What Are Lipopolysaccharides and What’s Their Role in Endometriosis Growth and Pain?

Today I want to talk about lipopolysaccharides and their role in endo growth and pain.References1) https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1363455/full2) Bacterial contamination hypothesis: a new concept in endometriosis - PMC, Evaluation of microecological therapy in endometriosis through modulation of the gut microbiota | European Journal of Medical Research3) Bacterial contamination hypothesis: a new concept in endometriosis - PMC, Significant increased isolation of Escherichia coli in Iranian women with endometriosis: a case control – study - PMC, The bidirectional relationship between endometriosis and microbiome - PMC4) Bacterial contamination hypothesis: a new concept in endometriosis - PMC, The process of microbial translocation - PubMed5) https://pmc.ncbi.nlm.nih.gov/articles/PMC7033038/6) https://link.springer.com/article/10.1007/s10620-005-2574-07) https://pubmed.ncbi.nlm.nih.gov/21070397/, https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2024.1505834/full, https://pmc.ncbi.nlm.nih.gov/articles/PMC9101724/8) https://pubmed.ncbi.nlm.nih.gov/19148789/9) https://pmc.ncbi.nlm.nih.gov/articles/PMC10954893/, https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1380713/full10) https://celiac.org/2024/04/25/new-research-shows-higher-risk-of-reproductive-disorders-for-women-with-celiac-disease/, https://pmc.ncbi.nlm.nih.gov/articles/PMC3988867/, https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/283195311) https://pmc.ncbi.nlm.nih.gov/articles/PMC12030604/12) Modern concepts of small intestinal bacterial overgrowth13) https://link.springer.com/article/10.1186/s40001-025-03334-4, https://pmc.ncbi.nlm.nih.gov/articles/PMC11370979/, https://pmc.ncbi.nlm.nih.gov/articles/PMC5902457/, https://link.springer.com/article/10.1186/s40001-025-03334-414) https://pubmed.ncbi.nlm.nih.gov/20511671/15) https://academic.oup.com/humrep/article-abstract/27/12/3417/65278216) https://link.springer.com/article/10.1186/s40001-025-03334-417) https://www.theendobellycoach.com/podcast/phgg-endo-belly-sibo-ibs18) https://pmc.ncbi.nlm.nih.gov/articles/PMC5740511/, https://pmc.ncbi.nlm.nih.gov/articles/PMC9645259/, https://www.mdpi.com/1422-0067/26/24/12021, https://www.imrpress.com/journal/FBL/31/1/10.31083/FBL4552419) https://www.theendobellycoach.com/podcast/probiotics-for-sibo-treatment, https://www.theendobellycoach.com/podcast/sibo-endometriosis-and-interstitial-cystitis-connection-wth-dr-allison-siebecker, https://www.theendobellycoach.com/podcast/endo-belly-endometriosis-how-to-treat-sibo-ibs-allison-siebecker Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today I want to talk very briefly on endo belly and IBS symptoms, and the three SIBO type gases and the specific symptoms they can cause, so that you can look for clues as to whether SIBO is behind your gut issues.References:https://pubmed.ncbi.nlm.nih.gov/29228433/, https://pubmed.ncbi.nlm.nih.gov/12591062/, https://pubmed.ncbi.nlm.nih.gov/22262197/, https://pubmed.ncbi.nlm.nih.gov/24627585/(https://www.youtube.com/watch?v=daNnGb-dnmM , https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234906, https://pubmed.ncbi.nlm.nih.gov/21286935/, https://eposters.ddw.org/ddw/2022/ddw-2022/354401/maria.jesus.villanueva-millan.comprehensive.characterization.of.the.html)https://pubmed.ncbi.nlm.nih.gov/21286935/https://www.siboinfo.com/what-is-sibo.htmlhttps://pubmed.ncbi.nlm.nih.gov/39959963/Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

