S3E6: From lab to jab - How to make a vaccine

Join Amy and Karl as they reflect on the LSHTM Viral season 3. They discuss how far have we come with vaccinations worldwide and key takeaways from the expert discussions throughout the season. Thank you to all the experts who appeared on the podcast and the dedicated LSHTM Viral listeners that helped LSHTM Viral win a Gold CASE Award for Digital Communications (Frequent Podcast Category). Goodbye for now!

In this episode of LSHTM Viral, Karl Byrne speaks with Beate Kampmann, Professor of Paediatric Infection & Immunity and Director of the Vaccine Centre at the London School of Hygiene & Tropical Medicine. They delve into the future of vaccines, our perception of risk and how vaccination programmes are going to be monitored in the future. Beate answers burning audience questions including, “Is the COVID-19 vaccine safe for pregnant women?”. You can find the LSHTM vaccine tracker here: https://vac-lshtm.shinyapps.io/ncov_vaccine_landscape/

The explosive COVID-19 outbreak in India has shone a striking light on one of the biggest moral issues of our time - vaccine equity. Subsequent halting of vaccine exports is severely affecting Africa and developing countries, and although 1.9 billion doses have been administered globally, many developing countries are yet to receive a single dose. In this episode we are joined by two global health leaders, Professor Peter Piot and Dr. Ayoade Alakija, who discuss vaccine nationalism, COVID-19 in Africa, and possible routes to improving health equity in the future.

How do countries get access to COVID-19 vaccines in the first place? In this episode, Prof Daniel Bausch of LSHTM shares his thoughts on the global vaccine purchasing and distribution systems. An expert in the control of emerging viruses, Dan also discusses with host Naomi Stewart what the focus on COVID-19 means for other vaccination programmes and trials, how the pandemic may end, and how prepared we will be for future epidemics and pandemics. If you would like to get in contact with the team, or if you have a question you would like to ask our experts, you can email us: [email protected].

This week, Karl Byrne talks about the latest vaccination figures as well as other breaking COVID-19 news, including an exciting citizen science project where over the last year gamers playing EVE Online- a massively multiplayer online role-playing game, have carried out real world research that would have taken scientists over 330 years to complete. In our main feature, Karl tells the incredible story of how the Pfizer-BioNTech is manufactured. The journey begins with a small, frozen tube of viral DNA in a facility in America's Midwest, involves travelling across states, and even continents, ending almost 2 months later with millions of doses of vaccine ready to be shipped to vaccination centres across the USA, Europe and beyond. If you would like to get in contact with the team, or if you have a question you would like to ask our experts, you can email us: [email protected]  Background music for the main feature is from MaxKoMusic

Who are the experts and groups around the world approving and regulating the new COVID-19 vaccines? And what do they need to consider amidst the urgency of vaccinating the world? In this episode ahead of World Immunization Week, Naomi Stewart speaks to Prof Annelies Wilder-Smith from the London School of Hygiene & Tropical Medicine. Prof Smith sits on WHO’s Strategic Advisory Group of Experts on Immunization, and walks us through the decisions involved in approving different vaccines - and how it could happen so quickly. If you would like to get in contact with the team, or if you have a question you would like to ask our experts, you can email us: [email protected]

In this episode we explore the crucial stages of clinical trials and testing vaccines. How do clinical trials account for different demographics? How do we know vaccines are safe for everyone? We are joined by Dr Ed Parker, Research Fellow at the London School of Hygiene & Tropical Medicine and member of the Vaccine Centre. Ed walks us through the purpose of a clinical trial and its roots in ancient history, and provides insight behind LSHTM’s vaccine tracker. Link to LSHTM short course on clinical trials: https://www.lshtm.ac.uk/study/courses/short-courses/clinical-trials

Vaccines have arguably made the greatest contribution to global health of any human intervention apart from the introduction of clean water and sanitation. With new vaccines being developed at an incredible rate to tackle the current pandemic, we take a look at how vaccines work and what goes into each shot. Karl is joined by Helen Fletcher, Professor of Immunology at LSHTM, to take a look at what goes into a vaccine, how you design one and how the COVID-19 vaccines were created so quickly and safely. They also dispel some of the myths floating around about vaccines. Professor Beate Kampmann, Director of the Vaccine Centre at LSHTM, also stops by to answer some questions sent in by you, our listeners. You can find the video on vaccine safety that Karl and Beate talk about here. Learn more about the Vaccine Centre here. If you would like to get in contact with the team, or if you have a question you would like to ask our experts, you can email us: [email protected]

How did vaccines come to be and how have they changed over time? In today's episode, Naomi Stewart speaks to historian Dr Gareth Millward from the University of Warwick, on the history of vaccines and how vaccination programmes have evolved in the 20th century. Professor Liam Smeeth from the London School of Hygiene & Tropical Medicine then walks us through the vaccine landscape at the turn of the 21st century, and public perceptions and attitudes towards vaccination in a COVID-19 world.

Welcome back to a new season of LSHTM Viral, where we will be taking a deep-dive into vaccines and speak to experts working real-time on COVID-19. LSHTM modeller Roz Eggo reacts to the UK’s roadmap announcement on 22 February for easing lockdown restrictions, explaining the science behind the government's decision and how vaccination will forge a way out of the pandemic. John Edmunds, a UK government science advisor and professor of infectious disease at LSHTM discussed how new, potentially dangerous variants of the virus can emerge and key considerations for vaccination at this scale.