveals the key signs of airway dysfunction, explains why teeth grinding is a critical warning sign that shouldn’t be ignored, and shares the five pillars of optimal oral and dental health. She also offers practical guidance for protecting your oral health throughout perimenopause and menopause. Dr. Leedia is a board-certified biological dentist and co-founder of ELEV8 Beverly Hills Biological Dentistry with a passion for prenatal and infant dental care. She created Koracare, a lifestyle brand dedicated to raising awareness about the importance of oral health during pregnancy and beyond for both mom and baby. She also created Little Jules, a unique candy line designed to bring children and adults joy and healthy smiles without contributing to cavities.  In this episode, Dhru and Dr. Leedia dive into: (00:00) Why Snoring After Pregnancy Is a Huge Red Flag (3:21) How a Missing Tooth Led to Breathing Problems (6:52) Dental Expansion Explained (9:27) Understanding Upper Airway Issues (12:48) Warning Signs of Airway Dysfunction (14:53) Teeth Grinding Shouldn’t Be Ignored (20:32) Myofunctional Therapy (23:01) The Five Pillars of Oral and Dental Health (27:56) Dr. Leedia’s Personal Story (34:24) How GLP-1s May Affect Your Airway (40:03) What Your Dry Mouth May Be Telling You (48:51) What Women Aren’t Told About Menopause (54:26) Why Flossing Matters More Than You Think (55:38) Choosing the Right Toothpaste (1:00:01) Do Air Purifiers and Humidifiers Really Help? (1:03:54) Why It’s Time to Take Oral Health Seriously Also mentioned in this episode: Videos of Myofunctional Exercises  Angie Bimat, Myofunctional Therapist  Heart & Soil Organ Supplements Risewell Pro Toothpaste The Forgotten Power of Breath and How to Use It to Radically Transform Your Health with James Nestor Millions Have This Sleep Disorder Without Knowing It—Here Are the Signs | Dr. Oliver Zolman WeNatal For more on Dr. Riman, follow her on Instagram, Threads, YouTube, Substack, or visit her Website.  This episode is brought to you by LMNT, Puori, and Birch Living. Right now, LMNT is offering my listeners a free 8-count sample pack with any purchase. Head over to drinkLMNT.com/dhru today. Quality protein matters. Get 32% off Puori Grass-Fed Whey Protein and a free shaker when you start a subscription at puori.com/DHRU and use code DHRU at checkout. Birch’s Labor Day sale continues! My community can get an exclusive 27% off a Birch Living mattress —just head to birchliving.com/dhru today.   Sign up for Dhru’s Try This Newsletter *Nothing discussed in this podcast should be construed as medical advice; always consult a qualified healthcare professional regarding your individual health needs. Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by Bon Charge, Fatty15, Our Place, and Branch Basics. Today on The Dhru Purohit Show, I sit down with Dr. Shefali to discuss the hidden battlefield parents and children are facing today. Dr. Shefali shares how algorithms and social media are hijacking attachment and attention, and the impact this is having on our children’s neurochemistry. She breaks down the red flags she’s seeing in both boys and girls, along with the common mistakes parents make when navigating the challenges of the modern world. She also explains what children need at each stage of development and how to rebalance their lives to restore the connection, resilience, and independence children need to thrive. Dr. Shefali is a clinical psychologist, a New York Times bestselling author, and the founder of the Conscious Parenting movement, redefining how families understand selfhood, connection, and children's inner lives. Her work sits at the intersection of psychology and consciousness, tracing the hidden forces that shape identity, relationships, and the way we inhabit the world. By bringing Western psychology and Eastern wisdom into lived practice, she offers a path for children and the adults who raise them to know themselves more fully. In this episode, Dhru and Dr. Shefali dive into: (00:00) The