The 2024 OREF Clinical Research Award: Progress Toward a Gene Therapy for Arthritis

Host Mikalyn DeFoor, MD Guest interviewee Nicholas A. Apseloff, MD, discussing his review article, “Primary Anterior Cruciate Ligament Injury: Extrinsic and Intrinsic Risk Factors” from the July 1, 2025 issue Article summarized from the July 1, 2025 issue Review article ““FATAL Graft”: A Diagnostic Algorithm for the Workup of Anterior Cruciate Ligament Reconstruction Graft Failure” Articles summarized from the July 15, 2025 issue Two-part series: Review article “Shoulder Arthroplasty: Current Evidence and Techniques on Infection Diagnosis and Treatment” Review article “Shoulder Arthroplasty: Current Evidence and Techniques on Infection Prevention” Follow this link to download these and other articles from the July 1, 2025 issue of JAAOS and the July 15, 2025 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Mikalyn DeFoor, MD Guest interviewee Annunziato Amendola, MD, FAAOS, AAOS President 2025-2026, discussing his presidential address, “Moving Forward” from the June 15, 2025 issue Article summarized from the June 1, 2025 issue Research article “Physician-Led Orthopaedic Hospitals Outperform Nonphysician-Led Orthopaedic Hospitals: An Analysis of the Top 200 Orthopaedic Hospitals” Article summarized from the June 15, 2025 issue Review article “Workplace Violence in Health Care: Current State of Affairs and Methods of Prevention” See also the AAOS Webinar in Workplace Violence in Health Care: Current State of Affairs and Methods of Prevention – Monday, July 14, 2025, 7:15-8:15 pm CST To register, go here. Follow this link to download these and other articles from the June 1, 2025 issue of JAAOS and the June 15, 2025 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Mikalyn DeFoor, MD Guest interviewee Gabriella E. Ode, MD, FAAOS, FAOA, discussing her research article, “Examining the Outliers: Characteristics of the Most and Least Diverse Programs in Orthopaedics” from the May 15, 2025 issue Article summarized from the May 1, 2025 issue Research article “Geographic Location Markedly Affects Academic Productivity of Pediatric Orthopaedic Surgeons” Article summarized from the May 15, 2025 issue Research article “Assessing the Linking Between the Orthopaedic In-Training Examination and the American Board of Orthopaedic Surgery Part I Certification Examination” Follow this link to download these and other articles from the May 1, 2025 issue of JAAOS and the May 15, 2025 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Katherine Mallett, MD Guest interviewee Mary K. Mulcahey, MD, FAAOS, discussing her research article, “Instagram Engagement Helps Increase Residency Applicant Interest in Orthopaedic Surgery” from the April 15, 2025 issue Article summarized from the April 1, 2025 issue  Research article “Characterizing the Rotational Profile of the Distal Femur: A Roadmap for Distal Femoral Replacement Surgery” Article summarized from the April 15, 2025 issue Research article “Is Periacetabular Osteotomy With Hip Arthroscopy Superior to Periacetabular Osteotomy Alone? A Systematic Review and Meta-Analysis” Follow this link to download these and other articles from the April 1, 2025 issue of JAAOS and the April 15, 2025 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Katherine Mallett, MD Guest interviewees Laura Y, Lu, MD, and Antonia F. Chen, MD, MBA, FAAOS, discussing their training room article, “Surgeon Age, Years in Practice, and Location of Training Are Associated With Patient Satisfaction” from the March 15, 2025 issue Articles summarized from the March 1, 2025 issue Research article “Intraoperative Cardiac Arrest in Orthopaedic Surgery: A Case Series of 42 Patients” Research article “Can Artificial Intelligence Deceive Residency Committees? A Randomized Multicenter Analysis of Letters of Recommendation” Follow this link to download these and other articles from the March 1, 2025 issue of JAAOS and the March 15, 2025 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Katherine Mallett, MD Guest interviewees Michael Kutschke, MD, and Paul Fadale, MD, FAAOS, discussing their review article, “Personal Financial Literacy for the Orthopaedic Trainee and Early Career Surgeon: A Review of the Basics” from the February 1, 2025 issue Article summarized from the February 1, 2025 issue Research article “Predicting Proximal Humerus Fracture Mechanical Complications: Are Computed Tomography Hounsfield Units the Answer?” Article summarized from the February 15, 2025 issue  Research article “Does Tranexamic Acid Improve Early Postoperative Shoulder Motion After Total Shoulder Arthroplasty?” Follow this link to download these and other articles from the February 1, 2025 issue of JAAOS and the February 15, 2025 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Katherine Mallett, MD Guest interviewee Jacob Sorenson, MD, discussing his training room article, “The Power of Preference Signaling: A Monumental Shift in the Orthopaedic Surgery Application Process” from the January 15, 2025 issue Articles summarized from the January 15, 2025 issue Research article “The Effect of Cemented Implants Placed During Initial TKA on Surgical Time and Expenses in Revision TKA” Research article “The Influence of Previous Joint Arthroplasty on Fulfillment of Patients' Expectations of Subsequent Lumbar Surgery” Follow this link to download these and other articles from the January 1, 2025 issue of JAAOS and the January 15, 2025 issue of JAAOS The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Katherine Mallett, MD Guest interviewee Christopher H. Evans, PhD, discussing his article, “The 2024 OREF Clinical Research Award: Progress Toward a Gene Therapy for Arthritis” from the December 1, 2024 issue Article summarized from the December 1, 2024 issue Research article “Opioid Prescription Trends Among Orthopaedic, Primary Care, and Pain Management Providers in Spine Surgery Patients” Article summarized from the December 15, 2024 issue Research article “Complete Blood Count Ratios Predict Adverse Events After Total Joint Arthroplasty” Follow this link to download these and other articles from the December 1, 2024 issue of JAAOS and the December 15, 2024 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Katherine Mallett, MD Guest interviewees Samir Mehta, MD and Monica Kogan, MD, FAAOS, discussing their Training Room article, “Let's Take a Look at the Tape: The Impact of ERAS Video Prompts on Interview Offerings for Orthopaedic Surgery Residency Applicants: A Prospective Observational Study” from the November 15, 2024 issue Article summarized from the November 1, 2024 issue Research article “Odds of Attaining Orthopaedic Leadership Based on Race, Ethnicity, and Sex” Article summarized from the November 15, 2024 issue  Research article “Prophylactic Antibiotic Choice and Deep Infection in Lower Extremity Endoprosthetic Reconstruction: Comparison of Cefazolin, Cefazolin-Vancomycin, and Alternative Regimens” Follow this link to download these and other articles from the November 1, 2024 issue of JAAOS and the November 15, 2024 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

Host Katherine Mallett, MD Guest interviewee Charles P. Hannon, MD, MBA, discussing his review article, “American Academy of Orthopaedic Surgeons Clinical Practice Guideline Summary Management of Osteoarthritis of the Hip” from the October, 15, 2024 issue (https://journals.lww.com/Jaaos/toc/2024/10150) Article summarized from the October 1, 2024 issue (https://journals.lww.com/Jaaos/toc/2024/10010) Research article “Standardization and Reproducibility of Dynamic Stress Testing for Occult Pelvic Ring Instability” Article summarized from the October 15, 2024 issue (https://journals.lww.com/Jaaos/toc/2024/10150) Research article “Trends in Preoperative Outcome Measures From 2013 to 2021 in Patients Undergoing Primary Total Joint Arthroplasty” Follow this link to download these and other articles from the October 1, 2024 issue of JAAOS (https://journals.lww.com/Jaaos/toc/2024/10010)and the October 15, 2024 issue of JAAOS (https://journals.lww.com/Jaaos/toc/2024/10150). The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly. In addition, this podcast is brought to you by our sponsor Avance Solo. To learn more about Avance Solo, visit avancesolo.com. Disclaimer: Neither AAOS nor JAAOS are associated with Avance Solo or any products or services advertised. AAOS does not endorse the advertiser or its products or services.