Ep. 346 Gut Health: Unveiling the Science of the Microbiome with Dr. Colleen Cutcliffe

I am thrilled to have the award-winning personal trainer, Doug Bopst, joining me today.  Doug is also an author and host of the Adversity Advantage Podcast. He is a former convicted felon and drug addict who spent time in jail and is now on a mission to inspire others to conquer adversity and realize their fullest potential. Today, Doug and I engage in a thought-provoking conversation on gratitude, how exercise enables individuals to confront their fears and connect with themselves, the distinction between healthy and unhealthy habits, and the restrictions associated with seeking validation externally. We also discuss the transformative power of resilience, faith, and learning to be comfortable with being uncomfortable.  Doug’s remarkable journey from adversity to triumph serves as a beacon of inspiration for countless individuals seeking transformation, and I am confident that our conversation will resonate deeply with listeners. Stay tuned for Doug’s profound insights on personal development. IN THIS EPISODE YOU WILL LEARN: How gratitude reshaped Doug’s life How people use drugs as a coping mechanism to numb emotional pain Doug explains how he realized he had power and was able to control his life despite feeling powerless  How exercise can catalyze self-discovery and growth Why anxiety and stress are normal responses for those raised in troubled environments Why do some individuals constantly seek external validation instead of seeking self-worth internally? How self-awareness can help to conquer the need for external validation The benefits of coaching and therapy for overcoming unhealthy relationships with food Why many women avoid pushing themselves to the limit during workouts How faith helped Doug to transform his pain and become a better person Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Doug Bopst On his website Instagram The Adversity Advantage Podcast

I am delighted to have the remarkable Dr. William Li joining me again today. He was previously with me on Episode 260, which became one of the most popular podcasts in 2023.  Dr. Li is a world-renowned physician-scientist and New York Times bestselling author known for his role as President and Medical Director of the Angiogenesis Foundation.  In our conversation today, we dive into the vocabulary surrounding health and microbiome-supporting foods, exploring how to measure the microbiome, the benefits of fermented foods, and the role of the appendix. We also look at pre, and post-biotics, strategies for supporting the microbiome after a colonoscopy prep, foods to avoid, immune function, and metabolic nuances, and discuss the differences between subcutaneous visceral fat, brown fat, and white fat, and polyphenol-rich beverages.  I know you will find today’s conversation with Dr. William Li as enlightening as I did. I eagerly anticipate inviting him back to the podcast later this year. IN THIS EPISODE YOU WILL LEARN: Dr. Li explains the importance of the gut microbiome  The interrelationship between the microbiome, body fat, and the metabolism How to measure your gut microbiome Foods that promote gut health and support the microbiome The role of the appendix How a colonoscopy prep impacts the gut microbiome How excess body fat can fuel the metabolism rather than slowing it down Why sleep is crucial for metabolism The role of brown fat in weight loss The benefits of polyphenols in coffee and tea Bio: William W. Li, MD, is an internationally renowned physician, scientist, and New York Times bestselling author of “Eat to Beat Your Diet: Burn Fat, Heal Your Metabolism, Live Longer”. His groundbreaking work has led to the development of more than 30 new medical treatments and impacts care for more than 70 diseases, including cancer, diabetes, blindness, heart disease, and obesity. His TED Talk, “Can We Eat to Starve Cancer?” has garnered more than 11 million views. Dr. Li has appeared on Good Morning America, CNN, CNBC, LIVE with Kelly and Ryan, and the Rachael Ray Show, and he has been featured in USA Today, Time Magazine, The Atlantic, and O Magazine. He is the president and medical director of the Angiogenesis Foundation. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. William Li On Social media: @ Dr William Li On his website Sign up for Dr. Li’s free newsletter Ep. 260 Eat To Beat Your Diet: Achieve a Balanced and Healthy Lifestyle with Dr. William Li

Today, I am thrilled to bring you our seventh AMA episode. I am super excited to connect with all of you today to share valuable insights and answer your questions about dysfunctional uterine bleeding, hormone replacement therapy, perimenopause, and menopause. I will also be addressing queries on blood loss thresholds and dysfunctional uterine bleeding and offering strategies for managing endometriosis and cravings.  Join me as I answer many questions from listeners, shedding light on all these critical concerns and several more. I love doing the AMA episodes, and I know you love listening to them, so keep your questions coming! IN THIS EPISODE YOU WILL LEARN: How an estrogen and progesterone imbalance could cause persistent bleeding  How much blood loss should there be in a menstrual cycle? Why some women crave sweet and salty foods at night during perimenopause and menopause Strategies for managing cravings during perimenopause and menopause How endometriosis often links to autoimmunity and digestive issues Why would someone experience unusual symptoms like itchy ears, crankiness, and bloating in menopause? Various hormone replacement therapy options for perimenopause Why you should implement lifestyle changes before considering HRT The benefits of oral progesterone for sleep and bone health Join my free Facebook group to have me answer your questions personally, or you can send your questions to my admin team ([email protected]) Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected]

