Santhera Pharmaceuticals provides hope for DMD sufferers with AGAMREE treatment

Hive Digital Technologies Executive Chairman Frank Holmes joined Steve Darling from Proactive to announce a significant milestone amid what he describes as the accelerating AI super cycle: the company has now reached 23 exahash per second (EH/s) in global Bitcoin-mining capacity, representing 283% year-to-date growth and positioning HIVE among the sector’s performance leaders in 2025. Holmes also shared that HIVE has finalized the acquisition of 32.5 additional acres in Grand Falls, New Brunswick, adjacent to its current operations. The expanded site is being developed as a cornerstone Tier III+ high-performance computing (HPC) campus capable of supporting more than 25,000 next-generation GPUs. Powered by renewable energy, the location is strategically aligned with the accelerating demand for hyperscale-ready infrastructure to support global AI deployment. HIVE is rapidly advancing its Tier III+ HPC roadmap across multiple regions. In Boden, Sweden, the company is converting an existing Tier I facility into a liquid-cooled data center that will be able to support 2,000 high-performance GPUs for European AI workloads, targeting a 9-to-12-month deployment timeline — significantly faster than a full greenfield data-center build. In Toronto, the BUZZ data-center acquisition is expected to bring 2,000 GPUs online in 2026, while a new Bell colocation partnership is set to add another 2,000 GPUs over the next nine months. By the end of 2026, HIVE anticipates operating 6,000 next-generation GPUs across these new facilities, complementing its existing fleet of 5,000 GPUs already in operation. With the planned mining-to-HPC conversion at Grand Falls — projected to achieve a power usage effectiveness (PUE) of 1.3 — the site alone could host an additional 25,000 GPUs, giving the company long-term capacity for approximately 36,000 high-performance GPUs globally. Holmes emphasized that HIVE’s strategy is built for the moment: in the AI super cycle, HPC infrastructure is not optional — it is the essential engine driving innovation. #proactiveinvestors #hivedigitaltechnologieslet #tsxv #hive #nasdaq #hive #CryptoMining #GreenEnergy #BuzzHPC #AIInfrastructure #NvidiaH200 #QuebecDataCenter #SustainableTech #GPUCluster #TorontoTech #AITraining #HiveDigital #LiquidCooling #Supercomputing #GreenEnergyAI #Exahash #HighPerformanceComputing

Ocean Power Technologies CEO Philipp Stratmann joined Steve Darling from Proactive to share that the company has been officially certified by the Association for Uncrewed Vehicle Systems International (AUVSI) as a Trusted Uncrewed Maritime Systems Operator Training Provider — marking a key milestone in the formalization and professionalization of uncrewed surface vehicle operations. With this designation, OPT joins a select group of organizations authorized to deliver AUVSI-aligned operator training under the nation’s first industry-led standards framework for uncrewed maritime systems. The programs are designed to serve government, defense, commercial, and academic customers seeking proficiency certification for uncrewed surface vehicle operations. Stratmann explained that training will leverage OPT’s proprietary WAM-V® or Wave Adaptive Modular Vessel platform, valued for its versatility, stability, and adaptability across diverse mission requirements and sea conditions. Courses — which generate a new recurring revenue stream — will be provided at both OPT’s Pacific and Atlantic coastal facilities, as well as directly at customer locations. The AUVSI Trusted UMS Operator Program establishes a unified benchmark for operational competency, ethics, and safety, advancing workforce development and aligning operators with evolving regulatory and security standards across the maritime autonomy sector. Stratmann says becoming a certified training provider enhances U.S. preparedness and supports the rapid growth of defense and commercial applications for uncrewed maritime technologies. #proactiveinvestors #oceanpowertechnologiesinc #nyseamerican #optt #PhillipStratmann, #USGovernmentContract, #OffshoreAutonomy, #MaritimeSecurity, #CommercialPlatforms, #GrowthStrategy, #BuoyBusiness, #VehicleBusiness, #InternationalExpansion, #ReadyToDeploy #AutonomousVehicles #MaritimeTech #CleanEnergySolutions #AUVSI #SustainableTechnology #MarineInnovation #EnergyEfficiency #UncrewedSystems #GlobalExpansion

