
In this episode of The Evolution of Medicine, host James Maskell interviews registered dietitian Ashley Koff about her new book Your Best Shot. The conversation explores the seismic impact of GLP-1 agonists like Ozempic and Wegovy—and how functional medicine can pivot from a "weight loss" mindset to a "weight health" approach.
Koff reframes these medications not as magic bullets, but as biosimilar hormone replacement tools that "switch on" receptor sites—without repairing the underlying ecosystem. She outlines a five-part Weight Health Hormone assessment and introduces a Physician–Dietitian–Health Coach triad to ensure sustainable outcomes.
The episode challenges practitioners to stay "agnostic about the agonist" and instead focus on metabolic repair, patient education, and structured team-based care.
About the Guest:
Ashley Koff, RD is a registered dietitian and functional nutrition expert focused on metabolic health, personalized nutrition, and hormone signaling. She is the author of Your Best Shot and advocates for a "Weight Health" approach that integrates assessment, repair, and team-based implementation.
Ashley Koff, RD
Instagram: https://www.instagram.com/ashleykoffapproved/?hl=en
Facebook: https://www.facebook.com/ashleykoffapproved/
Linkedin: https://www.linkedin.com/in/ashley-koff/
James Maskell
Website: https://www.jamesmaskell.com/
Instagram: https://www.instagram.com/mrjamesmaskell
Facebook: https://www.facebook.com/jamesedwardmaskell/
LinkedIn: https://www.linkedin.com/in/jamesmaskell
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