Dr. Thomas Dayspring joins me again today for the third class in our Lipid Masterclass Series. Dr. Dayspring brings a wealth of expertise as a certified specialist in internal medicine and clinical lipidology, holding fellowships with the American College of Physicians and the National Lipid Association. This hour-long class is devoted to women's health and abnormal lipids. We continue with our conversation about ApoB, discussing ways to look at other lipid abnormalities related to abnormal ApoBs and talking about our ideal lab values and lifestyle modifications, briefly touching on my lipid journey and the medication I have been taking for the past six months. We examine diagnostics and their limitations, getting into CACs, coronary artery calcification scoring, CIMT, the labs we need to look at, the role of Lp(a), and how it affects our heart. We look into the changes women experience from losing estrogen in menopause, clues women can use to predict future cardiovascular risk, how estrogen helps clear LDL from the body, and the changes occurring with menopause, including higher ApoBs. We also dive into risks women face for cardiovascular disease, the impact of the Women's Health Initiative study, and absorption and synthesis challenges with cholesterol. Stay tuned for more! IN THIS EPISODE YOU WILL LEARN: Why ApoB testing for inherited lipoprotein disorders is essential  Why hypo beta lipoproteins (HDL) are critical for maintaining good health The benefits of a holistic approach to treating high cholesterol The three stages of prevention for atherosclerosis How Lp(a) impacts heart health The importance of assessing early heart function through Lp(a) testing How your pregnancy history can help in predicting your risk for cardiovascular disease Why should women be more concerned about cardiovascular disease than breast cancer? How the Women’s Health Initiative led gynecologists to be more cautious about prescribing HRT How genetically mediated cholesterol abnormalities can impact our ability to absorb and synthesize cholesterol   Bio: Thomas Dayspring MD is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. After practicing in New Jersey for 37 years, in 2012, he moved to Virginia to serve as an educational director for a nonprofit cardiovascular foundation until mid-2019 as a Chief Academic Advisor for two major CV laboratories. Since then, he has served as a virtual cardiovascular / lipidology educator. Career-wise he has given over 4000 domestic (in all 50 states) and several international lectures, including over 600 CME programs on atherothrombosis, lipids/lipoproteins (and their treatment), vascular biology, biomarker testing, and women’s cardiovascular issues. He has authored several manuscripts and lipid textbook chapters and performed several podcasts. For several years, he was an Associate Editor of the Journal of Clinical Lipidology. He was the recipient of the 2011 National Lipid Association’s Presidents Award for services to clinical lipidology and the 2023 Foundation of NLA Clinician/Educator Award. He has over 34K followers on his educational Twitter (X) feed (@Drlipid). He has Gold Heart Member status as a professional member of the American Heart Association, and he serves as a Social Media Ambassador for the European Atherosclerosis Society and the National Lipid Association. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Thomas Dayspring On Twitter (@DrLipid) LinkedIn

It is my pleasure today to introduce Jodi Cohen, a best-selling author, award-winning journalist, functional practitioner, and the Founder of Vibrant Blue Oils, where her training in nutritional therapy and aromatherapy come together to craft unique and exclusive proprietary blends of organic and wildcrafted essential oils.  Jodi has assisted more than 50,000 individuals in overcoming brain-related issues such as anxiety, insomnia, and autoimmunity. In our discussion today, we dive into the fundamental aspects of essential oils, looking at what they are and how they work. We examine the role of the blood-brain barrier and the influence of the autonomic nervous system, focusing on the parasympathetic nervous system and vagus nerve. We explore the importance of vagal tone, the implications of vagal nerve dysfunction and toxicities, and the lymphatic system while also looking at the role of fascia in memories and trauma and the profound effects of essential oils on sleep quality, weight management, and more.  I am excited to share this insightful conversation with Jodi Cohen, as it provides invaluable insights into the vast potential of essential oils in promoting holistic well-being. IN THIS EPISODE YOU WILL LEARN: What essential oils are and how they work clinically The most effective way to use essential oils How emotional or mental dangers can trigger the autonomic nervous system   The autonomic nervous system can cause inflammation, impaired digestion, and compromised immune function if it is constantly activated Stimulating the vagus nerve can improve resilience and reduce stress Some natural ways to stimulate the vagus nerve The connection between the brain and digestion and how stress can impact digestion and overall health How fascia intertwines with the lymph and vagus nerve Essential oils can facilitate emotional release The benefits of essential oils for sleep and weight management during perimenopause and menopause Bio: Jodi Sternoff Cohen is a bestselling author, award-winning journalist, functional practitioner, and founder of Vibrant Blue Oils, where she has combined her training in nutritional therapy and aromatherapy to create unique proprietary blends of organic and wild-crafted essential oils. She has helped over 50,000 clients heal from brain-related challenges, including anxiety, insomnia, and autoimmunity. For the past ten years, she has lectured at wellness centers, conferences, and corporations on brain health, essential oils, stress, and detoxification. She has been seen in The New York Times, Wellness Mama, Elephant Journal, and numerous publications. Her website, vibrantblueoils.com, is visited by over 300,000 natural health seekers every year, and she has rapidly become a top resource for essential oils education on the Internet today. Connect with Cynthia Thurlow On Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Jodi Cohen Vibrant Blue Oils  On Instagram Facebook Use the coupon code WELCOME 10 for $10 off anything you purchase from the Vibrant Blue Oils Shop Jodi’s book, Essential Oils to Boost the Brain and Heal the Body, is available on Amazon and most anywhere books are sold.

