Betsy's MTHFR Story - Rheumatoid Arthritis, methotrexate, and MTHFR

Season 5, Episode 7 of the To Health With That! podcast. Betsy and I recorded this video several years ago (hence the hair!) and she was kind enough to consent to share it in this format as well. Betsy's history as a nurse gives her a wonderful, insightful perspective on healthcare and her journey with autoimmune disease and having to take an antifolate will help so many other individuals who are struggling with this issue.00:00 - Intro00:36 - Betsy’s Story with Autoimmune disease03:20 - Flexibility is Betsy’s most important thing04:51 - Highly Sensitive People05:36 - MTHFR and perfectionism06:53 - Personal responsibility in MTHFR07:21 - Taking methotrexate with MTHFR (an anti-folate medication)09:11 - Symptom tracking10:53 - Knowledge about your own health is power.Thanks so much for watching! I have so many other resources for you. Here is the full version of this interview: If you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ Order Dr. Amy's book MTHFR Easy: Get Healthy For Life: https://amzn.to/47tT31YPaperback and audiobook versions are coming soon.This story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

Thank you so much to Kristyn for sharing her MTHFR story with us. Kristyn has only known she had an MTHFR gene variant for three months, but it makes sense of many of the symptoms she has had her whole life like fatigue, difficulty sleeping, and anxiety. MTHFR could be contributing to her recurrent pericarditis and kidney disease.Kristyn shares her journey with diet and supplements and trying to balance more energy with more sleep.This story is generously shared with permission to post to Youtube.00:00 - Intro00:44 - Kristyn discovers MTHFR01:04 - Recurrent pericarditis02:04 - Long-standing fatigue02:28 - Anxiety03:36 - Sleep difficulty04:04 - Early menopause with MTHFR and COVID vaccine04:51 - Symptoms but nothing shows up on lab tests05:16 - High protein diet05:54 - Starting supplements with MTHFR07:11 - The balance between having more energy and not disturbing sleep07:39 - Bad reactions to medications08:03 - Arcas for pericarditis09:23 - Seeing signs of MTHFR in other people10:24 - Energy changes with diet10:59 - Possible food sensitivities11:48 - Cayenne pepper for pain13:09 - Thank you, KristynThanks so much for watching! I have so many other resources for you. Here is the full version of this interview: https://youtu.be/DGkmqSwDYkwIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ Order Dr. Amy's book MTHFR Easy: Get Healthy For Life: https://amzn.to/47tT31YPaperback and audiobook versions are coming soon.This story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

To Health With That! Podcast Season 5, Episode 5. Thank you so much to Tony for generously sharing his story - the full interview was fabulous and included much more than we could put in one podcast episode, so we broke it into two. In this episode, Tony continues to share with the idea of MTHFR being a rebirth, new information he has about a tumor and his concerns about folate and tumor growth, and questions about MTHFR and anesthesia.00:00 - Introduction00:43 - Manageable steps01:07 - Symptom tracking01:23 - Staying in control (or not).02:03 - MTHFR as a rebirth02:45 - tumor03:10 - folate and tumor growth04:40 - Do we get enough B12 from food06:15 - B12 and lithium rotate07:15 - MTHFR and detox09:42 - mental health struggles and folic acid10:31 - MTHFR and anesthesia11:11 - MTHFR and nitrous oxide and preparing for surgery12:32 - MTHFR and antibiotics13:33 - Building back good gut floraThanks so much for watching! I have so many other resources for you. Here is the full version of this interview: https://youtu.be/SZmHnyCKd8UIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2 Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): https://community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