Battle for Our Children’s Attention (4:38) How Technology Is Changing Conscious Parenting (7:16) Social Media Hijacks Connection (15:01) Red Flags Parents Should Watch for in Girls (21:14) Red Flags Parents Should Watch for in Boys (27:15) Parenting Mistakes We Don’t Realize We’re Making (30:41) Why Boys and Girls Need Different Things (31:41) This Generation of Children Is Different (42:45) Why Telling Girls to “Be Good” Can Backfire (54:38) When Children Become Symbols of Success (1:00:24) How to Own Your Mistakes  (1:05:02) Why Parents Were Never Meant to Do It Alone (1:08:52) How the Mother-Child Relationship Shapes Us (1:13:43) What It Really Means to Be Present for Your Children (1:17:07) How We Can Take Childhood Back Also mentioned in this episode: Raising Conscious Daughters: Building Confidence, Courage, and Inner Power in an Anxious World Raising Conscious Sons: Cultivating Purpose, Connection, and Inner Power in a Chaotic World The politics of depression: Diverging trends in internalizing symptoms among US adolescents by political beliefs Don’t Let Politics Cloud Your View of What’s Going On With Teens and Depression For more on Dr. Shefali, follow her on Facebook, Instagram, TikTok, YouTube, Apple Podcasts, Spotify, or visit her Website. This episode is brought to you by Bon Charge, Fatty15, Our Place, and Branch Basics. Right now, Bon Charge is offering my community 15% off their Red Light mask. Just go to boncharge.com/dhru and use code DHRU to save 15%. Fatty15 is offering an additional 15% off its 90-day subscription Starter Kit. Go to fatty15.com/dhru and use code DHRU to replenish your C15 levels for long-term health. Reduce your toxic load by upgrading your cookware! Go to fromourplace.com today and use promo code DHRU at checkout to receive 10% off any order. Branch Basics is now available nationwide at Target. Shop their lineup of safer cleaning essentials, including laundry detergent, surface cleaners, dishwasher tablets, and stain remover. And if you're grabbing the Premium Starter Kit, you can get 15% off at ⁠BranchBasics.com⁠ with my code DHRU.  Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by Cozy Earth, BiOptimizers, and Bon Charge. Today on The Dhru Purohit Show, I sit down with Dr. Tyna Moore to discuss the evolving landscape of GLP-1 drugs, what “microdosing” really means, and how these medications can impact health, especially for middle-aged women. Dr. Moore breaks down common misconceptions about GLP-1 dosing, the potential benefits and risks, and why working with an informed healthcare provider matters. She also shares what women should know about protecting muscle, supporting metabolic health, and taking a more personalized approach to GLP-1s and long-term disease prevention. Dr. Tyna Moore. She is a board-certified naturopathic and chiropractic physician and the founder and owner of Core Wellness Clinic in Portland, Oregon. She specializes in non-surgical pain management, natural pain solutions, and regenerative injection therapies for orthopedic and musculoskeletal conditions. Moore has a Doctor of Naturopathic Medicine (N.D.) from Western States Chiropractic College and a Doctor of Chiropractic (D.C.) from the National College of Naturopathic Medicine. In this episode, Dhru and Dr. Moore dive into: (00:00) The Evolution of GLP-1s (4:08) Microdosing vs. Standard Dosing (8:29) How GLP-1 Microdosing Works (13:34) GLP-1 Side Effects and Risks (27:16) Labs to Check Before Starting a GLP-1 (31:26) Finding the Right Healthcare Provider (35:43) What Standard GLP-1 Dosing Looks Like (38:40) The Benefits of Microdosing GLP-1s (48:44) GLP-1 Success Stories (54:15) What the GLP-1 Research Actually Shows (1:00:48) Debunking GLP-1 Myths (1:13:17) GLP-1s, Menstrual Cycles, and Hair Loss (1:16:58) GLP-1s, Heart Health, and Hormones (1:20:57) Can You Cycle On and Off GLP-1s? (1:24:55) Final Takeaways on GLP-1s Also mentioned in this episode: Try This - Are GLP-1 Drugs Making People Blind? The Menopause Rebellion For more on Dr. Moore, follow her on Facebook, Instagram, LinkedIn, YouTube, Apple Podcasts, Spotify, or visit her Website. This episode is brought to you by Cozy Earth, BiOptimizers, and Bon Charge. Right now, get 20% off your Cozy Earth sheets and sleepwear. Just head over to cozyearth.com/dhru and use the code DHRUP. Upgrade your sleep! Go to bioptimizers.com/dhru now and enter promo code DHRU to get 15% off your entire order and unlock free surprise gifts.  