Opus 4.5 changed everything (Interview)

Burke Holland works on GitHub Copilot by day and codes with his AI agents always. Early January, Burke posted about how Opus 4.5 changed everything. We were all still buzzing from the holiday-season 2x usage bump Claude gave us, and Opus 4.5 felt like a genuine step function in capability. Burke and I get into all the details. Opus 4.5 may have started the fire, but GPT-5.3 Codex is certainly living up to the hype.

Wes McKinney on the mythical agent-month, install Peon Ping to employ a Peon today, Andreas Kling explains why Ladybird is adopting Rust, Cloudflare has a new MCP server that's quite efficient, and Elliot Bonneville thinks the only moat left is money.

Steve Ruiz joins us for a deep-dive on tldraw (a very good free whiteboard) and the business he's built selling SDKs that help others build very good whiteboards (and more) with tldraw's high-performance web canvas. Along the way, we discuss the excitement/fear we share about keeping our agents busy, how SDK and infra companies are affected differently by agentic software than SaaS companies, how Steve is approaching the coming era of internal tooling, what will happen when we equip LLMs with an infinite canvas, and more.

Peter Steinberger joins OpenAI, ZeroClaw is "claw done right", MimiClaw runs on a $5 chip, Steve Yegge on managing the AI Vampire, and the day the telnet died.

Our ol' friend, Brett Cannon, is back to talk all things Python. But first! Star Wars, Machete Order, Lost, Babylon 5, Game of Thrones, Murderbot, Ted Lasso, Project Hail Mary, David Attenborough, perpetual voice rights, and the AI uncanny valley.

Paul Dix joins us to discuss the InfluxDB co-founder's journey adapting to an agentic world. Paul sent his AI coding agents on various real-world side quests and shares all his findings: what's going to prod, what's not, and why he's (at least for a bit) back to coding by hand. Update: He's back to letting the AIs write code, but with a lot more oversight. For now…

Mitchell Hashimoto's trust management system for open source, Nicholas Carlini has a team of Claudes build a C compiler, Stephan Schwab recounts the history of attempted developer replacement, NanClaw is an alternative to OpenClaw, and Sophie Koonin can't wrap her head around so many people going so hard on LLM-generated code.

Amal Hussein returns to tell us all about her new role at Istari, what life is like outside the web browser, how she's helping ambitious orgs in aerospace, what the SDLC looks like in 2026, and a whole lot more. Wait, moon vacuums?!

In May of 2025, Docker launched Hardened Images, a secure, minimal, production-ready set of images. In December, they made DHI freely available and open source to everyone who builds software. On this episode, we're joined by Tushar Jain, EVP of Engineering at Docker to learn all about it.

Jason Willems believes the tech monoculture is finally breaking, Don Ho shares some bad Notepad++ news, Tailscale's Avery Pennarun pens a great downtime apology, Milan Milanović explains why you can only code 4 hours per day, and Addy Osmani on managing comprehension debt when leaning on AI to code.