229: The New GLP-1 Pill That Could Replace Injections

Looking younger starts with what you do every day, not what cream you put on at night. In this episode, I walk you through exactly how I keep my skin and biological age younger than the number on my passport. This is a simple, realistic plan you can actually follow. We get into what makes your skin age faster than it should like collagen breaks down, too much sugar that causes glycation, UV light, blue light, stress and much more.  I break down the fundamentals first and then we move into the tools that actually work… red light therapy, sauna and other techniques, peptides and supplements. Nothing fancy, just proven, consistent habits. I also share my own morning and evening routine step by step. What I take, what I apply, and when I do it. If you want tighter skin, better confidence, and a younger biological age, start here. This is the exact protocol I use and the same one I give my clients. We Also Discuss: (00:01) What does it actually take to look 10 years younger? (02:48) Is sugar secretly aging your skin faster than anything else? (04:50) Do you really need sunscreen indoors and in front of screens? (07:22) Why isn't drinking more water fixing your skin and hydration? (09:58) Which anti-aging tools actually work, and which are a waste of money? (14:41) Peptides, red light, sauna, how do you stack them for real results? (20:52) What does a full morning-to-night anti-aging routine look like? Thank you to our sponsors: NAD + Cell Shield from Biostack Labs → https://biostacklabs.com/krisBiOptimizers — code KRIS10 for 10% off → https://bioptimizers.com/Timeline Nutrition — 20% off for my listeners → timeline.com/GETHIN LVLUP → Use code GETHIN for 20% off at https://lvluphealth.com/   Find more from Kris: Website: https://www.krisgethin.com/   Instagram: https://www.instagram.com/krisgethin/  Youtube: https://www.youtube.com/krisgethin   

Most people pop melatonin or magnesium before fixing what truly matters, their sleep hygiene. In this episode, I break down how to fall asleep faster and stay asleep longer without supplements. We cover why deep sleep drives recovery, hormone balance, and emotional stability, and how missing just a few hours can accelerate aging and blunt performance. I share simple, science-backed ways to optimize your environment: blackout blinds, air filtration, room temperature, and sound control. You'll also hear how tools like neurofeedback, red light, and grounding reset your nervous system and promote restorative rest. Plus, the habits that ruin sleep, late caffeine, blue light, and inconsistent bedtimes, and how to fix them. If you want better recovery, sharper focus, and more energy, start here. This is the blueprint for mastering sleep, no supplements required. What's Discussed: (00:01) How to Fall Asleep and Stay Asleep Naturally (03:48) What Really Happens During Deep Sleep (07:21) Simple Environment Fixes for Better Rest (09:11) Train Your Brain to Switch Off and Recover (11:48) Daily Habits That Build Unbreakable Sleep Quality Thank you to our sponsors:  NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/  Timeline: My friends at Timeline are offering 20% off, just for my listeners. Head to timeline.com/GETHIN to get started. LVLUP: Head over to LVLUPHealth.com and use code GETHIN at checkout to get 20% off.   Find more from Kris: Website: https://www.krisgethin.com/  Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin  Unmatched Supplements: https://www.unmatchedsupps.com/ 