Right now, Bon Charge is offering my community 15% off their Red Light mask. Just go to boncharge.com/dhru and use code DHRU to save 15%. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by One Skin, Dose, Branch Basics, and Momentous. Today on The Dhru Purohit Show, I sit down for round two with dermatologist and skin cancer and reconstructive surgery specialist Dr. Teo Soleymani to discuss the paradox of sun exposure. We explore the difference between sun exposure that accelerates skin aging and exposure that increases skin cancer risk. Dr. Teo also breaks down what the research reveals about who may be more likely to develop skin cancer, the surprising link between infections and certain cancers, and how we can protect ourselves. Plus, he shares his favorite skincare product and what he recommends avoiding. Dr. Teo Soleymani is a nationally recognized, double board-certified dermatologist and fellowship-trained Mohs Micrographic and Facial Plastic & Reconstructive Surgeon. A Stanford-trained physician and former clinical professor at UCLA, he specializes in treating complex, high-risk skin cancers and sun-damaged, aging skin. He now leads California Dermatology and Mohs Surgery Specialists in Pasadena, CA, and continues to contribute to academic research and innovation in dermatologic surgery. In this episode, Dhru and Dr. Soleymani dive into: (00:00) The Paradox of Sun Exposure (02:26) The Biggest Contributor to Skin Aging (04:59) Is Maximum Sunscreen Protection Necessary? (10:12) Does Tanning Cause DNA Damage? (13:14) Why Deadly Melanomas Can Develop on Sun-Naive Skin (21:10) Skin Aging vs. Skin Cancer: Two Different Pathways (25:48) Can Skin Damage in Your 20s Cause Cancer Later? (31:28) The Surprising Link Between Infections and Cancer (51:51) How Diet and Lifestyle Impact Skin Cancer Risk (55:41) Immune Suppression and Skin Cancer Risk (1:09:55) The Origin of Sun Powder (1:17:03) Indoor LED Light Damage (1:19:31) The “Holy Grail” of Skincare Products (1:34:44) Dr. Teo’s Final Takeaways Also mentioned in this episode: Sun Powder Try This Newsletter on Nonsmokers and Lung Cancer For more on Dr. Soleymani, follow him on Instagram, LinkedIn, and his Website. For more on Sun Powder: Facebook, Instagram, Threads, and TikTok,  This episode is brought to you by One Skin, Dose, Branch Basics, and Momentous. Right now, One Skin is offering my community 15% off; just go to oneskin.co and use the coupon code DHRU to save 15% and give your hair and skin the scientifically proven, gentle care it deserves. Support your liver with one simple daily habit. Visit dosedaily.co/DHRU and use code DHRU to get 35% off your first subscription. Branch Basics is now available nationwide at Target and Target.com. Shop their lineup of safer cleaning essentials including laundry detergent, surface cleaners, dishwasher tablets, and stain remover during your next Target run. And if you're grabbing the Premium Starter Kit, you can get 15% off at BranchBasics.com with my code DHRU. Right now, Momentous is offering our listeners up to 35% off their first order with promo code DHRU. Head to livemomentous.com and use code DHRU for 35% off your first subscription. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by Tiny Health, Branch Basics, Cozy Earth, and LMNT. Today on The Dhru Purohit Show, I sit down with Dr. Kristen Holmes to uncover why living out of sync with your body’s natural clock can undermine your health and longevity. Dr. Holmes breaks down the hidden costs of circadian misalignment and explains why the timing of your sleep, meals, and light exposure matters more than most of us realize. She shares practical strategies to help get your body back in rhythm. We also explore the psychological side of living in sync, including how stress, perception, and unresolved childhood experiences can shape our health, relationships, and sense of purpose. Dr. Kristen Holmes is the Global Head of Human Performance and Principal Scientist at WHOOP, where she leads research on the connection between physiology and behavior. A former U.S. National Field Hockey Team member and accomplished Ivy League coach, she holds a Ph.D. in Psychology from the University of Queensland. Her work focuses on translating science and data into practical strategies for improving health, performance, and recovery. In this episode, Dhru and Dr. Holmes dive into: (00:00) What Circadian Misalignment Looks Like (3:42) The Hidden Cost of Circadian Misalignment (9:36) Why Late-Night Eating Disrupts Your Health (12:56) How to Maximize Your Longevity Potential (19:48) Morning Light and Sleep Consistency (23:18) Timing vs. Willpower (25:52) The Psychology of Misalignment (35:05) How to Reset Your Circadian Rhythm (41:20) Dr. Kristen Holmes’ Personal Journey (46:13) Healing From Childhood Trauma (53:07) How Stress and Perception Shape Your Health (57:53) How Couples Can Get Back Into Alignment (1:05:44) The Path to Self-Love and Purpose Also mentioned in this episode Aligned: The Data-Driven Guide to Performance, Recovery, and Human Potential For more on Dr. Holmes, follow her on Instagram, Threads, and LinkedIn. For more on WHOOP: Instagram, X/Twitter, TikTok, and YouTube. This episode is brought to you by Tiny Health, Branch Basics, Cozy Earth, and LMNT. Right now, Tiny Health is offering my community their biggest offer yet: $50 off your first gut health test. Just head to tinyhealth.com/dhru for $50 off your first test. Your gut has a story to tell; Tiny Health helps you understand what it's saying. Branch Basics is now available nationwide at Target. Shop their lineup of safer cleaning essentials including laundry detergent, surface cleaners, dishwasher tablets, and stain remover. And if you're grabbing the Premium Starter Kit, you can get 15% off at BranchBasics.com with my code DHRU. Right now, get 20% off the Cozy Earth plush towels. Just head over to cozyearth.com/dhru and use code DHRUP. Right now, LMNT is offering my listeners a free 8-count sample pack with any purchase. Head over to drinkLMNT.com/dhru today. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by One Skin, Puori, Fatty15, and Our Place.  Today on The Dhru Purohit Show, I sit down with Dr. David Perlmutter to explore why decades of brain health research may have focused on the wrong target. We dive into why microglial cells, not beta-amyloid, may be key drivers of cognitive decline, how they’re connected to metabolic health, and what you can do to protect your brain. Dr. Perlmutter also shares why many Alzheimer’s drugs miss the mark, the supplements with the strongest evidence, and the lifestyle habits you can start today to support your cognitive health for years to come Dr. David Perlmutter is a board-certified neurologist, Fellow of the American College of Nutrition, and six-time New York Times bestselling author, best known for Grain Brain and Drop Acid. He earned his M.D. from the University of Miami School of Medicine, where he received the Leonard G. Rowntree Research Award, and currently serves as an Associate Professor at the University of Miami Miller School of Medicine. Dr. Perlmutter has published extensively in leading peer-reviewed medical journals, serves on the Editorial Board of the Journal of Alzheimer's Disease, and lectures worldwide on brain health, nutrition, and longevity. In this episode, Dhru and Dr. Perlmutter dive into: (0:00) The Biggest Mistake in Brain Health (3:09) The Brain Cells That Control Your Future (5:01) Why Microglia Are Suddenly Everywhere (8:41) Dr. Perlmutter’s Controversial Claim  (11:51) Decline