Genetics and Supplement Forms: When Activated Nutrients Actually Matter

Activated forms. Methylated forms. Chelated minerals. The supplement world often implies that newer or “activated” means better, but does it?In this episode, Dr. Ritamarie continues the supplementation conversation, this time through the lens of genetics, enzyme efficiency, and precision forms. She breaks down when activated nutrients truly matter, when they don’t, and why choosing the wrong form can stall progress just as much as choosing the wrong supplement.You’ll also learn how excipients, binders, and delivery systems can influence tolerance and outcomes, especially in sensitive people.If you’ve ever wondered whether you’re using the right form or just following a trend, this episode will help you think more precisely and prescribe more effectively.What’s Inside This Episode?• Activated forms: when they matter and when they don’t• Genetic variants: how they affect enzyme efficiency (not just deficiency)• Bottlenecks: why the limiting step, not the nutrient, guides decisions• Functional deficiency: when labs look normal but pathways aren’t• Absorption vs activation: why form doesn’t fix every problem• Excipients: what’s really in the capsule and when it matters• Delivery systems: powders, capsules, liquids, and what to consider• Overcorrection: how “more” and “activated” can create new imbalancesResources and Links:Download the full transcript hereDownload our FREE Smart Supplementation MatrixJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results.Check out our other podcast episodes here

You run the labs and a nutrient comes back low. What’s your first move?For many practitioners, the reflex is simple: replace it. But we’re living in the most over-supplemented era in history. People are taking magnesium for sleep, B12 for energy, iron for fatigue, adaptogens for stress, creatine for cognition without asking the most important question.Why is it low in the first place?That question is the difference between protocol prescribing and real clinical thinking. A deficiency isn’t a diagnosis but a clue. Until we understand the mechanism behind that clue, we’re reacting and not practicing true healthcare.What’s Inside This Episode?• Low nutrients: why they’re a clue, not a diagnosis• Six hidden drivers: the real causes of many deficiencies• Absorption problems: why adding more often fails• Activation issues: when nutrients can’t convert to active forms• Cellular transport: the overlooked signaling problem• Increased demand: how stress, toxins, and inflammation drain nutrients• Functional deficiency: when labs look normal but cells aren’t• Supplement decisions: when they help and when they miss the root causeResources and Links:Download the full transcript hereDownload our FREE Smart Supplementation MatrixJoin the Next-Level Health Practitioner Facebook group here for free resources and community support.Visit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing resultsCheck out other podcast episodes here

What if the biggest lever for metabolic health is not another protocol, supplement, or perfect diet? What if it’s the environment people live in, and the relationships that shape daily choices?In this conversation, Dr. Ritamarie speaks with Dan Buettner Jr. of Blue Zones about what the world’s longest-lived populations can teach us, and how entire U.S. cities are applying those lessons through practical changes in people, places, and policy. You’ll hear why individual discipline often fails, how small changes create massive health shifts over time, and what this means for practitioners who want results that actually stick.What’s Inside This Episode?Why willpower breaks down, even when motivation is highWhat the longest-living populations did instead of chasing healthHow small environmental shifts outperform big personal effortsThe longevity levers most health conversations sidestep, but communities can’tWhat changes when health becomes a shared identity rather than a personal projectA simple way to redesign your own environment so better choices happen automaticallyWhat modern culture is erasing from traditional longevity regions, and what still mattersHow practitioners can move beyond protocols and participate in population-level changeResources and Links:Download the full transcript here.Download our FREE Metabolic Health Guide here. Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes hereGuest Resources and LinksBlue Zones website: BlueZones.comBlue Zones ChallengeBlue Zones Project communities: BlueZones.comBlue Zones® Certification Course (with ACLM): LifestyleMedicine.org Guest BioDan Buettner Jr. is a driving force behind Blue Zones LLC and its success in deploying a well-being strategy across the US, leading transformative community health initiatives across America. With a focus on applying evidence-based longevity principles from global Blue Zones, he has spearheaded projects impacting over 10 million people in 80+ U.S. communities, achieving measurable reductions in obesity, smoking, and healthcare costs while boosting well-being and economic vitality through innovative partnerships and scalable models.

