#250 Jay Campbell — The Truth About Peptides, GLP-1s & Hormone Optimization for Longevity

My guest today is Roger Love - one of the world’s most renowned voice coaches. He has worked with top performers, executives, actors, and public figures, and his work sits at the intersection of voice, confidence, emotional expression, breath, nervous system regulation, communication, and identity. In this conversation, we explore how the way you sound shapes the way people perceive you and the way you perceive yourself.We get into Roger’s framework for mastering the five core voice variables — pitch, pace, tone, melody, and volume — and why most people unknowingly sound monotone, anxious, apologetic, or less confident than they really are. He explains how voice patterns influence emotion, why public speaking fear is really fear of judgment, and how changing the sounds of confidence can actually help build confidence in real life.We also discuss the connection between voice and longevity, Roger’s work using singing and airflow to help people with stuttering and post-stroke speech challenges, and why he believes your voice may be one of the most overlooked tools for improving relationships, self-expression, business, and quality of life.This episode is for anyone who wants to communicate with more clarity, warmth, authority, and authenticity.Timestamps00:00 Why your voice may be shaping your entire life 00:59 Intro to Roger Love and why voice matters beyond performance 02:54 Roger’s origin story — singing, happiness, and becoming a voice coach at 16 08:02 The 5 core voice variables: pitch, pace, tone, melody, and volume 09:50 How emotion shapes the way you should speak — fast vs. slow, loud vs. soft 11:18 Why people remember how you make them feel more than the words you say 16:00 Why monotone voices lose people — and how melody creates engagement 19:23 The “leading tone” technique to keep people listening and prevent interruptions 20:02 How vocal musicality creates emotion, attention, and connection 21:20 Voice, relationships, and longevity — Roger’s perspective on why communication keeps us young 23:14 Roger’s documentary Find Your Voice and the story of helping a lifelong stutterer 25:23 “Solid airflow” and Roger’s approach to stuttering and speech transformation 26:12 Singing, stroke recovery, and helping his mother speak again 27:32 Why public speaking fear is really fear of being judged 28:52 “The sound creates the reality” — how confident speech builds real confidence 46:32 Why voice is a learnable skill, not a fixed trait 47:34 Why nobody is stuck with the voice they have 49:37 The voice makeover idea that could change your life#RogerLove #CommunicationSkills #PublicSpeaking #Confidence

Dr. Darshan Shah is a board-certified surgeon, longevity physician, entrepreneur, and founder of Next Health. After performing more than 20,000 surgeries and training at the Mayo Clinic, Darshan realized something most people never hear from the medical system: treating disease is not the same as creating health. In this episode, he shares the personal health crisis that changed his life, the longevity pyramid he uses with patients, the key biomarkers and scans to know before disease appears, why muscle and metabolic health matter so much, how toxins and hormone disruption are affecting people earlier than ever, and what hyper-preventive medicine may look like in the years ahead.Timestamps 00:00 Intro 01:21 Darshan’s personal health crisis despite medical success 05:51 Why modern medicine treats disease but misses true health 09:51 The longevity pyramid and the few habits that move the needle most 13:27 Why tracking glucose can change how you eat 14:11 Why sitting all day harms metabolic health 17:29 Why muscle and grip strength predict longevity 19:46 DEXA scans, body composition, and key longevity baselines 22:14 The blood markers to know before disease shows up 26:51 Functional medicine testing - gut health, hormones, and stress 30:54 Microplastics, toxins, and why hormones are getting disrupted earlier 35:24 How to detox your home without getting overwhelmed 36:48 Hyper-preventive medicine for heart disease, cancer, brain health, and lung health 43:15 Peptides, stem cells, and when advanced therapies actually make sense 44:04 Why chronic disease may not need to be your destiny 45:24 What’s next for Darshan and Next Health #Longevity #HealthOptimization #MetabolicHealth #PreventiveMedicine #Biohacking