May Begin Decades Earlier (21:36) When Your Brain's Defenders Turn Against You (23:38) The Gut-Brain Connection (38:51) The Hidden Chemical Linked to Damage (41:58) Why Modern Life Is Rewiring Your Brain (45:30) Are Microplastics Harming Your Brain? (49:05) The Best Forms of Exercise  (59:37) The Key Biomarkers  (1:03:51) The Brain-Protective Diet  (1:16:04) Top Supplements to Support Brain Health (1:22:49) Building a Resilient Brain (1:31:08) Has the Science on Alcohol Changed? (1:36:38) What to Do If You're Already at Risk (1:43:13) Could GLP-1s Protect the Brain? (1:51:55) Final Thoughts Also mentioned in this episode: Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life Lichen Air For more on Dr. Perlmutter, follow him on Facebook, X/Twitter, Instagram, YouTube, or visit his Website. This episode is brought to you by One Skin, Puori, Fatty15 and Our Place. Quality protein matters. Get 32% off Puori Grass-Fed Whey Protein and a free shaker when you start a subscription at puori.com/DHRU and use code DHRU at checkout.  Right now, One Skin is offering my community 15% off; just go to oneskin.co and use the coupon code DHRU to save 15% and give your hair and skin the scientifically proven, gentle care it deserves. Fatty15 is offering an additional 15% off its 90-day subscription Starter Kit. Go to fatty15.com/dhru and use code DHRU to replenish your C15 levels for long-term health. Reduce your toxic load by upgrading your cookware! Go to fromourplace.com today and use promo code DHRU at checkout to receive 10% off any order. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by Tiny Health, Bon Charge, Branch Basics, and Dose.  Today on The Dhru Purohit Show, Dhru sits down with Dr. Joey Munoz to break down a practical, sustainable roadmap for losing up to 20 pounds in 90 days, without crash diets or extreme restrictions. Dr. Munoz shares his simple five-step framework for creating a calorie deficit, building muscle, staying consistent, and getting back on track when life inevitably gets in the way. He also opens up about his own journey with weight loss and emotional eating, revealing how his relationship with food shaped the coach he is today. Along the way, he details the exact strength training routine, meal structure, and nutrition strategies he recommends to clients over 40 to improve body composition and metabolic health. If you're looking for an evidence-based blueprint to lose fat, build muscle, and create lasting results, this episode is for you. Dr. Joey Munoz holds a PhD in Nutritional Sciences from Florida State University and is a published researcher specializing in nutrition and chronic disease prevention. He is the founder of Strong Standard, an online coaching company that helps adults over 40 lose fat, build muscle, and improve their metabolic health through sustainable, evidence-based strategies. He also hosts The Dr. Joey Munoz Show, has built an audience of more than 400,000 on Instagram, and has coached over 1,000 clients during the past decade. Growing up overweight in a broken household and nearly failing out of school, Joey credits fitness with changing the course of his life. Today, his mission is to help others transform their health through fundamentals—not restriction. In this episode, Dhru and Dr. Munoz dive into:  (00:00) Introduction (3:46) The One Question That Determines Your Success (7:33) Why "Losing 20 Pounds Fast" Backfires (10:35) Fat Loss vs. Weight Loss: The Difference That Changes Everything (14:52) The Hidden Mindset Traps Keeping You Stuck (27:01) Should You Count Calories? The Honest Answer (35:58) How Many Calories Does Your Body Actually Need? (46:16) The Simplest Way to Create a Calorie Deficit (51:28) Why the Scale Doesn't Tell the Whole Story (57:37) The Accountability System That Actually Works (1:02:45) Easy Ways to Cut Calories Without Feeling Deprived (1:10:36) Why Weight Loss Gets Harder During Perimenopause (1:19:25) The Best Way to Train for Long-Term Fat Loss (1:37:46) The Most Underrated Fat Loss Habit (1:40:09) The Ideal Protein, Fiber & Meal Formula (1:48:45) Build a Feedback Loop That Keeps You Consistent (1:54:13) Where to Learn More from Dr. Joey Munoz (1:57:12) Final Thoughts Also mentioned in this episode: Mayo Clinic Calorie Calculator  MyFitness Pal Calorie Tracker Try This Newsletter on Sleep Consistency For more on Dr. Munoz, follow him on Facebook, Instagram, Threads, LinkedIn, YouTube, Apple Podcasts, Spotify, or visit his Website. This episode is brought to you by Tiny Health, Bon Charge, Branch Basics, and Dose.  