LDN stands for low dose naltrexone. It is an immune modulating drug that also regulates the body’s pain relief system.It is non-addictive and safe, but it can come with side effects, so we’ll get to that - as thankfully, they can be reduced or eradicated entirely.Low-dose naltrexone works in two ways: it blocks opioid receptors which forces the body to increase its levels of other natural pain relieving chemicals, like endorphins.  But it also calms down immune cells in the brain called microglia. When these cells are overactive, they release inflammatory chemicals like cytokines that can drive symptoms like pain, fatigue, poor sleep, and brain fog, but are also heavily involved in endometriosis, so by dampening this response, LDN may help reduce inflammation-related symptoms in chronic inflammatory pain conditions.References:https://pmc.ncbi.nlm.nih.gov/articles/PMC3962576/https://www.gidoctor.net/wp-content/uploads/2024/11/1291965.pdf, https://pubmed.ncbi.nlm.nih.gov/17539894/, https://www.siboinfo.com/sibo-prevention.htmlhttps://www.gidoctor.net/wp-content/uploads/2024/11/1291965.pdfhttps://ldnresearchtrust.org/can-ldn-help-mast-cell-activation-syndrome-mcas, Does Low Dose Naltrexone help with Mast Cell Activation or Allergic or Histamine Reactions? | LDN Research Trust, Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment | BMJ Case ReportsComorbidity analysis and clustering of endometriosis patients using electronic health records - PubMedhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10039621/https://pubmed.ncbi.nlm.nih.gov/33228882/https://ldnresearchtrust.org/conditions, https://ldnresearchtrust.org/hashimoto-thyroiditis-and-low-dose-naltrexone-ldn-paula-johnsonhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7528597/https://www.siboinfo.com/what-causes-sibo.html, Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth - PubMed, Development and Validation of a Biomarker for Diarrhea-Predominant Irritable Bowel Syndrome in Human Subjects | PLOS One, Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model - PubMedNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

There are several reasons why SIBO and gut dysbiosis can influence endo growth, but today, I want to talk about just one of them, and that’s β-glucuronidase. References:1) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/2)  https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/3) https://pmc.ncbi.nlm.nih.gov/articles/PMC12942269/, https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1402-6431, https://pmc.ncbi.nlm.nih.gov/articles/PMC3768652/4) https://pubmed.ncbi.nlm.nih.gov/33839907/5) https://academic.oup.com/humupd/article/28/1/92/6412766, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261362, https://www.mdpi.com/1422-0067/24/22/16301, https://www.mdpi.com/1467-3045/47/7/502, https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1363455/full, https://www.mdpi.com/2077-0383/12/22/71766) https://www.fertstert.org/article/S0015-0282(23)00241-8/fulltext7) https://www.mdpi.com/2077-0383/12/22/7176, https://academic.oup.com/humupd/article/28/1/92/6412766, https://www.maturitas.org/article/S0378-5122(17)30650-3/fulltext, https://e-jmm.org/pdf/10.6118/jmm.240248) https://www.researchgate.net/publication/222032497_Dietary_fiber_and_activity_of_intestinal_tissue_ss-glucuronidase_in_rats, https://www.clinicalnutritionopenscience.com/article/S2667-2685(25)00039-7/pdf, https://pmc.ncbi.nlm.nih.gov/articles/PMC2858007/9) https://pmc.ncbi.nlm.nih.gov/articles/PMC6474371/,  https://pubmed.ncbi.nlm.nih.gov/17474873/, https://www.clinicalnutritionopenscience.com/article/S2667-2685(25)00039-7/pdf, https://www.sciencedirect.com/science/article/abs/pii/S027153171500315210) https://www.sciencedirect.com/science/article/pii/S0022316622105158, https://www.cancernetwork.com/view/high-fat-diet-not-associated-increased-estrogen-postmenopausal-women11) https://www.clinicalnutritionopenscience.com/article/S2667-2685(25)00039-7/pdf12) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/, https://pubmed.ncbi.nlm.nih.gov/32249416/13) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/14) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