World Models & General Intuition: Khosla's largest bet since LLMs & OpenAI

Glean started as a Kleiner Perkins incubation and is now a $7B, $200m ARR Enterprise AI leader. Now KP has tapped its own podcaster to lead it’s next big swing. From building go-to-market the hard way in startups (and scaling Palo Alto Networks’ public cloud business) to joining Kleiner Perkins to help technical founders turn product edge into repeatable revenue, Joubin Mirzadegan has spent the last decade obsessing over one thing: distribution and how ideas actually spread, sell, and compound. That obsession took him from launching the CRO-only podcast Grit (https://www.youtube.com/playlist?list=PLRiWZFltuYPF8A6UGm74K2q29UwU-Kk9k) as a hiring wedge, to working alongside breakout companies like Glean and Windsurf, to now incubating Roadrunner which is an AI-native rethink of CPQ and quoting workflows as pricing models collapse from “seats” into consumption, bundles, renewals, and SKU sprawl. We sat down with Joubin to dig into the real mechanics of making conversations feel human (rolling early, never sending questions, temperature + lighting hacks), what Windsurf got right about “Google-class product and Salesforce-class distribution,” how to hire early sales leaders without getting fooled by shiny logos, why CPQ is quietly breaking the back of modern revenue teams, and his thesis for his new company and KP incubation Roadrunner (https://www.roadrunner.ai/): rebuild the data model from the ground up, co-develop with the hairiest design partners, and eventually use LLMs to recommend deal structures the way the best reps do without the Slack-channel chaos of deal desk. We discuss: How to make guests instantly comfortable: rolling early, no “are you ready?”, temperature, lighting, and room dynamics Why Joubin refuses to send questions in advance (and when you might have to anyway) The origin of the CRO-only podcast: using media as a hiring wedge and relationship engine The “commit to 100 episodes” mindset: why most shows die before they find their voice Founder vs exec interviews: why CEOs can speak more freely (and what it unlocks in conversation) What Glean taught him about enterprise AI: permissions, trust, and overcoming “category is dead” skepticism Design partners as the real unlock: why early believers matter and how co-development actually works Windsurf’s breakout: what it means to be serious about “Google-class product + Salesforce-class distribution” Why technical founders struggle with GTM and how KP built a team around sales, customer access, and demand gen Hiring early sales leaders: anti-patterns (logos), what to screen for (motivation), and why stage-fit is everything The CPQ problem & Roadrunner’s thesis: rebuilding CPQ/quoting from the data model up for modern complexity How “rules + SKUs + approvals” create a brittle graph and what it takes to model it without tipping over The two-year window: incumbents rebuilding slowly vs startups out-sprinting with AI-native architecture Where AI actually helps: quote generation, policy enforcement, approval routing, and deal recommendation loops — Joubin X: https://x.com/Joubinmir LinkedIn: https://www.linkedin.com/in/joubin-mirzadegan-66186854/ Where to find Latent Space X: https://x.com/latentspacepod Substack: https://www.latent.space/ Chapters 00:00:00 Introduction and the Zuck Interview Experience 00:03:26 The Genesis of the Grit Podcast: Hiring CROs Through Content 00:13:20 Podcast Philosophy: Creating Authentic Conversations 00:15:44 Working with Arvind at Glean: The Enterprise Search Breakthrough 00:26:20 Windsurf's Sales Machine: Google-Class Product Meets Salesforce-Class Distribution 00:30:28 Hiring Sales Leaders: Anti-Patterns and First Principles 00:39:02 The CPQ Problem: Why Salesforce and Legacy Tools Are Breaking 00:43:40 Introducing Roadrunner: Solving Enterprise Pricing with AI 00:49:19 Building Roadrunner: Team, Design Partners, and Data Model Challenges 00:59:35 High Performance Philosophy: Working Out Every Day and Reducing Friction 01:06:28 Defining Grit: Passion Plus Perseverance

From applied cryptography and offensive security in France’s defense industry to optimizing nuclear submarine workflows, then selling his e-signature startup to Docusign (https://www.docusign.com/company/news-center/opentrust-joins-docusign-global-trust-network and now running AI as CTO of Superhuman Mail (Superhuman, recently acquired by Grammarly https://techcrunch.com/2025/07/01/grammarly-acquires-ai-email-client-superhuman/), Loïc Houssier has lived the full arc from deep infra and compliance hell to obsessing over 100ms product experiences and AI-native email. We sat down with Loïc to dig into how you actually put AI into an inbox without adding latency, why Superhuman leans so hard into agentic search and “Ask