Creatine is one of the most researched supplements in the world, yet it’s still surrounded by confusion, especially when it comes to kidney health and lab interpretation.In this episode of ReInvent Healthcare, Dr. Ritamarie looks at creatine through a clinical lens. She explains why creatinine levels often rise when someone takes creatine, why that change is frequently misinterpreted as kidney damage, and what labs actually tell us about kidney function.This conversation also opens a bigger question about supplements: how practitioners can develop real discernment. She is separating myths, marketing, and fear from meaningful science and clinical context.What’s Inside This Episode? Why creatinine often rises with creatine and why it doesn’t necessarily mean kidney damage The difference between creatinine production and kidney filtration Why lab markers can be misinterpreted when supplements are involved How creatine supports cellular energy and metabolic health The bigger clinical question: how practitioners develop discernment around supplements When creatine may be helpful and when it deserves a closer lookResources and Links:Download the full transcript hereDownload our FREE Guide to Customize your Food Plan for Health and LongevityJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes here

Why do some people experience sound, light, stress, and even social interactions so differently?In this episode of ReInvent Healthcare, Dr. Ritamarie sits down with functional practitioner Dr. Sam Shay to explore what he calls the “neuro-spicy brain.” They unpack how genetics, sensory processing, and nervous system signaling shape the way neurodivergent individuals experience the world.You’ll hear why many neurodivergent people are misunderstood in clinical settings, how sensory overload can drive chronic stress and health challenges, and what practitioners can do differently to create safer, more effective care.This conversation offers a fresh lens on neurodiversity, communication, and the biology behind why some brains respond to the world in profoundly different ways.What’s Inside This Episode?The question most practitioners never ask when someone feels constantly overwhelmed by everyday stimuliWhy some brains experience sound, light, stress, and social environments so intenselyWhat “neuro-spicy” really means and how genetics shape sensory processingWhy neurodiverse people are frequently misunderstood in healthcareThe clues that a patient or client may be experiencing sensory overloadHow practitioners can shift communication and care to better support neurodivergent patientsResources and Links:Download the transcript hereDownload our FREE Metabolic Health Guide here. Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes hereGuest Resources and LinksGuest Resources and LinksVisit Dr. Sam Shay’s websites here: www.FitgenesUSA.com and www.DrSamShay.comConnect with Dr. Sam on social media:Facebook InstagramYouTubeAccess Dr. Sam’s gift and practitioner genetics resources hereGuest BioDr. Sam Shay, DC, IFMCP is a functional medicine expert, speaker, and stand-up comic who helps practitioners unlock their client's ideal diet, reduce inflammation, and reclaim energy through simple genetic testing.Dr. Sam Shay started www.FitgenesUSA.com to help licensed practitioners and certified health professionals integrate powerful functional genetics to improve their practice outcomes.Dr. Sam’s mission is to make personalized genetic testing easy, effective, and actionable. He’s known for making cutting-edge science relatable and actionable, giving practitioners and their clients the tools to turn DNA into a blueprint for better health.Whether supporting exhausted parents, health-conscious professionals, or individuals seeking sustainable transformation, Dr. Sam makes cutting-edge science feel human, hopeful, and empowering. Featured on over 200 podcasts and summits, he delivers each conversation with insight, warmth, and a dose of sharp humor—helping audiences turn their genetic blueprint into a roadmap for thriving.

If you’ve practiced long enough, you’ve seen this pattern. Two clients present with nearly identical labs. You design the same protocol expecting similar progress, and the outcomes couldn’t be more different. One improves quickly. The other barely moves.In this episode, Dr. Ritamarie dives into metabolic readiness, why some protocols work beautifully for some clients and don’t move the needle for others. She explains how metabolic chaos (not dysfunction), and the body's readiness to respond to interventions, are the real game-changers.This episode is a must-listen if you’ve ever been puzzled by why the "right" protocol fails despite clear lab data. Discover how shifting from reactive to readiness-based thinking can transform your clinical outcomes.What’s Inside This Episode? Why sequencing plans is more important than just following lab dataThe critical gap between identifying dysfunction and understanding readinessHow metabolic chaos creates resistance, while readiness fosters responseWhy the same protocol can have opposite effects depending on the body’s stress, inflammation, and signaling statusThe order that must come before progress happensHow metabolic readiness shifts clinical thinking from chasing markers to stabilizing systemsResources and Links:Download the full transcript hereDownload our FREE Metabolic Health Guide here. Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes here

You’ve run the labs, designed the perfect plan, and your client is following it… but progress stalls. Why is that happening?In today’s episode, we dive into why even the most well-designed functional protocols can fall short. It's not that your plan was wrong. It’s about sequencing. The body doesn't respond to everything at once, and when we miss the critical regulatory hierarchy, even the best plans can stall.We’ll unpack the gap between lab data and clinical outcomes, and why understanding readiness and context is the missing link for sustainable transformation.If you've ever had a case where the labs looked fine, the protocol seemed right, but the results didn’t follow through, this episode will change how you approach your work.What’s Inside This Episode?Why lab data alone won’t tell you what the body is truly ready to healThe hidden cause of stalled protocolsHow understanding the body’s regulatory hierarchy can unlock treatment successWhy addressing multiple dysfunctions at once often derails progressThe game-changer: why context and readiness are key to true healingThe critical next step: how to know when the body is actually ready to respondResources and Links: Download the full transcript here.Download our FREE Metabolic Health Guide here. Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes here

