Dr. Joseph Mercola - Take Control of Your Health podkast

How Chronic Stress Increases Risk of Depression

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  • Chronic stress triggers a neutrophil invasion into brain-protective layers, driving depression-like behaviors through immune activation rather than just hormonal changes
  • Stress-induced immune signals hijack brain reward circuits, reducing dopamine and shifting neural activity toward threat detection over pleasure-seeking behaviors
  • Prolonged stress damages brain mitochondria, reducing cellular energy production while creating an inflammatory feedback loop that worsens mood and cognitive function
  • Interferon pathways and inflammatory cytokines like IL-6 cross into the brain, directly altering neuron firing patterns in emotional regulation centers
  • Natural interventions including healthy carbohydrates, regular exercise, positive thinking, creativity, and physical touch help counter stress-induced immune activation and protect mental health

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