Decentralized in Biotech: A Conversation with Ethan Perlstein of Perlara

This episode features leaders from two different sectors who are working together to advance the decentralized science movement. Allison Deuttmann is the CEO of Foresight Institute, a nonprofit that benefits the development of high-impact technologies. It was founded back in 1987 and continues to pave the way for new work in science and technology. We're also joined by Ela Madej, founding partner of 50 Years, a venture capital firm focused on deep tech and web3 (among other areas) and a mission statement of wanting to use capital as a force for good. So my question to our guests today is how do these two worlds support the growing DeSci movement? How are they thinking about what is happening in this space? And what are their hopes and fears for the future?If you've been enjoying our content, please subscribe wherever you listen to podcasts. Thanks for listening!Ela on Twitter: @elamadejhttps://fiftyyears.com/Allison on Twitter: @allisondmanhttps://foresight.org/Mentioned in episode:Gaming the Future Book Club: https://foresightinstitute.substack.com/p/coming-soon?showWelcome=true&r=18qub2&s=rForesight Tech Trees: https://foresight.org/tech-tree/Fifty Years Spinout Playbook: https://fiftyyears.com/spinout

Today's episode is a collaboration with David Lang, executive director of Experiment Foundation and creator and host of Science Better. David and Jocelynn talk about crowdfunding for science, some of the twists and turns of building new platforms, and lessons learned from open science and citizen science communities. They also get into the idealism of the DeSci movement and hopes and fears for what is to come. David’s Twitter: https://twitter.com/davidtlangInterviews with Scientists https://www.scibetter.com/ DeSci Musings Post: https://www.scibetter.com/desci Experiment (Crowdfunding platform) https://experiment.com/ Subscribe to UltraRare The Podcast wherever you listen to podcasts.

Ethan Perlstein started his company with Silicon Valley funding and a Bay Area lab, taking a traditional, centralized path to working on drug development and drug repurposing. But that was back in 2014. Today, his public benefit corporation (Perlara), looks like a very different business, made up of biotech consultants from around the world that work on guided cures for families and foundations with rare diseases. Ethan walks us through the evolution of his company through the years and how Perlara developed a drug entering a Phase 3 trial this year. Learn from Perlstein's decentralized approach to biotech in this episode. Company website: https://www.perlara.com/ Guest Twitter: https://twitter.com/eperlste Produced & Hosted by Jocelynn Pearl https://twitter.com/JocelynnPearl UltraRare Bio is a web3 collective focused on scientific storytelling for the greater good. Our podcast aims to educate people about decentralized science and social impact in web3. https://www.ultrarare.bio/

It started with a tweet. A 25 year old woman named Mallory was suffering from an infection that had failed all antibiotic treatments. A researcher named Dr. Steffanie Strathdee was using Twitter to hunt for the impossible - a scientist somewhere in the world who might have the right phage - a virus that infects bacteria - that could save this patient. When Jessica Sacher (a phage researcher) showed her friend Jan Zheng (a UI/UX developer) the tweet, the idea for Phage Directory was born. A simple, elegant solution to a global problem. Phage Directory started as a list of phage researchers and a newsletter called Capsid & Tail. To date, it has facilitated multiple phage cures, grown a global community of researchers who hold potential treatments for future drug-resistant infections, and built a model for discovery research from benchtop to bedside, N-of-1 cures. Jan and Jessica are making the leap to Australia to further their mission with Phage Directory and help build a safety net on a country-wide scale for these types of infections. Get inspired by the progress that Jan, Jessica, and their research community has made for cures of drug-resistant infections through a global, decentralized network of researchers.This is an UltraRare x VitaDAO collaborative podcast. Thank you for listening.Website: https://phage.directory/Guest Twitter:https://twitter.com/JessicaSacherhttps://twitter.com/yawnxyzJessica Sacher BLOGhttps://jessbio.substack.com/Hosted by Jocelynn Pearlhttps://twitter.com/JocelynnPearlVitaDAO is the world’s first decentralized intellectual property collective, funding and commissioning research into human longevity. Participate in the VitaDAO community! ⇛ Website : https://www.vitadao.com/⇛ Discord: https://discord.gg/vitadao⇛ Telegram: https://t.me/vitadao⇛ Twitter: https://twitter.com/vita_daoTimestamps00:00 Intro.1:07 Intro of Phage Directory co-founders2:13 How the idea of Phage Directory came about? (Jessica Sacher)4:57 Background and experience in tech (Jan Zheng)8:40 The first successes with Phage Directory12:04 How does the alert to cure process look like?16:20 The bottlenecks in the process18:58 The process of putting together Phage Directory23:41 Community onboarding29:40 How is Phage Directory monetized?33:28 The business model of Phage Directory35:13 Why is Australia a good place for phage Directory?40:28 Phage Directory strategy43:15 Ways to access the information about the Phage Directory process44:50 The relationship between the co-founders46:17 Web 3 space and Phage Directory53:00 The options of becoming a DAO54:14 The vision for Phage Directory for the next 5 to 10 years1:03:00 Ways to support the mission1:04:56 How big is the network?1:07:00 How to get involved and be part of the community?1:11:25 Closing

This episode brings you into conversation with Ben Hills (0xboodle) and Darren Zhu to talk about how the principles of the web3 movement might give scientific publishing a much-needed upgrade. Co-hosted by Jocelynn Pearl (UltraRare, Lady Scientist Podcast) and Vincent Weisser (VitaDAO), we dive into the thinking behind what Darren and Ben have written about this space. We hope it inspires future discussions and progress in this field. This is an UltraRare x VitaDAO collaborative podcast. Thank you for listening.Articles mentioned: Tokenized Thought by 0xboodle: https://0xboodle.substack.com/p/token...Magna Carta Scientia by Darren Zhu: https://atoms.org/scientiae#smart-res...Find our guests here:Darren https://twitter.com/atoms_orgBen https://twitter.com/0xboodleVincent https://twitter.com/vincentweisserJocelynn https://twitter.com/JocelynnPearl#blockchain #desci #web3 #daoSubscribe wherever you listen to podcasts:https://podcasts.apple.com/us/podcast...https://open.spotify.com/show/624VxO4...

We're bringing you into conversation with Niklas Rindtorff and Arye Lipman, two of the leaders behind LabDAO (https://www.labdao.com/). Hosted by Jocelynn Pearl, we dive into the ideas behind LabDAO and what the team hopes to accomplish with this decentralized endeavor. Future UltraRare x VitaDAO collaborative episodes will feature conversations at the intersection of science and web3. Connect with these communities here:LabDAO Discord: https://discord.com/invite/labdaoVitaDAO Discord: https://discord.com/invite/vitadaoFind our guests here:Niklas https://twitter.com/Niklas_TRArye https://twitter.com/aryelipmanJocelynn https://twitter.com/JocelynnPearl#blockchain #desci #web3 #dao_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _VitaDAO is the world’s first decentralized intellectual property collective, funding and commissioning research into human longevity. Participate in the VitaDAO community! ⇛ Website : https://www.vitadao.com/ ⇛ Discord: https://discord.com/invite/3S3ftnmZYD ⇛ Telegram: https://t.me/vitadao ⇛ Twitter: https://twitter.com/vita_dao