GLP-1s and Cardiovascular Risk: What the Latest Evidence Reveals

GLP-1 receptor agonists like semaglutide are often described as “game changers” for weight loss and cardiovascular health, and in many ways, the data support that claim. Clinical trials suggest meaningful reductions in major cardiovascular events, offering hope for individuals struggling with metabolic disease.But there’s an important nuance that deserves more attention: what happens when these medications are stopped?In this conversation, Dr. Bret Scher explores emerging real-world data showing that the benefits of GLP-1s, particularly for cardiovascular risk, appear to depend on continued use. For many individuals, stopping the medication leads to a reversal of progress, raising important questions about long-term strategy, sustainability, and what true metabolic healing looks like.Are we managing symptoms, or addressing root causes?What role should medications play in long-term care?How can we use powerful tools like GLP-1s to support, rather than replace, sustainable metabolic change?For some individuals, long-term use may be appropriate and beneficial. But we need to broaden the conversation toward approaches that aim to improve underlying metabolic health, support lasting behavior change, and ultimately reduce reliance on lifelong interventions when possible.If you’re exploring GLP-1s or are currently taking one, consider speaking with your healthcare provider about how to pair your treatment with sustainable lifestyle strategies such as nutrition, physical activity, and metabolic support, to help maintain progress over time.👉 How do GLP-1 medications impact mental health? Learn more on our blog:Ozempic, Wegovy, and Mental Health: Are GLP-1 Drugs Linked to Suicidal Thoughts?🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #GLP1 #FoodAsMedicineExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Glucagon-like peptide 1 receptor agonist discontinuation and risks of major adverse cardiovascular events in adults with type 2 diabetes: target trial emulationhttps://bmjmedicine.bmj.com/content/5/1/e002150Coalition for Metabolic Health: GLP-1 Policy Briefhttps://coalitionformetabolichealth.org/resources/glp-1-medications-and-metabolic-health/Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

We’re seeing increasingly compelling results from ketogenic therapy in serious mental illness, including schizophrenia, bipolar disorder, and major depression. But what happens when a potential concern emerges along the way?In this conversation, Dr. Bret Scher sits down with psychiatrist Dr. Lori Calabrese to walk through a real patient case that highlights both the promise and the complexity of metabolic treatment.A young woman with longstanding schizophrenia experienced dramatic improvements in her mental health, metabolic markers, and quality of life after starting a ketogenic intervention. But alongside these gains, her LDL cholesterol rose significantly, raising important clinical questions.Rather than defaulting to extremes, either stopping the therapy or ignoring the lab values, Dr. Calabrese takes a thoughtful, patient-centered approach:Investigating deeper cardiovascular risk markersExploring potential underlying causes, including familial hypercholesterolemiaCollaborating across specialties, including cardiologyPrioritizing both psychiatric recovery and long-term healthThis case illustrates a critical principle in metabolic psychiatry: context matters. Lab values don’t exist in isolation, and neither do patients.It also highlights a broader shift in medicine where clinicians are increasingly called to step beyond traditional silos and consider the full metabolic picture when treating brain-based conditions.At Metabolic Mind, we believe these nuanced conversations are essential. The goal isn’t to ignore risk or to abandon effective therapies, but to better understand both so individuals can make informed decisions alongside their care teams.You can learn more about this conversation in the documentary The Cholesterol Code. The film shares firsthand accounts from individuals whose lives improved with ketogenic therapy, even as their LDL levels rose dramatically. It also follows how they worked with their care teams to better understand their cardiovascular risk and what that approach could mean in your own situation.🎬 The Cholesterol Code is now streaming on Amazon: https://www.amazon.com/gp/video/detail/B0GS8ZFCYN/#MetabolicMind #KetogenicTherapy #FoodAsMedicineExpert Featured:Lori Calabresehttps://www.loricalabresemd.com/https://www.metabolicmind.org/team/lori-calabrese-md/https://www.linkedin.com/in/loricalabresemdFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

