1028 - The Histamine Treatment That Helped These Patients Get Their Lives Back

Could calming overactive mast cells help with chronic fatigue, brain fog, and food reactivity? Dr. Ruscio explores remarkable improvements reported in a Johns Hopkins case series using cromolyn sodium—a mast cell stabilizer developed from the plant compound khellin. Learn how it works in the gut, dosing and safety considerations, and how it may help highly reactive patients tolerate treatment for underlying triggers.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/   📖 Free Guides: MCAS Guide & Questionnaire: https://drruscio.com/guides/get-mcas-symptom-questionnaire/ Histamine Intolerance: https://drruscio.com/guides/get-histamine-intolerance-guide/   💊 Featured Products: NasalCrom Nasal Spray Allergy: https://www.amazon.com/dp/B000R829FO?lv=shuf&channelId=500&plpRedirect=mhFallback&th=1   👇 Watch more videos like this 👇  ➡️ This New Histamine Treatment Helped 89% of Patients: https://www.youtube.com/watch?v=cosOYisG-bQ  ➡️ 5 Warning Signs You're Histamine Intolerant (& What You Can Do): https://youtu.be/JPBAd9RzIf4?si=X-MXY1l7l71dDSe4   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1   And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇 Read these next 👇 ➡️ Low Histamine Diet: Foods to Eat, Avoid, and a 3-Week Plan: https://drruscio.com/low-histamine-diet/ ➡️ Can I Take Quercetin for Histamine Intolerance?: https://drruscio.com/quercetin-for-histamine-intolerance/   📌Timestamps 00:00 Intro  01:35 Cromolyn's Impact On Health  03:28 What Cromolyn Is 04:27 Patient Cases 06:49 Protocols Used In Cases 08:35 Gut & Other Benefits  10:00 Cromolyn & Root-Cause Treatment  12:28 Safety and Side Effects 13:15 Closing 🎧 Audio Episode & Featured Studies  📉https://pubmed.ncbi.nlm.nih.gov/41728426/ 📉https://pubmed.ncbi.nlm.nih.gov/2110198/ 📉https://pubmed.ncbi.nlm.nih.gov/2506913/ 📉https://pubmed.ncbi.nlm.nih.gov/6405650/ 📉https://pubmed.ncbi.nlm.nih.gov/37442295/ 📉https://pubmed.ncbi.nlm.nih.gov/2141132/ 📉https://pubmed.ncbi.nlm.nih.gov/6401954/ 📉https://pubmed.ncbi.nlm.nih.gov/101315/ 📉https://pubmed.ncbi.nlm.nih.gov/1742648/   Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.

What happens when you drink kefir every day? In this video, Dr. Ruscio breaks down findings from 70+ clinical trials on this traditional fermented drink, including its potential effects on gut health, digestion, inflammation, metabolic health, and even brain function. He also covers how much kefir to drink, whether homemade or store-bought is better, and what to look for on the label.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/ ✅ Get practical, science-based insights straight to your inbox: https://drruscio.com/signup/    📖 Kefir Guides How To Make Homemade Kefir: https://culturesforhealth.com/blogs/learn/milk-kefir-how-to-make-milk-kefir?srsltid=AfmBOorHufAS0ZLcH_xgznS4YBylr3EUs9sEYxdQPIQKiAgmZgBqZIO4&utm_  Recommended Kefir Grains:  https://culturesforhealth.com/collections/kefir/products/milk-kefir-grains  Healthy Gut Healthy You: https://store.drruscio.com/products/healthy-gut-healthy-you    👇 Watch more videos like this 👇  ➡️ 6 Fermented Foods You Must Eat for Better Gut Health: https://youtu.be/f-b16qAD4tI?si=-MdwGG_QDEpWyHvo  ➡️ If I Could Only Take ONE Gut Health Supplement:  https://youtu.be/qrJwfWa2r9Y?si=uYqPquBPA6rnYs2T    Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1  And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇 Read these next 👇 ➡️ Are Probiotic Drinks as Effective as Probiotic Supplements?: https://drruscio.com/probiotic-drinks/ ➡️ Types of Probiotics: https://drruscio.com/types-of-probiotics/   📌Timestamps 00:00 Intro  02:24 What is Kefir? 03:15 Gut Health 06:58 Lower Inflammation 08:21 Brain Health 10:00 Metabolic & Other Benefits 10:18 Homemade Kefir 11:00 Recommended Kefir Dose 11:33 Closing Thoughts   🎧 Audio Episode & Featured Studies 📉 https://pubmed.ncbi.nlm.nih.gov/41827605/ 📉 https://www.frontiersin.org/journals/food-science-and-technology/articles/10.3389/frfst.2025.1725280/full 📉 https://pubmed.ncbi.nlm.nih.gov/40469719/ 📉 https://pubmed.ncbi.nlm.nih.gov/42174008/ 📉 https://pubmed.ncbi.nlm.nih.gov/32171508/ 📉 https://pubmed.ncbi.nlm.nih.gov/25599776/ 📉 https://pubmed.ncbi.nlm.nih.gov/30662004/ 📉 https://pubmed.ncbi.nlm.nih.gov/42174008/ 📉 https://pubmed.ncbi.nlm.nih.gov/41314291/ 📉 https://www2.med.muni.cz/biomedjournal/pdf/2007/06/279-286.pdf 📉 https://pubmed.ncbi.nlm.nih.gov/37224566/ 📉 https://pubmed.ncbi.nlm.nih.gov/23621727/ 📉 https://pubmed.ncbi.nlm.nih.gov/35405603/ 📉 https://pubmed.ncbi.nlm.nih.gov/41076330/ 📉 https://pubmed.ncbi.nlm.nih.gov/35282787/ 📉 https://pubmed.ncbi.nlm.nih.gov/32411323/ 📉 https://pubmed.ncbi.nlm.nih.gov/30768439/ 📉 https://pubmed.ncbi.nlm.nih.gov/41076330/ 📉 https://www.sciencedirect.com/science/article/abs/pii/S2213434421000177 Follow Me  Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g   *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.

