Aspirin in PCI; Mavacamten in Nonobstructive Cardiomyopathy; Olezarsen and the Treatment of Hypertriglyceridemia

Dr. Eagle continues in this week’s View to analyze some of the key clinical content presented at the ESC Congress recently held in Spain. Dr. Eagle examines the TARGET-FIRST trial in which P2Y12-inhibitor monotherapy was compared to dual antiplatelet therapy (DAPT) in patients who have undergone percutaneous coronary intervention (PCI).  He then analyzes the results of the ODYSSEY-HCM trial which explored mavacamten versus placebo in patients with symptomatic nonobstructive hypertrophic cardiomyopathy (HCM). Finally, Dr. Eagle discusses the ESSENCE-TIMI 73b study that looked at olezarsen and its potential for lowering triglycerides in moderate hypertriglyceridemia with elevated cardiovascular risk.    Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at major trials presented at the recent ESC Congress in Spain. First, he discusses the MAPLE-HCM trial that investigates aficamten versus metoprolol monotherapy in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM).  He then explores a set of important presentations on beta blocker therapy following myocardial infarction. Finally, Dr. Eagle talks about new research on the use of reconditioned pacemakers that shows promise for strengthening global cardiovascular health.   Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle evaluates the potential value of self-service blood pressure (BP) kiosks and their potential to improve hypertensive health nationwide. He then discusses the FLAVOUR trial and its comparable outcomes with fractional flow reserve (FFR) and intravascular ultrasound (IVUS)-guided treatment for intermediate coronary stenosis. Finally, Dr. Eagle explores how continuous positive airway pressure {CPAP} may improve cardiovascular outcomes in patients with high-risk obstructive sleep apnea (OSA).  Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at the new ACC/AHA guideline for prevention, detection, evaluation and management of high blood pressure (BP). He then discusses new-onset right bundle branch block (RBBB) post-transcatheter aortic valve replacement (TAVR) and its association with a high risk of permanent pacemaker implantation (PPI). Finally, Dr. Eagle explores gender-affirming hormone therapies and their effect on cardiac repolarization.  Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at whether compression stockings reduce vasovagal syncope recurrence. He then discusses new concise clinical guidance that addresses the evaluation and management of pericarditis. Finally, Dr. Eagle explores early, safe cardiac rehabilitation for critically ill patients hospitalized with acute decompensated heart failure (ADHF).   Subscribe to Eagle’s Eye View    

In this week’s View, Dr. Eagle looks at the SUMMIT trial and considers how body mass index (BMI) and central adiposity affect tirzepatide outcomes for heart failure with preserved ejection fraction (HFpEF). He then discusses bicuspid aortic valves type 0 (BAV-0) and its association with better long-term prognosis in patients with severe aortic stenosis (AS) undergoing tricuspid aortic valve replacement (TAVR). Finally, Dr. Eagle examines long-term risk of infective endocarditis and why it is significantly higher for mitral valve (MV) replacement versus repair.    Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at the PREVENT model and its ability to predict ten-year atherosclerotic cardiovascular disease risk in diverse populations. He then discusses higher carbohydrate quality and fiber-rich foods and their links to better cardiac structure and function. Finally, Dr. Eagle explores increased use of radial access for percutaneous coronary intervention to achieve lower complication rates.   Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at predictors of high-grade atrioventricular block (AV) after transcatheter tricuspid valve replacement (TTVR). He then discusses the challenges and benefits of deep learning in automating cardiac imaging (IMG). Finally, Dr. Eagle explores higher survival benefits after the 2018 U.S. Heart Transplantation Allocation policy change.   Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at whether ischemic preconditioning provides benefit in noncardiac surgery. He then discusses the benefits of the microaxial flow pump in STEMI-cardiogenic shock (CS) patients undergoing hemodynamic monitoring. Finally, Dr. Eagle explores starting direct oral anticoagulants (DOACs) early after stroke, and whether it lowers the risk of future strokes and hemorrhage.    Subscribe to Eagle’s Eye View  

In this week’s View, Dr. Eagle looks at frailty status and increased risk of mortality in patients who undergo percutaneous coronary intervention (PCI). He then discusses the timely treatment and delays in treatment of ST-segment elevation myocardial infarction (STEMI) that are associated with worse outcomes. Finally, Dr. Eagle explores new insights on arterial events associated with heritable thoracic aortic disease and the relative risk in patients with pathogenic variants, as well as the prevalence, characteristics, and clinical outcomes of arterial aneurysms in Loeys-Dietz Syndrome.   Subscribe to Eagle’s Eye View