Immune reprogramming for cancer, and squeaky shoe science

For Endometriosis Awareness Month, we explore a condition which affects 10% of women around the world. Cells that form the lining of the uterus crop up in other parts of the pelvis, and elsewhere in the body. It prevents many patients from being able to carry out everyday tasks, and can also cause infertility. In this episode, we explore the condition, hear the experiences of those living with endometriosis, discuss the science behind it, and find out about the treatments of tomorrow... Like this podcast? Please help us by supporting the Naked Scientists

Coming up, we assess the environmental and health impact of conflict in the Middle East. Plus, the gene variants that affect how heavily someone smokes, a medication called ruxolitinib that could help the vitiligo community, and a fascinating new study on interbreeding between Neanderthals and humans... Like this podcast? Please help us by supporting the Naked Scientists

This week, we're exploring polio: a highly infectious viral disease that can attack the nervous system and cause paralysis, mainly in young children. Polio has been pushed to the brink of elimination thanks to global vaccination efforts - but it still persists. In this episode, we'll look at what polio is, how vaccines have helped control it, where the virus still exists today, and whether it can finally be eradicated... Like this podcast? Please help us by supporting the Naked Scientists

Coming up, we explore how CAR-T cell therapy is revolutionising personalised cancer treatment. Plus, how NASA's DART mission tested Earth's asteroid defence, what we are learning about the benefits of breastfeeding for mother and baby health, and we delve into the physics behind squeaky shoes... Like this podcast? Please help us by supporting the Naked Scientists

Our Titans of Science series continues with Mike Wooldridge, Ashall Professor of Foundations of Artificial Intelligence at the University of Oxford. He has conducted extensive work in the field of agentic AI, systems comprising multiple interacting AIs. In this episode, he tells Chris Smith what drew him to computers and AI in the first place, the pioneering work of Geoff Hinton, why ChatGPT isn't made to speak the truth, and what's in store for us as AI continues to develop... Like this podcast? Please help us by supporting the Naked Scientists

Today, how the brain harnesses immune cells to clear burned out fats during sleep: does this protect from Alzheimer's disease? Also, the nutrient-rich guano of seabirds that shaped society in ancient Peru, fast footage reveals how kangaroos hop faster at no extra energy cost, and how horses whinny! Like this podcast? Please help us by supporting the Naked Scientists

Our Titan of Science this week is leading light in the field of malaria, Jane Carlton. The first to sequence the genome of malaria parasite Plasmodium vivax, she also helped sequence the deadlier Plasmodium falciparum. Jane tells Chris Smith the ins and outs of malaria, her journey to become Director of the Malaria Research Institute at Johns Hopkins, and how stealing her brother's genetics textbook when she was just 8 years old led her to where she is today... Like this podcast? Please help us by supporting the Naked Scientists

This week, we look into the science behind Russian opposition leader Alexei Navalny's death, caused by dart frog poison, and why Russia resorted to such an exotic means of dispatch at all. Also, how cat cancer genomics can provide new insights into human malignancies, and - more with a whimper than a bang - how a dying star skipped the supernova and became an instant black hole. Plus, Barack Obama's stance on aliens sends conspiracy theorists into a frenzy... Like this podcast? Please help us by supporting the Naked Scientists

This week, in partnership with British Heart Foundation, we explore heart failure. Leading experts from the UK's largest independent funder of cardiovascular research tell us about the condition, the symptoms to look out for, what happens when a heart fails, how heart failure has traditionally been managed, and whether it is possible to regenerate a damaged heart... Like this podcast? Please help us by supporting the Naked Scientists

This week, we discuss a new antibody-based nasal spray that protects against the flu: how does it work? Plus, the tiny self-replicating molecule that may give clues to the origins of life on Earth, whether we should regulate "mirror life" research, and how bacteria protect oak trees from drought and other stresses... Like this podcast? Please help us by supporting the Naked Scientists