I am delighted to have the honor of connecting with Calley Means today. Calley is the Founder of Truemed, a company that facilitates tax-free spending on food and exercise. He also co-authored a book with his sister, Casey Means, called Good Energy, to be released later this year.  Calley graduated from Stanford and Harvard Business School. He was a consultant for food and pharmaceutical firms and now exposes their tactics to weaponize our trusted institutions. In our conversation today, Calley and I examine the impact of drug utilization, including GLP 1s, on obese children and discuss the relevance of his background in food and pharmaceuticals and the problem of treating obesity as a disease. We dive into the role of food stamps and subsidies and look at ways we can help improve food quality in the United States and reduce the influence of the pharmaceutical industry, also addressing conflicts of interest between the NIH and universities, the effects of reduced subsidies and processed food consumption on families, and dopamine regulation.  This conversation has been long-awaited, and as a dedicated fan of Calley's work, I am thrilled to share it with you. IN THIS EPISODE YOU WILL LEARN: Calley highlights the conflicts of interest in obesity research and the ineffectiveness of the US healthcare system in addressing chronic obesity in children. How the pharmaceutical industry prioritizes profit over health Why the American health crisis is not only a medical problem but also a moral issue The influence of processed food companies on nutritional research The crucial need to address the root causes of chronic diseases How the influence of pharmaceutical lobbyists corrupts Congress The growing distrust in American institutions  How nutrition research funding impacts US food guidelines The challenges of raising children when processed foods get weaponized to hook people Calley discusses his upcoming book, Good Energy, and explains how his company, Truemed, helps patients unlock tax-free spending on metabolically healthy items. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Calley Means On his website Truemed website Instagram Twitter

Today, I am delighted to connect with Caroline Alan, the Co-founder and CEO of Beam Minerals.  Coming from the corporate world, Caroline struggled until she discovered the incredible ability of plant-based minerals to support the body and restore its natural balance. She is now devoted to educating people about the benefits of mineral replenishment and the efficacy of plant-based humic and fulvic substances. In today’s discussion, Caroline shares her journey, and we dive into why we experience such significant mineral depletions in our modern-day lifestyles, looking at hidden hunger and the role of our mitochondria. We discuss the interrelationship between mineral storage and adrenal health, the extensive background of plant-based minerals, and the etiology of cramps and hydration. We also explore the signs and symptoms of mineral depletion and explain how to take mineral products for the best results. Join us to learn about the transformative power of plant-based minerals in our modern lives. IN THIS EPISODE YOU WILL LEARN: Why so many people experience mineral depletion at this time How soil health, food quality, and human health are all interrelated The fundamental role mitochondrial function plays in energy production and overall health Why adrenal health is critical for women during perimenopause and menopause The origins of humic and fulvic minerals How fulvic and humic acids help in preventing chronic diseases Why Caroline advocates for using fulvic acid products instead of salt-based electrolytes Caroline shares tips for managing Herxheimer reactions How do mineral deficiencies impact sleep and exercise performance? The benefits of magnesium spray for foot cramps and plantar fasciitis Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Caroline Alan On the Beam Minerals website  Find Beam Minerals on social media @beamminerals Caroline on social media @themineralgeek