💊 Dr. Ruscio Probiotics: https://store.drruscio.com/collections/probiotics    Not all probiotics are created equal, and even a good probiotic may not work if you're using the wrong formula, dose, or duration.   In this episode, Dr. Ruscio breaks down how to choose a high-quality probiotic, what GMP and third-party testing actually tell you, how long probiotics typically need to work, the most evidence-supported formula types and doses, and what to do if you're sensitive or don't respond.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/ ✅ Get practical, science-based insights straight to your inbox: https://drruscio.com/signup/    👇 Watch more videos like this 👇  ➡️ Cure SIBO FASTER (New Research): https://youtu.be/u8MsOY5rgAU?si=cQtkEYfM-jwabFMi ➡️ Prebiotics vs Probiotics - Which Is Best for Gut Health?: https://www.youtube.com/watch?v=3Efllxhj3ts   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1 And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇Read these next 👇 ➡️ How to Take Probiotics for the Best Results: https://drruscio.com/how-often-to-take-probiotics/ ➡️ Do Probiotics Make You Poop?: https://drruscio.com/do-probiotics-make-you-poop/ ➡️ What Happens When You Stop Taking Probiotics: Week by Week: https://drruscio.com/what-happens-when-you-stop-taking-probiotics/   📌 Timestamps 00:00 Intro  01:51 Selecting Quality Probiotics 07:04 Probiotic Guidelines 13:55 Formula Types  18:01 Probiotic Meta-Protocol 19:36 Sensitivity, Side Effects & Caveats 23:23 Closing Thoughts   🎧 Audio Episode & Featured Studies  https://pubmed.ncbi.nlm.nih.gov/21303743/  https://pubmed.ncbi.nlm.nih.gov/40995173/  https://pubmed.ncbi.nlm.nih.gov/32582075/  https://pubmed.ncbi.nlm.nih.gov/27857709/  https://pubmed.ncbi.nlm.nih.gov/21303743/  https://pubmed.ncbi.nlm.nih.gov/31105649/  https://www.consumerlab.com/news/problems-at-supplement-manufacturing-sites/03-20-2020/?utm_  https://www.wired.com/story/creatine-gummies-dubious-claims/  https://pubmed.ncbi.nlm.nih.gov/36178333/  https://pubmed.ncbi.nlm.nih.gov/35927504/  https://pubmed.ncbi.nlm.nih.gov/41394228/  https://pubmed.ncbi.nlm.nih.gov/23299716/  https://pubmed.ncbi.nlm.nih.gov/29128720/  Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.