/15) https://pmc.ncbi.nlm.nih.gov/articles/PMC10416750/, https://pubmed.ncbi.nlm.nih.gov/33733438/, https://www.sciencedirect.com/science/article/pii/S014181301939277316) https://pubmed.ncbi.nlm.nih.gov/12197785/, https://pubmed.ncbi.nlm.nih.gov/2346674/17) https://pubmed.ncbi.nlm.nih.gov/33733438/18) https://www.sciencedirect.com/science/article/abs/pii/S0308814623016242, https://www.theendobellycoach.com/podcast/phgg-endo-belly-sibo-ibs19) https://www.tandfonline.com/doi/pdf/10.1271/bbb.58.136420) https://journals.lww.com/co-gastroenterology/fulltext/2025/11000/modern_concepts_of_small_intestinal_bacterial.5.aspx21) https://www.monashfodmap.com/blog/getting-enough-fibre/23) https://www.theendobellycoach.com/podcast/low-fodmap-diet-endometriosis, https://www.theendobellycoach.com/podcast/low-fodmap-diet-endometriosis-siboNeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Endo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coachingLive and Thrive with Endo 2.0 DIY online course⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Affiliate PartnershipsmBIOTA - You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFEFree resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

This week on the podcast I want to do a mini episode on improving your progesterone to oestrogen ratio in the luteal phase. And the reason being is that I track a lot of my client’s hormones with Mira, which is an at home hormone tracker, and I frequently see higher oestrogen levels and lower progesterone levels in the luteal phase.References:1) https://academic.oup.com/jcem/article-abstract/77/5/1215/26499612) https://pmc.ncbi.nlm.nih.gov/articles/PMC4700980/3) https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-e/4) https://www.fertstert.org/article/s0015-0282(0300657-5/5) https://rbej.biomedcentral.com/articles/10.1186/s12958-023-01126-1, https://www.mdpi.com/2072-6643/15/12/2773, https://onlinelibrary.wiley.com/doi/full/10.1155/2021/5529741, https://pmc.ncbi.nlm.nih.gov/articles/PMC3484190/Oxidative stress episodes:https://www.theendobellycoach.com/podcast/what-is-oxidative-stress?https://www.theendobellycoach.com/podcast/endo-early-perimenopause-menopause?https://www.theendobellycoach.com/podcast/lower-oxidative-stress-strategiesAffiliate PartnershipsmBIOTA -mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFENeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coaching⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today’s episode is a quick but informative one as I have a very packed week of client calls.So, I wanted to do a mini episode on gastroparesis and delayed gastric emptying (stomach emptying) in hEDS and POTS patients, because as you probably know by now if you listen to my show, people with endo have a higher risk of having one or both of these conditions.References:https://pubmed.ncbi.nlm.nih.gov/39990556/, https://pubmed.ncbi.nlm.nih.gov/39990556/,https://jchr.org/index.php/JCHR/article/view/5363, https://pmc.ncbi.nlm.nih.gov/articles/PMC3413773/, https://pmc.ncbi.nlm.nih.gov/articles/PMC12283190/https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/, https://pmc.ncbi.nlm.nih.gov/articles/PMC7255528/, https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/, https://pubmed.ncbi.nlm.nih.gov/26376608/, https://assets.cureus.com/uploads/original_article/pdf/30528/1612430138-1612430130-20210204-18203-dyitxb.