IHC Talk: Salivary Gland Neoplasia

The Chromogen Siblings are back to talk about nomenclature in pleomorphic adenomas with atypia! Dr. Mike Arnold (@MArnold_PedPath),  Dr. Andrew Bellizzi (@IHC_guy), and Dr. Sanam Loghavi (@sanamloghavi) speak with Dr. Grayson Cole of University Hospitals of Case Western Reserve University and Dr. Nicole Cipriani (Instagram @nac.ceramics) of the University of Chicago. Hear about their paths to Oral and Head and Neck Pathology, as well as their 2025 article in Head and Neck Pathology: Pleomorphic Adenoma with Epithelial Atypia, Apocrine Metaplasia, and/or In situ/Intracapsular Salivary Duct Carcinoma Are Indolent Lesions with Good Prognosis: A Proposal for Unified Nomenclature and Clinical Observation   Featured public domain music: Alpha Hydrae, Won't see it comin'

In this episode, host Dr. Michael Arnold (@MArnold_PedPath) speaks with medical students Taranjit Kaur and Harnoor Galani from the William Carey University College of Osteopathic Medicine about the Grossly Speaking podcast! Taranjit is the creator of Grossly Speaking and the Tissue Tuesday histology review series. She is currently completing a post-junior pathology fellowship between her third and fourth year of medical school at UCLA.    Harnoor is the co-founder of the podcast and serves as the social media chair! Come tune in to hear about how the podcast began, what sparked their strong interest in pathology and mentorship, and how they hope to make pathology feel more approachable and accessible for all students from every background and stage of learning.    We listen to their episode of the Grossly Speaking podcast about autopsy, public health and forensics featuring their guest Dr. Nicole Jackson.   Follow the Grossly Speaking podcast on social media:    LinkedIn: Grossly Speaking Instagram: @grosslyspeaking   Featured public domain music: Main Stem by US Army Blues

In this segment, Beyond the Scope, we speak to pathologists about their pursuits and interests in and outside of pathology. On this episode, hosts Dr. Kamran Mirza (@KMirza) and Dr. Sara Jiang (@Sara_Jiang) speaks with Dr. Kalisha Hill, Regional Chief Medical Officer for Ascension Illinois (Saint Joseph-Joliet and Saint Mary-Kankakee) and Medical Director of Pathology and Laboratory Services for Ascension Saint Mary-Kankakee. She is the owner of her independent medical practice, Mediexperts, LLC.    Hear their conversation about Dr. Hill's book PINNACLES: Visible and Invisible and her journey as a leader in Pathology and President Elect for the College of American Pathologists.   Featured public domain music: US Army Blues, BugaBlue

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth. Today, we hear about the practice of Neuropathology. Our hosts, Dr. Mike Arnold (@MArnold_PedPath) and Dr. Sara Jiang (@Sara_Jiang) speak with Dr. Michael Williams, a Forensic Neuropathologist at the Oklahoma Office of the Medical Examiner in Tulsa, Oklahoma; Dr. Neda Wick, an Assistant Professor of Neuropathology at the University of Alabama, Birmingham; Dr. Maria Gubbiotti, an Assistant Professor of Neuropathology at MD Anderson Cancer Center in Houston, Texas; and Dr. Simmi Patel, a Neuropathology Fellow at the University of Pittsburgh Medical Center. Hear what is unique about neuropathology training and practice, and find out how the USA Brain Bee (https://usabrainbee.com/) inspired interest in Neuropathology.   Public domain music: Main Stem by US Army Blues

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth. Today, we hear about how trainees in Osteopathic Medical Schools gain exposure to the field of Pathology. Our hosts, Dr. Mike Arnold (@MArnold_PedPath) and Dr. Sara Jiang (@Sara_Jiang) talk with Dr. Meredith Herman (X: @MeredithKHerman TikTok: @meredithkherman), a third year Pathology Resident at the University of Michigan; Dr. Paul Kowalski, Pathologist and Educator at Michigan State University; Dr. Adam Berry (@Aberry_Med) a first year Pathology Resident at the University of Michigan; and Dr. Peace Preston a third year Pathology Resident at the University of Pittsburgh. What variability exists in how Osteopathic Medical Schools gain exposure to the field of Pathology? Hear our guests learned writing their article, A cross-sectional analysis of pathology exposure across COCA-accredited osteopathic medical schools: Gaps and opportunities in pathology undergraduate medical education, and find out how Pathologists can help more Osteopathic Medical Students gain experience in Pathology.   Featured article: A cross-sectional analysis of pathology exposure across COCA-accredited osteopathic medical schools: Gaps and opportunities in pathology undergraduate medical education. https://www.researchgate.net/publication/392789084_A_cross-sectional_analysis_of_pathology_exposure_across_COCA-accredited_osteopathic_medical_schools_Gaps_and_opportunities_in_pathology_undergraduate_medical_education   Public domain music: Main Stem by US Army Blues