In this episode, Dr. Ruscio and Dr. Scott Spiridigliozzi break down why mold and fungal treatments often fail—and what may improve the odds of success. They discuss how to get clearer on the diagnosis, why herbal therapies may not be enough for some patients, the importance of reaching therapeutic antifungal levels, why underdosing can backfire, and how targeting the right tissues may help prevent relapse. They also share insights from their own experiences with chronic fungal illness and how those lessons are shaping their evolving treatment approach.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/   💊 Antifungal Protocol 🔹 Triple Therapy Probiotic Powder Sticks: https://store.drruscio.com/products/triple-therapy-probiotic  🔹 Gut Rebuild Nutrients: https://store.drruscio.com/products/gut-rebuild-nutrients-powder-chocolate  🔹 Biota-Boost: https://store.drruscio.com/products/biota-boost 🔹 Biota Resistant Starch: https://store.drruscio.com/products/biota-resistant-starch 🔹 Biota Fiber: https://store.drruscio.com/products/biota-fiber   🌿 Herbal Antimicrobials 🔹 Biota-Clear 1a: https://store.drruscio.com/products/biota-clear-1a 🔹 Biota-Clear 1b: https://store.drruscio.com/products/biota-clear-1b 🔹 Biota-Clear 2a: https://store.drruscio.com/products/biota-clear-2a 🔹 Biota-Clear 2b: https://store.drruscio.com/products/biota-clear-2b   👃 Nasal irrigation: 🔹 NeilMed Squeeze Bottle https://shop.neilmed.com/products/sinus-rinse-bottle-3ct-and-nasadock-plus 🔹 NeilMed Xylitol https://www.amazon.com/NeilMed-Sinus-Rinse-Xylitol-Count/dp/B08FPK73R7?th=1 🔹 NAC Packet https://www.amazon.com/SinuMed-Packets-Allergy-Congestion-Symptoms/dp/B0FLPQFN99/ 🔹 LiviaOne Probiotic Nasal Spray: https://store.drruscio.com/products/liviaone-probiotic-nasal-spray   👇 Watch more videos like this 👇  ➡️ Fungus – The Hidden Reason Symptoms Keep Coming Back: https://www.youtube.com/watch?v=lIb2DXdInv4 ➡️ How to Tell If You Have Mold in Your Home (And What To Do Next): https://www.youtube.com/watch?v=utLr0rQghfs   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1   And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇 Read these next 👇 ➡️ Everything You Need to Know about SIFO (Small Intestinal Fungal Overgrowth): https://drruscio.com/everything-need-know-sifo-small-intestinal-fungal-overgrowth/ ➡️ Black Mold Symptoms: What's Real, What's Not, and What to Do: https://drruscio.com/black-mold-symptoms/   📌Timestamps 00:00 Intro  05:25 Clues of Fungal Infection 10:32 Diagnostic Clarity 17:50  Herbal Therapy Alone Is Insufficient 19:36  Natural Fungal Protocol 23:46 Medications Must Hit Therapeutic Levels 35:56 Don't Be Timid On The Battlefield 55:35 Medications Must Hit Target Tissues 🎧Audio Episode & Featured Studies  📉Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/ 📉Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis: https://pubmed.ncbi.nlm.nih.gov/9378812/ 📉Population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in paediatric cystic fibrosis and bone marrow transplant patients: https://pubmed.ncbi.nlm.nih.gov/17048974/ 📉Effect of omeprazole on the pharmacokinetics of itraconazole: https://pubmed.ncbi.nlm.nih.gov/9626921/ 📉Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox: https://pubmed.ncbi.nlm.nih.gov/33132781/ Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.

Gallbladder removal may not always be the only option. In this video, Dr. Scott Spiridigliozzi explains how SIBO and gut dysbiosis may contribute to gallstones, sludge, and poor gallbladder function. He also shares two patient cases and the gut-focused protocol used to resolve their symptoms and help them avoid surgery.   ✅ Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/   💊 Supplement Protocol 📖Free Low FODMAP Diet Guide: https://drruscio.com/guides/get-low-fodmap-diet-guide/ Triple Therapy Sticks: https://store.drruscio.com/products/triple-therapy-probiotic?variant=40164201922757 62 billion CFU per serving Dose range: 1-3 packets per day  May be taken with or without food Herbal antimicrobials (SIBO Biofilm Protocol: https://drruscio.com/biofilm-protocol/) 1st month: Biota-Clear 1a: https://store.drruscio.com/products/biota-clear-1a?variant=31925255471156 4 pills, 2x per day, best with food.  2 bottles of 120 capsules needed per month Biota-Clear 1b: https://store.drruscio.com/products/biota-clear-1b?variant=5245784522789 2 pills, 2x per day, best with food.  2 bottles of 60 capsules needed per month 2nd month: Biota-Clear 2a: https://store.drruscio.com/products/biota-clear-2a?variant=4964993171493 3 pills, 2x per day, best with food.  2 bottles of 90 capsules needed per month Biota-Clear 2b: https://store.drruscio.com/products/biota-clear-2b?variant=5245785145381 3 pills, 2x per day, best with food.  2 bottles of 90 capsules needed per month Take along with antimicrobials: Biota Dissolve: https://store.drruscio.com/products/biota-dissolve 3 capsules, 2x per day, on an empty stomach Glycine: https://www.amazon.com/Life-Extension-Glycine-Vegetarian-Capsules/dp/B00B35A394/ref=sr_1_6 3 capsules 2x daily with or without food  TUDCA: https://www.amazon.com/Supplement-Servings-Double-Wood-Supplements/dp/B07YQ6J6FW/ref=sr_1_4?th=1 1-2 caps 2x daily with food Optimal PC: https://www.amazon.com/Seeking-Health-Supplement-Phospholipid-Sunflower/dp/B00SLVJ54M/ref=sr_1_2 Start with 1 capsule 2x daily with food.  