Acute Symptomatic Seizures During CAR T-Cell Therapy for Hematologic Malignancies - Part 2

In part two of this three-part series, Dr. Andy Southerland and Dr. Seemant Chaturvedi discuss the OPTIMISTmain Trial, which was presented at the 2025 European Stroke Organization Conference. Show reference:  https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00549-5/abstract 

In part one of this three-part series, Dr. Andy Southerland and Dr. Seemant Chaturvedi discuss the BRIDGE-TNK Trial, which was presented at the 2025 European Stroke Organization Conference. Show reference:  https://www.nejm.org/doi/full/10.1056/NEJMoa2503867   

Dr. Elizabeth Coon and Dr. Peter Novak discuss how central sensitization plays a role in the autonomic symptoms-sings dichotomy and the importance of addressing both conditions for optimal treatment. Show references:  https://www.neurology.org/doi/10.1212/CPJ.0000000000200463 

In this episode of the Neurology Minute, Dr. Alison Christy delves into another women's history minute to discuss Jean Holowach-Thurston. 

In the second installment of this two-part series, Dr. Jeff Ratliff and Dr. Brin E. Freund discuss clinical guidance for managing patients who may experience neurotoxicity from CAR T-cell, with a specific focus on seizure risk.  Show reference:  https://www.neurology.org/doi/10.1212/WNL.0000000000213535 

In the June episode of the President's Spotlight, Dr. Jason Crowell and Dr. Natalia Rost discuss advocacy opportunities.  Show reference:  https://www.aan.com/about-the-aan/presidents-spotlight  

In part one of this two-part series, Dr. Jeff Ratliff and Dr. Brin E. Freund discuss the incidence of acute symptomatic seizures during CAR T-cell therapy.  Show reference:  https://www.neurology.org/doi/10.1212/WNL.0000000000213535   

Dr. Halley Alexander and Dr. Serena Yin discuss the effectiveness of an electronic medical record best practice alert in preventing iatrogenic interventions for patients with a diagnosis of PNES. Show references:  https://www.neurology.org/doi/10.1212/CPJ.0000000000200457 

In the first episode of this new series, Dr. Andy Southerland discusses the June updates from the AAN's Capitol Hill Report (CHR). This month's CHR update includes a member story from Dr. José Posas.  Stay updated with what’s happening on the hill by visiting aan.com/chr.  Learn how you can get involved with AAN advocacy. 

Dr. Aaron Zelikovich discusses a phase 3 trial that looked at the use of inebilizumab in generalized myasthenia gravis.  Show reference:  https://www.nejm.org/doi/full/10.1056/NEJMoa2501561