How Tumor-on-a-Chip Technology Is Transforming Cancer Treatment and Drug Testing

The DACH startup ecosystem closed 2025 with unusually clear signals for 2026 — AI mega-rounds, defense-grade dual use, and a restructuring of Europe’s venture capital stack. What you’ll learn in this episode: – Why €3B AI valuations change Europe’s startup narrative – How dual use moved from story to category – What founders must understand about capital, compute, and procurement – Where Germany, Austria, and Switzerland are quietly reorganizing advantage 🎙 Hosts: Jörn Menninger — Founder, Startuprad.io Chris Fahrenbach — Startup News Co-Host Enjoy the show? Follow, review, and share this episode with your team - Blog: https://www.startuprad.io/post/this-month-in-german-swiss-and-austrian-startups-december-2025-top-news - YouTube: https://youtu.be/zRt1qwR3lj0 ✉️ Work with us: [email protected] Subscribe across platforms: https://linktr.ee/startupradio 💬 Feedback: https://forms.gle/Qp53eVuc9P1RMqWj8 💼 Follow Jörn on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger © Startuprad.io Startuprad.io™ - All Rights Reserved

A short update on our publishing schedule. A technical issue caused a brief pause — all content is safe, and we’re back to regular releases from here. 🚪 Connect with UsPartner with us: [email protected] Subscribe: https://linktr.ee/startupradio Feedback: https://forms.gle/SrcGUpycu26fvMFE9 Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved

What if the tools we use to test cancer drugs don’t behave like human tumors at all? That’s the question that pushed Ghazaleh Madani, CEO and co-founder of CanChips, to build one of the most compelling innovations in oncology today: tumor-on-a-chip platforms that replicate human tumor biology with unprecedented accuracy. In this episode, we explore how microfluidics, 3D co-cultures, endothelial layers, and real-time biosensing combine to replace outdated 2D cultures and reduce reliance on animal models. The result: faster, more predictive cancer drug testing — and a pathway toward truly personalized oncology. Our sponsor:🚀 Exclusive Black Friday offer – NordStellar x Startuprad.io. NordStellar, developed by the team behind NordVPN, gives startups and scaleups real-time insights into leaked credentials, darknet threats, and unprotected assets – before attackers can exploit them. 👉 Get 20% off with code blackfriday20 at nordstellar.com/startupradio. 🕒 Offer valid until December 10, 2025 – protect your business before your data is offered for sale on the darknet. NordStellar – Know what attackers know. Act first. You’ll learn: – Why 2D cultures and animal models fail – How tumor-on-chip platforms replicate human tumor environments – How patient-derived cells lead to 72-hour drug response predictions – What this means for biotech founders, pharma teams, and investors – How German startups are shaping deep-tech innovation in the DACH region – What it takes to build and lead a cross-disciplinary biotech team – Why founder visibility matters as much as scientific rigor Whether you're building in Germany, Austria, or Switzerland, this episode offers one of the clearest explanations of capital-efficient growth, B2B startup scaling, and long-term founder wealth creation. Guest Spotlight Ghazaleh Madani is a biotech founder whose mission began when her mother was diagnosed with cancer. Her work at CanChips merges engineering, biology, and human urgency — delivering one of the most promising tumor-modeling systems in Europe. If this episode helped you, follow the podcast and share it with a founder who needs this playbook. Enjoy the show? 📖 Blog recap: https://www.startuprad.io/post/tumor-on-a-chip-explained-the-future-of-cancer-drug-testing Watch on YouTube: https://youtu.be/JIow-O-AM50 🎧 The Audio PodcastSubscribe here: https://linktr.ee/startupradio 🚪 Connect with UsPartner with us: [email protected] Subscribe: https://linktr.ee/startupradio Feedback: https://forms.gle/SrcGUpycu26fvMFE9 Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved

What happens when voice AI stops being a demo — and becomes something contact centers can trust? In this episode, Hakob Astabatsyan, Co-Founder & CEO of Synthflow AI, breaks down how memory-enabled voice agents reduce AHT, lift FCR, and eliminate repetitive customer conversations. Synthflow now runs millions of calls with sub-second latency, a reliability engineering culture, and a memory framework built for regulated industries. We explore the point where voice AI transitions from novelty to enterprise infrastructure: real-time interruption handling, multi-turn context retention, deterministic guardrails, HIPAA/GDPR compliance, and the orchestration pipelines that make AI feel natural instead of artificial. Our sponsor:🚀 Exclusive Black Friday offer – NordStellar x Startuprad.io. NordStellar, developed by the team behind NordVPN, gives startups and scaleups real-time insights into leaked credentials, darknet threats, and unprotected assets – before attackers can exploit them. 👉 Get 20% off with code blackfriday20 at nordstellar.com/startupradio. 🕒 Offer valid until December 10, 2025 – protect your business before your data is offered for sale on the darknet. NordStellar – Know what attackers know. Act first. What You’ll Learn– Why memory is the “missing layer” in voice AI – How Synthflow delivers sub-second latency at scale – What breaks at 1M+ calls — and how to prevent it – The BELL framework for safe enterprise AI deployment – How to measure the real KPIs: AHT, FCR, CSAT, containment, ROI – When to rely on deterministic flows vs. LLM reasoning – How regulated industries deploy voice AI without risk – Where voice-to-voice LLMs are heading in 2025 Guest SpotlightHakob Astabatsyan is the Co-Founder & CEO of Synthflow AI, one of Europe’s fastest-growing contact center AI platforms. His team builds voice agents with memory, reliability, and real-time orchestration — used across healthcare, finance, BPOs, and high-volume CX teams. Enjoy the show? Follow, review, and share this episode with your team. 📖 Blog recap: https://www.startuprad.io/post/synthflow-voice-ai-with-memory-the-contact-center-breakthrough Watch on YouTube: https://youtu.be/k7BulYtZWfA 🎧 The Audio PodcastSubscribe here: https://linktr.ee/startupradio 🚪 Connect with UsPartner with us: [email protected] Subscribe: https://linktr.ee/startupradio Feedback: https://forms.gle/SrcGUpycu26fvMFE9 Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved

AI is no longer the shiny object. It’s becoming infrastructure. And that single shift is transforming the German startup ecosystem in 2025 faster than most founders expected. This month, the DACH region crossed a new threshold: AI is moving from hype into the industrial backbone of Europe — compute scarcity is now strategic, sovereign cloud has become political, and robotics, automation, and vertical AI stacks are pulling in more capital than consumer apps ever did. But that’s just the start of the story. In this deep-dive edition of Startup News, we break down five structural shifts shaping Germany, Austria, and Switzerland right now: What You’ll Learn– How AI’s shift to infrastructure will define Europe’s next decade – Why DeepTech & DefenseTech are becoming unavoidable categories for VCs – Where funding is actually flowing in 2025 – What the newest founder wave means for operators, investors & talent – Which German startups raised the biggest rounds this month – What founders should prepare for next Our Sponsor:🚀 Exclusive Black Friday Offer — NordStellar x Startuprad.io Built by the team behind NordVPN, NordStellar gives startups and scaleups real-time visibility into leaked credentials, dark-web threats, and exposed assets — before attackers can exploit them. 👉 Get 20 percent off your plan with code black friday 20 at nordstellar.com/startupradio 🕒 Offer valid until December 10 th 2025 — protect your business before your data ends up for sale on the dark web. NordStellar — Know what attackers know. Act first. 🎙 About the HostsJörn “Joe” Menninger, Founder & Editor-in-Chief of Startuprad.io (Frankfurt) Chris Fahrenbach, Co-host & Global Analyst (Hanover / New York) Together, they track the most important startup stories in the DACH ecosystem — AI, deep tech, fintech, and scale-up growth. Follow, review, and share this episode with your team. — Blog: https://www.startuprad.io/post/this-month-in-dach-startups-november-2025-deep-dive  — YouTube: https://youtu.be/K2Syfa3P6HY  🎧 The Audio Podcast Subscribe here: https://linktr.ee/startupradio  🚪 Connect with Us Partner with us: [email protected]  Subscribe: https://linktr.ee/startupradio  Feedback: https://forms.gle/SrcGUpycu26fvMFE9  Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger  Startuprad.io™ - All Rights Reserved

Europe's startup narrative is changing fast — from apps and valuations to sovereignty, infrastructure and resilience. In this month's DACH Startup News, we unpack the moves that made European tech sovereignty the defining theme of 2025. What you’ll learn:– Why sovereign cloud is becoming foundational for startups and enterprise buyers – How AI, robotics, defense, and climate infrastructure shape Europe’s industrial strategy – Why deep tech is rising while fintech normalizes – The funding signals behind pre-seed to late-stage capital flows – How DACH is becoming Europe’s proving ground for strategic innovation – What European tech sovereignty actually means for your business If this episode helps you see the DACH ecosystem more clearly, share it with a founder or operator who should hear it. And subscribe so you never miss a briefing. Our Sponsor:🚀 Exclusive Black Friday Offer — NordStellar x Startuprad.io Built by the team behind NordVPN, NordStellar gives startups and scaleups real-time visibility into leaked credentials, dark-web threats, and exposed assets — before attackers can exploit them. 👉 Get 20 percent off your plan with code black friday 20 at nordstellar.com/startupradio 🕒 Offer valid until December 10 th 2025 — protect your business before your data ends up for sale on the dark web. NordStellar — Know what attackers know. Act first. 🎙 About the HostsJörn “Joe” Menninger, Founder & Editor-in-Chief of Startuprad.io (Frankfurt) Chris Fahrenbach, Co-host & Global Analyst (Hanover / New York) Together, they track the most important startup stories in the DACH ecosystem — AI, deep tech, fintech, and scale-up growth. Enjoy the show? Follow, review, and share this episode with your team. - Blog: https://www.startuprad.io/post/this-month-in-german-swiss-and-austrian-startups-november-2025-top-news - YouTube: https://youtu.be/0XtIE695VE4 ✉️ Work with us: [email protected] Subscribe across platforms: https://linktr.ee/startupradio 💬 Feedback: https://forms.gle/Qp53eVuc9P1RMqWj8 💼 Follow Jörn on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved

What if you could build a startup that survives downturns, grows profitably, and never depends on constant fundraising? That’s the core of the camel startup strategy — and in this episode, STS Ventures investor Stephan Schubert breaks it down with 25+ years of operator-investor experience. From founding OnVista in the early internet era to backing some of Germany’s most successful exits, Stephan has refined a model built on capital efficiency, high-margin niches, and KPI-driven execution. Our sponsor:🚀 Exclusive Black Friday offer – NordStellar x Startuprad.io. NordStellar, developed by the team behind NordVPN, gives startups and scaleups real-time insights into leaked credentials, darknet threats, and unprotected assets – before attackers can exploit them. 👉 Get 20% off with code blackfriday20 at nordstellar.com/startupradio. 🕒 Offer valid until December 10, 2025 – protect your business before your data is offered for sale on the darknet. NordStellar – Know what attackers know. Act first. In this episode, you’ll learn: – Why camel startups outperform hype-driven growth – How to use high-margin niches to scale from customer revenue – The KPI playbook STS Ventures uses with every founder – Why raise when you can, not when you must is a game-changer in DACH – How to stay capital-efficient without limiting your growth potential – Why Stephan avoids hype cycles like LLM infrastructure and focuses on AI as a tool for real industries like waste processing – What founders can learn from exits like Audibene, Emma, JustWatch, and others Whether you're building in Germany, Austria, or Switzerland, this episode offers one of the clearest explanations of capital-efficient growth, B2B startup scaling, and long-term founder wealth creation. Guest Spotlight: Stephan Schubert, Investor & Managing Director, STS Ventures Founder of OnVista and Ligatus, early investor in Audibene, Emma, JustWatch, and other major DACH success cases. If this episode helped you, follow the podcast and share it with a founder who needs this playbook. Enjoy the show? Follow, review, and share this episode with your team. - Blog: https://www.startuprad.io/post/camel-startups-in-dach-the-sts-ventures-playbook-with-stephan-schubert - YouTube: https://youtu.be/BYs50t7oZ14 🎧 The Audio PodcastSubscribe here: https://linktr.ee/startupradio 🚪 Connect with UsPartner with us: [email protected] Subscribe: https://linktr.ee/startupradio Feedback: https://forms.gle/SrcGUpycu26fvMFE9 Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved

What if the biggest cyber risk inside your company wasn’t malware — but identity? In this episode, I sit down with Santhosh Jayaprakash, founder & CEO of UnoSecur, to unpack one of the fastest-moving transformations in cybersecurity: the rise of identity as the new perimeter. Attackers don’t break in anymore — they log in. And with AI agents, LLM workflows, and machine-to-machine communication exploding, identity risk is growing faster than security teams can react. UnoSecur is building an identity security platform that monitors identity behavior after login, detecting stolen credentials, risky machine identities, and AI agent misuse in real time. Think of it as the layer that finally answers the question: Who is actually doing what inside your systems — and should they be doing it? Our sponsor:🚀 Exclusive Black Friday offer – NordStellar x Startuprad.io. NordStellar, developed by the team behind NordVPN, gives startups and scaleups real-time insights into leaked credentials, darknet threats, and unprotected assets – before attackers can exploit them. 👉 Get 20% off with code blackfriday20 at nordstellar.com/startupradio. 🕒 Offer valid until December 10, 2025 – protect your business before your data is offered for sale on the darknet. NordStellar – Know what attackers know. Act first. What you’ll learn in this episode: – Why 80% of attacks now start with credential theft – How AI agents bypass MFA and create 40× more identity surface – Why agentless security is the only scalable model – How machine identities become high-risk without teams noticing – Real-world identity failures from fintech & healthcare – Why identity sprawl is the silent crisis inside every enterprise – How UnoSecur’s real-time identity detection works behind the scenes – What identity security will look like by 2030 About the Guest: Santhosh is a 3× founder with 18 years in cloud & security, previously scaling Anchor Cloud before building UnoSecur in Berlin. He’s one of the most compelling thinkers in the identity-first security movement. If you’re building in SaaS, cloud, AI, DevOps, or cybersecurity, this conversation is a wake-up call. Enjoy the show? Follow, review, and share this episode with your team. - Blog: https://www.startuprad.io/post/the-ai-identity-threat-no-one-saw-coming-and-how-to-stop-it - YouTube: https://youtu.be/hXsCGES5Chk 🎧 The Audio PodcastSubscribe here: https://linktr.ee/startupradio 🚪 Connect with UsPartner with us: [email protected] Subscribe: https://linktr.ee/startupradio Feedback: https://forms.gle/SrcGUpycu26fvMFE9 Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved

What if AI could give craftsmen their time back? In this episode of Startuprad.io, host Jörn Menninger sits down with Julian Wiedenhaus, CEO and Co-Founder of PlanCraft, to explore how AI agents and voice interfaces are reshaping Europe’s construction sector. From a family carpentry shop to a €38 M Series B, PlanCraft built an AI-first SaaS that helps over 20 000 craft businesses quote, invoice and coordinate projects without paper chaos. Our sponsor:🚀 Exclusive Black Friday offer – NordStellar x Startuprad.io. NordStellar, developed by the team behind NordVPN, gives startups and scaleups real-time insights into leaked credentials, darknet threats, and unprotected assets – before attackers can exploit them. 👉 Get 20% off with code blackfriday20 at nordstellar.com/startupradio. 🕒 Offer valid until December 10, 2025 – protect your business before your data is offered for sale on the darknet. NordStellar – Know what attackers know. Act first. What You’ll Learn:– How PlanCraft bridged the gap between Excel and enterprise ERP systems. – Why AI agents are becoming digital coworkers for the trades. – How product-led growth and creator referrals drove organic expansion. – The “Robin Hood” pricing model balancing affordability and ARR. – How values-based culture can scale across countries without breaking. Julian explains how PlanCraft builds tools for people who don’t sit at desks — making software fit human workflows, not the other way around. The result is a human-centered AI platform transforming construction SMBs across the DACH region and beyond. Guest Spotlight: Julian Wiedenhaus, CEO & Co-Founder @ PlanCraft — recognized for bringing AI to the craft industry while keeping empathy at the core of technology. - Blog: https://www.startuprad.io/post/ai-agents-are-rebuilding-europes-construction-industry - YouTube: https://youtu.be/DjeoSnq3JyE 🎧 The Audio PodcastSubscribe here: https://linktr.ee/startupradio 🚪 Connect with UsPartner with us: [email protected] Subscribe: https://linktr.ee/startupradio Feedback: https://forms.gle/SrcGUpycu26fvMFE9 Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved

Can “screen time” actually make kids smarter? That’s the question Irene Klemm, Co-Founder and Co-CEO of Edurino, set out to answer — and in doing so, built one of Europe’s fastest-growing edtech startups. From lockdown chaos to scaling across the DACH region and the UK, Irene shares how Edurino redefined hybrid learning for kids by combining physical play with digital apps that teach real skills. Our sponsor: 🚀 Exclusive Black Friday offer – NordStellar x Startuprad.io. NordStellar, developed by the team behind NordVPN, gives startups and scaleups real-time insights into leaked credentials, darknet threats, and unprotected assets – before attackers can exploit them. 👉 Get 20% off with code blackfriday20 at nordstellar.com/startupradio. 🕒 Offer valid until December 10, 2025 – protect your business before your data is offered for sale on the darknet. NordStellar – Know what attackers know. Act first. What You’ll Learn:– How Edurino turned tablets into teachers for children aged 4–8 – Why building parent trust in digital learning is the ultimate growth hack – How to scale an edtech startup in Europe without losing quality – What AI means for the future of early education – How female founders like Irene are reshaping Germany’s startup ecosystem Guest Spotlight:Irene Klemm — Female Entrepreneur of the Year 2025 (German Startup Awards) — leads Edurino’s mission to make digital education safe, playful, and measurably effective. Her story proves that trust, evidence, and empathy can scale just as fast as funding. Key Insights:Cambridge University study shows Edurino boosts problem-solving by 35 % and reading skills by 25 %. 400 000 families across Europe use Edurino’s hybrid learning system. Female founder success case in a trust-sensitive industry. Blog: https://www.startuprad.io/post/how-edurino-built-europes-hybrid-learning-revolution YouTube: https://youtu.be/ZjVUmDfg9aw 🎧 The Audio PodcastSubscribe here: https://linktr.ee/startupradio 🚪 Connect with UsPartner with us: [email protected] Subscribe: https://linktr.ee/startupradio Feedback: https://forms.gle/SrcGUpycu26fvMFE9 Follow Joe on LinkedIn: http://www.linkedin.com/comm/mynetwork/discovery-see-all?usecase=PEOPLE_FOLLOWS&followMember=joernmenninger Startuprad.io™ - All Rights Reserved