Endometrial carcinoma: Systemic therapies. Part 1 - The physicians' perspective

Advanced or recurrent endometrial cancer: Molecular classification and treatment decisions   Key clinical takeaways:   MMR status should be tested in all patients at diagnosis and upon disease progression to guide personalised treatment decisions   ICI and ChT combination, including with maintenance olaparib, demonstrates benefits in patients with non-dMMR advanced/recurrent endometrial cancer, with greater efficacy observed in dMMR populations  Lenvatinib plus pembrolizumab is a viable option not only as 2nd line therapy but also as 1st line treatment for patients with non-dMMR advanced/recurrent endometrial cancer who have progressed after prior systemic therapy in any setting  Shared decision-making, supported by patient education, is essential for optimising treatment outcomes   The treatment landscape for advanced and recurrent endometrial cancer (EC) is evolving, with molecular classification playing a key role in guiding decisions. In this podcast, Prof. Xavier Matias-Guiu (Pathologist) and Dr Jurjees Hasan (Medical Oncologist) discuss the latest advancements in personalised treatment approaches for EC.  Key topics include:  The role of molecular classification in guiding treatment selection and testing strategies  Treatment options for patients with pMMR status  Effective patient communication for shared decision-making  Tune in for expert insights and practical guidance to optimise treatment strategies in advanced and recurrent EC  You can also watch a video of the experts in conversation and download the accompanying transcript on our website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/endometrial-cancer-molecular-classification-treatment-decisions/  Or watch on YouTube: https://youtu.be/KvYIB7PBpyQ    Follow us on social media:  LinkedIn: https://www.linkedin.com/company/ob-gyn-connect/?viewAsMember=true   X: https://x.com/OBGynConnect     This content is intended for healthcare professionals only.  The medical experts in this podcast are expressing their own views and not those of COR2ED, Supporters or their institution.  This programme has been sponsored by Eisai Europe Limited ("Eisai"). Eisai has had no input on the educational content of, or speakers involved in this podcast.    This podcast is developed by cor2ed.com  Published February 2025    Subscribe to this channel to stay up to date with new Independent Education programmes as they’re released. 

Appropriate management of postpartum hemorrhage (PPH) requires prompt diagnosis and treatment. However, there's some debate on various PPH prevention and management strategies and the corresponding scientific evidence. What do you believe is the right strategy to prevent and treat PPH? In this third episode of a four-part podcast series on severe PPH, Prof. Loïc Sentilhes (Professor of Obstetrics and Gynecology, Chairman of the Gynecology and Obstetric Department at Bordeaux University Hospital, France) and Prof. Christian von Heymann (Chief Physician of the Clinic for Anesthesia, Intensive Care Medicine and Pain Therapy and Medical Director at the Vivantes Clinic in Friedrichshain, Germany) discuss various topics on the treatment of severe PPH, and we also explore the scientific evidence combined with the clinical experience of the experts. With Dr Homa Ahmadzia as moderator, experts share learnings from their own clinical practice and explore: (1) The role of prophylactic tranexamic acid to prevent PPH, (2) When to initiate blood transfusions or other blood products, (3) Pharmacological treatments and their use and (4) The importance of multidisciplinary collaboration in the management in PPH. Prefer to watch as well as listen? Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatments/ Or go to the video on YouTube: https://youtu.be/e9hEa5tczZo?si=H6jrK6PwIsXtQZuZ We are pleased to share that this podcast is endorsed by UNITE GLOBE (UNITed Efforts to reduce GLobal OBstetric HemorrhageE). You can find out more about UNITE GLOBE at https://ahmadziaresearch.smhs.gwu.edu/unite-globe The medical experts in this podcast are expressing their own views and not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk. This educational podcast is developed by cor2ed.com.

COR2ED Medical Education: In this podcast, Prof. Andra H. James (Professor Emeritus of Obstetrics and Gynecology, Division Maternal Fetal Medicine, Duke University Hospital, Durham, North Carolina, US) and Dr Maria Elisa Mancuso (Senior Haematology Consultant at the Center for Thrombosis and Hemorrhagic Diseases of IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy) discuss various treatment options for severe postpartum haemorrhage (also called PPH). Experts discuss what causes PPH and how to determine the risk before and during labour with algorithms and other helpful tools. The discussion moves to when haematologic expertise is required and how collaboration can be optimized to provide the best care for patients. Furthermore, the experts share their learnings from clinical practice through discussion of specific patient cases, including patients with and without underlying bleeding disorders, as well as where haemostatic agents fit in the protocol.

Innovation is the key to achieving success in the future, including recent scientific research to explore novel therapeutic options to improve the treatment of severe postpartum hemorrhage (PPH). If you're curious about the latest advancements in this field and how they can impact future treatment strategies for women who suffer from severe PPH, then listen to the fourth and final part of a podcast series on severe PPH. Experts will discuss the latest treatment advances and their perception of how the management of PPH will evolve in the future. Don't miss out on this opportunity to learn more about the latest scientific breakthroughs that can transform the lives of women suffering from PPH. Prefer to watch as well as listen? Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatment-developments/ Or go to the video on YouTube: https://www.youtube.com/watch?v=6HXtMNxgr1c The medical experts in this podcast express their own views, not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk. This educational podcast is developed by cor2ed.com.

