Hacking the Revolution: Quantitative Biology at UC San Diego

Nobel Laureate and physicist Barry Barish, professor at UC Riverside, reflects on his life in science, being curious, experiencing imposter syndrome, and working in the field of physics with Brian Keating, host of the "Into the Impossible" podcast and professor of physics at UC San Diego. [Humanities] [Science] [Show ID: 38727]

The American Physical Society has designated UC San Diego’s Mayer Hall as a historic site in recognition of research conducted by physicists Walter Kohn and Lu Jeu Sham on density functional theory. Their development of the "Kohn-Sham equation" inside Mayer Hall became the foundation for the computation of the material properties of electrons and nuclei. Understanding the electronic properties of complex systems is essential to the design and engineering of new materials and drugs. Kohn and Pierre Hohenberg on sabbatical in Paris developed a theorem for the electron ground state energy to depend on the electron density distribution instead of the usual potential energy due to the nuclei. In Building C (later named Mayer Hall), from 1964-66, Kohn and Sham laid the foundation of a computation method, based on a single-particle equation composed of its quantum kinetic energy and the potential energy including the interaction effects. [Science] [Show ID: 38313]

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Particle accelerators have been revolutionizing discoveries in science, medicine, industry and national security for over a century. An estimated 30,000 particle accelerators are currently active around the world. In these machines, electromagnetic fields accelerate charged particles, such as electrons, protons, ions or positrons to velocities nearing the speed of light. Although their scientific appeal will remain evident for many decades, one limitation of the current generation of particle accelerators is their tremendous size, typically a mile long, and cost, which often limits access to the broader scientific community. Acceleration of electrons in plasmas, in particular in laser-driven plasmas, has been drawing considerable attention over the past decade. These laser wakefield accelerators promise to dramatically reduces the size of accelerators and revolutionize applications in medicine, industry, and basic sciences. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33429]

The 2012 discovery of the Higgs boson completes a powerful and comprehensive description of nature known as the standard model of particle physics. The next step is to find the new physics that underpins this model, which many physicists believe could solve mysteries first seen in astrophysical and cosmological data, such as dark matter and neutrino mixing. Joseph Incandela, UCSB Professor of Physics, gives a general overview of where things stand and what’s being planned, including his own research plans to address very fundamental questions about the universe. Series: "Scientific Horizons" [Science] [Show ID: 31621]

The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory (LLNL) is the world's largest and most powerful laser system. Experimental physicist Tammy Ma explores how and why scientists and engineers are working hard to demonstrate sustainable fusion burn - the same reaction that occurs in the sun - to one day harness as a source of limitless, clean energy. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 31523]

A simple question from his wife – Does physics really allow people to travel back in time? – propelled physicist Richard Muller on a quest to resolve a fundamental problem that had puzzled him throughout his 45-year career: Why does the arrow of time flow inexorably toward the future, constantly creating new "nows"? Series: "UC Berkeley News" [Science] [Show ID: 31548]

A brief overview of how UC San Diego scientists are leading the next revolution in biology. Series: "UCTV Prime" [Science] [Show ID: 30564]

Joseph Polchinski explores the battle in physics: either quantum mechanics must break down, or our understanding of spacetime must be wrong. The latest is the ‘firewall’ paradox: if quantum mechanics is to be saved, then an astronaut falling into a black hole will have an experience very different from what Einstein’s theory predicts. This has led to many new ideas that may lead to the unification of these two great theories. Series: "GRIT Talks" [Science] [Show ID: 30519]

We are visual beings, and qualities such as “insight” and “vision” describe our understanding well beyond sensory input. Light and more generally, electromagnetic radiation, has dramatically changed our knowledge of the physical world. It is also the source of the oxygen we breathe, the food we eat, and the energy that has powered the world since the beginning of the industrial revolution. Nobel Laureate Steven Chu, Professor of Physics, Professor Molecular & Cellular Physiology, Stanford University, discusses how light will continue to expand our scientific horizons and redefine our daily lives: from the measurement of time, to biology, medicine, and combating climate change. Series: "Scientific Horizons" [Science] [Show ID: 30224]