Dr. Bilal Chughtai is a board-certified urologist and expert in women’s urinary health, recurrent urinary tract infections, the urinary microbiome, and preventative urology.In this episode, Claudia speaks with Dr. Chughtai about why bladder health deserves far more attention in the longevity conversation - especially for women dealing with recurrent UTIs, menopause, changing hormones, and the often-overlooked effects urinary health can have on cognition, confidence, intimacy, travel, and quality of life.They explore why UTIs are so common in women, why they often become more frequent with age, how estrogen loss during menopause changes the bladder environment, and why repeated antibiotic use may not always be the best long-term solution. They also discuss the emerging science of the urinary microbiome, the link between UTIs and neurological symptoms in older adults, and practical tools that may help reduce recurrence and support long-term urinary health.We discuss:Why bladder health matters for longevity and healthy agingWhy women are more prone to recurrent UTIsThe connection between menopause, estrogen decline, and bladder healthWhy UTIs can sometimes show up as confusion or delirium in older adultsThe urinary microbiome and how the science is evolvingThe downside of repeated antibiotic useCranberry, D-mannose, vaginal estrogen, pelvic floor therapy, and other prevention toolsPractical habits to support urinary health over timeTimestamps 00:00 Intro 01:23 Why bladder health matters for longevity 02:30 Why UTIs are so common in women 03:39 UTIs, confusion, and cognitive symptoms in older adults 05:01 What happens during a UTI 06:52 What healthy bladder aging looks like 07:24 Why urinary health needs a personalized approach 08:48 Hydration and bladder health 09:39 The problem with repeated antibiotic use 11:44 Cranberry and non-antibiotic prevention tools 13:59 D-mannose and what the evidence says 18:02 Stress, sleep, exercise, and urinary function 19:19 Menopause, estrogen, and bladder health 21:19 Pelvic floor therapy and age-related changes 23:00 Symptoms to raise with your doctor early 24:32 Daily urinary health habits 30:06 Future innovations in bladder health 31:54 First steps for recurrent UTIs 34:26 Where to find Dr. Bilal Chughtai 34:55 Final thoughtsReady to upgrade your health, energy, and longevity? Download my free 10 Life & Longevity Hacks Playbook and start living smarter, stronger, and longer → https://longevity-and-lifestyle.com/freebie If you enjoy science-backed conversations on longevity, metabolic health, biohacking, brain health, women’s health, and performance optimization, subscribe and turn on notifications so you don’t miss upcoming episodes. #longevity #womenshealth #uti #menopause #bladderhealth #healthyaging #microbiome #preventativehealth #urology 

What if sweetness itself isn’t the real problem?In this episode, Claudia welcomes back Sakiko Reuterskiöld, founder and CEO of NOMOSU, to explore the science of sugar, fructose, fiber, cravings, sweeteners, the microbiome, and metabolic health. Sakiko explains why many people may be blaming the wrong thing when it comes to blood sugar, weight gain, and long-term metabolic dysfunction and why the bigger issue may be excess sugar, especially liquid fructose, low fiber intake, and the structure of modern foods.They discuss the difference between sweet taste and metabolic harm, why liquid fructose may be especially damaging over time, how fiber supports satiety, insulin sensitivity, and gut health, and what the science really says about stevia, erythritol, cacao, and so-called “healthy” sugars. This episode is especially relevant for anyone who wants better energy, fewer cravings, improved blood sugar control, and a smarter, more science-backed relationship with sweetness.Ready to upgrade your health, energy, and longevity? Download my free 10 Life & Longevity Hacks Playbook and start living smarter, stronger, and longer → https://longevity-and-lifestyle.com/freebie Timestamps00:00 Intro and Sakiko’s mission to rethink sweetness through metabolic and gut health 02:08 Why sweetness itself may not be the real problem 03:57 Glucose vs fructose — and why fructose can be more harmful over time 05:32 Why liquid fructose is especially damaging for metabolic health 06:44 Sakiko’s personal story with sugar, cravings, and energy 08:39 Dates, honey, maple syrup, and agave — are they really healthier? 12:18 The biggest misinformation around sweeteners and health headlines 13:55 Stevia, monk fruit, erythritol, xylitol, allulose, and sweet proteins explained 16:19 Erythritol controversy — what people may be misunderstanding 19:38 Stevia deep dive — insulin sensitivity, cravings, and misconceptions 24:17 Have we lost the ability to taste real sweetness? 26:57 How to reset your palate and reduce sugar cravings 27:45 Why fiber is foundational for metabolic health and healthspan 29:49 Fiber, satiety hormones, GLP-1, and fullness signals 30:46 Easy fiber upgrades and practical daily strategies 31:12 Fiber, cravings, short-chain fatty acids, and the microbiome 32:28 Inulin, fructose handling, and the gut-liver connection 34:00 Fiber and cardiovascular health, LDL, ApoB, and inflammation 44:33 Where to find Sakiko and learn more about NOMOSULearn more about Peptides for High Performance; https://peptidefoundation.lumaralearn.com/ If you enjoy science-backed conversations on longevity, metabolic health, biohacking, brain health, women’s health, and performance optimization, subscribe and turn on notifications so you don’t miss upcoming episodes.#longevity #metabolichealth #bloodsugar #fiber #guthealth #biohacking #nutrition #healthoptimization #sugar

