Relentless Health Value podcast

Cash Pay From the Pharma Manufacturer Point of View, With Ophelia Johnson

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Only about half of new GLP-1 prescriptions got approved for coverage in 2023 — a gap Ophelia Johnson says is why pharma manufacturers started building cash-pay and direct-to-employer channels instead of waiting on PBMs. Johnson, who built new channels for the manufacturer behind the GLP-1 boom and now runs e-fi.works, walks Stacey Richter through how the money moves with GoodRx and telehealth, including the buydown math behind a $500 list-price drug becoming a $100 cash price.

This is Episode 516 (EP516) of Relentless Health Value.

WHAT YOU'LL LEARN

✅ Why IRA maximum fair price pressure, PBM reform lawsuits, and roughly 50% of new GLP-1 prescriptions going unapproved for coverage in 2023 pushed manufacturers to build cash-pay channels

✅ The buydown math behind cash pay: a manufacturer pays savings-coupon providers like GoodRx a flat fee instead of a PBM rebate to bring a $500 list-price drug down to a $100 cash price

✅ How telehealth and white-label or manufacturer-owned pharmacies add a second cash-pay channel, with new shipping and supply-chain costs once the PBM is cut out

✅ Why "direct-to-employer" GLP-1 deals are a misnomer — PBM exclusivity clauses bar manufacturers from selling straight to employers, routing them through third-party transparent administrators

✅ Ophelia Johnson's advice to plan sponsors: shift formulary conversations from rebate yields toward auditable medication abandonment rates and total cost of care

WHY THIS MATTERS

Stacey Richter's follow-the-dollar lens usually points at employers and patients as the ultimate purchasers — but the incentives driving pharma manufacturers matter just as much for collaboration to work. Legislative pressure on rebates, PBM reform litigation, and a GLP-1 boom that left half of new prescriptions unfilled in 2023 are pushing manufacturers toward cash-pay and direct-to-employer models that bypass PBM rebates entirely. That changes formulary math for plan sponsors and raises the stakes on gross-to-net accuracy for manufacturers. As Richter puts it, fair profit versus profiteering comes down to making more money when a patient does worse.

MENTIONED IN THIS EPISODE

Post by David Alderman

Post by Ann Lewandowski

Post by Madelaine Feldman, MD

Post by Bryce Platt, PharmD

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00:00 Introduction to this episode.

08:07 The conversation with Ophelia Johnson.

08:14 What is cash pay?

08:59 Why is this a thing and how did we get here?

12:28 The different ways that a patient could go about receiving and paying for their drug.

13:22 What's going on behind the scenes between GoodRx and the pharma manufacturer.

17:02 What dispense fees are and how they work.

17:41 A sidenote about next week's episode.

20:03 A sidenote about the pharma manufacturer POV.

21:44 The pharma supply chain in telehealth.

25:27 Why claims validation has never been more important.

28:19 Where do employers fit in all of this?

32:45 Where does it make sense to consider these alternative business models in lieu of the risks?

35:04 Why mapping the incentives is important.

38:42 Ophelia's advice to pharma manufacturers.

40:41 Ophelia's advice to plan sponsors.

42:46 More of Ophelia's advice to payers.

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