
What does it really take to lose weight and keep it off for good? Ethan sits down with Dr. Holly Wyatt to unpack the science of metabolism, appetite regulation, and long term weight management. They explore why the body resists weight loss, how biology influences hunger, and what actually works beyond willpower. Dr. Wyatt shares practical insights drawn from decades of clinical research, offering clarity in a space full of confusion.
If you are serious about understanding sustainable fat loss, this conversation delivers real answers.
For more insights and updates from Ethan, sign up for his newsletter at https://ethansuplee.substack.com/subscribe.
SHOW HIGHLIGHTS
00:00:00 Welcome, Dr. Holly Wyatt
00:02:09 Ethan’s Weight Loss History
00:04:32 Appetite and Hormones Explained
00:12:31 The Reality of Weight Loss Maintenance
00:13:57 Extreme Calorie Restriction
00:16:37 Why We Regain Weight
00:18:28 Metabolism Adaptation
00:30:45 Set Point and Biological Defense
00:40:26 Exercise and Long-Term Health
00:50:34 Final Takeaways on Sustainable Fat Loss
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