GLP-1s have dominated the headlines, but the next wave of compounds is already here, and they're changing the conversation on fat loss, performance, and longevity. In this episode, I break down the science behind four emerging therapies and why you need to know about them now. We cover how Afoglipron, the first oral non-peptide GLP-1, removes the barrier of injections while delivering results on par with semaglutide. You'll hear why Teriparatide, originally used for osteoporosis, may reduce visceral fat and protect bone density at the same time. I also dive into Mazdutide, a dual GLP-1/glucagon agonist that suppresses appetite while boosting energy expenditure, and Tesofensine, a brain-targeting appetite suppressant with powerful effects on cravings. I share what the latest clinical data shows, the benefits and risks for both general populations and athletes, and how these compounds could fit into the bigger picture of training, nutrition, and longevity. This is a must-listen. What's Discussed: 00:05 — Why GLP-1s have exploded and what's next beyond semaglutide 01:53 — Afoglipron: The first oral GLP-1 and why it's a game changer 07:16 — Teriparatide: Surprising fat loss potential in a bone health drug 10:29 — Mazdutide: The "eat less, burn more" dual agonist 13:17 — Tesofensine: Targeting food noise and cravings in the brain 16:20 — Are these drugs the future of fat loss, or a Pandora's box? Thank you to our sponsors:   NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/  Timeline: My friends at Timeline are offering 20% off, just for my listeners. Head to timeline.com/GETHIN to get started. LVLUP: Head over to LVLUPHealth.com and use code GETHIN at checkout to get 20% off.   Find more from Kris: Website: https://www.krisgethin.com/   Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin Unmatched Supplements: https://www.unmatchedsupps.com/  

Glutathione isn't just another supplement, it's the master antioxidant your body depends on for performance, recovery, and longevity. In this episode, I break down the science behind glutathione and why I've made it part of my daily stack for nearly a decade. We cover how glutathione neutralizes free radicals, supports detoxification, strengthens your immune system, and protects mitochondria, the power plants of your cells. You'll hear what the latest research shows about oral glutathione (yes, it works), why consistency is key, and how it directly impacts your recovery, energy, and even skin health. I also share exactly how I use it, when I double up while traveling, how I stack it with pre-workouts for better pumps, and why I recommend fermented, clinically studied forms like CellShield. If you want to train harder, recover faster, and slow down biological aging, this is a must-listen. What's Discussed: (00:04) The Importance of Glutathione Supplementation (06:41) Beneficial Effects of Glutathione Supplementation (11:08) Glutathione and Training Recovery (16:53) Glutathione, Sleep, and Stress (20:34) Optimizing Health and Performance Thank you to our sponsors:  NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    Find more from Kris: Website: https://www.krisgethin.com/   Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin Unmatched Supplements: https://www.unmatchedsupps.com/  

Most people using GLP agonists are doing it wrong. Semaglutide? Tirzepatide? They're not magic pills, they're misunderstood tools. In this episode, I answer your most common questions and break down what these drugs actually do inside the body. We get into the real science: how GLPs suppress appetite, slow digestion, improve insulin sensitivity, and change energy balance. I explain the difference between GLP‑1, dual agonists like tirzepatide (GLP + GIP), and next-gen options like retatrutide (GLP + GIP + glucagon). You'll learn why fat loss happens, why muscle loss is a major risk, and how to train, eat, and supplement so you stay jacked, not soft. We cover the rebound effect when you stop, what stacks are worth considering, and how to avoid wrecking your gut or your gains in the process. If you're serious about fat loss, muscle retention, and metabolic health, this is mandatory listening. These compounds can change your trajectory. Or wreck it. The difference is your discipline. What's Discussed: (00:01) Are GLP Drugs Just Fancy Appetite Suppressants? (02:57) The Real Reason You're Losing Muscle on Semaglutide (05:23) What Happens When You Come Off? The Rebound Most Miss (06:59) Using GLPs as an Athlete? Here's What Can Go Sideways (13:06) How to Actually Maximize GLPs Without Wrecking Your Gains Thank you to our sponsors: NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/      Find more from Kris: Website: https://www.krisgethin.com/  Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin   Unmatched Supplements: https://www.unmatchedsupps.com/   