Santhera Pharmaceuticals chief medical officer Dr Shabir Hasham talked with Proactive's Stephen Gunnion about the company’s progress in launching AGAMREE, a dissociative corticosteroid for Duchenne muscular dystrophy (DMD). Santhera is a Swiss specialty pharmaceutical company focused on treatments for pediatric rare diseases. Its lead product, AGAMREE, aims to offer comparable efficacy to traditional corticosteroids while reducing the debilitating side effects often associated with long-term steroid use in DMD patients. Hasham noted that current treatments are frequently discontinued or reduced after a few years due to growth stunting, weight gain, and other complications. “Our drug AGAMREE is a corticosteroid, but we’ve been able to modify the structure of it… we offer the same efficacy… but we are able to avoid many of the debilitating side effects,” said Hasham. The treatment has already launched in Germany, Austria, and the UK, with further European rollouts expected in the coming months. Commercialisation in the US is underway via a partnership with Catalyst Pharmaceuticals, and entry into China has begun through Spirit Genetics. New long-term data from the Guardian study shows patients treated for up to eight years exhibited no growth stunting and significantly fewer fractures. Hasham said the data may encourage wider use in countries where steroid uptake has been low and added, “This will make a very positive impact in terms of our ability to roll the drug out.” For more interviews like this, visit Proactive’s YouTube channel. Don’t forget to like the video, subscribe to the channel, and turn on notifications so you never miss an update. #SantheraPharmaceuticals #AGAMREE #DuchenneMuscularDystrophy #RareDiseaseTreatment #PediatricHealth #SteroidAlternatives #PharmaNews #BiotechUpdates #HealthcareInnovation #ProactiveInvestors

Trust Stamp EVP John Bridge joined Steve Darling from Proactive to announce a new cryptocurrency and tokenized-asset initiative anchored by the company’s biometrically validated, quantum-secure TSI Wallet. The wallet will function as both a non-custodial digital wallet and a “wallet of wallets,” enabling secure management of multiple assets in a single interface. A waitlist is now open, with commercial availability expected January 1, 2026. Bridge highlighted a growing challenge in the digital asset sector: inaccessible or abandoned wallets. An estimated 2.3–3.7 million Bitcoin are believed to be permanently lost due to misplaced or unrecoverable wallet credentials. In custodial wallets, recovery processes can mirror standard online password-reset workflows, requiring identity validation to regain access. However, non-custodial wallets rely solely on a seed phrase, meaning that if it is lost, forgotten, or never passed on to beneficiaries, the assets may be irretrievable. In addition to the issue of asset loss, fraud and credential compromise remain major threats. Bridge noted that with the rapid global expansion of stablecoins, the scale and sophistication of criminal activity is expected to grow. The TSI Wallet is designed to ensure the legitimate owner — or an authorized beneficiary — must biometrically approve every transaction, improving both security and rightful recovery. Trust Stamp also plans to introduce patented technology enabling tokenized identity attributes to be embedded into digital assets. This feature would support authentication of rightful ownership and enable meaningful KYC/AML compliance while still preserving user privacy. #proactiveinvestors #truststamp #nasdaq #idai #IdentityTech #DigitalIdentity #Fintech #GhanaID #SouthKoreaStartup #AsiaExpansion #KStartupChallenge #FinancialServices #Biometrics #TechExpansion #ProactiveInvestors #AndrewGowasack #wallet #TSI3 wallet #biometrics #DigitalIdentity #CryptoWallet #BiometricWallet #StableIT2 #DeFiSecurity #KYC #CryptoRecovery #LostCryptoKeys #Stablecoin #BlockchainTechnology #Web3

Meren Energy Inc (TSX:MER, OTCQX:MRNFF) investor relations manager Shahin Amini talked with Proactive's Stephen Gunnion about the company’s upgrade from the OTC Pink to the OTCQX market, describing it as a strategic move to enhance investor outreach and market visibility. Amini said the upgrade supports Meren’s broader plan for active engagement with investors, following the company’s earlier consolidation and rebranding from Africa Oil. “The upgrade from OTC Pink to OTCQX is a very important step in our investor relations and communication plans,” he told Proactive. He explained the move is designed to boost visibility with brokers, funds and retail platforms in the US, leveraging the presence OTCQX provides on high-tier market data systems. Amini noted that OTCQX offers many of the benefits of a full listing but at a lower cost and regulatory burden, while still relying on Meren’s existing Canadian disclosure standards. Looking ahead, he flagged the upcoming Q3 results, set to be published on 13 November, with potential for another quarterly dividend—bringing the total for the year to $100 million if approved. Operational catalysts include infill drilling in Nigeria, a potential final investment decision on the Preowei project, and a high-impact exploration opportunity in Namibia. He also highlighted progress on farm-down efforts in Equatorial Guinea. Visit Proactive's YouTube channel for more company updates, and don’t forget to like the video, subscribe to the channel, and turn on notifications for future content. #MerenEnergy #OTCQX #OilAndGas #NigeriaOil #NamibiaExploration #EquatorialGuinea #InvestorRelations #DividendStocks #USInvestors #EnergyStocks #OilExploration #OTCMarkets #CapitalMarkets