Despite the rising popularity of high-protein, low-carb diets and macro tracking, metabolic disease is still on the rise. So why isn’t the perfect macro balance solving the problem? In today’s episode, Dr. Ritamarie explores why focusing solely on macronutrients isn’t enough to restore metabolic health. While macros are important, they’re only one piece of the puzzle. The real key lies in understanding how the body responds to those inputs and why your clients might still struggle even when they’re following the "perfect" protocol.What’s Inside This Episode? Why just tweaking macros doesn’t address the deeper metabolic issuesThe hidden truth: metabolic health is driven by how the body responds, not just what you eatWhy insulin resistance, thyroid issues, and weight struggles persist even with the "right" macrosHow chronic stress, inflammation, and nervous system imbalances shift how the body handles foodThe vital shift from focusing on numbers to understanding the body’s signalsWhy looking at metabolic health through a systems lens changes everything in practiceThe real question practitioners should be asking to restore metabolic healthResources and Links:Download the full transcript here.Download our FREE Metabolic Health Guide here. Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes here

A sudden loss can shake even the most grounded among us.In this deeply personal solocast, Dr. Ritamarie reflects on the unexpected death of a colleague in the natural health community and the vulnerability it surfaced. When someone who appears healthy dies suddenly, it forces a difficult but necessary question: what silent risks might be accumulating beneath the surface?This episode explores the quiet progression of cardiovascular disease, the limitations of standard lab panels, and why doing everything “right” is not the same as measuring what matters. Dr. Ritamarie shares her own experience with elevated lipoprotein(a), what she did in response, and why awareness is not fear, it is responsibility.If you are a practitioner, this conversation is a reminder to screen earlier and look deeper. If you are on your own health journey, it is an invitation to measure what matters before symptoms ever appear.What’s Inside This Episode?Why sudden death in “healthy” people feels different and what it revealsThe silent progression of cardiovascular disease over decadesWhy standard cholesterol panels miss critical risk markersWhat lipoprotein(a) is and why most doctors never test for itHow inflammation, insulin resistance, and endothelial dysfunction quietly accumulateDr. Ritamarie’s personal experience lowering elevated Lp(a)Why genetics influence risk but do not dictate destinyThe difference between helplessness and awarenessWhat practitioners should be screening for now, not laterA powerful question to ask yourself about hidden riskResources and Links:Download the transcript hereDownload our FREE Cardiovascular Risk Assessment GuideJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results.Check out other podcast episodes here

Trauma isn't just something that lives in our minds. It has a profound impact on our biology. In this episode, Dr. Ritamarie sits down with Dr. Aimie Apigian, a double board-certified physician and expert in trauma biology, to explore the hidden impact of trauma on metabolism, immunity, and the nervous system. Dr. Apigian explains how unresolved trauma can trigger physical symptoms, including chronic illness.You’ll discover the biological processes that make trauma a root cause of illness, why the body keeps the score, and how trauma creates a feedback loop that keeps people stuck in their symptoms. Dr. Apigian shares actionable strategies for practitioners and self-healers to help break the trauma cycle, understand the body’s response, and guide their clients toward healing.What’s Inside This Episode?How unresolved trauma rewires your metabolism, immunity, and nervous systemThe "Body Trauma Loop": Why trauma keeps you in fight or flightHow childhood trauma shapes adult health, metabolism, and immunityThe 3-phase healing process: From safety to expansionWhy “little T” trauma can be just as damaging as “big T” traumaHow to recognize when trauma is the root cause of chronic symptomsResources and Links:Download the full transcript hereDownload our FREE Guide to Fasting for Health and LongevityJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced practitioner training and tools to elevate your clinical skillsCheck out other podcast episodes hereGuest Resources and Links:Dr. Aimie Apigian’s Website: biologyoftrauma.comDr. Aimie Apigian’s Book - The Biology of Trauma: Get the book hereDr. Aimie Apigian’s Podcast: Biology of Trauma PodcastFree Gift: Nervous System Reset - Five Somatic PracticesConnect with Dr. Aimie on Social Media:Instagram: @dr.aimieLinkedIn: Dr. Aimie ApigianYouTube: Dr. Aimie ApigianGuest BioDr. Aimie Apigian, double board-certified physician (Preventive/Addiction Medicine) with master's degrees in biochemistry and public health, revolutionizes trauma healing by revealing how our cells—not just our minds—store trauma. Her book "The Biology of Trauma" (foreword by Gabor Maté) transforms our understanding of how the body experiences and holds trauma. After adopting a child during medical school sparked her journey, she developed an integrative science-based sequence for the healing journey. Through her practitioner training, podcast, YouTube channel, and international speaking, she bridges functional medicine, attachment and trauma therapy, proving that repairing trauma's impact on the mind, body, and biology is possible.