I am honored to connect with Dr. Susan Peirce Thompson today. Dr. Peirce Thompson is an adjunct associate professor of Brain and Cognitive Sciences at the University of Rochester and an expert in the psychology of eating. She is also the New York Times bestselling author of Bright Line Eating. In our conversation today, we dive into the complexities of food addiction, exploring why it is even more challenging than drug or alcohol addiction, the importance of awareness around food addiction, and the impact of genetics and trauma. We discuss the addictive properties of sugar and flour, the bliss point in the processed food industry, and misconceptions surrounding artificial sugars. Dr. Peirce Thompson also shares her journey of addiction and recovery, offering invaluable insights on breaking the cycle of addiction and reframing our relationship with hunger.  I am confident that today’s discussion with Dr. Susan Peirce Thompson will provide valuable insights and provoke thoughtful reflections. Join us to learn how to break the cycle of addiction and reclaim control over your relationship with food. IN THIS EPISODE YOU WILL LEARN: Why food addiction is more challenging to treat than other addictions What are the signs of food addiction? The role of genetics in obesity and food addiction How trauma can lead to food addiction Why hyper-palatable processed foods are so addictive How sugar impacts the brain Why it is best to avoid high fructose corn syrup and all artificial sugars How food companies use the bliss point to make their products addictive Why structured eating is essential in modern society Why hunger is not an emergency Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Susan Peirce Thompson Bright Line Eating

I am honored to reconnect with Dave Feldman today. Our last encounter was in December 2020, for Episode 128, where we delved deeply into the topic of cholesterol. Dave is an engineer by profession. He is profoundly clever and commands great respect within the low-carb and keto community due to his willingness to challenge prevailing narratives, encouraging us to explore alternative perspectives on lipid metabolism and reconsider our understanding of LDL, particularly in the context of lean mass hyper-responders like myself. In our discussion today, we dive into how LDL became so vilified, with Dave shedding light on several crucial research findings. We explain what low-mass hyper-responders are, examine biases and cognitive dissonance, touch on Dave’s new LMHR study, and discuss the Miami Heart study, a longitudinal study of the roles of LDL and plaque burden. We also explore the impact of ApoB and reflect on the essence of science as a pursuit of truth, and Dave shares what lies ahead for himself and his research. I trust you will find this conversation engaging and thought-provoking. IN THIS EPISODE YOU WILL LEARN: Why LDL is considered a villain  How AMRs and APB lipoproteins have influenced how we look at risk stratification What is a lean mass hyper-responder? How a low-carb, high-fat diet can improve the metabolic health of lean mass hyper-responders How Dave, an engineer turned scientist, challenges conventional wisdom in the health and wellness space Dave discusses a study on plaque progression in healthy individuals, focusing on correlating LDL levels  How we are at the forefront of finding the significance of lean mass hyper-responders and LDL Dave shares the next thing he and his team will look at to substantiate his findings on lean mass hyper-responders Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dave Feldman On his website Instagram X     Facebook Previous Episode Mentioned Ep. 128 – Cholesterol Obsession: Why It’s the Intellectual Property of the Animal Kingdom with Dave Feldman

I am delighted to have Dr. Colleen Cutcliffe, the CEO and Co-founder of Pendulum, joining me today.  Dr. Cutcliffe is a proud alumnus of Johns Hopkins, with over 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotech. Before starting Pendulum, she was the Senior Manager of Biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals.  In our discussion today, we dive into the emerging science of the gut microbiome, examining the effects of aging, antibiotics, nutrition, stress, travel, and menopause on gut health and discussing how vaginal and C-section deliveries differ in impact. We explore differentiators for various categories of bacteria and the roles of butyrate and fiber, looking at fecal transplants and the difference between probiotics, prebiotics, and post-biotics, and explaining why Akkermansia is an essential bacteria for regulating insulin satiety, fortifying the mucin layer, and facilitating targeted delivery of butyrate. Dr. Cutcliffe also shares her top tips for mitigating the effects of travel on the gut microbiome and offers a special discount for listeners.  I am confident that you will find today’s discussion with Dr. Colleen Cutcliffe engaging and enlightening. Stay tuned to learn how to adjust your lifestyle for a healthier gut microbiome. IN THIS EPISODE YOU WILL LEARN: The benefits of a vaginal delivery Various factors that disrupt the gut microbiome Why it is essential to get enough fiber in your diet What are the signs and symptoms of an unhealthy gut microbiome? The benefits of fecal transplants How the vagus nerve fosters communication between the gut and brain Why artificial sweeteners might not be as harmful to the gut microbiome as previously thought How prebiotics, probiotics, and postbiotics are interconnected and necessary for overall health The role of Akkermansia in the gut microbiome How to maintain a healthy gut microbiome while traveling   Bio: Dr. Colleen Cutcliffe: Colleen Cutcliffe, PhD, is the CEO and Co-Founder of Pendulum. She has over 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Before starting Pendulum, Colleen was the Senior Manager of Biology at Pacific Biosciences and a Scientist at Elan Pharmaceuticals. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Colleen Cutcliffe On the Pendulum Life website Use code THURLOW for 20% off your first order of Pendulum products.