In this episode of the Longevity & Lifestyle Podcast, Claudia sits down with Jay Campbell to unpack the truth about peptides, GLP-1s, hormone optimization, metabolic health, and the future of longevity medicine.Jay explains why peptides are tools, not magic bullets, why hormone optimization should come before advanced peptide protocols, and how many people are misunderstanding GLP-1s entirely. They also explore microdosing, growth hormone peptides, mitochondrial support, NAD, nootropic peptides, metabolic dysfunction, and the serious risks of fake or contaminated peptide products.If you want to better understand what actually matters before using peptides or GLP-1s, and how to think about fat loss, performance, and long-term optimization more intelligently, this episode is packed with practical insight.Learn more about Peptides for High Performance; https://peptidefoundation.lumaralearn.com/Timestamps 00:00 Introduction to Jay Campbell 01:20 Why peptides and AI are tools, not magic bullets 23:11 Modern toxic load, obesity, and metabolic dysfunction 28:17 Why hormone optimization comes first 31:26 Why peptides could change the future of medicine 39:41 Peptide categories explained 40:54 GLP-1s, tirzepatide, retatrutide, and what most people get wrong 45:03 Growth hormone peptides and the “holy trinity” stack 46:06 Hormones, GLP-1 microdosing, and fat loss synergy 46:46 Mitochondrial peptides and advanced performance protocols 52:36 NAD, mitochondrial support, and energy 56:19 Nootropic peptides and brain optimization 1:00:48 The peptide quality problem and how to avoid fake products 1:02:16 Final thoughts#Longevity #Peptides #GLP1 #HormoneOptimization #MetabolicHealth #Biohacking #JayCampbell

What if your microbiome is influencing far more than digestion - from your brain and immune system to aging, energy and chronic disease risk?In this fascinating episode, Dr. Momchil “Momo” Vuyisich joins Claudia to unpack the science of the microbiome, microbial function and personalized nutrition.We explore:• Why Your Gut Microbiome Shapes Human Health • The Difference Between Microbes and Microbial Function • How Gut Bacteria Influence Brain Health and Cognition • Why Antibiotic Overuse May Increase Chronic Disease Risk • The Role of Fermented Foods and Probiotics • Why Personalized Nutrition Is the Future of Healthcare • The Importance of Keystone Species Like Akkermansia • How Food Preservatives and Modern Diets Affect the Gut • Why Testing and Data Create Actionable Health Insights • The Future of Microbiome Science and Precision HealthThis conversation is a powerful reminder that longevity starts with understanding the invisible ecosystem living inside us.Timestamps 00:00 - Why chronic stress may be destroying your body 00:38 - Dr. Momchilo Vuyisich’s background and work at Viome 01:33 - Why humans are an ecosystem, not just an individual 03:58 - Why fiber is essential for feeding the microbiome 04:52 - How the microbiome is shaped at birth 06:31 - Why asthma, food allergies, and IBD may be rising 08:13 - How mothers can support a healthier microbiome before pregnancy 09:40 - The hidden long-term cost of antibiotics 11:06 - How preservatives and non-organic meat may harm the microbiome 12:22 - How to rewild your microbiome after disruption 16:46 - Why some keystone strains are so hard to restore 18:19 - Microbial function vs. microbial strains 20:49 - How microbial metabolites affect the brain and body 24:25 - Why personalized nutrition may matter more than generic healthy eating 27:20 - The four pillars of health: food, exercise, Zen, and sleep 29:58 - Why there is no single optimal diet for everyone 32:34 - Minimum effective exercise for longevity 34:21 - Why stress management is non-negotiable 37:48 - Why sleep sets up your entire next day 39:33 - Are naps helpful or harmful? 40:22 - The microbiome and neurodivergence 43:07 - Can chronic disease become preventable? 44:31 - Preventive maintenance for the human body 46:34 - How the microbiome may influence immune memory 48:13 - What Dr. Vuyisich is building at Viome now 51:15 - Where to follow Dr. Vuyisich and learn moreSubscribe to Longevity & Lifestyle for science-backed insights on longevity, health optimization, brain health, metabolic health, women’s health, and performance.#microbiome #guthealth #longevity #healthoptimization #immunity #brainhealth #metabolichealth #personalizednutrition #biohacking #healthyaging

