Clinical Reasoning: Rapidly Progressive Cranial Neuropathies, Weakness, and Ataxia in a Patient With MS

Dr. Aaron Zelikovich discusses how gefurulimab may offer an effective and convenient treatment option for adults with generalized myasthenia gravis. Show citation: Gwathmey KG, Saccà F, Howard JF Jr, et al. Efficacy and Safety of Gefurulimab in Generalized Myasthenia Gravis: The PREVAIL Phase 3 Randomized Clinical Trial. JAMA Neurol. 2026;83(9):841-850. doi:10.1001/jamaneurol.2026.2333 

Dr. Andy Southerland and Dr. Matthew Gusler discuss how emergent interfacility transfers for ischemic stroke have changed and the factors associated with which patients are transferred.  Show citation: Gusler MT, Deligkaris C, Zha AM, Burke JF. Trends in Emergent Interfacility Ischemic Stroke Transfers, 2016-2022. Neurology. 2026;107(7):e218499. doi:10.1212/WNL.0000000000218499

Dr. Zohaib Siddiqi and Dr. Michel Toledano discuss the diagnosis and management of infectious rhombencephalitis in patients receiving immunomodulatory therapy. Show citation: Trentadue T, Martinez Sosa S, Itoh CY, et al. Clinical Reasoning: A 30-Year-Old Female Patient With Multiple Sclerosis Presenting With Rapidly Progressive Cranial Neuropathies, Weakness, and Ataxia. Neurology. 2025;105(12):e214429. doi:10.1212/WNL.0000000000214429 

Dr. Tesha Monteith shares practical tips for improving outcomes for patients with episodic cluster headache.

Dr. Tesha Monteith discusses growing evidence supporting CGRP-targeted therapies as first-line preventive treatment options for people with migraine. Show citation:  Reuter U, Dycke AV, Versijpt J, et al. Tolerability, safety, and efficacy of atogepant versus topiramate in adults with migraine (TEMPLE): a randomised, head-to-head, phase 3b trial. Lancet Neurol. 2026;25(9):806-817. doi:10.1016/S1474-4422(26)00214-0 

Dr. Casey Kozak discusses why most patients referred with seronegative NMOSD ultimately receive alternative diagnoses, underscoring the challenges of accurate diagnosis in antibody-negative cases.  Show citation: Lang MV, Welk GM, Tajfirouz DA, et al. Unveiling Misdiagnosis: Rethinking Seronegative NMOSD. Mult Scler. 2025;31(11):1381-1384. doi:10.1177/13524585251360648 

Dr. Katie Krulisky and Dr. Kelsey Smith discuss the impact of menopause on women with epilepsy, including therapeutics and clinical management during midlife. Show citation:  Smith KM, Faubion SS, Vadlamudi L, et al. The Menopause Transition and Epilepsy: A Focus on Therapeutics. Neurol Clin Pract. 2026;16(5):e200650. doi:10.1212/CPJ.0000000000200650

Dr. Katie Krulisky and Dr. Kelsey Smith discuss the impact of menopause on women with epilepsy, including therapeutics and clinical management during midlife. Show citation:  Smith KM, Faubion SS, Vadlamudi L, et al. The Menopause Transition and Epilepsy: A Focus on Therapeutics. Neurol Clin Pract. 2026;16(5):e200650. doi:10.1212/CPJ.0000000000200650

Dr. Casey Kozak discusses a new scoring system for MOGAD identification.  Show citation: Vilaseca A, Filippatou AG, Said Y, et al. TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-IgG Test Results. Neurol Neuroimmunol Neuroinflamm. 2026;13(5):e200617. doi:10.1212/NXI.0000000000200617 

Dr. Hailey Katulski discusses limb compression therapy and chemotherapy-induced peripheral neuropathy in women with gynecologic cancers.  Show citation: Başkurt K, Uyar GC, Yeşilbaş E, et al. Limb Compression Therapy and Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self-Controlled Study(NEURO-GLOVE Trial). Int J Cancer. 2026;159(9):2300-2313. doi:10.1002/ijc.70601