Increase as tolerated to 3 caps 2x daily with food.  Diarrhea can occur initially, and should improve over time. If it doesn't improve, lower the dose to whichever dose doesn't cause diarrhea.  👇 Watch more videos like this 👇  ➡️ How to Get Rid of Gallstones Naturally: https://www.youtube.com/watch?v=Sm2ENwJ-F1g ➡️ Cure SIBO FASTER (New Research): https://www.youtube.com/watch?v=u8MsOY5rgAU   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1 And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇Read these next 👇 ➡️ The 5 Most Evidence-Backed Gallstone Supplements: https://drruscio.com/gallstone-supplements/   📌Timestamps 00:00 Intro 01:47 Warning Signs 02:37 The Microbiome's Role  04:29 2 Types of Gut Imbalance 06:46 Patient Cases 09:44 Treatment Protocol 15:35 Patient Results 16:53 Key Takeaways   🎧 Audio Episode & Featured Studies 📉 Gastrointestinal microbiome and cholelithiasis: https://pubmed.ncbi.nlm.nih.gov/36970590/ 📉 The characteristics of small intestinal bacterial overgrowth in patients with gallstone diseases: https://pubmed.ncbi.nlm.nih.gov/29392773/ 📉 Intestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation: https://pubmed.ncbi.nlm.nih.gov/32143645/ 📉 Effects of oral tauroursodeoxycholic acid and/or intestinal probiotics on serum biochemical indexes and bile composition in patients with cholecystolithiasis: https://pubmed.ncbi.nlm.nih.gov/36353477/ 📉 Effects of oral tauroursodeoxycholic acid and/or intestinal probiotics on serum biochemical indexes and bile composition in patients with cholecystolithiasis: https://pubmed.ncbi.nlm.nih.gov/36353477/ 📉 Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/ 📉 The effect of ursodeoxycholic acid in dissolving gallstones formed after laparoscopic sleeve gastrectomy: retrospective cohort study: https://pmc.ncbi.nlm.nih.gov/articles/PMC11885402/   Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.

📖 Full Mold Checklist & Resources Guide (Free Download) : https://drruscio.com/guides/get-home-mold-guide/  Could hidden fungus or mold exposure be driving recurring gut symptoms? In this episode, Dr. Scott Spiridigliozzi interviews Dr. Pejman Katiraei about a novel "backdoor" mechanism through which inhaled fungal toxins may reach the gut through the bloodstream, disrupt the microbiome, increase intestinal permeability, and contribute to persistent symptoms such as bloating, food reactions, fatigue, brain fog, and anxiety. They also discuss how to identify possible fungal or environmental triggers and the practical steps that may help restore gut health and reduce symptoms.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/   ➡️ Learn more about Dr. Pejman Katiraei: https://drkatiraei.com/ https://wholistickids.com/ https://www.instagram.com/wholistickids/ We Tested Our Home and We Don't Have Mold! https://www.youtube.com/watch?v=lcdjPSD5QDo Mold Substack Protocol: https://pkatiraei.substack.com/p/mold-protocol-for-children-with-asd   💊 Featured Products & Supplements EnviroBiomics Tests: https://www.envirobiomics.com/ref/27392/ Lis Biotech Tests: https://lisbiotech.com/ Hista Digest: https://store.drruscio.com/products/hista-digest-capsules?variant=4217464743546 Mirica: https://www.amazon.com/gp/product/B07365MZLY/ref=as_li_qf_asin_il_tl?ie=UTF8&tag=hghy-google-ads-20&creative=9325&linkCode=as2&creativeASIN=B07365MZLY&linkId=7bc6f62e0f4e5c01f94c938d05ed7823 ANRC Essentials Plus Capsules 180 ct:  https://www.autism-store.com/products/anrc-essentials-plus-capsules-180-ct?gad_source=1&gad_campaignid=21403744485&gbraid=0AAAAA97GzlK2RDtK29lVrexVnymTqdwVB&gclid=Cj0KCQjwsMLSBhD9ARIsAIpUTDr9cycb71lEU5qWznfBoY1L5_UT4h5NfDHQHm29X5E8zLo3gk8S-scaAhPJEALw_wcB  NeuroNeeds Energy Needs: https://www.neuroneeds.com/product/energyneeds/     👇 Watch more videos like this 👇  ➡️ How to Tell If You Have Mold in Your Home (And What To Do Next): https://www.youtube.com/watch?v=utLr0rQghfs ➡️ Fungus – The Hidden Reason Symptoms Keep Coming Back: https://www.youtube.com/watch?v=lIb2DXdInv4 ➡️ Mold Exposure Story: Healing Cordila's Fatigue, Weight Gain, & Nausea: https://www.youtube.com/watch?v=zdVGK5J2Skg ➡️ Top Treatments To Detox Mold Exposure and Mycotoxins For Good: https://www.youtube.com/watch?v=KSLtfGRNPKI   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1   And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇Read these next 👇 ➡️ Mold Detox Diet: Foods that May Support Recovery: https://drruscio.com/mold-detox-diet/ ➡️ Black Mold Symptoms: What's Real, What's Not, and What to Do: https://drruscio.com/black-mold-symptoms/ ➡️ Are Your Seasonal Allergies Actually An Allergy to Mold?: https://drruscio.com/allergy-to-mold/   📌 Timestamps   00:00 Intro  03:36 Hidden Effects of Fungus & Mold 07:15 Surprising Fungus & Mold Facts 11:44 Signs of Mold Exposure 17:21 MCAS & Nervous System Signs 18:33 Gut Symptoms  22:31 How It Triggers Leaky Gut 42:29 Gut-Brain Effects & Inflammation 50:17 Sinus Problems 52:54 Neurodegenerative Disease Connection 54:28 Best Mold Tests 01:28:25 Mold Diagnostic Framework 01:31:31 Dr. Katiraei's Protocol 01:37:57 Mitochondria Supplements 01:38:56 Gut & Antifungal treatments 01:45:50 Key Takeaways  🎧 Audio Episode & Featured Studies  📉 Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth: https://pubmed.ncbi.nlm.nih.gov/23574267/ 📉 Gut-Brain Inflammation and Disrupted Homeostasis Due to Activation of Mast Cells and Microglia: https://pubmed.ncbi.nlm.nih.gov/41751904/ 📉 Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure: https://pubmed.ncbi.nlm.nih.gov/32987679/ 📉 Chronic rhinosinusitis and cognition: https://pubmed.ncbi.nlm.nih.gov/40619980/ 📉 A positive correlation between autonomic nervous system function and endoscopic disease severity in chronic rhinosinusitis: https://pubmed.ncbi.nlm.nih.gov/40988571/   Follow Me  Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.   Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g    *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video. Guest Links https://drkatiraei.com/ https://wholistickids.com/ https://www.instagram.com/wholistickids/ We Tested Our Home and We Don't Have Mold! https://www.youtube.com/watch?v=lcdjPSD5QDo Mold Substack Protocol: https://pkatiraei.substack.com/p/mold-protocol-for-children-with-asd

SIBO & Parasite Antimicrobial Protocol: https://drruscio.com/biofilm-protocol/?nab=0&utm_source=youtube  Elemental Diet: https://store.drruscio.com/pages/elementalheal  Triple Therapy Probiotics: https://store.drruscio.com/products/triple-therapy-probiotic  Gut Rebuild Nutrients: https://store.drruscio.com/products/gut-rebuild-nutrients-powder-chocolate?srsltid=AfmBOopnMhnrTlDklAWPUIyuoOFwM3FwTahLXX4888KzfgBc-Ym9bUvt    Parasites are an often-overlooked factor in chronic gut symptoms, food intolerance, histamine-type reactions, fatigue, and cases where patients feel stuck despite addressing SIBO, Candida, or other common gut imbalances. In this episode, Dr. Ruscio, Dr. Jake Vonfeldt, and Dr. Scott Spiridigliozzi discuss common parasites like Giardia, Cryptosporidium, Blastocystis, pinworms, and helminths, why standard testing can miss them, and how clinical history can help determine when parasites deserve closer consideration. They also share both natural and pharmaceutical parasite protocols, along with practical guidance on when each approach may be appropriate.   ✅Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/ 📖Healthy Gut Healthy You Book by Dr. Michael Ruscio: https://store.drruscio.com/products/healthy-gut-healthy-you   👇 Watch more videos like this 👇  ➡️Expert Reveals Signs You Have Parasites (And How to Treat):  https://www.youtube.com/watch?v=EiiGdORqOek ➡️Cure SIBO FASTER (New Research):  https://youtu.be/u8MsOY5rgAU?si=Bvi5qBXv_NeNO_-l   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1 And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇Read these next 👇 ➡️ Protozoan Parasites: What They Mean and How to Treat Them: https://drruscio.com/protozoan-parasite/ ➡️SIBO Biofilm Explained: Symptoms, Causes, and a Treatment Protocol: https://drruscio.com/sibo-biofilm/   📌Timestamps  00:00 Intro  02:26 About Dr. Vonfeldt & Dr. Spiridigliozzi 06:04 Common Parasites, Sources & Key Symptoms 18:59 Prevalence  & challenges 25:59 Testing 43:05 Treatment 01:07:38 Natural Protocol 01:19:36 Pharmaceutical Protocol 01:36:56 Cases 01:43:31 Chronic symptom recovery map 01:48:08 Key insights   🎧Audio Episode & Featured Studies  📉Intestinal parasitism in the United States: update on a continuing problem: https://pubmed.ncbi.nlm.nih.gov/8024063/ 📉Perceived food intolerance and irritable bowel syndrome in a population 3 years after a giardiasis-outbreak: https://pubmed.ncbi.nlm.nih.gov/26585714/ 📉Irritable bowel syndrome and chronic fatigue 6 years after giardia infection: https://pubmed.ncbi.nlm.nih.gov/25115874/ 📉Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/ 📉Blastocystis, urticaria, and skin disorders: https://pubmed.ncbi.nlm.nih.gov/31873864/ 📉Urticaria by Blastocystis hominis. Successful treatment with paromomycin: https://pubmed.ncbi.nlm.nih.gov/8237719/ 📉An atypical urticaria case caused by Giardia intestinalis: https://pubmed.ncbi.nlm.nih.gov/36449653/ 📉The Landscape of Parasitic Infections in the United States: https://www.modernpathology.org/article/S0893-3952(23)00122-9/fulltext 📉Utility of multiple-stool-specimen