What if your body starts warning you long before real symptoms appear? In this episode, Claudia sits down with Mila Reeves to unpack what real health ownership looks like - from reading your body’s early signals to understanding NAD+, peptides, supplement quality, diagnostics, hormones, energy, and the dangerous gap between good science and good marketing.Maila shares her personal path into longevity, why she believes prevention is no longer optional, how NAD+ moved from addiction clinics into the mainstream longevity world, what most people misunderstand about delivery methods, why quality control in supplements matters far more than most consumers realize, and how to think more clearly about peptides, personalization, and aging well.This is a practical conversation on how to stay sharp, energized, and resilient for longer - without falling for hype.Timestamps00:00 - Your body gives signals before breakdown01:33 - Intro to Maila Reeves03:07 - Maila’s origin story: fashion, law, strategy, and longevity06:35 - The problem with snake oil in longevity08:36 - What to check before buying supplements09:13 - When longevity became personal12:59 - Visualizing the future: how do you want to age?13:59 - Why people still outsource their health16:42 - The knowledge gap in medicine and women’s health19:01 - Why your doctor is not always right for your body21:27 - Mila’s non-negotiables: positivity, gratitude, NAD, NAC, vitamin D22:51 - What NAD+ actually is24:27 - Why NAD+ was first used in addiction recovery26:20 - IV vs subcutaneous vs capsules28:05 - Why delivery method matters for NAD+30:02 - What’s the most effective way to take NAD+?31:55 - Claudia’s experience using NAD+ for travel and energy33:29 - Hair, libido, brain clarity, skin, sleep, and hormones35:12 - Who should not take NAD+36:12 - Why quality and certification matter38:06 - Peptides explained simply40:49 - Why peptides are becoming so popular41:25 - The fundamentals still matter most42:40 - Final message: prevention is not optionalReady to upgrade your health, energy, and longevity? Download my free 10 Life & Longevity Hacks Playbook and start living smarter, stronger, and longer → https://longevity-and-lifestyle.com/freebie#longevity #NAD #peptides #biohacking #healthoptimization #womenshealth #supplements #antiaging #podcast #ClaudiaVonBoeselager

What if your home is quietly accelerating your aging… or actively supporting your longevity?In this solo episode, Claudia explores one of the most overlooked pillars of health: your environment.We spend over 90% of our lives indoors - yet most people focus only on nutrition, exercise, and supplements while ignoring the space their body lives in.Claudia breaks down:The five key environmental factors shaping your biologyWhy air, water, light, materials and nervous system load matterHow your environment impacts energy, sleep, inflammation and performanceThe role of mitochondria and energy allocation in healthWhy you can’t optimize your biology in a survival stateThe truth about “healthy” swaps like saltwater poolsWhy wellness real estate is becoming the future of luxury and investmentThis episode is an invitation to shift from optimizing your body… to optimizing the environment that supports it.Watch the full episode here

Claudia von Boeselager is a former Goldman Sachs banker turned biohacker, longevity entrepreneur, peak performance coach, and investor who reversed her biological age by 18 years.In this conversation, she shares the burnout moment that changed everything, what biohacking really means beyond supplements and gadgets, how purpose and alignment affect health and performance, and why women can use their biology as an advantage in leadership, business, and life.[00:00] Introduction to Claudia’s journey[03:00] Purpose, alignment, and “following your bliss”[07:00] What biohacking really means[15:00] The burnout moment that changed everything[20:00] Women, leadership, and playing small[30:00] Female biology as a business advantage[40:00] Sales, money mindset, and impact[50:00] Building businesses with purpose[58:00] Rapid-fire insights and lessonsClaudia von Boeselager is the founder of Longevity & Lifestyle, a platform focused on helping ambitious people optimize health, performance, and lifespan through science-backed tools, expert insights, and practical strategies. Her work sits at the intersection of longevity, women’s health, biohacking, and high performance.Newsletter: https://longevity-and-lifestyle.com/llinsiderWebsite: https://longevity-and-lifestyle.com/Follow on Instagram: https://www.instagram.com/longevityandlifestyle/Follow Claudia on LinkedIn: https://www.linkedin.com/in/claudia-von-boeselagerSubscribe on YouTube: https://www.youtube.com/channel/UCZF-s8jsUejc0TpVqnFE1lQ

Ever blanked in a meeting or "frozen" during a big presentation? You aren't alone.Communication expert Matt Abrahams joins Claudia von Boeselager to explain the science of why high performers blank out and how to rewire your brain to stay calm and clear.Download my FREE 10 Life & Longevity Hacks Playbook to start living smarter and stronger: https://longevity-and-lifestyle.com/freebieIn this episode, we dive into:00:00 – Why smart people "freeze" when the stakes are high05:30 – The biology of anxiety and cognitive overload12:00 – Why connection matters more than perfection18:45 – The "Pace, Space, Grace" framework for better listening25:10 – How to use structure instead of memorization32:00 – Practical tools for high-stakes interviews & meetings40:00 – The key to becoming a master communicatorAdditional Resources: ✨ Join the LLInsider for peak performance strategies: https://longevity-and-lifestyle.com/llinsider ✨ Full show notes & links: http://longevity-and-lifestyle.com/podcast-245-matt-abrahams#LongevityAndLifestyle #CommunicationSkills #MattAbrahams #PublicSpeaking #MindsetShift #PeakPerformance #LeadershipDevelopment