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6874806/, https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/https://pmc.ncbi.nlm.nih.gov/articles/PMC9169754/, https://www.ehlers-danlos.org/information/gastrointestinal-problems-in-hypermobile-ehlers-danlos-syndrome-and-hypermobility-spectrum-disorders/, https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/fullhttps://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/full, https://pmc.ncbi.nlm.nih.gov/articles/PMC9169754/Can nausea and vomiting be treated with ginger extract? - PubMed, Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials - PubMed, Ginger in gastrointestinal disorders: A systematic review of clinical trials - PMC, https://www.mdpi.com/2072-6643/10/11/1715Ginger in gastrointestinal disorders: A systematic review of clinical trials - PMC, https://pubmed.ncbi.nlm.nih.gov/10442508/, https://www.europeanreview.org/article/10145, https://pubmed.ncbi.nlm.nih.gov/18403946/The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data | BMC Complementary Medicine and Therapies | Springer Nature Link, https://pubmed.ncbi.nlm.nih.gov/17653649/https://www.gidoctor.net/wp-content/uploads/2024/11/1291965.pdf, https://pubmed.ncbi.nlm.nih.gov/17539894/, https://www.siboinfo.com/sibo-prevention.htmlhttps://ldnresearchtrust.org/beth-livengood-nd-gastroparesis-case-study-2017-conference-ldn-low-dose-naltrexonehttps://pmc.ncbi.nlm.nih.gov/articles/PMC9169754/https://pmc.ncbi.nlm.nih.gov/articles/PMC9169754/https://www.theendobellycoach.com/podcast/low-fodmap-diet-endometriosis-pots-edshttps://pubmed.ncbi.nlm.nih.gov/11213895/https://pmc.ncbi.nlm.nih.gov/articles/PMC9169754/https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1379646/full#ref30Affiliate PartnershipsmBIOTA - You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFENeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coaching⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today I want to talk to you about an alternative SIBO protocol I have been using with clients since last year - and that’s probiotics. I know, controversial, so let’s get started and you’ll learn why I have begun using them.References:https://journals.lww.com/ajg/fulltext/2020/02000/acg_clinical_guideline__small_intestinal_bacterial.9.aspxhttps://pubmed.ncbi.nlm.nih.gov/28267052/https://pubmed.ncbi.nlm.nih.gov/29228433/https://pubmed.ncbi.nlm.nih.gov/36630947/https://drruscio.com/sibo-probiotics/https://drruscio.com/sibo-symptoms-causes-treatment/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080482, https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31310070, https://pubmed.ncbi.nlm.nih.gov/21153437https://www.europeanreview.org/wp/wp-content/uploads/1702-1708-L.-reuteri-in-methane-producer-constipated-patients.pdfhttps://pubmed.ncbi.nlm.nih.gov/34201542/, https://pubmed.ncbi.nlm.nih.gov/25531996/https://pubmed.ncbi.nlm.nih.gov/34201542/https://pubmed.ncbi.nlm.nih.gov/34201542/https://pubmed.ncbi.nlm.nih.gov/38337613/Bacterial contamination hypothesis: a new concept in endometriosis - PMC, Significant increased isolation of Escherichia coli in Iranian women with endometriosis: a case control – study - PMC, The bidirectional relationship between endometriosis and microbiome - PMChttps://pubmed.ncbi.nlm.nih.gov/36630947/https://pubmed.ncbi.nlm.nih.gov/31549334/https://pmc.ncbi.nlm.nih.gov/articles/PMC4311312/https://pubmed.ncbi.nlm.nih.gov/19352343/https://pubmed.ncbi.nlm.nih.gov/29397491/https://journals.lww.com/ajg/fulltext/2018/10001/recent_probiotic_use_is_independently_associated.1151.aspxSIBO Episodes (there are more, this is just a selection)https://www.theendobellycoach.com/podcast/low-fodmap-diet-endometriosis-sibo?rq=SIBOhttps://endometriosisnews.com/2020/12/17/elemental-diet-sibo-treatment/https://endometriosisnews.com/2020/11/05/antimicrobial-herbs-treat-sibo-right-for-me/https://endometriosisnews.com/2020/10/08/antibiotics-treat-sibo-guide/https://endometriosisnews.com/2020/09/24/sibo-treatment-what-to-know/https://www.theendobellycoach.com/this-endolife-podcast-episodes/how-to-treat-sibo-with-dr-allison-siebeckerhttps://www.theendobellycoach.com/podcast/latest-research-on-elemental-diet-for-sibo-with-mbiota-ceo-nicola-wodlinger?rq=SIBOAffiliate PartnershipsmBIOTA - mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFENeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coaching⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today’s episode is with Dr Alexis Cutchins and we’re talking all about pelvic congestion syndrome (or pelvic venous disease as it’s also known as) and its connection to endometriosis, POTS, MCAS and Hypermobility Spectrum Disorders.Dr Cutchins is a board certified cardiologist with a passion for caring for patients with Postural Orthostatic Tachycardia Syndrome, Mast Cell Activation Syndrome and Hypermobility Spectrum Disorders. After 13 years as Assistant Professor of Medicine in the division of Cardiology at Emory University she became founder and CEO of Cutchins Cardiovascular Medicine in New York City.She has been recognized globally for her clinical excellence in the care and management of patients with complex chronic illness, specifically, POTS, Dysautonomia and Long COVID. She is also known for her research contributions in this area specifically related to POTS and its comorbid conditions highlighting the role of Pelvic Venous Disease in Orthostatic Intolerance. She serves as a board member for the International Society for Mast Cell Activation Syndromes (ISMCAS), Standing Up To POTS, and SAFIRE (Spencer’s Association For Interventional Research & Education) a nonprofit organisation advocating for care and research for underdiagnosed syndromes such as POTS, Pelvic Venous Disease and others.Pelvic congestion syndrome can manifest as symptoms very similar to endo, so it’s often not investigated in our demographic, despite it being very common in our community. So today Dr Cutchins is being our advocate and sharing the symptoms, how to get diagnosed and what tests to ask for, and the treatment options available to us.If you have daily chronic pelvic pain, or leg pain, or you suspect or know you have POTS, HSD or hEDS or MCAS, this is worth a listen.Affiliate PartnershipsmBIOTA- mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DUFFJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFENeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coaching⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today’s episode is with Dr Lizzie Alexander (PhD), an Integrative Nutrition Health Coach (who is also currently training as a Naturopath & Nutritionist) specialising in endometriosis and fertility.After 25 years of undiagnosed endo, chronic pain, and her own fertility struggles, Lizzie found healing through working with a naturopath in New Zealand and embracing functional nutrition. She became a mother at 39 and is currently navigating secondary infertility and IVF herself.What’s so special about Lizzie’s work is that she is not only an expert through training, but also through lived experience. She uses this incredible wealth of knowledge to help women with endometriosis reclaim their health and build the families they dream of through evidence-based nutrition, personalised protocols, and compassionate guidance.In today’s episode we’re discussing the stats behind endo and fertility, the challenges people with endo can come up against with fertility and the core foundations for supporting both natural and assisted fertility journeys.Affiliate PartnershipsmBIOTA- mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.DITTO - DITTO is a clinically studied PMS and PMDD supplement with 10 ingredients that target both the mental and physical challenges that come along with the menstrual cycle, developed by a PhD Nutrition Scientist. You can use the code: ENDOBELLY (all caps) for 20% off any and all orders, now and in the future. Mira - Mira is an at-home hormone testing device for every day use. Use this link and code 2DJESS20 to get 20% off the device and any future wand orders.Tempdrop- Track fertility effortlessly with Tempdrop’s Wearable Sensor. Get 15% off with code: ENDOLIFENeed more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coaching⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠

Today I am continuing with my series on the trifecta of POTS, MCAS and h-EDS/hypermobile spectrum disorders and how they are connected to endo, and today we are basically doing a little MCAS 101.Affiliate PartnershipsmBIOTA - mBIOTA Elemental is the next generation of the elemental diet and is developed with leading gastroenterologists and food scientists. It’s both clinically effective and easy to drink. And for eligible United States customers, mBIOTA Elemental can be purchased with Health Savings Accounts (HSA) and Flexible Spending Accounts (FSA) funds. You can learn more about the formula at mbiota.com and get 20% off with code ENDOLIFE (all caps). Code is valid for the two-week protocol and until June 14th.DITTO - You can use the code: ENDOBELLY (all caps) for 20% off any and all orders, now and in the future. Need more help or want to learn how to work with me?Ways to work with me:⁠One to one coaching info and application⁠‍ ‍Live and Thrive with Endo 2.0 DIY online courseEndo Sessions: Single and mini-package one to one endo coachingSIBO Sessions: Single and mini-package one to one SIBO coaching⁠Masterclasses in endo nutrition, surgery prep and recovery and pain relief⁠⁠This EndoLife, It Starts with Breakfast digital cookbook⁠Free resources:This podcast! ⁠Endometriosis Net Column⁠⁠Endometriosis News Column⁠⁠Substack ⁠⁠Instagram⁠References1) https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf, https://pubmed.ncbi.nlm.nih.gov/32324159/2) https://pmc.ncbi.nlm.nih.gov/articles/PMC12079877/ 3) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829454, https://jamanetwork.com/journals/jama/article-abstract/2828511 4) https://pubmed.ncbi.nlm.nih.gov/24098785/ 5) https://pmc.ncbi.nlm.nih.gov/articles/PMC8459548/, https://www.sciencedirect.com/science/article/pii/S1201971220307323 6) https://pubmed.ncbi.nlm.nih.gov/34166845/, https://pubmed.ncbi.nlm.nih.gov/35623575/, https://pubmed.ncbi.nlm.nih.gov/32324159/ 7) https://braininflammation.org/mast-cell-activation-syndrome-mcas-dr-lawrence-afrin/ 8) https://pmc.ncbi.nlm.nih.gov/articles/PMC1797832/ , https://pmc.ncbi.nlm.nih.gov/articles/PMC2603032/9) https://pubmed.ncbi.nlm.nih.gov/7588332/10) https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf, https://www.degruyterbrill.com/document/doi/10.1515/dx-2020-0005/html11) https://pubmed.ncbi.nlm.nih.gov/29074615/,https://pmc.ncbi.nlm.nih.gov/articles/PMC9945179/,https://pubmed.ncbi.nlm.nih.gov/36016927/,https://pubmed.ncbi.nlm.nih.gov/15494048/,https://pubmed.ncbi.nlm.nih.gov/27841046,https://pubmed.ncbi.nlm.nih.gov/26550518/,https://pubmed.ncbi.nlm.nih.gov/17631002/,https://pubmed.ncbi.nlm.nih.gov/40028674,https://pubmed.ncbi.nlm.nih.gov/34630429/,https://pmc.ncbi.nlm.nih.gov/articles/PMC6964357/, https://pubmed.ncbi.nlm.nih.gov/37664916/12) https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1727183/full13) https://pubmed.ncbi.nlm.nih.gov/22369407/, https://pubmed.ncbi.nlm.nih.gov/24857310/, https://www.nichd.nih.gov/newsroom/releases/endometriosis, https://www.ejog.org/article/S0301-2115(14)00234-6/abstract14) https://pubmed.ncbi.nlm.nih.gov/39990556/, https://jchr.org/index.php/JCHR/article/view/5363, https://pmc.ncbi.nlm.nih.gov/articles/PMC3413773/15) https://pmc.ncbi.nlm.nih.gov/articles/PMC11348541/, https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2020/06/Mast-Cell-Activation-Syndrome-June-2020.pdf16) https://pmc.ncbi.nlm.nih.gov/articles/PMC7282488/17) https://ard.bmj.com/content/80/Suppl_1/965.1, https://pubmed.ncbi.nlm.nih.gov/35449490/, https://pmc.ncbi.nlm.nih.gov/articles/PMC9022617/ 18) https://www.ahajournals.org/doi/10.1161/JAHA.121.021002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed19) https://pmc.ncbi.nlm.nih.gov/articles/PMC11348541/#sec14