Episode 313 - Daniel Dombeck, PhD

On October 9, 2025 we met with Maria Geffen to discuss the how three kinds of inhibitory neurons in the auditory cortex each contributes to individual features of auditory experience.Guest:Maria Geffen, Professor of Otorhinolaryngology, Neuroscience, and Neurology, University of PennsylvaniaParticipating:Alfonso Apicella, Department of Neuroscience, Regenerative and Developmental Biology, UTSAAlice Bertero, Department of Neuroscience, Regenerative and Developmental Biology, UTSAJon-Paul Moler, Department of Neuroscience, Regenerative and Developmental Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Regenerative and Developmental Biology, UTSAThanks to James Tepper for original music

On October 2, 2025 Dan Lodge returned to the podcast to talk about the physiological changes in brain circuits associated with schizophrenia. We reviewed the status of the dopamine hypothesis of schizophrenia and the brain circuits responsible for its negative, positive, and cognitive symptoms.Guest: Dan Lodge, Professor and Chair, Department of Pharmacology, Long School of Medicine, UT San AntonioParticipating:Matt Wanat, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San AntonioThanks to Jim Tepper for original music

On September 25, 2025 we met with Daniel Dombeck to talk about cognitive maps and place coding by neurons in the hippocampus. Conversation topics included the spatial organization of cells with a map, mappings based on visual versus olfactory cues, changes in spatial scale with the size of the environment, and remapping of the place cells with changes in context. Guest:Daniel Dombeck, Professor, Department of Neurobiology, Northwestern UniversityParticipating:Francesco Savelli, Department of Neuroscience, Developmental and Regenerative Biology, UTSAStephen Jones, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On September 18, 2025, and we got to talk with Ricardo Mozzachiodi about what was learned and what we continue to learn about the cellular and molecular basis of memory by studying simple behaviors in a mollusk, Aplysia california, the sea hare. Ricardo filled us in on the original rationale for studying cell biology of learning in this animal, and current findings on the role of neuromodulators in learning.Guest:Ricardo Mozzachiodi, Professor, Department of Life Sciences, Texas A&M University, Corpus Christi. Participating:Alfonso Apicella, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On September 4, 2025 we talked with Michael Roberts about exploring complex brainstem circuitry of the auditory system, identifying its characteristic cell types, connections, synaptic features and cellular dynamics. We discussed the challenges encountered in studying brain circuits in general, and the particular difficulties and opportunities that attend this effort in the inferior colliculus.Guest: Michael Roberts, Associate Professor, Department of Otolaryngology-Head and Neck Surgery, and the Department of Molecular and Integrative Physiology at the University of Michigan. Participating:Marina Silveira, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On May 8, 2025 we met with Kevin Bieniek to talk about the nature of brain injury seen in chronic traumatic encephalopathy in athletes and others who experience repeated concussion. Kevin explained the commonalities and unique features of those injuries compared to neurodegenerative diseases.Guest:Kevin Bieniek, Associate Professor, Department of Pathology and Laboratory Medicine and Director of the Brain Bank at the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases at UT Health San Antonio.Participating:Melanie Carless, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On April 17, 2025 we met with Nicholas Priebe to describe developments in the study of neuronal representations of the visual world. We discussed the origin of variability the temporal patterns of responses, and the possibility that responses are influenced by non-visual pathways.Guest:Nicholas Priebe, Department of Neuroscience, University of Texas at AustinParticipating:Todd Troyer, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

On April 10th (I said April 4th, but it was the 10th), 2025 we spoke with Punam Pokam about the molecular mechanisms that control osmotic balance of neurons and glia, and their changes after brain injury. She also explained the pathological membrane potential changes and ionic currents that are associated with injury and their relation to cell swelling.Guest:Punam Pokam, Assistant Professor, Department of Neuroscience and Experimental Therapeutics, Texas A&M School of MedicineHostCharles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On April 3, 2025 we met with Lorena Saelices to talk about what we know about the structure of amyloids, how they form by misfolding and aggregation of proteins, and how they damage cells and tissues in a range of disorders (including Alzheimer's and Parkinson's diseases). Guest:Lorena Saelices, Assistant Professor, Department of Biophysics and the Center for Alzheimer's and Neurodegenerative Diseases at the UT Southwestern Medical School.Participating:Chris Gamblin, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson , Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to James Tepper for original music

On March 27, 2025, we spoke with Nace Golding about the auditory pathways in the brainstem and midbrain. We focused on the inferior colliculus, and on identifying the key cell types that make up that essential but mysterious midbrain auditory nucleus. Guest:Nace Golding, Professor, Department of Neuroscience and the Center for Learning and Memory, University of Texas at Austin.Participating:Marina Silveira, Department of Neuroscience, Developmental and Regenerative Biology, UTSAHost:Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSAThanks to Jim Tepper for original music