Appropriate management of postpartum hemorrhage (PPH) requires prompt diagnosis and treatment. However, there's some debate on various PPH prevention and management strategies and the corresponding scientific evidence. What do you believe is the right strategy to prevent and treat PPH? In this third episode of a four-part podcast series on severe PPH, Prof. Loïc Sentilhes (Professor of Obstetrics and Gynecology, Chairman of the Gynecology and Obstetric Department at Bordeaux University Hospital, France) and Prof. Christian von Heymann (Chief Physician of the Clinic for Anesthesia, Intensive Care Medicine and Pain Therapy and Medical Director at the Vivantes Clinic in Friedrichshain, Germany) discuss various topics on the treatment of severe PPH, and we also explore the scientific evidence combined with the clinical experience of the experts. With Dr Homa Ahmadzia as moderator, experts share learnings from their own clinical practice and explore: (1) The role of prophylactic tranexamic acid to prevent PPH, (2) When to initiate blood transfusions or other blood products, (3) Pharmacological treatments and their use and (4) The importance of multidisciplinary collaboration in the management in PPH. Prefer to watch as well as listen? Watch a video of the experts in conversation and download the full transcript on the COR2ED website: https://cor2ed.com/obstetrics-gynecology-connect/programmes/severe-pph-treatments/ Or go to the video on YouTube: https://youtu.be/e9hEa5tczZo?si=H6jrK6PwIsXtQZuZ We are pleased to share that this podcast is endorsed by UNITE GLOBE (UNITed Efforts to reduce GLobal OBstetric HemorrhageE). You can find out more about UNITE GLOBE at https://ahmadziaresearch.smhs.gwu.edu/unite-globe The medical experts in this podcast are expressing their own views and not those of COR2ED, supporters, or their institution. This podcast is supported by an Independent Medical Education Grant from Novo Nordisk. This educational podcast is developed by cor2ed.com.

Welcome to the "Addressing Anxiety and Pain Around IUD Placement" podcast, where experts in the field, Carolyn Westhoff MD, Michal Yaron MD, and Patty Cason RN, MS, FNP-BC, delve into the world of intrauterine contraception. These seasoned clinicians share their vast experience in providing IUD placements, training others, and contributing to research trials aimed at making the process more comfortable. IUDs are highly effective contraceptive options, but misconceptions and fears can deter patients from choosing them. In this podcast, our experts aim to dispel these concerns by discussing strategies to address anxiety and pain at every stage of IUD placement. Join us as we explore pre-placement conversations that involve eliciting patient concerns, informed consent, and setting realistic expectations. Discover how patient engagement and tailored information play a crucial role in enhancing the overall experience.  The experts also share insights on factors that may influence pain during IUD insertion, such as cervical blocks, NSAIDs, and the importance of verbal analgesia. They shed light on the significance of patient-driven distractions and creating a calm environment to alleviate anxiety. Tune in to uncover tips for predicting potential difficulties during insertion and the importance of adapting to each patient's unique needs. Whether discussing uterine length, history of dysmenorrhea, or a patient's past gynaecological experiences, our experts guide you through considerations that can help optimize the process. Don't miss out on this informative and insightful podcast, where the experts provide valuable guidance to clinicians and patients alike on navigating the world of IUDs with confidence and comfort.

Dr Homa K. Ahmadzia (Maternal-Fetal Medicine specialist and Assistant Professor in the Department of Obstetrics and Gynecology at George Washington University hospital, USA) and Dr Jarmila A. Zdanowicz (Senior Consultant in Obstetrics and Gynecology, Clinical Head Maternity Unit, Fellow in Feto-Maternal Medicine, Department of Obstetrics and Gynecology, Bern University Hospital, Switzerland), discuss severe postpartum haemorrhage (also called PPH). To set the scene, they explain important definitions and real-world incidence, in particular in higher resourced and less resourced countries. What is the difference between non-severe and severe PPH? What specialities are involved? And what are the consequences when PPH is not treated correctly? Additionally, Dr Ahmadzia and Dr Zdanowicz consider who is at risk, what measures can be used to diagnose, and the importance of prevention as well as treatment.

Join Lead Nurse Andreia Fernandes and Clinical Nurse Specialist Jo Pearson as they explain how to help patients navigate the side effects of systemic therapies in endometrial carcinoma. Specialist nurses have a critical role helping women stay on treatment and at home for as long as possible. They discuss their privileged position supporting women with endometrial carcinoma and how they continue to educate and advocate for women in a fast-changing therapeutic environment.

Join world-renowned gynaecological oncology experts Dr Domenica “Ketta” Lorusso and Dr Mansoor Mirza as they explore the changing landscape of systemic treatment in endometrial carcinoma. Single-agent immunotherapies (pembrolizumab and dostarlimab), and now immunotherapy and antiangiogenic therapy combinations (pembrolizumab and lenvatinib), are transforming treatment pathways, with OS benefits in the second-line now achievable. They offer tips for managing the toxicity of these novel therapeutic options and set the stage for 2023, a year which promises a paradigm shift in the use of systemic treatments in this once underserved malignancy.

In this podcast, Dr Sarah O’Brien and Dr Homa Ahmadzia discuss gynaecological considerations in women and girls who have an underlying bleeding disorder. The experts discuss the two sides of the coin regarding women with bleeding disorders: women may have uterine bleeding due to their bleeding disorder, however there can also be gynaecological causes for the heavy bleeding. Dr O’Brien and Dr Ahmadzia also review the signs and symptoms of bleeding disorders, as well as gynaecological causes for uterine bleeding including endometriosis, adenomyosis fibroids, and uterine anomalies. They discuss treatment as well as specific situations such as gynaecological surgery, and the importance of collaboration with other specialists. Dr Sarah O’Brien is a Paediatric Haematologist at Nationwide Children’s Hospital in Columbus, OH, USA and Dr Homa Ahmadzia is a Maternal and Foetal Medicine Physician at George Washington University, DC, USA