Tonix Pharmaceuticals and Makana partner to advance research with Anti-Rejection therapy

EnWave Corporation CEO Brent Charleton joined Steve Darling from Proactive to announce the company has received a second progress payment from Procescir, a vertically integrated Mexican agriculture firm, for the purchase of a 120kW Radiant Energy Vacuum (REV™) machine. The machine will be used for commercial production of fruit and vegetable products in Mexico. Charleton revealed that Procescir plans to produce both private-label and branded snacks, as well as provide toll drying services to established and emerging brands. A significant boost to EnWave’s royalty stream is expected, as Procescir has signed a two-year toll drying agreement with a leading American healthy snack company, which will likely utilize the majority of the 120kW unit’s capacity. To stay ahead of demand, EnWave began manufacturing the 120kW REV™ machine in late 2024, ensuring timely delivery to Procescir by July 2025. In addition, EnWave will immediately begin building another large-scale REV™ system to meet anticipated future orders from its growing sales pipeline. #proactiveinvestors #enwavecorporation #tsxv #enw #DehydrationTech #VacuumMicrowave #RoyaltyBusinessModel #BluechipClients #FoodTech #BusinessNews #Investing #RadiantEnergyVacuum #Agritech #Procescir #DehydrationTechnology #FoodInnovation #SupplyAgreement #InvestmentNews #ProactiveInvestors

Tonix Pharmaceuticals Holdings has announced a groundbreaking collaborative research agreement with Makana Therapeutics, aiming to explore the potential of TNX-1500, Tonix’s anti-CD40L monoclonal antibody candidate, in advancing the field of xenotransplantation—the transplantation of animal-derived organs into human patients. In an interview with Steve Darling from Proactive, Tonix CEO Dr. Seth Lederman shared details of the preclinical partnership, which will evaluate TNX-1500 in combination with Makana’s proprietary human-compatible organs and cells, derived from genetically engineered pigs. The collaboration will initially focus on kidney, heart, and islet cell transplant models, with the broader objective of developing new treatment options for patients suffering from organ failure. The preclinical studies are designed to generate data to support a future Investigational New Drug (IND) application to the U.S. Food and Drug Administration, with the goal of enabling compassionate use of xenotransplantation therapies in patients who have no alternative treatment options. Makana’s approach centers around genetically engineered pigs that have been modified to lack swine leukocyte antigen (SLA), a key driver of immune rejection. These animals demonstrate enhanced compatibility with human biology and offer several potential advantages over competing technologies, including high fertility rates, increased litter sizes, and robust health profiles—key factors that support scalability and commercial viability in global markets. TNX-1500 is a next-generation anti-CD40L monoclonal antibody designed to modulate immune response while minimizing the risk of thrombosis—a common side effect associated with earlier anti-CD40L agents. The drug candidate holds promise in preventing organ transplant rejection, making it an ideal component of xenotransplantation protocols. #proactiveinvestors #tonixpharmaceuticalsholdingcorp #nasdaq #tnxp #Biotech #MPOXVaccine #Smallpox #TNX801 #VaccineDevelopment #ClinicalTrials #PharmaceuticalNews #MedicalResearch #WHO #GlobalHealth #InfectiousDiseases #Biopharma #ProactiveInvestors

KEFI Gold and Copper PLC (AIM:KEFI, OTC:KFFLF) executive chairman Harry Anagnostaras-Adams talked with Proactive's Stephen Gunnion about significant developments regarding the company's Tulu Kapi gold project in Ethiopia. Anagnostaras-Adams confirmed the addition of BCM Group as both a syndicate member and the preferred mining contractor for the project. He explained, "BCM was part of the spearhead to make West African mining happen," highlighting the company’s strong background in mining across Africa. He noted that BCM’s commitment includes a contribution of US$23 million in pre-production costs, meaning KEFI's project development budget is now fully covered. He emphasised, "In essence, we're done," although some final procedural steps remain, such as certifying resettlement costs and finalising formal documentation. Anagnostaras-Adams also addressed KEFI’s strategic stance on its Saudi Arabian interests. With financial pressures alleviated by progress at Tulu Kapi, KEFI is no longer compelled to sell its Saudi assets and will focus on optimising its position in that market. Overall, the conversation highlighted that KEFI is transitioning from solving challenges to executing plans at Tulu Kapi, marking a critical inflection point for the company. Visit Proactive’s YouTube channel for more interviews and updates. Don’t forget to like the video, subscribe to the channel, and enable notifications to stay updated on future content. #KEFIGoldAndCopper #TuluKapi #GoldMining #MiningInvestment #EthiopiaMining #BCMGroup #MiningProjects #ResourceDevelopment #GoldExploration #ProactiveInvestors