AI” over your entire email history, how they design tools vs. agents and fight agent laziness, what box-priced inference and local-first caching mean for cost and reliability, and his bet that your inbox will power your future AI EA while AI massively widens the gap between engineers with real fundamentals and those faking it. We discuss: Loïc’s path from applied cryptography and offensive security in France’s defense industry to submarines, e-signatures, Docusign, and now Superhuman Mail What 3,000+ engineers actually do at a “simple” product like Docusign: regional compliance, on-prem appliances, and why global scale explodes complexity How Superhuman thinks about AI in email: auto-labels, smart summaries, follow-up nudges, “Ask AI” search, and the rule that AI must never add latency or friction Superhuman’s agentic framework: tools vs. agents, fighting “agent laziness,” deep semantic search over huge inboxes, and pagination strategies to find the real needle in the haystack How they evaluate OpenAI, Anthropic, Gemini, and open models: canonical queries, end-to-end evals, date reasoning, and Rahul’s infamous “what wood was my table?” test Infra and cost philosophy: local-first caching, vector search backends, Baseten “box” pricing vs. per-token pricing, and thinking in price-per-trillion-tokens instead of price-per-million The vision of Superhuman as your AI EA: auto-drafting replies in your voice, scheduling on your behalf, and using your inbox as the ultimate private data source How the Grammarly + Coda + Superhuman stack could power truly context-aware assistance across email, docs, calendars, contracts, and more Inside Superhuman’s AI-dev culture: free-for-all tool adoption, tracking AI usage on PRs, and going from ~4 to ~6 PRs per engineer per week Why Loïc believes everyone should still learn to code, and how AI will amplify great engineers with strong fundamentals while exposing shallow ones even faster — Loïc Houssier LinkedIn: https://www.linkedin.com/in/houssier/ Where to find Latent Space X: https://x.com/latentspacepod Substack: https://www.latent.space/ Chapters 00:00:00 Introduction and Loïc's Journey from Nuclear Submarines to Superhuman 00:06:40 Docusign Acquisition and the Enterprise Email Stack 00:10:26 Superhuman's AI Vision: Your Inbox as the Real AI Agent 00:13:20 Ask AI: Agentic Search and the Quality Problem 00:18:20 Infrastructure Choices: Model Selection, Base10, and Cost Management 00:27:30 Local-First Architecture and the Database Stack 00:30:50 Evals, Quality, and the Rahul Wood Table Test 00:42:30 The Future EA: Auto-Drafting and Proactive Assistance 00:46:40 Grammarly Acquisition and the Contextual Advantage 00:38:40 Voice, Video, and the End of Writing 00:51:40 Knowledge Graphs: The Hard Problem Nobody Has Solved 00:56:40 Competing with OpenAI and the Browser Question 01:02:30 AI Coding Tools: From 4 to 6 PRs Per Week 01:08:00 Engineering Culture, Hiring, and the Future of Software Development

From building Medal into a 12M-user game clipping platform with 3.8B highlight moments to turning down a reported $500M offer from OpenAI (https://www.theinformation.com/articles/openai-offered-pay-500-million-startup-videogame-data) and raising a $134M seed from Khosla (https://techcrunch.com/2025/10/16/general-intuition-lands-134m-seed-to-teach-agents-spatial-reasoning-using-video-game-clips/) to spin out General Intuition, Pim is betting that world models trained on peak human gameplay are the next frontier after LLMs. We sat down with Pim to dig into why game highlights are “episodic memory for simulation” (and how Medal’s privacy-first action labels became a world-model goldmine https://medal.tv/blog/posts/enabling-state-of-the-art-security-and-protections-on-medals-new-apm-and-controller-overlay-features), what it takes to build fully vision-based agents that just see frames and output actions in real time, how General Intuition transfers from games to real-world video and then into robotics, why world models and LLMs are complementary rather than rivals, what founders with proprietary datasets should know before selling or licensing to labs, and his bet that spatial-temporal foundation models will power 80% of future atoms-to-atoms interactions in both simulation and the real world. We discuss: How Medal’s 3.8B action-labeled highlight clips became a privacy-preserving goldmine for world models Building fully vision-based agents that only see frames and output actions yet play like (and sometimes better than) humans Transferring from arcade-style games to realistic games to real-world video using the same perception–action recipe Why world models need actions, memory, and partial observability (smoke, occlusion, camera shake) vs. “just” pretty video generation Distilling giant policies into tiny real-time models that