The Chromogen Siblings are back to talk about TRBC1 IHC in T-cell Lymphomas! Dr. Mike Arnold (@MArnold_PedPath),  Dr. Andrew Bellizzi (@IHC_guy), and Dr. Sanam Loghavi (@sanamloghavi) speak with Dr. Pranav Patwardhan and Dr. Erika Moore of the University of Pittsburgh Medical Center about their publication in the American Journal of Surgical Pathology: The Utility of TRBC1 Immunohistochemistry in the Evaluation of T-Cell Lymphomas.  Hear about the Hematopathology practice in different institutions, and the challenges in diagnosing T-cell lymphomas. We also hear about how Hematopathologists can use TRBC1 IHC to identify clonal populations of T-cells to support the diagnosis of T-cell lymphoma.   Featured article:  The Utility of TRBC1 Immunohistochemistry in the Evaluation of T-Cell Lymphomas https://journals.lww.com/ajsp/abstract/9900/the_utility_of_trbc1_immunohistochemistry_in_the.563.aspx   Featured public domain music: Alpha Hydrae, Won't see it comin'

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth. Today, we hear about prostate pathology and how optimization of Gleason grading can improve prognostic information. Our hosts, Dr. Mike Arnold (@MArnold_PedPath) and Dr. Andrew Bellizzi (@IHC_guy) talk with Dr. Jesse McKenney, Dr. Jane Nguyen (@janenguyen44) and Dr. Sean Williamson (@Williamson_SR) of the Cleveland Clinic. Hear about how PSA screening changed the biopsies that pathologists see, and how the art and science of re-examining Gleason grading refined prognosis for patients with prostate cancer.   Featured articles: Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort: https://pubmed.ncbi.nlm.nih.gov/27635949/ Correlation of large cribriform carcinoma and "unfavorable histology" with other Gleason pattern 4 subtypes: A proof-of-principle study evaluating 485 radical prostatectomy specimens with proposal for the concept of "borderline histology": https://pubmed.ncbi.nlm.nih.gov/39644729/ Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage: https://pubmed.ncbi.nlm.nih.gov/38828674/ Classification of prostatic adenocarcinoma as favourable/unfavourable histology has high interobserver agreement in prostate needle core biopsies: https://pubmed.ncbi.nlm.nih.gov/40762236/   Public domain music: Main Stem by US Army Blues

In this episode, host Dr. Michael Arnold (@MArnold_PedPath) speaks with Dennis Strenk (@dstrenkpa), Pathologists' Assistant at Wisconsin Diagnostic Laboratories, about the podcast he started in 2019, the People of Pathology podcast. Hear about how he got started as a Pathologists' Assistant and what got him interested in starting the People of Pathology podcast. Hear what he enjoys about podcasting and what he's learned. We also celebrate the 200th episode of the People of Pathology Podcast by listening to a special episode he selected. Hear about what he learned making episode 38 of the podcast, and how the connection he made with his guest, Dr. Ralph Hruban, continued in person.     You can read more about Dennis Strenk and the People of Pathology Podcast in his recent profile in The Pathologist magazine.   Featured public domain music: Main Stem by US Army Blues

In this series, PathPod gathers pathologists and trainees Around The Scope to discuss their work in depth. Today, we hear about social media, from #PathArt to TikTok. Our hosts, Dr. Sara Jiang (@Sara_Jiang) and Dr. Mike Arnold (@MArnold_PedPath) speak with Dr. Meredith Herman (X: @MeredithKHerman TikTok: @meredithkherman) and Julia Kochanowski (TikTok: @myforensicpath) about now pathology and medical education on social media is changing. Hear about how they create for social media, from videos to #PathArt, the connections they've made on social media and how their interactions are helping change perceptions about pathology.   Public domain music: Main Stem by US Army Blues

The Chromogen Siblings return to talk about small cell lung carcinomas. Drs. Mike Arnold (@MArnold_PedPath),  Andrew Bellizzi (@IHC_guy), and Sanam Loghavi (@sanamloghavi) speak with Dr. Natasha Rekhtman (@natasharekhtman) of Memorial Sloan Kettering Cancer Center. Hear about how Pathologists use IHC to identify subsets of small cell lung carcinomas, and the cycle of how molecular data informs IHC approaches and histologic classifications in Pathology.   Featured articles:  SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization https://www.jto.org/article/S1556-0864(20)30755-3/fulltext   POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC https://linkinghub.elsevier.com/retrieve/pii/S1556-0864(22)00299-4   Featured public domain music: Alpha Hydrae, Won't see it comin'