Harena Resources (LSE:HREE) managing director Joe Belladonna talked with Proactive's Stephen Gunnion about the company's Ampasindava Project in Madagascar, a significant ionic clay rare earths resource positioned to meet growing global demand. Harena is advancing a large-scale JORC-compliant project with a focus on magnet metals, including neodymium, praseodymium, dysprosium, and terbium. Belladonna highlighted the project's strategic location, stating, "Madagascar is right on the doorstep of Europe. We can go across to Australia or Asia, or through the canals to the US." The company aims to produce a high-quality carbonate product from Ampasindava, serving markets worldwide. Belladonna noted that Ampasindava stands out due to its independence from China and the US, ensuring flexibility in supplying critical rare earth elements. In discussing market dynamics, Belladonna emphasised the impact of Chinese export restrictions, spotlighting a heightened need for secure supplies of magnet metals essential for applications such as AI-enabled robotics and defence technologies. Harena Resources recently reported that the Ampasindava deposit offers a mine life exceeding 100 years, with simple processing methods leading to high recoveries of rare earths. The company is progressing a pre-feasibility study to transition its current exploration license to a mining licence. Visit Proactive's YouTube channel for more videos. Don't forget to like the video, subscribe to the channel, and enable notifications for future updates! #RareEarths #Mining #AmpasindavaProject #HarenaResources #MagnetMetals #RareEarthSupply #CriticalMinerals #MadagascarMining #ElectricVehicles #CleanEnergy

Rome Resources Plc (AIM:RMR) CEO Paul Barrett talked with Proactive's Stephen Gunnion about the company's latest operational update from its Bisie North project. Barrett highlighted that preparations are underway to mobilise and restart drilling operations, with helicopters now en route to DRC from Entebbe, Uganda. The drilling campaign will focus on deeper and offset drill holes at Mont Agoma, with no further drilling needed at Kalayi following previous results. Barrett confirmed that core samples from holes 24 and 26 have been sent to Johannesburg for assay results, which are expected next week. "We have our program set out for what we're going to do going forward," he stated. Barrett also discussed the improving security situation in the region, noting that M23 forces have withdrawn from Walikale, enhancing operational safety. Furthermore, peace talks between Rwanda and the DRC are progressing, with a ceasefire and peace plan anticipated soon. The short drilling program is expected to conclude by the end of June, with resource work continuing in parallel. Rome Resources plans to provide further updates including drill results and project diagrams to stakeholders. For more videos like this, visit Proactive's YouTube channel. Don't forget to like this video, subscribe to the channel, and enable notifications for future content. #RomeResources #BisieNorth #TinExploration #MiningUpdate #DRCMining #ResourceDevelopment #DrillingOperations #MiningNews #InvestingInMining #ProactiveInvestors

Empire Metals Ltd (AIM:EEE, OTCQB:EPMLF) managing director Shaun Bunn talked with Proactive's Stephen Gunnion about the latest Air Core drilling results at the company’s Pitfield project in Western Australia. Bunn described the results as "very encouraging", highlighting the advantages of using air core drilling for speed and cost efficiency compared to previous methods. Empire Metals Ltd successfully drilled on a 100 x 100 metre grid across targeted high-grade zones at Pitfield, an ore body that extends over 40km. Bunn noted that the drilling confirmed widespread, continuous mineralisation, with some grades reaching up to 18% titanium dioxide. Bunn also revealed that over 70 tonnes of metallurgical samples were collected, allowing the company to upscale its test work. "Every one of those holes is in mineralisation. The continuity of the ore body is absolutely amazing," Bunn stated. The company plans to continue drilling to expand the high-grade zones and is moving towards a maiden mineral resource estimate (MRE) in the coming months. For more exclusive interviews and updates, visit Proactive’s YouTube channel. Don’t forget to give this video a like, subscribe to our channel, and enable notifications so you never miss future content. #EmpireMetals #Titanium #PitfieldProject #MiningUpdate #ShaunBunn #ResourceDrilling #AirCoreDrilling #Metallurgy #InvestingInMining #ProactiveInvestors

Atlantic Lithium Ltd (AIM:ALL, OTCQX:ALLIF, ASX:A11) CEO Keith Muller talked with Proactive's Stephen Gunnion about the company's engagement with the Ghanaian government regarding the mining lease for the Ewoyaa Lithium Project. Muller explained that Ewoyaa is one of the very few hard rock spodumene projects globally that is "essentially shovel-ready," emphasising that the mining lease ratification is the final step before securing financing and offtake arrangements. He outlined how the lease was initially signed under different market conditions in October 2023, with spodumene prices then falling from highs above $6,000 per tonne to around $800 per tonne currently. Muller stated, "We must recognise that there is a significant change in what has been to what is today," highlighting the proactive engagement with the government to secure a mutually beneficial outcome amid a challenging commodity market. Muller stressed the importance of the Ewoyaa project's low operating costs in ensuring resilience, even at suppressed pricing levels. He noted that Ewoyaa could bring over 900 direct and up to 2,500 indirect jobs to Ghana's Central Region, making it a catalyst for regional economic development. In closing, Muller reassured investors of the project's sustainability, saying, "There’s no doubt in my mind that this mine will be built." Visit Proactive's YouTube channel for more interviews like this one. Don't forget to like this video, subscribe to the channel, and turn on notifications so you never miss an update! #AtlanticLithium #EwoyaaProject #LithiumMining #Spodumene #GhanaMining #MiningInvestment #BatteryMetals #LithiumMarket #ResourceDevelopment #MiningNews