ova and parasite examinations in a high-prevalence setting: https://pubmed.ncbi.nlm.nih.gov/10405376/ 📉Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/ 📉The effectiveness of empirical anti-parasitic treatment in returning travellers with persistent abdominal symptoms: https://pubmed.ncbi.nlm.nih.gov/29232458/ 📉Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: https://pmc.ncbi.nlm.nih.gov/articles/PMC5953358/ 📉Saccharomyces boulardii and infection due to Giardia lamblia: https://pubmed.ncbi.nlm.nih.gov/16798698/ 📉Clinical efficacy of Saccharomyces boulardii or metronidazole in symptomatic children with Blastocystis hominis infection: https://pubmed.ncbi.nlm.nih.gov/20922415/ 📉N-acetylcysteine and intestinal health: a focus on its mechanism of action: https://pubmed.ncbi.nlm.nih.gov/25553484/ 📉Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome: https://pubmed.ncbi.nlm.nih.gov/30108163/ 📉Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific Giardia spp infections in Brazilian children: https://pubmed.ncbi.nlm.nih.gov/20038852/ 📉Impact of vitamin A on selected gastrointestinal pathogen infections and associated diarrheal episodes among children in Mexico City, Mexico: https://pubmed.ncbi.nlm.nih.gov/17041847/ 📉Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: https://pubmed.ncbi.nlm.nih.gov/28069350/ 📉Use of berberine in treatment of giardiasis: https://pubmed.ncbi.nlm.nih.gov/1096596/ 📉Inhibition of enteric parasites by emulsified oil of oregano in vivo: https://pubmed.ncbi.nlm.nih.gov/10815019/   Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/ DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.  

In this episode, Dr. Ruscio breaks down the surprising gut and systemic benefits of NAC (N-acetylcysteine), including how it may help break down biofilms, support SIBO and H. pylori treatment, improve gut lining repair, boost nutrient absorption, and support glutathione, mitochondria, and brain health. You'll also learn when sustained-release NAC may be useful, how to dose NAC properly, and what side effects or cautions to keep in mind.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/   💊 Featured Products: Biota Dissolve: https://store.drruscio.com/products/biota-dissolve Jarrow Formulas N-A-C Sustain 600 mg: https://www.amazon.com/Jarrow-Formulas-Sustain-Supports-Function/dp/B0013OVVK0/   👇 Watch more videos like this 👇  ➡️ Cure SIBO FASTER (New Research): https://www.youtube.com/watch?v=u8MsOY5rgAU ➡️ 5 Reasons You Need Glutathione & How To Boost It: https://www.youtube.com/watch?v=7k7YT70MnA4 ➡️ 8 Ways to Beat Brain Fog & Boost Your Cognition:  https://www.youtube.com/watch?v=Tk_ICGk0RwQ ➡️ Butyrate – The SIBO Treatment Nobody Talks About:  https://www.youtube.com/watch?v=5B4l1yOn9UA   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1   And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇 Read these next 👇 ➡️ SIBO Biofilm Explained: Symptoms, Causes, and a Treatment Protocol: https://drruscio.com/sibo-biofilm/ ➡️ What are Biofilms?: https://drruscio.com/biofilms/ ➡️ The Best Glutathione Foods (and When to Supplement): https://drruscio.com/glutathione-foods/ ➡️ 8 Best Microbiome Supplements for a Happier, Healthier Gut: https://drruscio.com/best-microbiome-supplements/   📌 Timestamps 00:00 What is NAC? 01:47 H. pylori 04:50 SIBO & biofilms 11:00 Gut lining & nutrient absorption 15:22 IBD 18:18 Systemic benefits 24:16 Gut health protocol 26:14 Systemic protocol 27:29 Side effects   Supplementary endoscopy video reproduced from: Baumgartner M, Lang M, Holley H, et al. Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis. Gastroenterology (2021). Available on PubMed Central. Licensed under CC BY 4.0.  Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8527885/  License: https://creativecommons.org/licenses/by/4.0/  Changes: trimmed   🎧 Audio Episode & Featured Studies  📉 N-acetylcysteine and intestinal health: https://pubmed.ncbi.nlm.nih.gov/25553484/ 📉 Biofilm demolition and antibiotic treatment to eradicate resistant Helicobacter pylori: https://pubmed.ncbi.nlm.nih.gov/20478402/ 📉 N-acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication: https://pubmed.ncbi.nlm.nih.gov/30746681/ 📉 N-acetylcysteine as powerful molecule to destroy bacterial biofilms: https://pubmed.ncbi.nlm.nih.gov/25339490/ 📉 Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis: https://pubmed.ncbi.nlm.nih.gov/34146566/ 📉 Low dose rifaximin combined with N-acetylcysteine is superior to rifaximin alone in a rat model of IBS-D: https://pubmed.ncbi.nlm.nih.gov/39103611/ 📉 Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/ 📉 Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: https://pubmed.ncbi.nlm.nih.gov/33067169/ 📉 Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: https://pubmed.ncbi.nlm.nih.gov/33783984/ 📉 N-Acetylcysteine Supplementation Elevates Human Brain Glutathione In