Episode 5 I Balancing Complexity and Efficiency: The Next Generation of Clinical Trials

What if the data generated through everyday healthcare could help unlock the next generation of discovery? In this episode of The Nucleus, a Regeneron podcast, Will Salerno, PhD, Executive Director of Genome Informatics & Data Engineering at Regeneron Genetics Center (RGC), sits down with Jeff Brown, PhD, Chief Scientific Officer at TriNetX, to explore how real-world, de-identified data and genomics can come together to unlock knowledge of human health and disease.  From building large, representative datasets to connecting genomic information with electronic health records and other clinical data, they discuss the opportunities and challenges of bringing these sources together, including how crucial responsible use of data is, especially when it comes to AI, privacy and governance. 

Host Dr. Seblewongel Asrat, PhD, Director of Immunology & Inflammation at Regeneron, speaks with Dr. Brian Kim, MD, FAAD, Vice Chair of Research in Dermatology at Mount Sinai, about the biology of itch and its connection to type 2 inflammation. Together, they explore how chronic itch is driven by distinct biological pathways, why it has long been overlooked, and how new scientific insights are reshaping how we understand its impact on patients’ lives.  

We’ll dive into the future of clinical trials, including your work with sponsors to understand the challenges and how toovercome them — from what’s changing, what still needs to change and how we can leverage technology to make them more efficient. 

In this collaborative episode of The Nucleus, Dr. John Overton, Vice President and Chief Sequencing Officer at our Regeneron Genetics Center (RGC), joins STAT Brand Studio’s Jesse McQuarters to explore how integrating proteomics and multi-omics can deliver deeper insight into how diseases develop, and how science can better predict and prevent them. 

What if CRISPR could do more than cut DNA? In this episode of The Nucleus, a Regeneron podcast, Leah Sabin, PhD, Executive Director, Regeneron Genetic Medicines, sits down with Janice Chen, PhD, Co-founder and CTO of Mammoth Biosciences to dive into the scientific collaboration to potentially change the future of genetic medicine.

What happens when large-scale, cutting-edge genetic research meets broad population representation? In this episode of The Nucleus, a Regeneron podcast, listen to Eric Jorgenson, PhD, Senior Director, Statistical Genetics, Regeneron Genetics Center (RGC) and Marylyn Ritchie, PhD, Vice Dean of AI and Computing at the Perelman School of Medicine, University of Pennsylvania, explore how these two forces are revolutionizing precision medicine.

In our debut episode of The Nucleus, a Regeneron podcast, our first host Jeffrey Reid, PhD, VP, Chief Data Officer, Regeneron Genetics Center (RGC) and Daphne Koller, PhD, Founder and CEO, insitro examine how AI and ML are already being applied to tackle some of the most pressing challenges in science to transform the industry for years to come.