Buccaneer Energy Plc CEO Paul Welch talked with Proactive's Stephen Gunnion about the company’s latest operational updates in East Texas, including the spudding of the Allar #1 well and its plans to monetise associated gas via Bitcoin mining. Welch explained that Buccaneer expects the Allar #1 well to perform similarly to its previous Fouke 1 and Fouke 2 wells. While the gross production could reach 140 barrels per day, the field allowable limits it to 120 barrels daily, translating to a net 40 barrels per day for Buccaneer. At a WTI price of $60 per barrel, this would yield approximately $55,000 in monthly revenue for the company. Welch noted that the company had raised £500,000 to advance a strategic Bitcoin mining project in the Pine Mills field. The field's unique gas profile means gas volumes are insufficient to justify traditional takeaway infrastructure. Instead, Buccaneer plans to generate electricity onsite and use it to power a Bitcoin mining operation, potentially producing an additional $75,000 in monthly free cash flow if the company owns the full value chain. "This is essentially turning what is currently a kind of waste product into a revenue stream," Welch said, adding that it could also relieve back pressure on existing wells, enabling higher production rates. He highlighted that the company is open to partnering with firms experienced in Bitcoin mining to manage the infrastructure, equipment, and operations. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #BuccaneerEnergy #BitcoinMining #OilAndGas #EnergyTransition #TexasOil #StrandedGas #AllarWell #CryptoMining #EnergyInnovation #OilProduction #FreeCashFlow #OilInvesting

American Resources Corp CEO Mark Jensen joined Steve Darling to discuss a major development involving the company’s affiliated entity, ReElement Technologies Corporation. ReElement has entered into a $1.4 billion strategic partnership with the U.S. Department of War’s Office of Strategic Capital to accelerate the build-out of a 100% domestically sourced and vertically integrated rare earth magnet supply chain in the United States. The landmark initiative supports the expansion of ReElement’s collaboration with Vulcan Elements, combining critical materials processing with metallization and magnet manufacturing — capabilities currently dominated by foreign supply chains. Jensen noted that this partnership represents a transformational step toward national independence in rare earth magnet production, especially for NdFeB magnets, which are essential for defense systems, clean energy technologies, and electric vehicles. Under the OSC commitment, two major capital allocations will be deployed, each matched by private-sector investment. $620 million has been designated for Vulcan Elements and $80 million directed to ReElement Technologies This funding will fuel the scale-up of advanced processing infrastructure across both companies, enabling the U.S. to reach 10,000 metric tonnes of NdFeB magnet production capacity. According to Jensen, this expansion will dramatically narrow the current U.S. supply gap and reposition the country as a competitive force in rare earth industrial production. As part of the financing arrangement, the U.S. Department of War will receive warrants in ReElement Technologies, strengthening government alignment with the success of the program. The OSC loans are backed by the One Big Beautiful Bill Act, federal legislation providing up to $100 billion in lending to accelerate domestic production of critical minerals and advanced materials, including those considered vital to U.S. national security and industrial resilience. #proactiveinvestors #americanresourcescorporation #nasdaq #arec #SustainableMining, #MineralRefining, #RecyclingInnovation, #CriticalMinerals, #RareEarthRecycling, #EVRecycling, #BatteryRecycling, #princialminerals #adamjohnson #RareEarths #EWasteRecycling #ReElement #CriticalMinerals #SustainableTech #MagnetRecycling #TechInnovation #GreenSupplyChain #ElectrifiedMaterials

First Phosphate Corp. CEO John Passalacqua joined Steve Darling from Proactive to share a significant milestone in the company’s capital markets strategy, announcing that its common shares are now listed for trading on Tradegate Exchange in Germany using “KD0”. This expanded trading access will enable European investors to buy and sell First Phosphate shares during regular EU market hours and extended trading windows across multiple European time zones. Passalacqua says the new listing is designed to increase visibility, accessibility, and international shareholder participation as the company advances its role in securing the North American and European lithium iron phosphate (LFP) battery supply chain. The Tradegate listing complements as to the company’s other existing public market presence on the Canadian Securities Exchange, OTCQX, and Frankfurt Stock Exchange. Tradegate, known for supporting globally focused companies, offers another platform for European investors who share First Phosphate’s mission to onshore critical battery materials and reduce supply-chain reliance on offshore phosphate sources. Passalacqua highlighted that the company recently achieved a major technological breakthrough, producing commercial-grade LFP 18650 battery cells made entirely from North American critical minerals. These cells were manufactured using high-purity phosphoric acid and iron powder derived from rare igneous anorthosite rock at the company’s Bégin-Lamarche property in Quebec — underscoring First Phosphate’s ability to deliver a fully integrated and localized LFP cathode supply chain solution. #proactiveinvestors #firstphosphatecorp #cse #phos #otcqx #frspf #frspf #phosphate #CriticalMinerals #BatteryMaterials #LFPCathode #FirstPhosphate #CanadaMining #GreenEnergy #SupplyChain #QuebecMining #EVBatteries #dod