Vivo: https://cds.ismrm.org/protected/17MProceedings/PDFfiles/4553.html?utm_ 📉 Treatment effects of N-acetyl cysteine on resting-state functional MRI and cognitive performance in patients with chronic mild traumatic brain injury: https://pubmed.ncbi.nlm.nih.gov/38299014/ 📉 Clinical trials of N-acetylcysteine in psychiatry and neurology: https://pubmed.ncbi.nlm.nih.gov/25957927/ 📉 Influence of N-Acetylcysteine Supplementation on Physical Performance and Laboratory Biomarkers in Adult Males: https://pubmed.ncbi.nlm.nih.gov/37299425/ 📉 COVID-19 clinical outcomes and N-acetylcysteine (CoViNAC study): https://pubmed.ncbi.nlm.nih.gov/40418545/ 📉 Sinus Irrigation with N-Acetylcysteine after Endoscopic Sinus Surgery for Chronic Rhinosinusitis:https://pubmed.ncbi.nlm.nih.gov/39125554/ 📉 The effects of N-acetylcysteine supplement on metabolic parameters in women with polycystic ovary syndrome: https://pubmed.ncbi.nlm.nih.gov/37841396/ 📉 The role of N-acetyl-cysteine (NAC) orally daily on the sperm parameters and serum hormones in idiopathic infertile men: https://pubmed.ncbi.nlm.nih.gov/33405232/ 📉 Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine:https://pubmed.ncbi.nlm.nih.gov/39064168/   Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.

New research suggests that low-dose peptide therapy may help calm histamine-driven inflammation and mast cell activation in people with stubborn symptoms like food reactions, brain fog, fatigue, flushing, itching, hives, bloating, and digestive distress. In this episode, Dr. Ruscio explains how the gut, histamine, and mast cells are connected, what the latest human research shows, and why this approach may help some patients who haven't fully responded to diets, supplements, or other natural therapies.   📉 Utility of glucagon-like-peptide-1-receptor agonists in mast cell activation syndrome: https://pubmed.ncbi.nlm.nih.gov/40675372/   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/   📖 Free Guides Histamine Intolerance: https://drruscio.com/guides/get-histamine-intolerance-guide/ MCAS  Questionnaire: https://drruscio.com/guides/get-mcas-symptom-questionnaire/   💊 Featured Products https://koramd.com/products/personalized-glp-1-treatments   👇 Watch more videos like this 👇  ➡️ 4-Step Protocol to Treat Histamine Intolerance (Best Diet & Supplements): https://www.youtube.com/watch?v=9Da_Dar8Cjo ➡️ The Best And Worst Foods For Histamine Intolerance: https://www.youtube.com/watch?v=hird4u7tHis ➡️ SIBO, Histamine & the Vagus Nerve: https://www.youtube.com/watch?v=V2IeX9qRZzE ➡️ The Top Anti-Inflammatory Foods You Should Eat Every Day: https://www.youtube.com/watch?v=NF5gOX-VsFY   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1   And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇 Read these next 👇 ➡️ Everything You Need To Know About Histamine Intolerance: https://drruscio.com/everything-you-need-to-know-about-histamine-intolerance/ ➡️ Can I Take Quercetin for Histamine Intolerance?:  https://drruscio.com/quercetin-for-histamine-intolerance/ ➡️ GLP-1 Benefits Beyond Weight Loss: IBS, PCOS, and Risks: https://drruscio.com/glp-1-benefits/ ➡️ Understand Diamine Oxidase & Manage Your Histamine in 5 Steps: https://drruscio.com/diamine-oxidase/ 📌 Timestamps  00:00 89% improved with peptides 02:44 Root causes of histamine intolerance 04:51 How peptides  help 07:17 Breakthrough study on peptides & histamine 11:27 Do doctors agree? 14:17  Other supportive data  16:11 Recommended peptide protocol 19:01 Safety & side effects 20:29 Where to source 22:53 Close   🎧 Audio Episode & Featured Studies  📉 Utility of glucagon-like-peptide-1-receptor agonists in mast cell activation syndrome: https://pubmed.ncbi.nlm.nih.gov/40675372/ 📉 Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption: https://pubmed.ncbi.nlm.nih.gov/28042564/ 📉 Improvement of Chronic Spontaneous Urticaria After Glucagon-Like Peptide 1 Receptor Agonist Therapy: Report of Two Cases: https://pubmed.ncbi.nlm.nih.gov/41535531/ 📉 Unintended Benefit of GLP-1 Treatment for Obesity: Resolution of Chronic Systemic Mastocytosis Symptoms: https://bariatrictimes.com/glp1-resolution-chronic-systemic-mastocytosis-symptoms/?utm_ 📉 Pain relief and pain intensity response to GLP-1 receptor agonist ROSE-010 in irritable bowel syndrome: https://pubmed.ncbi.nlm.nih.gov/35234561/ 📉 Glucagonlike Peptide-1 Receptor Agonists and Asthma Risk in Adolescents With Obesity: https://pubmed.ncbi.nlm.nih.gov/41632171/ 📉 Association of glucagon-like peptide-1 agonist use with atopic dermatitis in obese patients: https://pubmed.ncbi.nlm.nih.gov/41033491/ 📉 Effects of six months treatment with liraglutide among patients with psoriasis and obesity, beyond metabolic control?: https://pubmed.ncbi.nlm.nih.gov/40267547/ 📉 International Society for Mast Cell Activation Syndromes:https://ismcas.org/   Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.