still navigate, hide, and peek corners like real players Pim’s path from RuneScape private servers, Tourette’s, and reverse engineering to leading a frontier world-model lab How data-rich founders should think about valuing their datasets, negotiating with big labs, and deciding when to go independent GI’s first customers: replacing brittle behavior trees in games, engines, and controller-based robots with a “frames in, actions out” API Using Medal clips as “episodic memory of simulation” to move from imitation learning to RL via world models and negative events The 2030 vision: spatial–temporal foundation models that power the majority of atoms-to-atoms interactions in simulation and the real world — Pim X: https://x.com/PimDeWitte LinkedIn: https://www.linkedin.com/in/pimdw/ Where to find Latent Space X: https://x.com/latentspacepod Substack: https://www.latent.space/ Chapters 00:00:00 Introduction and Medal's Gaming Data Advantage 00:02:08 Exclusive Demo: Vision-Based Gaming Agents 00:06:17 Action Prediction and Real-World Video Transfer 00:08:41 World Models: Interactive Video Generation 00:13:42 From Runescape to AI: Pim's Founder Journey 00:16:45 The Research Foundations: Diamond, Genie, and SEMA 00:33:03 Vinod Khosla's Largest Seed Bet Since OpenAI 00:35:04 Data Moats and Why GI Stayed Independent 00:38:42 Self-Teaching AI Fundamentals: The Francois Fleuret Course 00:40:28 Defining World Models vs Video Generation 00:41:52 Why Simulation Complexity Favors World Models 00:43:30 World Labs, Yann LeCun, and the Spatial Intelligence Race 00:50:08 Business Model: APIs, Agents, and Game Developer Partnerships 00:58:57 From Imitation Learning to RL: Making Clips Playable 01:00:15 Open Research, Academic Partnerships, and Hiring 01:02:09 2030 Vision: 80 Percent of Atoms-to-Atoms AI Interactions

Fei-Fei Li and Justin Johnson are cofounders of World Labs, who have recently launched Marble (https://marble.worldlabs.ai/), a new kind of generative “world model” that can create editable 3D environments from text, images, and other spatial inputs. Marble lets creators generate persistent 3D worlds, precisely control cameras, and interactively edit scenes, making it a powerful tool for games, film, VR, robotics simulation, and more. In this episode, Fei-Fei and Justin share how their journey from ImageNet and Stanford research led to World Labs, why spatial intelligence is the next frontier after LLMs, and how world models could change how machines see, understand, and build in 3D. We discuss: The massive compute scaling from AlexNet to today and why world models and spatial data are the most compelling way to “soak up” modern GPU clusters compared to language alone. What Marble actually is: a generative model of 3D worlds that turns text and images into editable scenes using Gaussian splats, supports precise camera control and recording, and runs interactively on phones, laptops, and VR headsets. Fei-fei’s essay (https://drfeifei.substack.com/p/from-words-to-worlds-spatial-intelligence) on spatial intelligence as a distinct form of intelligence from language: from picking up a mug to inferring the 3D structure of DNA, and why language is a lossy, low-bandwidth channel for describing the rich 3D/4D world we live in. Whether current models “understand” physics or just fit patterns: the gap between predicting orbits and discovering F=ma, and how attaching physical properties to splats and distilling physics engines into neural networks could lead to genuine causal reasoning. The changing role of academia in AI, why Fei-Fei worries more about under-resourced universities than “open vs closed,” and how initiatives like national AI compute clouds and open benchmarks can rebalance the ecosystem. Why transformers are fundamentally set models, not sequence models, and how that perspective opens up new architectures for world models, especially as hardware shifts from single GPUs to massive distributed clusters. Real use cases for Marble today: previsualization and VFX, game environments, virtual production, interior and architectural design (including kitchen remodels), and generating synthetic simulation worlds for training embodied agents and robots. How spatial intelligence and language intelligence will work together in multimodal systems, and why the goal isn’t to throw away LLMs but to complement them with rich, embodied models of the world. Fei-Fei and Justin’s long-term vision for spatial intelligence: from creative tools for artists and game devs to broader applications in science, medicine, and real-world decision-making. — Fei-Fei Li X: https://x.com/drfeifei LinkedIn: https://www.linkedin.com/in/fei-fei-li-4541247 Justin Johnson X: https://x.com/jcjohnss LinkedIn: https://www.linkedin.com/in/justin-johnson-41b43664 Where to find Latent Space X: https://x.com/latentspacepod Substack: https://www.latent.space/ Chapters 00:00:00 Introduction and the Fei-Fei Li & Justin Johnson Partnership 00:02:00 From ImageNet to World Models: The Evolution of Computer Vision 00:12:42 Dense Captioning and Early Vision-Language Work 00:19:57 Spatial Intelligence: Beyond Language Models 00:28:46 Introducing Marble: World Labs' First Spatial Intelligence Model 00:33:21 Gaussian Splats and the Technical Architecture of Marble 00:22:10 Physics, Dynamics, and the Future of World Models 00:41:09 Multimodality and the Interplay of Language and Space 00:37:37 Use Cases: From Creative Industries to Robotics and Embodied AI 00:56:58 Hiring, Research Directions, and the Future of World Labs

Fei-Fei Li and Justin Johnson are cofounders of World Labs, who have recently launched Marble (https://marble.worldlabs.ai/), a new kind of generative “world model” that can create editable 3D environments from text, images, and other spatial inputs. Marble lets creators generate persistent 3D worlds, precisely control cameras, and interactively edit scenes, making it a powerful tool for games, film, VR, robotics simulation, and more. In this episode, Fei-Fei and Justin share how their journey from ImageNet and Stanford research led to World Labs, why spatial intelligence is the next frontier after LLMs, and how world models could change how machines see, understand, and build in 3D. We discuss: The massive compute scaling from AlexNet to today and why world models and spatial data are the most compelling way to “soak up” modern GPU clusters compared to language alone. What Marble actually is: a generative model of 3D worlds that turns text and images into editable scenes using Gaussian splats, supports precise camera control and recording, and runs interactively on phones, laptops, and VR headsets. Fei-fei’s essay (https://drfeifei.substack.com/p/from-words-to-worlds-spatial-intelligence) on spatial intelligence as a distinct form of intelligence from language: from picking up a mug to inferring the 3D structure of DNA, and why language is a lossy, low-bandwidth channel for describing the rich 3D/4D world we live in. Whether current models “understand” physics or just fit patterns: the gap between predicting orbits and discovering F=ma, and how attaching physical properties to splats and distilling physics engines into neural networks could lead to genuine causal reasoning. The changing role of academia in AI, why Fei-Fei worries more about under-resourced universities than “open vs closed,” and how initiatives like national AI compute clouds and open benchmarks can rebalance the ecosystem. Why transformers are fundamentally set models, not sequence models, and how that perspective opens up new architectures for world models, especially as hardware shifts from single GPUs to massive distributed clusters. Real use cases for Marble today: previsualization and VFX, game environments, virtual production, interior and architectural design (including kitchen remodels), and generating synthetic simulation worlds for training embodied agents and robots. How spatial intelligence and language intelligence will work together in multimodal systems, and why the goal isn’t to throw away LLMs but to complement them with rich, embodied models of the world. Fei-Fei and Justin’s long-term vision for spatial intelligence: from creative tools for artists and game devs to broader applications in science, medicine, and real-world decision-making. — Fei-Fei Li X: https://x.com/drfeifei LinkedIn: https://www.linkedin.com/in/fei-fei-li-4541247 Justin Johnson X: https://x.com/jcjohnss LinkedIn: https://www.linkedin.com/in/justin-johnson-41b43664 Where to find Latent Space X: https://x.com/latentspacepod Substack: https://www.latent.space/ Chapters 00:00:00 Introduction and the Fei-Fei Li & Justin Johnson Partnership 00:02:00 From ImageNet to World Models: The Evolution of Computer Vision 00:12:33 Dense Captioning and Early Vision-Language Work 00:19:39 Spatial Intelligence: Beyond Language Models 00:28:49 Introducing Marble: World Labs' First Spatial Intelligence Model 00:33:24 Gaussian Splats and the Technical Architecture of Marble 00:35:50 Physics, Dynamics, and the Future of World Models 00:44:00 Multimodality and the Interplay of Language and Space 00:37:37 Use Cases: From Creative Industries to Robotics and Embodied AI 00:57:03 Hiring, Research Directions, and the Future of World Labs

