Future of Business: Moderna’s Founder on Innovation That Breaks Through

What are CEOs across industries doing to build resilience and strong cultures in an age of uncertainty? In this Future of Business series, IdeaCast hosts Alison Beard and Adi Ignatius sat down with four leading CEOs to understand where global business is going. In this episode, host Alison Beard speaks with Noubar Afeyan, the CEO of Flagship Pioneering and Chairman of Moderna. Afeyan shares the organizational models and practices that work best to produce innovation, the difference between managing risk and managing uncertainty, and what separates true breakthrough innovation from everyday, incremental improvements.

It's harder than ever for companies to get their marketing messages in front of the right customers. One increasingly popular -- but also risky -- tactic is fastvertising, the rapid development of ads that tap into a cultural moment, aiming to increase brand relevance and awareness. Harvard Business School associate professor Ayelet Israeli shares pitch-perfect examples, including those from her coauthor, the actor Ryan Reynolds, and his marketing firm Maximum Effort. She explains the importance of timing, describes the talent, culture, and processes you need to succeed, and outlines how to extend the impact of these ads. Ayelet, along with Leonard Schlesinger, Matt Higgins, and Ryan Reynolds, wrote the HBR article "Marketing at the Speed of Culture."

Even in difficult times, leadership must be about empathy, authenticity, fairness and service. That's according to Darren Walker, the outgoing CEO of the Ford Foundation, a nonprofit with an endowment of billions of dollars and a charge to reduce poverty and injustice. Drawing on his own upbringing in rural Texas to his time at the helm of one of the world’s largest philanthropies, Walker explains how inequality erodes hope, why discomfort is essential for meaningful change, and how leaders can build the courage to speak honestly.

In uncertain times, leaders at all levels can learn from what the world's best CEOs are doing to protect themselves and forge a path ahead. In this Future of Business series, IdeaCast hosts Alison Beard and Adi Ignatius sat down with four leading CEOs who manage across different industries and geographies to understand where global business is going. In this episode, host Adi Ignatius speaks with Walmart CEO Doug McMillon, who since announced he'll be retiring in early 2026. They discuss how the world's largest company makes it through global disruption and supply chain shocks, their ongoing digital transformation including the implementation of AI, and how McMillon aims to stay close to the original purpose of the company.

Geopolitics are no longer a tailwind for businesses today, opening markets and boosting global trade. Instead, argues ESSEC Business School associate professor Srividya Jandhyala, rising national security concerns and protectionist economic policies have created a headwind for many organizations, and that's changing how executives need to operate. She explains what’s changed in the global balance of power, how it's affecting even small to medium-sized companies and unexpected industries —from shrimp farming to fast fashion -- and why leaders need new talent and risk management strategies to adapt. Jandhyala is the author of the book The Great Disruption.

In uncertain times, leaders at all levels can learn from what the world's leading CEOs are doing to protect their companies from risk and forge a path forward. In this Future of Business series, IdeaCast hosts Alison Beard and Adi Ignatius interview four chief executives from different industries and geographies to better understand where global business is going. In this episode, Alison speaks with Sim Tshabalala, the CEO of Standard Bank. He explains how his childhood in apartheid South Africa informed his decision to go into finance, why purpose drives the company's approach to everything from strategy to customer service, and the role he believes businesses like his must play in promoting sustainable growth.

Leadership takes daring and steadfastness even in the best of times. In eras of shaky political, economic, and social stability, researcher and author Brené Brown argues it is more important than ever to stay true to your values, make thoughtful decisions, and avoid succumbing to external pressures. The podcast host and University of Houston research professor shares what she's learned in her latest studies and explains how to avoid reactivity as an organizational leader navigating a distrusting and disconnected world. Brown is author of Strong Ground: The Lessons of Daring Leadership, the Tenacity of Paradox, and the Wisdom of the Human Spirit.

It isn't always easy to feel like you can have it all: career, family, hobbies and inner peace. Harvard professor Arthur C. Brooks studies happiness and says it is a direction, not a destination. Brooks believes happiness is especially important for leaders, as the higher you climb the more stressful the job can get - and the wider impact you can have on others. Live in conversation at Harvard Business School's Klarman Hall, he speaks with IdeaCast host and HBR editor at large Adi Ignatius about the importance of empathy and having a greater purpose in your life, not just in your career. Brooks is author of the book The Happiness Files: Insights on Work and Life.

When Wikipedia was founded in 2001, the idea that people around the world could come together to create an accurate online encyclopedia covering virtually any topic seemed far-fetched. But today many people see the website as a trusted source of well-curated and -cited information. That's because of careful decisions that its leaders made about how to operate. Cofounder Jimmy Wales explains how introducing a simple purpose, insisting on certain rules of engagement, and other strategies helped the organization to build trust with contributors and users -- and maintain it even in a world bombarded by misinformation. Wales is the author of The Seven Rules of Trust: A Blueprint for Building Things That Last.

When you hit a roadblock in your career, it's easy to blame external factors like the economy, the organization, or your boss. But leaders are just as often stymied by their own beliefs about how they need to show up and operate at work, shares executive coach Muriel Wilkins. Through decades of work counseling high-powered executives, she's uncovered the seven main ways that people limit their own success and has advice on how to overcome those mental blocks. Wilkins is author of the HBR article "The Hidden Beliefs That Hold Leaders Back" and the book Leadership Unblocked: Break Through the Beliefs That Limit Your Potential.