BioHarvest Sciences CEO Ilan Sobel joined Steve Darling from Proactive to announce a significant milestone — a strategic Contract Development and Manufacturing Organization agreement with Saffron Tech, an agritech leader pioneering advanced and scalable saffron cultivation. The collaboration is focused on developing and commercializing saffron-derived botanical compounds using BioHarvest’s patented Botanical Synthesis™ platform. Under the partnership structure, Saffron Tech will own 75% of any newly developed saffron compositions and their associated IP and commercialization rights, while BioHarvest will retain a 25% stake. Sobel explained that once development is completed, BioHarvest plans to leverage its large-scale production capabilities to manufacture the compound for a new line of saffron-based nutraceutical products, sold directly through its consumer channels. These formulations will aim to harness saffron’s well-established functional benefits, including support for cognitive performance, eye health, mood balance, and antioxidant activity. Saffron Tech brings a groundbreaking production model to the partnership. It is the first company to successfully produce multiple cycles of premium-grade saffron year-round, rather than relying on traditional seasonal farming. This innovation is especially impactful given saffron’s market dynamics — it is widely known as the world’s most expensive spice, commonly priced above $10,000 per kilogram due to high labor intensity and limited global supply, with Iran accounting for more than 80% of current production. Alongside the partnership announcement, Sobel provided a business update, reporting preliminary unaudited Q3 2025 revenue guidance of approximately $9.1 million, aligned with management expectations. Unaudited adjusted EBITDA is projected between ($0.7M) and ($0.4M) for the quarter, while cash and cash equivalents as of September 30, 2025 total approximately $11 million, supporting continued operational and commercialization progress. Sobel emphasized that the collaboration with Saffron Tech marks an exciting entry into a new, high-value market segment and further demonstrates BioHarvest’s ability to apply its Botanical Synthesis™ technology to multiple natural compounds with strong consumer demand and health-driven applications. #proactivinvestors #nasdaq #bhst #pharma #biotech #hearthealth #BioHarvestSciences, #IlanSobel, #Vinia #SportsNutrition #Resveratrol #InformedSport #AthleteWellness #FunctionalFoods #DailySupplements #BloodFlowSupport #HydrationMarket #PlantBasedInnovation #SaffronTech #SuperSaffron #BotanicalSynthesis #Nutraceuticals

Trust Stamp President Andrew Gowasack joined Steve Darling from Proactive to share that the company has been selected to join Founders Arena, a premier accelerator program that supports emerging innovators in the rapidly growing WealthTech sector. Gowasack noted this milestone comes as Trust Stamp surpasses its 100th financial institution client, a reflection of increasing demand for advanced identity protection and secure authentication across the wealth management industry. He emphasized that wealth advisors face many of the same evolving fraud risks as banks and insurance providers — particularly because they oversee high-value, high-profile accounts that are attractive to cybercriminals. Recent incidents highlight how sophisticated attacks have become. In February 2024, a global financial firm suffered a $25 million loss after staff were deceived by a deepfake impersonating the company’s CFO on a video call. According to JP Morgan Wealth Management, fraud losses exceeded $16.6 billion in 2024, up 33% year-over-year, driven largely by AI-enabled scams and targeted social engineering. As Gowasack explained, Trust Stamp’s technology is built specifically to combat these new forms of digital identity manipulation, delivering enterprise-grade security without compromising user privacy. Founders Arena also highlighted a point of pride: this cohort welcomes its first founder from Arlington, Texas, the accelerator’s hometown. Gowasack said joining Founders Arena will provide meaningful support for Trust Stamp’s continued growth in the WealthTech industry, accelerating the deployment of innovative fraud-prevention solutions at a time when financial institutions are urgently seeking stronger defenses. #proactiveinvestors #truststamp #nasdaq #idai #IdentityTech #DigitalIdentity #Fintech #GhanaID #SouthKoreaStartup #AsiaExpansion #KStartupChallenge #FinancialServices #Biometrics #TechExpansion #ProactiveInvestors #AndrewGowasack