What do you do when keto is genuinely changing your life, but your LDL goes up?That's exactly the question Dr. Bret Scher sits down to answer in this conversation with podcast producer Erica Gerard.Erica started ketogenic therapy for two reasons: to support her taper off long-term antidepressants, and to address symptoms of complex PTSD. Six months in, the results were remarkable. A smoother taper, less anxiety, fewer flashbacks, and a greater sense of calm than she'd ever experienced.Then she got her labs back. Her LDL had jumped from 94 to 150.In this episode, Dr. Scher walks through one way to think about a rising LDL in the context of ketogenic therapy, and why the answer is almost never "stop doing what's working."You'll hear:Why total cholesterol is the least useful number to focus onWhy LDL is not the disease, vascular disease isWhat advanced imaging options exist for a more complete picture of heart healthWhy an initial LDL rise on keto may resolve on its own within a yearHow to have a productive conversation with your doctor about thisThis conversation sits at the heart of a bigger question, one that The Cholesterol Code documentary explores in depth.Featuring individuals whose lives were transformed by ketogenic therapy, only to see their LDL rise dramatically, the film asks an important question. Is abandoning a life-changing intervention really the right answer based on one biomarker alone? Is there a better way to assess heart health?🎬 The Cholesterol Code is now streaming on Amazon: https://www.amazon.com/gp/video/detail/B0GS8ZFCYN/AFTER YOU WATCH — Do this to help this film make a bigger impact 👇Leaving an honest review on Amazon can make a real difference. Reviews help this film qualify as an Amazon Prime listing, putting it in front of a much larger audience who might never have found it otherwise.You can also help this film reach more people by sending it directly to friends, family, and colleagues who you think could benefit from watching it. Start now by tagging a friend in the comments!Expert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

How do the latest Dietary Guidelines for Americans (DGA) and the American Heart Association (AHA) recommendations compare, and why do they differ?In this video, Dr. Bret Scher breaks down where these two major nutrition guidelines align, where they diverge, and what that means for your health. At the center of the conversation is a key question: should health be defined by a single lab marker, or by a broader view of metabolic function?In this video, you’ll learn:Why LDL cholesterol is only one piece of cardiovascular riskWhy the two guidelines differ on saturated fat, red meat, and full-fat dairyThe role of markers like fasting insulin, triglycerides, HDL, and body compositionHow different dietary patterns influence metabolic health in different waysWhy recommendations around saturated fat and full-fat dairy remain controversialHow historical beliefs and evolving evidence shape nutrition guidelinesThis discussion also highlights a critical point: nutrition science is complex, and population-wide recommendations don’t always translate clearly to individual health.While both organizations emphasize whole foods and reducing processed sugars and refined grains, the DGA reflects a growing recognition that there is more than one way to eat well, while the AHA continues to take a more prescriptive stance on saturated fat and animal-based foods.💡 Learn more about the role of saturated fat and animal products in a well-formulated ketogenic diet on our blog: Understanding the Well-Formulated Ketogenic Diet🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #DietaryGuidelinesExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