To Health With That! Podcast Season 5, Episode 4. Thank you so much to Tony for generously sharing his story - the full interview was fabulous and included much more than we could put in one podcast episode, so we broke it into two. In this episode, Tony shares his frustration at feeling bad, but doctors telling him he's "normal", the relief at finding MTHFR, which makes his symptoms make more sense, and the beginnings of his journey so far. He talks about brain fog, fears of cognitive decline, overwhelm, and more.00:00 - Introduction00:48 - Tony doesn't feel good, but doctors say he's fine01:18 - Being stuck in the disabled veteran category02:11 - Found out about MTHFR02:27 - Eliminating folic acid03:05 - Methyl folate feels like too much03:21 - Trying B1203:48 - The beginning is hardest with MTHFR04:53 - Methyl-free multivitamin05:42 - Tony's perfect storm of triggers08:07 - MTHFR and blood sugar dysregulation08:33 - Things we wish we knew when we were young09:33 - Brain fog or cognitive decline10:55 - Overwhelm and high sensitivity13:03 - Highly sensitive person as a form of neurodiversity14:27 - Not alone in this.hanks so much for watching! I have so many other resources for you. Here is the full version of this interview: https://youtu.be/SZmHnyCKd8UIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2  Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future. 

Thank you so much to Karene for generously sharing her story! Karene is new to MTHFR - she just found out that she and her children have an MTHFR gene mutation one week ago. Karene tested because of ADHD for herself and one of her sons, and is just starting to learn about the gene SNP and what to do. 00:30 - Introducing Karene01:03 - ADHD diagnosis01:39 - Why MTHFR explains so much for her son02:14 - MTHFR and ADHD02:47 - Methyl folate start02:14 - Trying to make sense of all the information04:01 - Diet and fortified foods with MTHFR05:04 - The folate issue06:19 - Dairy and MTHFR06:36 - MTHFR and overload07:13 - MTHFR and HSP07:51 - Interest in healthy eating is what we can leave our children when we die08:53 - What is the right dose of methyl folate09:42 - Methyl folate and the ADHD brain10:17 - Zeolites for detox in kids10:48 - Methyl folate supplements and doses11:57 - Does methyl folate build up?12:20 - Weekends off of supplements13:17 - BlessingsThanks so much for watching! I have so many other resources for you. Here is the full version of this interview: https://youtu.be/Gsj3F-9g55wIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2 Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, YouTube, and in print if that happens in the future.

MTHFR Stories are interviews with regular people who have MTHFR and are willing to share their health journey to help others. Mary's MTHFR journey centers around pregnancy loss with several second-trimester miscarriages and a stillbirth. She bravely talks about the exhaustion that she has struggled with after such a deep physical toll was taken on her body by the pregnancies, and the emotional journey she has been on. Mary has other issues associated with MTHFR as well including hypermobility and hypothyroidism, both of which contributed to her difficult pregnancies. Mary's journey is a reminder to women to advocate for themselves, not to blindly trust it when your doctor says "it's normal," and to do their own research about recommendations, such as 5 mg of folic acid for women struggling with infertility who also have MTHFR gene mutations. 00:46 - Mary and MTHFR01:46 - Hypermobility and MTHFR02:29 - Bad reactions to methylfolate (migraines)03:15 - More about hypermobility04:14 - Pregnancy loss and infertility with MTHFR06:04 - Hypothyroidism, MTHFR and stillbirth06:53 - Nutritional deficiencies08:05 - MTHFR is linked to all of these - infertility, multiple pregnancy loss, hypermobility, and hypothyroidism.09:04 - Raising awareness for women10:15 - Emotional impact of pregnancy loss11:30 - The societal value of childless women12:25 - problems with 5mg folic acid as a fertility intervention with MTHFRHere is a link to Mary's full-length interview: https://youtu.be/kw3srswszyEThanks so much for watching! I have so many other resources for you. If you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: ⁠https://calendly.com/amy-tohealthwiththat/new-meeting⁠Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2 Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