Arizona Gold and Silver CEO Mike Stark joined Steve Darling from Proactive to announce the company has acquired approximately 300 acres of strategic land to support future development of the Philadelphia Project in northwestern Arizona. The land, acquired through claim staking, has no underlying financial obligations aside from standard annual claim maintenance fees to the U.S. government. Stark explained the newly acquired PAD claims are situated less than 1.5 kilometers southwest of the mineralized zone, accessible by existing gravel roads from both Arizona Highway 68 and the Philadelphia project site. The area’s terrain—composed primarily of unconsolidated alluvial gravels—is ideal for cost-effective construction of leach pads, tailings storage, or plant infrastructure for future mining operations. Importantly, the site offers ample capacity to accommodate tens of millions of tonnes of processed material and associated facilities, providing long-term operational flexibility as exploration progresses. In addition, Arizona Gold and Silver has strengthened its treasury to over $3.24 million following the recent exercise of warrants and options, primarily by company insiders. This robust financial position will support the ongoing drilling program and sustain exploration efforts well beyond year-end. #proactiveinvestors #arizonagoldandsilverinc #tsxv #azs #otcqb #azasf #GoldExploration #MiningNews #GoldInvesting #PreciousMetals #BLMProperty #PhiladelphiaProject #JuniorMining #ResourceDevelopment #GoldMining

Nevis Brands CEO John Kueber joined Steve Darling from Proactive to share highlights from the company’s first quarter financial results, marking a strong start to the year driven by strategic market expansion and operational efficiencies. Kueber reported that Nevis achieved “close to record revenue” in Q1, with a 61% increase in overall revenue compared to the previous period. This substantial growth was largely fueled by robust performance in New Jersey and Missouri, where the company’s flagship 100mg cannabis beverage line has secured a dominant market share. In addition, Nevis continues to hold a strong foothold in its home state of Washington, maintaining its presence in an increasingly competitive landscape. One of the most notable financial milestones was a record-setting 78% gross margin. Kueber credited this achievement to a year-long focus on optimizing the company’s supply chain and reducing packaging costs. “We’ve really been able to dial in our suppliers,” he said, underscoring Nevis’ lean operational model and its focus on long-term profitability through cost discipline and operational efficiency. Beyond financial performance, Kueber also highlighted the company’s commitment to innovation, particularly the growing success of Happy Apple, a hemp-derived THC beverage. With hemp's federal legality, the product offers a broader path to market entry compared to traditional cannabis-based beverages. This not only enables cross-state distribution but also opens up retail opportunities beyond traditional dispensaries. Looking ahead, Kueber shared that Nevis expects to expand into at least one new U.S. territory in the coming quarter and hinted at additional announcements on the horizon. With its strong financial performance, product innovation, and expanding national footprint, Nevis Brands is positioning itself as a key player in the cannabis beverage market. #proactiveinvestors #nevisbrandsinc #cse #nevi #otcqb #nevif #majorbrand #cannabis #CannabisInvesting #THCDrinks #HappyApple #CannabisStocks #HempTHC #CannabisBeverages #InvestorUpdate #JohnKueber #CannabisNews #CannabisRevenue #DebtReduction #ProactiveInvestors

Valereum Plc head of VLRM Markets Global Adrian Hogg and head of VLRM Markets El Salvador Carmen Ochoa talked with Proactive's Stephen Gunnion about the latest developments at the company. Hogg explained that Valereum is preparing to launch its new RWA trading platform and digital wallet service next month, with a strong pipeline across multiple asset classes including equities, debt, sports, real estate, and arts. He emphasised, "We've been working hard to build a pipeline of various asset classes," highlighting the breadth of initiatives underway. Hogg further noted that the tokenised real-world assets (RWA) sector is rapidly growing, describing El Salvador as the ideal jurisdiction due to government and regulatory alignment. "We have absolute certainty in El Salvador," he said, referencing the supportive environment created by President Bukele's government and the country's adoption of bitcoin as legal tender. Ochoa shared insights into a recent meeting with the US Securities and Exchange Commission (SEC), where she was part of a delegation discussing a cross-border sandbox initiative. She explained, "Through the National Commission of Digital Assets (CNAD), El Salvador is working hard to maintain a digital ecosystem that provides strong consumer protection and transparent regulation." To stay updated on Valereum’s developments, visit Proactive’s YouTube channel for more videos. Don’t forget to like the video, subscribe to the channel, and enable notifications for future content. #ValereumPlc #RealWorldAssets #Tokenization #DigitalAssets #Blockchain #ElSalvador #CryptoRegulation #RWAMarketplace #ProactiveInvestors #DigitalWallet