Right now, Tiny Health is offering my community their biggest offer yet: $50 off your first gut health test. Just head to tinyhealth.com/dhru for $50 off your first test. Your gut has a story to tell; Tiny Health helps you understand what it's saying. Right now, Bon Charge is offering my community 15% off their Red Light mask. Just go to boncharge.com/dhru and use code DHRU to save 15%. Branch Basics is now available nationwide at Target and Target.com. Shop their lineup of safer cleaning essentials including laundry detergent, surface cleaners, dishwasher tablets, and stain remover during your next Target run. And if you're grabbing the Premium Starter Kit, you can get 15% off at BranchBasics.com with my code DHRU. Support your liver with one simple daily habit. Visit dosedaily.co/DHRU and use code DHRU to get 35% off your first subscription. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by BiOptimizers, Momentous, Cozy Earth, and Bon Charge. Today on The Dhru Purohit Show, Dhru sits down with Dr. Florence Comite to unpack the biggest lessons she's learned from more than three decades at the forefront of personalized medicine. She explains the lifestyle factors that drive heart disease in both men and women, why diabetes is often at the root of cardiovascular disease, and the key biomarkers everyone should monitor early to help prevent chronic illness. Dr. Comite also ranks the most important lifestyle habits for longevity and reveals the hormones that play a critical role in preventing osteoporosis, maintaining strength, and reducing the risk of falls as we age. Dr. Florence Comite is a New York Times bestselling author, Yale-trained clinician-scientist, and one of the world's leading experts in precision medicine and healthy longevity. A former Yale faculty member for 25 years and founder of the nation's first women-only clinic at Yale, she later founded the Comite Center for Precision Medicine & Healthy Longevity, where she pioneered the Nof1™ approach to personalized healthcare. She is the author of Keep It Up and Invincible: Defy Your Genetic Destiny to Live Better Longer, and her research has been published in leading medical journals, including The New England Journal of Medicine and JAMA.  In this episode, Dhru and Dr. Comite dive into: (00:00) Introduction (2:40) Journey into Precision Health & Longevity (6:39) Why Hormonal Shifts Increase the Risk of Heart Disease (12:07) How to Assess Your Risk of Heart Disease (15:27) The Truth About Sugar, Blood Pressure, and Insulin (24:20) Diet vs. Building Muscle: Which Matters More? (31:05) The Five Most Important Biomarkers to Track (33:59) Why Dr. Comite Started Taking Testosterone (38:34) Calcium vs. Vitamin D: What Matters Most? (44:48) Is a DEXA Scan Worth It? (46:45) The Two Habits That Protect Your Healthspan (57:05) Everything You Need to Know About Running (1:00:07) What Are the Optimal ApoB and HDL Levels? (1:07:28) Fasting Insulin vs. A1C (1:09:29) How to Get Enough High-Quality Sleep (1:12:07) Rethinking the Importance of Sleep, Exercise, and Nutrition (1:14:50) GLP-1s: The Antibiotics of the 21st Century (1:17:45) Final Thoughts and Takeaways Also mentioned in this episode: Invincible: Defy Your Genetic Destiny to Live Better, Longer Keep It Up: The Power of Precision Medicine to Conquer Low T and Revitalize Your Life! For more on Dr. Comite, follow her on X/Twitter, Instagram, TikTok, YouTube, LinkedIn, or visit her Website. This episode is brought