Lisa's story is a testament to what having a community of people can do for your health journey. Lisa touches on many familiar MTHFR issues - allergies, impatience, food sensitivities, blood sugar imbalance, struggles with weight, lip tie, and perfectionism. Her biggest hurdles on this journey have been about self-acceptance and also learning to have patience and not over-push her body. She is sharing those lessons with her children and grandchildren in a way that is so inspiring for all of us with MTHFR.OO:41 - Lisa's health journey02:17 - Learning patience02:37 - One step at a time03:07 - Signs of MTHFR in the family tree04:01 - Highly Sensitive Person (HSP)05:12 - The power of community05:55 - Restaurant food and food sensitivities08:23 - Blood sugar and weight loss10:00 - Accepting yourself11:07 - Trust yourselfThanks so much for watching! I have so many other resources for you. Here is the full-length version of this interview: https://youtu.be/WJkUGiMWMXYIf you would like to tell your own MTHFR story, you can schedule with Dr. Amy here: https://calendly.com/amy-tohealthwiththat/new-meetingCheck out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ You can now Pre-order the book MTHFR Easy: Get Healthy For Life. https://www.amazon.com/MTHFR-Get-Started-Guide-Healthy-ebook/dp/B0FLFCY1YQ/ref=sr_1_2?crid=3E616JJOYSA12&dib=eyJ2IjoiMSJ9.7WXbrOZ6vkAu5Ncg9lJLavpPvim_O1kOvqp3LTim_snTq6Gahvu-NhWvC1mZurA6.XnOpY_FYGI_DbfEx9NmEwRrSM2USTXkw_HTykBFrMtw&dib_tag=se&keywords=amy+neuzil&qid=1755710249&sprefix=amy+neuzil%2Caps%2C98&sr=8-2 Look for Kindle, audiobook, and paperback versions also to be released on October 24, 2025.GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.comThis story was shared graciously and generously with permission to post on the podcast, Youtube, and in print if that happens in the future.

The To Health With That! Podcast for MTHFR folks has been a wild ride, but so far it's really just Dr. Amy talking about MTHFR.In Season Five, which will start airing in September, I want YOU to talk. Tell me about your experience of being a person with MTHFR gene mutations, tell me what has helped you, what hasn't been helpful, and what you want all the other MTHFR folks out there to know.Your journey probably has other conditions intersecting as well. Maybe it's diabetes, migraines, thyroid conditions, infertility, or breast implant illness. Maybe it's chronic fatigue, mold illness, or something totally different. I want to hear about all of it. If you're an MTHFR mutant, I'd love to hear from you.Share your story on the podcast! Schedule your interview at tohealthwiththat.com or email me with questions. [email protected], go straight to the calendar link here: https://calendly.com/amy-tohealthwiththat/new-meetingThanks so much for watching! I have so many other resources for you. Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.comAFFILIATE LINKS: Thanks so much for using these links to buy the products you would buy anyway. This allows me to keep putting information out there at no cost to you. You’re the best!SEEKING HEALTH (methylation and histamine support supplements - ships internationally): https://bit.ly/3afXYH4STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwtQUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more

In the last episode, we talked about CBD as a methylation adaptogen, but we haven' talked too much about that term so let's dive in. We know that everyday methylation is important for people with the MTHFR gene or with any methylation dysfunction, but it turns out that long-term methylation care is important too and this can be achieved by getting methylation adaptogens.Methylation adaptogens are substances that help to regulate the amount your genes are methylated. Remember that when genes are methyalted, they are turned off and when they are unmethylated they are turned on. So having stretches of your genome that are undermethylated means the genes in there are allowed to function out of control, and that could lead to bigger problems like cancer.Methylating your genes appropriately is one of the long-term ways to prevent disease and even benefit your children, because research has shown that the way you methylate your genes might pass to your children. Not just the genes themselves, but the methylation tags.The most researched compounds that have been called methylation adaptogens come from food sources - things like caffeic acid from coffee and cruciferous veggies, lycopene from tomatoes and watermelon, resveratrol from red wine. Thanks so much for watching! I have so many other resources for you. Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.com

Pot is the third most used drug in North America after alcohol and tobacco, so questions about Cannabis and MTHFR are important to ask. The answers, of course, are mixed with some serious pitfalls and also some surprising benefits of CBD for people with MTHFR gene mutations.Nothing is ever fully good or fully bad, and marijuana for MTHFR is the same. When you have an MTHFR gene variant, it is important to know your own risks to make an educated decision about what you want to put in your body. Medical marijuana is widely available and can come in various strengths of THC and CBD, which will affect people with the MTHFR gene mutation in different ways.With MTHFR we do have a different risk profile than average, so educate yourself, advocate for yourself, and be careful about what you put in your body.Thanks so much for watching! I have so many other resources for you. Check out the website first for lots of FREE stuff:WEBSITE: https://tohealthwiththat.com/ GENETIC ROCKSTARS (an MTHFR, methylation, and genetics community): community.tohealthwiththat.com