Alex Lieberman and Arman Hezarkani, co-founders of Tenex, reveal how they're revolutionizing software consulting by compensating AI engineers for output rather than hours—enabling some engineers to earn over $1 million annually while delivering 10x productivity gains. Their company represents a fundamental rethinking of knowledge work compensation in the age of AI agents, where traditional hourly billing models perversely incentivize slower work even as AI tools enable unprecedented speed. The Genesis: From 90% Downsizing to 10x Output The story behind 10X begins with Arman's previous company, Parthian, where he was forced to downsize his engineering team by 90%. Rather than collapse, Arman re-architected the entire product and engineering process to be AI-first—and discovered that production-ready software output increased 10x despite the massive headcount reduction. This counterintuitive result exposed a fundamental misalignment: engineers compensated by the hour are disincentivized from leveraging AI to work faster, even when the technology enables dramatic productivity gains. Alex, who had invested in Parthian, initially didn't believe the numbers until Arman walked him through why LLMs have made such a profound impact specifically on engineering as knowledge work. The Economic Model: Story Points Over Hours 10X's core innovation is compensating engineers based on story points—units of completed, quality output—rather than hours worked. This creates direct economic incentives for engineers to adopt every new AI tool, optimize their workflows, and maximize throughput. The company expects multiple engineers to earn over $1 million in cash compensation next year purely from story point earnings. To prevent gaming the system, they hire for two profiles: engineers who are "long-term selfish" (understanding that inflating story points will destroy client relationships) and those who genuinely love writing code and working with smart people. They also employ technical strategists incentivized on client retention (NRR) who serve as the final quality gate before any engineering plan reaches a client. Impressive Builds: From Retail AI to App Store Hits The results speak for themselves. In one project, 10X built a computer vision system for retail cameras that provides heat maps, queue detection, shelf stocking analysis, and theft detection—creating early prototypes in just two weeks for work that previously took quarters. They built Snapback Sports' mobile trivia app in one month, which hit 20th globally on the App Store. In a sales context, an engineer spent four hours building a working prototype of a fitness influencer's AI health coach app after the prospect initially said no—immediately moving 10X to the top of their vendor list. These examples demonstrate how AI-enabled speed fundamentally changes sales motions and product development timelines. The Interview Process: Unreasonably Difficult Take-Homes Despite concerns that AI would make take-home assessments obsolete, 10X still uses them—but makes them "unreasonably difficult." About 50% of candidates don't even respond, but those who complete the challenge demonstrate the caliber needed. The interview process is remarkably short: two calls before the take-home, review, then one or two final meetings—completable in as little as a week. A signature question: "If you had infinite resources to build an AI that could replace either of us on this call, what would be the first major bottleneck?" The sophisticated answer isn't just "model intelligence" or "context length"—it's controlling entropy, the accumulating error rate that derails autonomous agents over time. The Limiting Factor: Human Capital, Not Technology Despite being an AI-first company, 10X's primary constraint is human capital—finding and hiring enough exceptional engineers fast enough, then matching them with the right processes to maintain delivery quality as they scale. The company has ambitions beyond consulting to build their own technology, but for the foreseeable future, recruiting remains the bottleneck. This reveals an important insight about the AI era: even as technology enables unprecedented leverage, the constraint shifts to finding people who can harness that leverage effectively. Chapters 00:00:00 Introduction and Meeting the 10X Co-founders 00:01:29 The 10X Moment: From Hourly Billing to Output-Based Compensation 00:04:44 The Economic Model Behind 10X 00:05:42 Story Points and Measuring Engineering Output 00:08:41 Impressive Client Projects and Rapid Prototyping 00:12:22 The 10X Tech Stack: TypeScript and High Structure 00:13:21 AI Coding Tools: The Daily Evolution 00:15:05 Human Capital as the Limiting Factor 00:16:02 The Unreasonably Difficult Interview Process 00:17:14 Entropy and Context Engineering: The Future of AI Agents 00:23:28 The MCP Debate and AI Industry Sociology 00:26:01 Consulting, Digital Transformation, and Conference Insights