to you by BiOptimizers, Momentous, Cozy Earth, and Bon Charge. Upgrade your sleep! Head to bioptimizers.com/dhru to take advantage of BioOptimizers ''Back to School, Back to You " sale, happening August 3–16. Get 20% off select products, plus a free tote bag with orders of $99 USD or more. Right now, Momentous is offering our listeners up to 35% off their first order with promo code DHRU. Head to livemomentous.com and use code DHRU for 35% off your first subscription. Right now, get 20% off the Cozy Earth plush towels. Just head over to cozyearth.com/dhru and use code DHRUP. Right now, Bon Charge is offering my community 15% off their Red Light mask. Just go to boncharge.com/dhru and use code DHRU to save 15%. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by Tiny Health, Bon Charge, Cozy Earth, and Puori. GLP-1 medications have transformed the conversation around obesity and diabetes. But researchers are now uncovering benefits that extend far beyond weight loss. Emerging evidence suggests these drugs may influence everything from inflammation and heart health to cancer risk, opening an exciting new chapter in preventive medicine. Today on The Dhru Purohit Show, Dhru sits down with Dr. William Li to explore some of the most exciting advancements in cancer prevention, early detection, and the emerging science behind GLP-1 medications. Dr. Li breaks down cutting-edge research on how GLP-1s may help reduce cancer risk, influence cancer cells, and potentially lower the chances of recurrence and metastasis. He also unpacks the alarming rise in colon cancer, the lifestyle strategies that can help reduce your risk, his perspective on choosing the right healthcare provider, and the latest breakthroughs in cancer screening and early detection. Dr. William W. Li, MD, is an internationally renowned physician, scientist, and author of the New York Times bestsellers “Eat to Beat Disease: The New Science of How Your Body Can Heal Itself” and “Eat to Beat Your Diet: Burn Fat, Heal Your Metabolism, and Live Longer.”  His groundbreaking research has led to the development of more than 40 new medical treatments that impact care for more than 70 diseases, including diabetes, blindness, heart disease, and obesity. He is President and Medical Director of the Angiogenesis Foundation, and he is leading global initiatives on food as medicine.  In this episode, Dhru and Dr. Li dive into: (00:00) Introduction (4:15) Headlines About GLP-1s and Cancer (13:19) Recent Observations on GLP-1s (23:11) The Heart Health Benefits of GLP-1s (28:42) How GLP-1s May Decrease the Risk of Various Cancers (43:25) Why Is Colon Cancer on the Rise? (55:59) Why the Right Medical Team Matters for Recovery (1:07:42) How to Build the Right Medical Team (1:14:37) The Mixed Opinions on GLP-1s (1:19:46) Dr. Li's Key Reminders and Recommendations (1:28:45) The Right Interventions for Overall Health (1:33:48) Foods That Support Natural GLP-1 Production (1:40:21) GRAIL's Cancer Test: Is It Worth It? (1:51:27) Final Thoughts and Takeaways Also mentioned in this episode: American Society of Clinical Oncology  Grail Test  For more on Dr. Li, follow him on Facebook, Instagram, X/Twitter, YouTube, and his Website. This episode is brought to you by Tiny Health, Bon Charge, Cozy Earth, and Puori. Right now, Tiny Health is offering my community their biggest offer yet: $50 off your first gut health test. Just head to tinyhealth.com/dhru for $50 off your first test. Your gut has a story to tell; Tiny Health helps you understand what it's saying. Right now, Bon Charge is offering my community 15% off their Red Light mask. Just go to boncharge.com/dhru and use code DHRU to save 15%. Right now, get 20% off your Cozy Earth sheets and sleepwear. Just head over to cozyearth.com/dhru and use code DHRUP. Quality protein matters. Get 32% off Puori Grass-Fed Whey Protein and a free shaker when you start a subscription at puori.com/DHRU and use code DHRU at checkout.  Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices