486 | Steven Rofrano | From Industrial Food to Whole Ingredients and Better Health

Dr. Jeff Graham talks with Dr. Mattias Bernow, a physician, economist, and CEO of Cellcolabs — about the current state of stem cell therapy. They discuss how mesenchymal stem cells (MSCs) function through signaling rather than cell replacement, where evidence supports their use today, and why good manufacturing practices (GMP) are essential for safety and efficacy. The conversation explores clinical data on cardiovascular, autoimmune, and neurodegenerative diseases, and what large-scale, evidence-based production could mean for the future of regenerative medicine.

Dr. Erin Faules and longevity expert Nathalie Niddam discuss how peptides and bioregulators can help the body maintain equilibrium at the cellular level. They unpack how these small protein molecules influence signaling and gene expression, the difference between supporting adaptation versus overstimulation, and how thoughtful use of these tools fits into a holistic approach to health and aging.

Dr. Jeff Graham sits down with Dr. Damon Forbes to explore the emerging concept of "lean mass hyper-responders"— fit, low-carb individuals who present with unusually high LDL levels. They unpack the physiology behind this pattern, discuss how it differs from familial hypercholesterolemia, and review new data on cardiovascular risk. The conversation offers a nuanced look at how metabolism, diet, and lipid transport intersect in precision medicine.

In this episode, Dr. Erin Faules speaks with Joel Greene, author of The Immunity Code, about the importance of balance and adaptability in human health. They discuss how real-world factors—time, context, and individual biology—shape sustainable nutrition and fitness strategies. From cycling foods and supplements to aligning with circadian and weekly rhythms, Greene explains how physiological balance supports metabolic health, microbiome diversity, and longevity.

Dr. Tommy Wood, physician-scientist and professor of pediatrics and neuroscience at the University of Washington, shares how the brain develops, adapts, and recovers from injury across the lifespan. He explains how genetics, exercise, nutrition, sleep, and other daily habits shape cognitive performance and resilience. Drawing on research and clinical insights, Dr. Wood highlights practical, evidence-based strategies to support brain health at every stage of life.

This episode features health coach and nurse Michele Miller in conversation with Dr. Erin. They discuss why eating less isn't always the path to better health, how metabolism adapts to prolonged calorie restriction, and the concept of "reverse dieting"—gradually increasing food intake to support energy, hormone balance, and body composition. The conversation emphasizes practical strategies, like eating breakfast and fueling around exercise, while addressing common fears about eating more.

Can your grip lower your blood pressure? In this episode, Dr. Erin Faules talks with Mark Young, CEO of Zona Health, about how isometric training can support cardiovascular health and help manage blood pressure without medication. We also cover early detection, self-monitoring, and nervous system regulation in protecting healthspan and preventing chronic disease. Topics covered: The Air Force origins of isometric training research How isometric exercise improves vascular health and lowers blood pressure Using data and self-tracking for early detection of dementia and heart disease The role of inflammation and nervous system balance in longevity

In this conversation, Dr. Erin Faules and Dr. Jeff Graham discuss the shift from traditional medical care toward a precision medicine model that integrates genomics, biomarkers, and lifestyle interventions. They share patient stories that illustrate how personalized care can uncover hidden risks, such as cardiovascular disease, while also supporting sustainable behavior change. The discussion emphasizes prevention, accountability, and evidence-based strategies for improving healthspan.

Steven Rofrano discusses how everyday food choices influence health and well-being. Drawing on his background in functional medicine and passion for regenerative health, he explores the importance of ingredient quality, accessibility, and taste in shaping healthier habits. Key topics covered: Shifting from industrial food norms toward nutrient-rich, traditionally prepared foods Why eliminating seed oils and using whole, heritage ingredients matters Making healthier foods the default option in society Balancing flavor with nutrition to create sustainable dietary change Considering regulation, sourcing, and the role of GMOs in modern agriculture

This episode with health coach Ray Fernandez explores how popular wearables like the Oura Ring, WHOOP, Morpheus, and continuous glucose monitors can inform daily decisions about training, sleep, and stress. Rather than chasing single numbers, Ray emphasizes looking at trends over time to understand recovery, cardiovascular fitness, and metabolic health. The discussion highlights how, when used thoughtfully, wearables can support lifestyle changes without becoming a source of added stress