Free Candida Guide: https://drruscio.com/guides/get-candida-diet-guide/ Free Home Mold Guide: https://drruscio.com/guides/get-home-mold-guide/   Dr. Ruscio and Dr. Scott discuss a clinical framework for fungus, Candida, and mold as potential drivers of persistent gut, sinus, brain fog, fatigue, and inflammatory symptoms. They cover key diagnostic clues, sinus involvement, blood mold antibodies, sinus CT, limitations of urine mycotoxin testing, and treatment options including diet, probiotics, herbals, biofilm support, sinus therapies, and prescription antifungals.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/   💊 Featured Products Biofilm Disruptor: https://store.drruscio.com/products/biota-dissolve Biota Clear 1a (Oregano Oil): https://store.drruscio.com/products/biota-clear-1a PARI SINUS2: https://www.pari.com/int/products/inhalation-devices/pari-sinus2/ Biofilm Clear-X: https://store.drruscio.com/products/biofilm-clear-x-silver-free-edta-nasal-spray Xlear Nasal Spray: https://store.drruscio.com/products/xlear-nasal-spray   👇 Watch more videos like this 👇  ➡️ Eat These 7 Foods EVERY DAY for SIFO & Candida: https://www.youtube.com/watch?v=KIKgNtxC3Mw ➡️ Get Rid Of Candida & SIFO in 4 Simplified Steps (Works Fast): https://www.youtube.com/watch?v=EenuIwuJ7h0 ➡️ Mold Toxicity Symptoms & Solutions: Expert Guide to Testing and Treatment: https://www.youtube.com/watch?v=qolB9bIH7DQ ➡️ How to Tell If You Have Mold in Your Home (And What To Do Next): https://www.youtube.com/watch?v=utLr0rQghfs   Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1   And if you have any questions or topics you would like covered in the future, let me know in the comments!   👇 Read these next 👇 ➡️ A Practitioner-Approved Candida Cleanse That Works: https://drruscio.com/candida-cleanse/ ➡️ What Is the Strongest Candida Killer? (Evidence-Based Answer): https://drruscio.com/strongest-candida-killer/ ➡️ Black Mold Symptoms: What's Real, What's Not, and What to Do: https://drruscio.com/black-mold-symptoms/ ➡️ Mold Detox Diet: Foods that May Support Recovery: https://drruscio.com/mold-detox-diet/   📌Timestamps 00:00 Fungal treatment problems 03:24 How prevalent is fungus? 05:08 Surprising forms of fungus (mold) 07:49 Why mold & fungus co-occur 09:22 Common mold testing issues   15:50 Mold & fungus symptoms 23:27 Our mold diagnostic framework 27:30 Sinus testing & why it's important 44:54 Best diets 46:24 Natural supplements 47:19 Sinus treatment 01:06:29 Medications 🎧 Audio Episode & Featured Studies  📉 Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/ 📉 Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth: https://pubmed.ncbi.nlm.nih.gov/23574267/ 📉 The diagnosis and incidence of allergic fungal sinusitis: https://pubmed.ncbi.nlm.nih.gov/10488788/ 📉 Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox: https://pubmed.ncbi.nlm.nih.gov/33132781/ 📉 Efficacy of generic forms of itraconazole capsule in treating subjects with chronic pulmonary aspergillosis: https://pubmed.ncbi.nlm.nih.gov/36967117/ Follow Me Facebook - https://www.facebook.com/DrRuscio Instagram - https://www.instagram.com/drruscio/   DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.