Most NAD+ supplements are fluff. NMN? NR? They're precursors, half the story. In this episode, I break down why NAD3 isn't just another molecule, it's the master key for energy, recovery, and longevity. We get into the real science: how NAD+ fuels your mitochondria, repairs DNA, activates sirtuins, and slows aging at the cellular level. I explain why levels crash after 40, how stress, toxins, and training hammer your reserves, and why NMN/NR often fail thanks to CD38 and PARP overactivity. You'll learn why NAD3 bypasses the weak links, how it stacks with spermidine, glutathione, and autophagy activators, and why Regen NAD is the one I actually use daily, because it works. Forget the hype. This is metabolic firepower that hits. If you're overtrained, under-recovered, or want to stay biologically younger for longer: listen in. What's Discussed: [00:30] – What Is NAD+ and Why It's Non-Negotiable [03:30] – Why Your NAD Levels Plummet After 40 [07:15] – NMN & NR: Overhyped Precursors That Don't Deliver [09:30] – NAD3: The Smarter, More Effective Upgrade [11:00] – My Daily NAD Protocol (and Why IVs Suck)   Thank You for Our Sponsors: NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/  Peptide Flask - Get your here and use KRIS10 is the code for 10% off.  My Go-To for Gut Health: Glutamine and Imuno-IGG from Unmatched Supplements: https://www.unmatchedsupps.com/collections/digestion-gut-health Find more from Kris: Website: https://www.krisgethin.com/ Website:https://www.unmatchedsupps.com Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin 2 Shred: https://www.unmatchedsupps.com/products/2shred 

Most guys fall apart with age. Excuses pile up. Strength fades. But Mike Ryan proves you can get stronger every decade. At nearly 60, he's outlifting men half his age, and he's been doing it while training Hollywood's biggest names like Dwayne "The Rock" Johnson . In this episode, we break down what actually drives longevity in fitness. Mindset over motivation. Why recovery, hydration, and sleep matter more than the latest trend. And why your environment will dictate your results more than any program. Mike gets real about TRT and peptides, the role of cheat days, and what decades at Gold's Gym Venice have taught him about strength, discipline, and staying relevant. We also tackle overrated vs. underrated exercises, celebrity training under pressure, and how to avoid the social media nonsense that's making lifters weaker. Mike Ryan is a Gold's Gym Venice legend who's trained top celebrities and athletes, including Dwayne "The Rock" Johnson. At nearly 60, he's still pushing massive weight and proving that longevity comes from discipline, mindset, and consistency. What's Discussed: (00:00) From Gold's Gym to Celebrity Training and Longevity (10:31) Evolution of the Fitness Industry and Staying Relevant (16:56) Training Secrets Recovery Habits and Performance Enhancers (27:05) Pop Culture Conversations and Personal Insights (33:47) The Shocking Cyberbullying Documentary That Left Us Speechless Thank you to our sponsors:  NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    Find more from Kris: Website: https://www.krisgethin.com/  Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin    2 Shred: https://www.unmatchedsupps.com/products/2shred     Find more from Mike Ryan: Instagram: @mike_ryan_celebritytrainer   

"Destroyed by the gut." "Zero absorption." "Only injectables work." This is BS. In this episode, I break down why oral peptides aren't just working, they're evolving. I cover the science, the delivery tech, and the results I've lived through: cartilage regrowth, hormonal optimization, cognitive firepower. You'll learn how short-chain peptides bypass gut breakdown via PEPT1. Why nano-carriers, mucoadhesive polymers, and smart pH triggers are rewriting absorption. And why anyone still parroting the "oral doesn't work" myth is stuck in 2005. I show you my travel peptide stack, how I keep everything cold, and why oral bioregulators like Sigma, Testolutin, and Biomind are now staples in my rotation. This isn't hype. This is recovery, immunity, and performance…elevated. What's Discussed: (00:06) Oral Peptides: Why the "Destroyed by the Gut" Claim is BS (02:42) My Travel Stack: Fridge, Injectables, and Immune Armor (04:39) Brain on Fire: The Peptides That Keep You Sharp (08:19) Biohacking Absorption: How Oral Peptides Actually Work (16:54) What Makes Next-Level Recovery My Go-To for Gut Health: Glutamine and Imuno-IGG from Unmatched Supplements: https://www.unmatchedsupps.com/collections/digestion-gut-health Find more from Kris: Website: https://www.krisgethin.com/ Website:https://www.unmatchedsupps.com Instagram: @krisgethin  Youtube: https://www.youtube.com/krisgethin 2 Shred: https://www.unmatchedsupps.com/products/2shred    