People with treatment-resistant depression and anxiety are seeing real improvements through ketogenic therapy. Now there's real-world clinical data to back it up.In this interview, Dr. Bret Scher sits down with Dr. Erin Bellamy to discuss her newly published findings from a clinical program bringing ketogenic therapy into everyday mental health care.While this was not a randomized controlled trial, the results offer an important look at how these interventions may work in everyday clinical practice, with meaningful improvements reported across both depression and anxiety measures.In this conversation, you’ll learn:What the study found and how to interpret the resultsThe difference between real-world evidence and randomized trialsWhy some individuals were able to achieve clinically meaningful improvements, including remissionThe role of structure, education, and ongoing support in implementing ketogenic therapyCommon challenges people face and how group support can help navigate themHow ketogenic therapy can be personalized based on individual needsThe real-life improvements participants experienced in mood, anxiety, daily functioning, and quality of lifeDr. Bellamy also shares powerful insights from her clinical experience, including how individuals with long-standing, treatment-resistant symptoms were able to make meaningful lifestyle changes, challenging the idea that people with mental health conditions cannot adhere to dietary interventions.Looking ahead, Dr. Bellamy is launching a new study through the Metabolic Psychiatry Scholar Award to further explore and scale this approach.Learn more about the impact of metabolic therapies on depression and mood disorders on our Depression Topic Page: https://www.metabolicmind.org/resources/topics/keto-for-depression/🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #DepressionExpert Featured:Dr. Erin BellamyIKRT.orghttps://x.com/ikrt_orghttps://www.instagram.com/ikrt_org/Resources Mentioned:Papershttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1751564/fullVideoshttps://www.youtube.com/watch?v=LXvKhdRqXiwAdditional resourceshttps://www.metabolicmind.org/resources/awards/(Metabolic Psychiatry Scholar Award)IKRT.org/trialFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Are we turning to ADHD and depression medications too quickly for kids?The Wall Street Journal and New York Times recently published powerful investigations into the overuse of psychiatric medications in children. In this video, Dr. Bret Scher unpacks the key takeaways, the risks of polypharmacy, and why a comprehensive, root-cause approach is more important than ever for kids facing mental health challenges.🔍 In this episode, Dr. Scher covers:The risks of overmedicating: side effects, polypharmacy, and long-term consequencesWhy behavioral therapy is being overlooked, even though it's supposed to be first-lineHow nutrition and metabolic health impact focus, mood, and behavior in kidsWhy low-carb and ketogenic therapies may offer new hopeThe growing research into metabolic therapies for pediatric mental healthAs the youth mental health crisis continues to worsen, it's time we examine our current treatment options and consider what's missing and how we can prioritize nutrition, behavioral therapy, and safer first-line care.👉 To learn more about ketogenic therapy for youth mental health, check out our Youth Mental Health Hub: https://www.metabolicmind.org/resources/topics/youth-mental-health/🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #YouthMentalHealth #ADHDExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Millions of Kids Are on ADHD Pills. For Many, It’s the Start of a Drug Cascade.https://www.wsj.com/health/wellness/kids-adhd-drugs-medication-06dfa0b7?gaa_at=eafs&gaa_n=AWEtsqcVhhl0bubzA_1q6yvfc7z3u0t44jw3AzUR9AZSyNO6avhB6NAoOJw72qVmojw%3D&gaa_ts=692b4191&gaa_sig=J0FYmn3CRlIzfq4EpHUykmVvbcGCu-cxuLnKihjrGx1rkjdeoIP693bQ3368UEKDGO2StTwq0maWdWb1L_TTdA%3D%3DWhat to Know About Teen Sexual Development and S.S.R.I.shttps://www.nytimes.com/2025/11/12/magazine/what-to-know-teen-sexual-development-ssris.htmlOxford’s Keto for ADHD & Depression Randomized Controlled Trial – with Ally Houstonhttps://www.metabolicmind.org/resources/news-views/podcasts/metabolic-mind-podcast/oxfords-keto-for-adhd-depression-randomized-controlled-trial-with-ally-houston/What Happens When Kids Try Keto for Bipolar? featuring Elizabeth Erricohttps://www.metabolicmind.org/resources/news-views/podcasts/metabolic-mind-podcast/what-happens-when-kids-try-keto-for-bipolar-featuring-elizabeth-errico/Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

If you carry the ApoE4 gene, you’ve likely been told your risk for Alzheimer’s disease is significantly higher. But what does that really mean, and how much control do you actually have?In this video, Dr. Bret Scher breaks down the science behind ApoE4, one of the strongest genetic risk factors for Alzheimer’s disease, and explains why increased risk does not mean a predetermined outcome.You’ll learn how ApoE4 may influence brain health through inflammation, lipid metabolism, and energy use, and why lifestyle and environment play a critical role in shaping these pathways.This video also explores:Why ApoE4 does not guarantee Alzheimer’s diseaseWhat research shows about traditional populations with low dementia ratesHow metabolic health, diet, and lifestyle may influence brain agingNew research challenging common assumptions about meat, fat, and dementia riskThe role of key nutrients like B12, iron, and amino acids in brain functionDr. Scher also reviews recent observational studies suggesting that higher meat consumption may be associated with lower dementia risk in ApoE4 carriers, challenging long-standing dietary narratives.The takeaway: your genes are one piece of the puzzle. Your daily choices, environment, and metabolic health may play a powerful role in shaping long-term brain outcomes.💡 To learn more about metabolic approaches to brain and mental health, visit metabolicmind.org🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #FoodAsMedicine #AlzheimersDiseaseExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Meat Consumption and Cognitive Health by APOE GenotypeDOI: https://doi.org/10.1001/jamanetworkopen.2026.6489A gradient risk of cognitive impairment with vegetarian diets in older adults: highest for vegan and potential benefit for pescatarianDOI: https://doi.org/10.1016/j.foodres.2026.118455Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

