358: Gut Microbes and ALS

TWiM explains how movement of DNA among gut bacteria drive large-scale genome mosaicism, and validation of a method for detection of Cyclospora cayetanensis in outbreak-linked fresh produce. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Become a patron of TWiM.   Links for this episode:   Natural DNA transformation in the gut (ISME J) The transformation factor (J Exp Med) Validating cyclospora assay (J Food Prot) Cyclosporiasis (CDC)   Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to [email protected]

TWiM explains the discovery of an avirulent bacterial signature associated with the development of recurrence following colorectal cancer surgery, and phage-derived proteins and conjugates that induce pilus detachment. Hosts:  Vincent Racaniello, Michael Schmidt, and Petra Levin Become a patron of TWiM. Links for this episode: Bacterial signature is associated with colon cancer recurrence (Nat Comm) Phage-derived proteins induce pilus detachment (J Bact) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to [email protected] Take the TWiM Survey

TWiM explains major implications of the link between plastic pollution and antimicrobial resistance, and the discovery of a new organelle, the nitrogen-fixing nitroplast. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Plastic pollution and antimicrobial resistance (Appl Envir Micro) The great Pacific garbage patch (YouTube) Rumen microbiome (Nat Biotech) Nitrogen-fixing organelle in marine alga (Science) This cell just changed biology (YouTube) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM explains how cannibalism shapes biofilm structure and composition in Bacillus subtilis, and the importance of manganese uptake in uropathogenic E. coli during urinary tract infection. Become a patron of TWiM. Links for this episode: Cannibalism shapes biofilm structure (mBio) Manganese and uropathogenic E. coli (mBio) Regulation of Bacterial MntH Genes (NLM Bookshelf) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to [email protected]

TWiM explains the connection between inflammation caused by microbial glycogen in the gut and amyotrophic lateral sclerosis, and how disruption of cysteine metabolism leads to synthetic lethality and in vivo fitness impairment in Acinetobacter baumannii. Become a patron of TWiM. Links for this episode: Myeloid cell gene prevents inflammatory response to microbial glycogen (Cell Rep) Cysteine metabolism and fitness impairment in Acinetobacter baumannii (mBio) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to [email protected]

TWiM visits Tufts University School of Medcine and are joined by John Coffin, Michael Malamy, and Verna Manni for a tribute to Elio Schaechter who was chair of Molecular Biology and Microbiology for 23 years. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Petra Levin Guests: John Coffin, Michael Malamy, and Verna Manni Subscribe to TWiM (free) on Apple Podcasts, Stitcher, RSS, or by email. Become a Patron of TWiM! Music used on TWiM is by Ronald Jenkees. Send your microbiology questions and comments to [email protected]

TWiM explains how Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae facilitating transformation, and microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on Apple Podcasts, Stitcher, RSS, or by email. Links for this episode Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae (mBio) Microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing (J Inf Dis) Diabetic foot ulcer review (World J Clin Cases) How nanopore sequencing works (YouTube) Become a Patron of TWiM! Music used on TWiM is by Ronald Jenkees. Send your microbiology questions and comments to [email protected]

TWiM explains how an enhanced domestication method allows for growth of uncultured bacteria, and identification of the oncogene SLC35F2 as is a high-specificity transporter for the micronutrients queuine and queuosine. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Guest: Mark O. Martin Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Domestication method for uncultured bacteria (ISME Comm) Transporter for the micronutrients queuine and queuosine (PNAS) How diet and microbiome can impact your health (UF blog) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM explains a candidate signature of health in the gut microbial community, and how an intestinal bacterium exacerbates cardiac ischemia/reperfusion injury. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Petra Levin. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode A candidate signature of health in the gut microbiome (Cell Host Microbe) 204,938 reference genomes from the human gut microbiome (Nat Biotech) A human gut metagenome-assembled genome catalogue spanning 41 countries (Nat Micro) A comprehensive ruminant microbial catalog (Gigascience) Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury (Cell Host Microbe) The Great Ozempic Experiment (NY Times, paywall) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM explains how to use microbes to enhance maize yield and reduce corn rootworm damage, and how the human microbiota modulates IgE-mediated reactions to foods through allergen metabolism. Hosts: Michael Schmidt, Petra Levin, and Michele Swanson. Guest: Mark O. Martin Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Harnessing Microbes for Crop Production (Phytobiome J) Microbes take on corn rootworm (Science) Microbial metabolism of food allergens (Cell Host Microbe) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to [email protected]