​​You take creatine. You think it's working. But if you're bloated, cramping, or seeing zero gains, you're not absorbing it right. Here's the truth: monohydrate saturates one transport pathway. Once that's full, you're done. Up to 30% of users feel nothing. Add GI issues and brain access problems, and you're building strength on a weak foundation. In this episode, I break down CreGAAtine, a next-gen formula with creatine monohydrate, GAA, and B vitamins. It hits four pathways, not one. That means better muscle saturation, stronger brain uptake, and zero bloating. I cover absorption, ATP regeneration, neuroprotection, and why this crushes the "non-responder" excuse. You get more power, more cognitive resilience, and faster recovery, without these side effects. I show you how I take it, why it works year-round, and how it fits into a performance-first lifestyle. Listen in. Then upgrade your creatine. Your strength, brain, and gut will thank you. What's Discussed: (00:01) Evolution of Creatine (01:22) Limitations of Monohydrate (04:13) Brain Absorption & Non-Responders (05:26) What Makes CreGAAtine Different (11:42) Benefits of Creatine Supplementation Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    My Go-To Creatine: CreGAAtine from Unmatched Supplements: https://www.unmatchedsupps.com/cregaatine-capsules Find more from Kris: Website: https://www.krisgethin.com/  Instagram: https://www.instagram.com/krisgethin/  Youtube: https://www.youtube.com/krisgethin   2 Shred: https://www.unmatchedsupps.com/products/2shred   

My Go-To Protein: UK Pasture-Raised Whey Isolate from Unmatched Supplements SHOP HERE: (BOGO 50% OFF SALE HAPPENING NOW): https://www.vitaminshoppe.com/p/isolate-grass-fed-whey-protein-rich-chocolate-2-lb-powder/unm-14114 You check the label. It says "grass-fed." You think you're getting the cleanest, most nutrient-rich protein possible. But here's the truth: in the U.S., that label can mean almost nothing. Loopholes, grain finishing, inconsistent nutrient profiles, even hidden contaminants. And if you're using that protein daily? You're building your results on a shaky foundation. In this episode, I break down the real difference between UK/Irish pasture-raised whey isolate and most U.S. "grass-fed" protein. You'll learn why sourcing, animal welfare, and processing methods matter for muscle growth, fat loss, recovery, and long-term health. We'll talk nutrient density, bioactive fractions, contamination risks, sweetener choices, and how to spot marketing tricks designed to make cheap protein look premium. I'll show you exactly what I use, why I use it, and how to make sure your protein works with your health, not against it. No fillers. No hype. Just facts you can use to choose better, recover faster, and perform longer. Listen in. Then upgrade your protein. What's Discussed: 00:01 – Why "grass-fed" on the label might not mean what you think 03:01 – The hidden factor that makes UK whey stand out 10:44 – The sweetener choice that could sabotage your results   My Go-To Protein: UK Pasture-Raised Whey Isolate from Unmatched Supplements SHOP HERE: (BOGO 50% OFF SALE HAPPENING NOW): https://www.vitaminshoppe.com/p/isolate-grass-fed-whey-protein-rich-chocolate-2-lb-powder/unm-14114 Thank you to our sponsors:    NAD + Cell Shield from Biostack Labs https://biostacklabs.com/kris  BiOptimizers - code KRIS10 for 10% off  https://bioptimizers.com/    Find more from Kris: Website: https://www.krisgethin.com/  Instagram: https://www.instagram.com/krisgethin/  Youtube: https://www.youtube.com/krisgethin   2 Shred: https://www.unmatchedsupps.com/products/2shred