How do we actually define “healthy food”? And how is it possible that processed, sugary cereals like Lucky Charms score higher than natural foods like eggs and meat in some food scoring systems?Dr. Bret Scher sits down with Dr. Ty Beal to explore a newly developed nutritional value scoring system designed to better reflect nutrient density, bioavailability, and chronic disease risk.Unlike many existing systems that can produce confusing or counterintuitive rankings, this approach aims to take a more comprehensive and transparent look at what makes food truly nourishing.In this interview, you’ll learn:Why many popular food scoring systems fall shortWhat “nutrient density” really means and why it’s more complex than it soundsHow bioavailability, protein quality, and nutrient diversity factor into food qualityThe role of ultra-processing, fiber, omega-3s, and nutrient ratios in shaping health outcomesWhy animal-source foods like meat, fish, eggs, and dairy can play an important role in a healthy dietHow this system can be adapted to different dietary patterns, including plant-based, omnivorous, and ketogenic approachesDr. Beal also shares the challenges of developing a system like this, from navigating scientific trade-offs to facing intense peer review, and why transparency and flexibility are essential when translating nutrition science into real-world tools.Importantly, this scoring system offers a framework to help individuals, clinicians, and policymakers better understand food quality within the context of overall dietary patterns and metabolic health. Rather than relying on overly simplistic labels like “good” or “bad,” tools like this can help guide more informed, personalized decisions.💡 Explore more resources on metabolic health, mental health, and the current state of nutrition research atmetabolicmind.org🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #FoodAsMedicine #NewPublicationExpert Featured:Dr. Ty Bealtybeal.comhttps://x.com/TyBealPhDhttps://www.instagram.com/tybealphd/Resources Mentioned:Nutritional Value Score Rates Foods Based on Nutrient Density and Noncommunicable Disease Preventionhttps://jn.nutrition.org/article/S0022-3166(26)00092-1/fulltextFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Nurturing your relationship with yourself and your body can play a meaningful role in how you move forward from a mental health setback.Nicole Laurent shares a grounded, compassionate perspective on navigating setbacks. She explores how these moments can sometimes disrupt trust in ourselves, creating an internal tension that makes progress feel harder than it needs to be.She explores:Why setbacks can shake trust in your body, and how to rebuild itHow to approach challenges with curiosity instead of self-judgmentCommon triggers that can lead to going off trackHow mindset and framing influence long-term successHow your relationship with food and your body can evolve over timeThe key takeaway: setbacks are part of the learning process. Reconnecting with the idea that your body is working toward balance can help you move forward with more clarity, confidence, and resilience.💡Learn more about navigating setbacks on the mental health journey in our blog: How to Bounce Back from Challenges and Setbacks.🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #MetabolicPsychiatryExpert Featured:Nicole Laurent, LMHChttps://mentalhealthketo.com/nicole-laurent-lmhc-about-me/https://x.com/KetoCounselorhttps://www.linkedin.com/in/nlaurent/https://www.instagram.com/mentalhealthketo/Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Is high LDL cholesterol always a red flag?For a growing group of people known as Lean Mass Hyper-Responders (LMHRs), the answer might not be so black and white.In this video, Dr. Bret Scher unpacks the science and questions behind LMHRs—metabolically healthy, lean individuals who see a dramatic rise in LDL cholesterol after starting a ketogenic diet. Unlike people with familial hypercholesterolemia (FH), their elevated LDL occurs in a unique metabolic context: low insulin, high HDL, low triglycerides, excellent metabolic health, and comes on only after adopting a ketogenic diet.🔍 In this video, you'll learn:• What defines a Lean Mass Hyper-Responder• Why conventional cholesterol risk frameworks may not apply to LMHRs• The key differences between LMHRs and those with familial hypercholesterolemia• Why context, like insulin sensitivity and metabolic health, might matter• Why this phenomenon deserves thoughtful study, not assumptionsThis growing curiosity around LMHRs is the focus of a powerful new documentary: The Cholesterol Code. Featuring researchers, clinicians, and individuals living with this phenotype, the film challenges long-held beliefs about cholesterol, risk, and metabolic health, and opens the door to a more nuanced conversation🎬 Real change starts with real conversations. Join us in sharing The Cholesterol Code, a powerful film that challenges outdated thinking about cholesterol and heart health. Sign up to host a screening or find one near you at 🔗 https://cholesterolcodemovie.com/host-a-screening/.Together, we can reach the people who need this most.🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #FoodAsMedicine #LDLCholesterolExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:https://cholesterolcodemovie.comFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.