Deedy Das, Partner at Menlo Ventures, returns to Latent Space to discuss his journey from Glean to venture capital, the explosive rise of Anthropic, and how AI is reshaping enterprise software and coding. From investing in Anthropic early on when they had no revenue to managing the $100M Ontology Fund, Das shares insider perspectives on the fastest-growing software company in history and what's next for AI infrastructure, research investing, and the future of engineering. We cover Glean’s rise from “boring” enterprise search to a $7B AI-native company, Anthropic's meteoric rise, the strategic decisions behind products like Claude Code, and why market share in enterprise AI is shifting dramatically. Das explains his investment thesis on research companies like Goodfire, Prime Intellect, and OpenRouter and how the Anthology Fund is quietly seeding the next wave of AI infra, research, and devtools. Chapters 00:00:00 Introduction and Deedy's Return to Latent Space 00:01:20 Glean's Journey: From Boring Enterprise Search to $7B Valuation 00:15:37 Anthropic's Meteoric Rise and Market Share Dynamics 00:17:50 Claude Artifacts and Product Innovation 00:41:20 The Anthology Fund: Investing in the Anthropic Ecosystem 00:48:01 Goodfire and Mechanistic Interpretability 00:51:25 Prime Intellect and Distributed AI Training 00:53:40 OpenRouter: Building the AI Model Gateway 01:13:36 The Stargate Project and Infrastructure Arms Race 01:18:14 The Future of Software Engineering and AI Coding

Jared Palmer, SVP at GitHub and VP of CoreAI at Microsoft, joins Latent Space for an in-depth look at the evolution of coding agents and modern developer tools. Recently joining after leading AI initiatives at Vercel, Palmer shares firsthand insights from behind the scenes at GitHub Universe, including the launch of Agent HQ which is a new collaboration hub for coding agents and developers. This episode traces Palmer’s journey from building Copilot inspired tools to pioneering the focused Next.js coding agent, v0, and explores how platform constraints fostered rapid experimentation and a breakout success in AI-powered frontend development. Palmer explains the unique advantages of GitHub’s massive developer network, the challenges of scaling agent-based workflows, and why integrating seamless AI into developer experiences is now a top priority for both Microsoft and GitHub.

Jed Borovik, Product Lead at Google Labs, joins Latent Space to unpack how Google is building the future of AI-powered software development with Jules. From his journey discovering GenAI through Stable Diffusion to leading one of the most ambitious coding agent projects in tech, Borovik shares behind-the-scenes insights into how Google Labs operates at the intersection of DeepMind's model development and product innovation. We explore Jules' approach to autonomous coding agents and why they run on their own infrastructure, how Google simplified their agent scaffolding as models improved, and why embeddings-based RAG is giving way to attention-based search. Borovik reveals how developers are using Jules for hours or even days at a time, the challenges of managing context windows that push 2 million tokens, and why coding agents represent both the most important AI application and the clearest path to AGI. This conversation reveals Google's positioning in the coding agent race, the evolution from internal tools to public products, and what founders, developers, and AI engineers should understand about building for a future where AI becomes the new brush for software engineering. Chapters 00:00:00 Introduction and GitHub Universe Recap 00:00:57 New York Tech Scene and East Coast Hackathons 00:02:19 From Google Search to AI Coding: Jed's Journey 00:04:19 Google Labs Mission and DeepMind Collaboration 00:06:41 Jules: Autonomous Coding Agents Explained 00:09:39 The Evolution of Agent Scaffolding and Model Quality 00:11:30 RAG vs Attention: The Shift in Code Understanding 00:13:49 Jules' Journey from Preview to Production 00:15:05 AI Engineer Summit: Community Building and Networking 00:25:06 Context Management in Long-Running Agents 00:29:02 The Future of Software Engineering with AI 00:36:26 Beyond Vibe Coding: Spec Development and Verification 00:40:20 Multimodal Input and Computer Use for Coding Agents

Today’s guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE, rbio1, VariantFormer, and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases. Chapters 00:00:00 Introduction and CZI's 10-Year Anniversary 00:00:56 Learning from Bill Gates 00:04:05 Science vs Translation 00:10:45 The Power of Physical Proximity in Science 00:13:55 Building the Virtual Cell: From Data to Models 00:15:51 Microscopes, Imaging, and Converting Atoms to Bits 00:23:18 AI Meets Biology: The Frontier Lab Concept 00:27:25 How Models Can Enable More Ambitious Research 00:30:15 Precision Medicine and Clinical Impact 00:45:17 The Virtual Immune System and Cellular Engineering 00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease 00:28:45 Joining Forces with Evolutionary Scale